Patents by Inventor Yat S. Or
Yat S. Or has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20090304629Abstract: The present invention relates to compounds of Formula I, II or III, or a pharmaceutically acceptable salt, ester, or prodrug, thereof: wherein W is a substituted or unsubstituted heterocyclic ring system. The compounds inhibit serine protease activity, particularly the activity of hepatitis c virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis c virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.Type: ApplicationFiled: January 9, 2009Publication date: December 10, 2009Inventors: Zhenwei Miao, Ying Sun, Suanne Nakajima, Datong Tang, Frank Wu, Guoyou Xu, Yat S. Or, Zhe Wang
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Patent number: 7601709Abstract: The present invention relates to compounds of Formula I, II or Ill, or a pharmaceutically acceptable salt, ester, or prodrug, thereof: wherein W is a substituted or unsubstituted heterocyclic ring system. The compounds inhibit serine protease activity, particularly the activity of hepatitis c virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis c virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.Type: GrantFiled: February 6, 2004Date of Patent: October 13, 2009Assignee: Enanta Pharmaceuticals, Inc.Inventors: Zhenwei Miao, Ying Sun, Suanne Nakajima, Datong Tang, Frank Wu, Guoyou Xu, Yat S. Or, Zhe Wang
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Publication number: 20090018189Abstract: Disclosed herein are compound useful for inhibition of hormone sensitive lipase, pharmaceutical compositions of these compounds, and methods of treatment using these compounds.Type: ApplicationFiled: June 26, 2008Publication date: January 15, 2009Inventors: Jean-Frederic Sauniere, Yat S. Or
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Patent number: 7273851Abstract: The present invention relates to compounds of Formula I, or a pharmaceutically acceptable salt, ester, or prodrug, thereof: which inhibit serine protease activity, particularly the activity of hepatitis c virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis c virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.Type: GrantFiled: May 19, 2004Date of Patent: September 25, 2007Assignee: Enanta Pharmaceuticals, Inc.Inventors: Zhenwei Miao, Ying Sun, Suanne Nakajima, Datong Tang, Zhe Wang, Yat S. Or
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Patent number: 5612350Abstract: Novel macrolide compounds of the formula ##STR1## and pharmaceutically acceptable salts, esters, amides and prodrugs thereof, wherein X is a substituent selected from among radicals having the subformulae ##STR2## and other heterocyclic radicals, as well as pharmaceutical compositions and methods of immunomodulatory treatment utilizing the same.Type: GrantFiled: April 19, 1995Date of Patent: March 18, 1997Assignee: Abbott LaboratoriesInventors: Yat S. Or, Jay R. Luly
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Patent number: 5604294Abstract: Immunomodulatory macrocyclic compounds having the formula ##STR1## and the pharmaceutically acceptable salts, esters, amides and prodrugs thereof, wherein Y is selected from one of the formulae ##STR2## as well as pharmaceutical compositions containing the same and methods of their use.Type: GrantFiled: March 14, 1994Date of Patent: February 18, 1997Inventors: Jay R. Luly, Megumi Kawai, Yat S. Or, Paul E. Wiedeman, Rolf Wagner
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Patent number: 5604234Abstract: Immunomodulatory macrocyclic compounds having the formula: ##STR1## and pharmaceutically acceptable salts, esters, amides and prodrugs thereof, as well as pharmaceutical compositions containing such compounds and therapeutic methods of their use.Type: GrantFiled: September 18, 1995Date of Patent: February 18, 1997Assignee: Abbott LaboratoriesInventors: Yat S. Or, Jay R. Luly
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Patent number: 5599927Abstract: Novel macrolide compounds of the formula ##STR1## and pharmaceutically acceptable salts, esters, amides and prodrugs thereof, wherein X is a substituent selected from among radicals having the subformulae ##STR2## and other heterocyclic radicals, as well as pharmaceutical compositions and methods of immunomodulatory treatment utilizing the same.Type: GrantFiled: December 15, 1995Date of Patent: February 4, 1997Assignee: Abbott LaboratoriesInventors: Yat S. Or, Jay R. Luly
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Patent number: 5563172Abstract: Immunomodulatory macrocyclic compounds having the formula: ##STR1## and pharmaceutically-acceptable salts, esters, amides and prodrugs thereof, as well as pharmaceutical compositions containing the same, which possess immunosuppressive, antimicrobial, antifungal, antiviral, antiinflammatory and antiproliferative activity, as well as the ability to reverse chemotherapeutic drug resistance.Type: GrantFiled: March 14, 1994Date of Patent: October 8, 1996Assignee: Abbott LaboratoriesInventors: Rolf Wagner, Jay R. Luly, Yat S. Or
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Patent number: 5561228Abstract: Immunomodulatory macrocyclic compounds having the formula ##STR1## and pharmaceutically acceptable salts, esters, amides and prodrugs thereof, wherein X is a group having the formula ##STR2## as well as pharmaceutical compositions containing the same.Type: GrantFiled: March 7, 1994Date of Patent: October 1, 1996Assignee: Abbott LaboratoriesInventors: Yat S. Or, Jay R. Luly, Megumi Kawai, Rolf Wagner, Paul E. Wiedeman
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Patent number: 5561137Abstract: Immunomodulatory macrocyclic compounds having the formula: ##STR1## and pharmaceutically acceptable salts, esters, amides and prodrugs thereof,where R.sup.8 and R.sup.9 are selected such that one of R.sup.8 and R.sup.9 is hydrogen and the other is --S(O).sub.s --heterocyclic,as well as pharmaceutical compositions containing such compounds and therapeutic methods of their use.Type: GrantFiled: March 14, 1994Date of Patent: October 1, 1996Assignee: Abbott LaboratoriesInventors: Yat S. Or, Jay R. Luly
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Patent number: 5541193Abstract: Immunomodulatory macrocyclic compounds having the formula ##STR1## and pharmaceutically acceptable salts, esters, amides and prodrugs thereof, wherein one of R.sup.107, R.sup.108, R.sup.109 and R.sup.110 is a radical having the formula ##STR2## as well as pharmaceutically compositions containing such compounds and methods of immunomodulatory therapy utilizing the same.Type: GrantFiled: June 6, 1995Date of Patent: July 30, 1996Assignee: Abbott LaboratoriesInventors: Megumi Kawai, Yat S. Or, Jay R. Luly
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Patent number: 5534632Abstract: Immunomodulatory macrocyclic compounds having the formula: ##STR1## and the pharmaceutically acceptable salts, esters, amides and prodrugs thereof, wherein R.sup.8 and R.sup.9 are selected such that one of R.sup.8 and R.sup.9 is hydrogen, and the other is chosen from the group consisting of:(1) --OC(.dbd.NR.sup.10)-NHR.sup.10 ;(2) --OC(.dbd.O)-R.sup.11 ; and(3) --OC(.dbd.O)-NR.sup.12 R.sup.13 ;(4) --OC(.dbd.O)-N(OR.sup.14)R.sup.12 ;(5) --OC(.dbd.O)-NHNR.sup.12 R.sup.13 ;(6) --OC(.dbd.O)-NH-NHC(.dbd.O)-NR.sup.12 R.sup.13 ;(7) --OC(.dbd.O)-NH-NHS(O).sub.2 --NR.sup.12 R.sup.13 ; and(8) --OC(.dbd.O)-NH-NHC(.dbd.NR.sup.21 )-NR.sup.12 R.sup.13. as well as pharmaceutical compositions containing such compounds and methods for their use in immunosuppressive, antimicrobial, antifungal, antiviral, antiinflammatory and antiproliferative therapy.Type: GrantFiled: March 14, 1994Date of Patent: July 9, 1996Assignee: Abbott LaboratoriesInventors: Yat S. Or, Jay R. Luly
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Patent number: 5527907Abstract: Novel macrolide compounds of the formula ##STR1## and pharmaceutically acceptable salts, esters, amides and prodrugs thereof, processes for the preparation of the compounds of the invention, intermediates useful in these processes, a pharmaceutical composition, and a method of treating immunomodulatory disorders are disclosed.Type: GrantFiled: October 26, 1994Date of Patent: June 18, 1996Assignee: Abbott LaboratoriesInventors: Yat S. Or, Jay R. Luly, Rolf Wagner
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Patent number: 5508397Abstract: Activated macrolactam compounds having the formula ##STR1## wherein n is zero or one, R.sup.101 is selected from the group consisting of methyl, ethyl, allyl, propyl and cyclopropylmethyl;R.sup.102 is hydrogen, and R.sup.103 is selected from the group consisting of hydrogen, hydroxy and a protected hydroxy group or, taken together, R.sup.102 and R.sup.103 form a bond;R.sup.104 and R.sup.105 are chosen such that one is hydrogen while the other is -OS(O).sub.2 F; andR.sup.106 is selected from the group consisting of hydrogen, a protected hydroxy group, loweralkyl, alkenyl, cycloalkyl, aryl and arylalkyl,as well as processes for making such compounds and methods for their use in the preparation of C-32-modified derivatives of ascomycin or the congeners or analogs thereof.Type: GrantFiled: December 16, 1994Date of Patent: April 16, 1996Assignee: Abbott LaboratoriesInventors: Yat S. Or, Jay R. Luly
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Patent number: 5457111Abstract: Immunomodulatory macrocyclic compounds having the formula ##STR1## and pharmaceutically acceptable salts, esters, amides and prodrugs thereof, wherein X is selected from one of the formulae ##STR2## as well as pharmaceutical compositions containing the same.Type: GrantFiled: November 9, 1993Date of Patent: October 10, 1995Assignee: Abbott LaboratoriesInventors: Jay R. Luly, Megumi Kawai, Yat S. Or, Paul Wiedeman, Rolf Wagner
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Patent number: 5395507Abstract: An electrochemical gas sensor comprises sensing and counter electrodes (1,2). A conduit (15) permits access of gas to the sensing electrode (1). An electrolyte reservoir (23). A porous, block-like body (24) is positioned in the reservoir (23) for conveying electrolyte to the sensing and counter electrodes and at least partly supporting other components of the sensor.Type: GrantFiled: November 17, 1993Date of Patent: March 7, 1995Inventors: William J. Aston, Yat S. Chan
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Patent number: 5387671Abstract: Oligopeptide compounds or oligopeptide analogue compounds of the formula A-B-D-E-G-J-L-M-Q are ligands for the anaphylatoxin receptor and are useful in the treatment of inflammatory disease states.Also disclosed are anaphylatoxin receptor ligand compositions and a method for modulating anaphylatoxin activity.Type: GrantFiled: December 27, 1990Date of Patent: February 7, 1995Assignee: Abbott LaboratoriesInventors: Megumi Kawai, Paul Wiedeman, Jay R. Luly, Yat S. Or
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Patent number: 5386011Abstract: Oligopeptide compounds or oligopeptide analogue compounds of the formula A-B-D-E-G-J-L-M-Q are ligands for the anaphylatoxin receptor and are useful in the treatment of inflammatory disease states.Also disclosed are anaphylatoxin receptor ligand compositions and a method for modulating anaphylatoxin activity.Type: GrantFiled: December 27, 1990Date of Patent: January 31, 1995Assignee: Abbott LaboratoriesInventors: Paul E. Wiedeman, Megumi Kawai, Jay R. Luly, Yat S. Or, Rolf Wagner
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Patent number: 5321971Abstract: A gas diffusion control assembly comprises a gas inlet; a restriction to the rate of flow of gas or vapor from the gas inlet in the form of a porous diffusion barrier extending across the gas inlet; and a polythene disc for causing all gas or vapor passing out of the inlet into the diffusion barrier to diffuse through part of the barrier along a path with a lateral outward component relative to the direction of action through the gas inlet.Type: GrantFiled: November 10, 1992Date of Patent: June 21, 1994Assignee: The Governor and Company of the Bank of ScotlandInventors: Bryan S. Hobbs, Yat S. Chan