Patents by Inventor Yataro Ichikawa

Yataro Ichikawa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7033547
    Abstract: An exhaust gas treating an apparatus and a vehicle vehicles equipped with the apparatus, wherein a liquid-including substance having salt including oxygen acid radical of nitrogen is installed in an exhaust gas passage to treat exhaust gas having carbon-containing particles and nitrogen oxides for removal of these harmful components.
    Type: Grant
    Filed: January 18, 2000
    Date of Patent: April 25, 2006
    Inventor: Yataro Ichikawa
  • Patent number: 6270118
    Abstract: An apparatus and a vehicle equipped with the apparatus for preventing slip and keeping a good running on the ground including a road covered with frozen water such as ice and/or snow by cooling a wheel surface of the vehicle and/or a ground surface just in front of a point where the wheel comes into contact therewith by using cold air directly produced by expansion of compressed air in the running of the vehicle in response to change in the vehicle driving condition and further, dealing with a hydroplaning of the wheel on a wet ground surface at not freezing seasons by injection of the compressed air.
    Type: Grant
    Filed: March 18, 1999
    Date of Patent: August 7, 2001
    Inventor: Yataro Ichikawa
  • Patent number: 5576193
    Abstract: A protein having human plasmin inhibiting activity, substantially equivalent reactivity with human plasmin to a human .alpha..sub.2 -plasmin inhibitor derived from plasma, a binding ability to human fibrin about 1/4 to about 1/3 of that of the human .alpha..sub.2 -plasmin inhibitor derived from plasma, and a molecular weight of about 50,000 to about 77,000.
    Type: Grant
    Filed: May 8, 1995
    Date of Patent: November 19, 1996
    Assignee: Teijin Limited
    Inventors: Yoshihiko Sumi, Yataro Ichikawa, Nobuo Aoki, Masami Muramatsu
  • Patent number: 5534255
    Abstract: This invention provides a monoclonal antibody or its fragment specific to a human .alpha..sub.2 -plasmin inhibitor, said antibody having the function of specifically blocking that site of the human .alpha..sub.2 -plasmin inhibitor which inhibits the fibrinolytic activity of plasmin, and of suppressing said fibrinolytic activity inhibiting function of said .alpha..sub.2 -plasmin inhibitor, and also a hybridoma capable of producing the monoclonal antibody. Said monoclonal antibody or its fragment is useful for the immunological determination of a human .alpha..sub.2 -plasmin inhibitor, the separation or recovery of a human .alpha..sub.2 -plasmin inhibitor from a liquid containing the human .alpha..sub.2 -plasmin inhibitor, and the treatment of a thrombotic disease.
    Type: Grant
    Filed: June 17, 1991
    Date of Patent: July 9, 1996
    Assignee: Teijin Limited
    Inventors: Yoshihiko Sumi, Yukiya Koike, Yataro Ichikawa, Nobuhiko Yoshida, Nobuo Aoki
  • Patent number: 5463025
    Abstract: A protein having human plasmin inhibiting activity, substantially equivalent reactivity with human plasmin to a human .alpha..sub.2 -plasmin inhibitor derived from plasma, a binding ability to human fibrin about 1/4 to about 1/3 of that of the human .alpha..sub.2 -plasmin inhibitor derived from plasma, and a molecular weight of about 50,000 to about 77,000.
    Type: Grant
    Filed: January 24, 1994
    Date of Patent: October 31, 1995
    Assignee: Teijin Limited
    Inventors: Yoshihiko Sumi, Yataro Ichikawa, Nobuo Aoki, Masami Muramatsu
  • Patent number: 5369038
    Abstract: In methods for immunologically assaying free lipoprotein associated coagulation inhibitor (hereafter abbreviated as "LACI") in a human inspection sample using a first antibody immobilized on an insoluble carrier and a labeled second antibody, a method for immunological assay of free LACI and a kit therefor wherein(i) any one antibody of the first antibody and the second antibody is a monoclonal antibody recognizing the polypeptide (K3) of the following amino sequence ##STR1## (hereafter referred to as a "K3-antibody"), and (ii) the other antibody is a monoclonal antibody recognizing the polypeptide (K1) of the following amino acid sequence ##STR2## (hereafter referred to as a "K1-antibody").
    Type: Grant
    Filed: October 30, 1992
    Date of Patent: November 29, 1994
    Assignee: Teijin Limited
    Inventors: Yukiya Koike, Koji Suzuki, Yataro Ichikawa
  • Patent number: 5262309
    Abstract: This invention relates to a novel physiologically active polypeptide containing modified amino acids on both terminals at the amino-terminus and the carboxy-terminus in the amino acid sequence of the human tumor neclosis factor (human TNF), a recombinant plasmid containing a DNA region encoding the polypeptide, a recombinant microorganism cell transformed with the recombinant plasmid, a method of producing the polypeptide by cultivating the microorganism cell, a pharmaceutical composition containing the polypeptide and a method of purifying and recovering the polypeptide. The polypeptide in this invention has excellent antitumor activity compared to the human TNF and can be utilized as an active ingredient of a pharmaceutical composition having antitumor activity.
    Type: Grant
    Filed: March 22, 1991
    Date of Patent: November 16, 1993
    Assignee: Teijin Limited
    Inventors: Satoshi Nakamura, Masami Fukuoka, Tsukio Masegi, Kazuo Kitai, Arata Kato, Yataro Ichikawa
  • Patent number: 5221738
    Abstract: cDNA encoding a human .alpha..sub.2 -plasmin inhibitor precursor protein represented by an amino acid sequence from the -39th Met to the 452nd Lys in FIG. 1 of the accompanying drawings; an amino acid sequence of a human .alpha..sub.2 -plasmin inhibitor precursor represented by an amino acid sequence from the -39th Met to the 452nd Lys in FIG. 1 of the accompanying drawings; and genomic DNA encoding a human .alpha..sub.2 -plasmin inhibitor protein which is composed of exons II, III, IV, V, VI, VII, VIII, IX and X in FIG. 4 of the accompanying drawings, said exons being bonded to one another via introns.
    Type: Grant
    Filed: December 9, 1991
    Date of Patent: June 22, 1993
    Assignee: Teijin Limited
    Inventors: Yoshihiko Sumi, Yataro Ichikawa, Masami Murakami, Nobuo Aoki
  • Patent number: 5187067
    Abstract: A method of immunologically determining free human protein S in an assay sample, which comprises contacting a primary antibody fixed to an insoluble solid carrier and a labelled secondary antibody with the assay sample, the primary and secondary antibodies having the property of binding to different epitopes of free human protein S, and one of the primary and secondary antibodies being a monoclonal antibody having the property of not binding to a complex of the human protein S and human complement cofactor C4b-binding protein (C4bp) but specifically binding to the free human protein S.
    Type: Grant
    Filed: March 14, 1991
    Date of Patent: February 16, 1993
    Assignee: Teijin Limited
    Inventors: Yukiya Koike, Kenji Wakabayashi, Yoshihiko Sumi, Yataro Ichikawa
  • Patent number: 5180676
    Abstract: A method of cultivating animal or plant cells, which consists essentially of contacting a cultivation liquor having animal or plant cells suspended therein with a liquid fluorocarbon having molecular oxygen dissolved therein, characterized in that said cultivation liquor forms a continuous suspension phase which has cell densities of at least 4.times.10.sup.6 cells/ml, that said contact is made by feeding said liquid fluorocarbon into the cultivation liquor from above the cultivation liquor such that 1 ml of liquid fluorocarbon has a surface area of about 6 to about 300 cm.sup.2 whereby the liquid fluorocarbon falls downward through the cultivation liquor by gravity, and that said cultivation liquor has a volume of at least about 10 liters.
    Type: Grant
    Filed: March 13, 1991
    Date of Patent: January 19, 1993
    Assignee: Teijin Limited
    Inventors: Yataro Ichikawa, Kimihiko Hamamoto, Michiyuki Tokashiki
  • Patent number: 5101024
    Abstract: The present invention provides an enhancer DNA segment, a gene fragment having (a) the enhancer DNA segment and (b) a structural gene such as human D, V and J gene, and a promoter. A hybrid DNA (1) having a phage DNA fragment from Charon 4A phage vector and human DNA fragments, a Charon 4A phage containing the hybrid DNA (1), a hybrid DNA (2) having a PBR322 fragment and human DNA fragment, a transformant of E. coli C600 strain transformed with the hybrid DNA (2), plasmid pSV2-H1G1 obtained by inserting a human DNA fragment into a vector pSV-2gpt, a transformant of E. coli MC 1000 strain transformed with the plasmid pSV2-H1G1 and a transformant of mouse myeloma cells J558L or NS-1 transformed with the plasmid pSV2-H1G1 are also provided.
    Type: Grant
    Filed: March 21, 1989
    Date of Patent: March 31, 1992
    Assignee: Teijin Limited
    Inventors: Akira Kudo, Satoshi Nakamura, Yoshihiko Sumi, Yataro Ichikawa, Takeshi Watanabe
  • Patent number: 5075236
    Abstract: A method of confirming the diagnosis of Kawasaki disease in a patient which comprises assaying the patient's body fluid for the presence of elevated levels of a substance specifically bound by an anti-tumor necrosis factor monoclonal antibody.
    Type: Grant
    Filed: April 25, 1988
    Date of Patent: December 24, 1991
    Assignee: Teijin Limited
    Inventors: Kenji Yone, Jun Suzuki, Noriyuki Tsunekawa, Arata Kato, Satoshi Nakamura, Tsukio Masegi, Kazuo Kitai, Yataro Ichikawa
  • Patent number: 5028420
    Abstract: A novel physiologically active polypeptide having antitumor activity obtained by improving human tumor necrosis factor (TNF). The amino acid sequence of the polypeptide essentially corresponds to that of human tumor necrosis factor, except that ten amino acids Nos. 1 to 10 are deleted and (Met).sub.n -Arg-Lys-Arg are added to the amino (NH.sub.2)-terminus, where n is 0 or 1. Other amino acid modifications can also be made to the polypeptide while retaining high antitumor activity. The novel polypeptide has less side effects that the natural-type TNF, particularly with respect to cytotoxicity. A a DNA fragment encoding the polypeptide, a recombinant plasmid containing the DNA fragment, a recombinant microorganism cell transformed with the plasmid, a method of producing a novel physiologically active polypeptide using the microorganism cell, and a pharmaceutical composition comprising the polypeptide as an active ingredient are also provided.
    Type: Grant
    Filed: July 26, 1988
    Date of Patent: July 2, 1991
    Assignee: Teijin Limited
    Inventors: Tsukio Masegi, Satoshi Nakamura, Kazuo Kitai, Masami Fukuoka, Kenji Yone, Arata Kato, Jun Suzuki, Noriyuki Tsunekawa, Yataro Ichikawa
  • Patent number: 4935496
    Abstract: A mouse-human chimaeric immunoglobulin heavy chain comprising (a) the amino acid sequence of a mouse immunoglobulin heavy chain variable region and (b) the amino acid sequence of a human immunoglobulin heavy chain constant region and reacting specifically with human common acute lympohocytic leukemia antigen and a chimaeric DNA fragment which encodes the amino acid sequence of the above mouse-human chimaeric immunoglobulin heavy chain.
    Type: Grant
    Filed: December 4, 1985
    Date of Patent: June 19, 1990
    Assignee: Teijin Limited
    Inventors: Akira Kudo, Yushi Nishimura, Yataro Ichikawa, Takeshi Watanabe
  • Patent number: 4902614
    Abstract: A monoclonal antibody which is specific to human protein C which has calcium bound at the gammacarboxyglutamic acid(Gla) domain and does not recognize human protein C which is not bound to calcium at the Gla domain. The monoclonal antibody is used in an immunoassay method for determining human protein C having a Gla domain and in a method for recovering human protein C having a Gal domain.
    Type: Grant
    Filed: December 3, 1985
    Date of Patent: February 20, 1990
    Assignee: Teijin Limited
    Inventors: Kenji Wakabayashi, Yoshihiko Sumi, Yataro Ichikawa, Yoichi Sakata, Jun Mimuro, Nobuo Aoki
  • Patent number: 4902334
    Abstract: A plant metabolism regulating agent comprising as an active ingredient an alpha,beta or beta,gamma-un-saturated carboxylic acid or its derivative. It is useful for controlling the metabolism of a plant, facilitating the growth of a beneficial plant such as cereals by inhibiting the growth of undesirable plants or eradicating them, regulating the growth of a plant and dwarfing a plant.
    Type: Grant
    Filed: October 31, 1984
    Date of Patent: February 20, 1990
    Assignee: Teijin Limited
    Inventors: Shizuo Azuma, Toshiyuki Hiramatsu, Teizo Yamaji, Yataro Ichikawa
  • Patent number: 4855237
    Abstract: Double-stranded DNA characterized by having sequences complementary to a single-stranded DNA which has a molecular size of about 2.67 Kb and is derived from mungbean yellow mosaic virus, and giving the restriction endonuclease cleavage map shown in FIG. 1 of the accompanying drawings; and double-stranded DNA characterized by having sequences complementary to a single-stranded DNA which has a molecular size of about 2.70 Kb and is derived from mungbean yellow mosaic virus, and giving the restriction endonuclease cleavage map shown in FIG. 2 of the accompanying drawings; and hybrid DNAs having the double-stranded DNAs inserted thereinto.
    Type: Grant
    Filed: August 21, 1984
    Date of Patent: August 8, 1989
    Assignee: Teijin Limited
    Inventors: Tsuto Morinaga, Kin-ichiro Miura, Kunitada Shimotohno, Masato Ikegami, Yataro Ichikawa
  • Patent number: 4846877
    Abstract: A plant growth promoter comprising as an active ingredient for plant growth promotion at least one phenylglycine selected from the group consisting of(1) monomeric phenylglycines,(2) N-phenylglycylphenylglycines, and(3) cyclic dimers of phenylglycines.
    Type: Grant
    Filed: May 19, 1987
    Date of Patent: July 11, 1989
    Assignee: Teijin Limited
    Inventors: Shizuo Azuma, Toshiyuki Hiramatsu, Koji Nakagawa, Teizo Yamaji, Yataro Ichikawa
  • Patent number: 4845264
    Abstract: A novel phenoxycarboxylic acid of formula (I) is disclosed. The compound is effective as herbicide for eradicating broad-leaved weeds. A combination of the phenoxycarboxylic acid and a N-phosphonomethylglycine or a glufosinate which is known as a herbicide is very effective for eradicating both broad-leaved weeds and narrow-leaved weeds.
    Type: Grant
    Filed: March 1, 1988
    Date of Patent: July 4, 1989
    Assignee: Teijin Limited
    Inventors: Shizuo Azuma, Toshiyuki Hiramatsu, Koji Nakagawa, Yataro Ichikawa
  • Patent number: H1148
    Abstract: A method of separating activated human protein C, which comprises bringing a mixture containing activated human protein C having a gamma-carboxyglutamic acid (Gla) domain in the presence of a calcium ion into contact with a fixed antibody comprising an insoluble carrier and fixed thereto an antibody to a complex of human protein C and a calcium ion bound to the Gla domain whereby the activated human protein C is captured by the fixed antibody in the form in which the calcium ion is bound to the Gla domain.
    Type: Grant
    Filed: January 3, 1992
    Date of Patent: March 2, 1993
    Inventors: Kenji Wakabayashi, Yoshihiko Sumi, Yataro Ichikawa, Yoichi Sakata, Nobuo Aoki