Patents by Inventor Yawei Ni

Yawei Ni has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7022683
    Abstract: The inventions disclosed herein relate to compositions for the sustained release of pharmacological agents comprising pectins having a combination of both a high molecular weight and a low degree of methoxylation.
    Type: Grant
    Filed: June 3, 1999
    Date of Patent: April 4, 2006
    Assignee: Carrington Laboratories, Inc.
    Inventors: Yawei Ni, Kenneth M. Yates, Ryszard Zarzycki
  • Publication number: 20050084534
    Abstract: In-situ gelation of a pectic substance. Composition, method of preparation, and method of use of a pectin in-situ gelling formulation for the delivery and sustained release of a physiologically active agent to the body of an animal. The pectin can be isolated from Aloe vera.
    Type: Application
    Filed: August 29, 2003
    Publication date: April 21, 2005
    Inventors: Yawei Ni, Kenneth Yates
  • Patent number: 6777000
    Abstract: In-situ gelation of a pectic substance. Composition, method of preparation, and method of use of a pectin in-situ gelling formulation for the delivery and sustained release of a physiologically active agent to the body of an animal. The pectin can be isolated from Aloe vera.
    Type: Grant
    Filed: February 28, 2001
    Date of Patent: August 17, 2004
    Assignee: Carrington Laboratories, Inc.
    Inventors: Yawei Ni, Kenneth M. Yates
  • Publication number: 20030220485
    Abstract: Pectins having a combination of unexpectedly high molecular weights and low degrees of methylation have been isolated. These high molecular weight, low degree of methylation pectins form gels at unexpectedly low concentrations. Such pectins can be obtained by extracting homogenized Aloe Vera plants or portions thereof. These pectins can be used to prepare pharmaceutical compositions comprising pharmacological agents encapsulated in a pectin gel, for application to animals and humans so as to provide controlled release of the pharmacological agent.
    Type: Application
    Filed: April 23, 2003
    Publication date: November 27, 2003
    Applicant: Carrington Laboratories, Inc.
    Inventors: Yawei Ni, Kenneth M. Yates, Ryszard Zarzycki
  • Publication number: 20030147876
    Abstract: A composition combining an extracellular matrix-degrading protease and a growth factor related to epithelial cell functions together without inactivation or degradation of the growth factor by the protease. Preferably, the protease is plasmin/plasminogen or a related one, and the growth factor is KGF or a related one. The combination associates two independent, but synergistic functions essential to the re-epithelialization process or healing process, i.e, stimulating epithelial cell proliferation/differentiation and facilitating its migration by clearing the extracellular matrix components. The combination may be constructed in various ways and can be used to treat wounds or any other disease conditions involving cells of epithelial origin or any other cell types that the growth factor may affect.
    Type: Application
    Filed: January 29, 2002
    Publication date: August 7, 2003
    Applicant: Carrington Laboratories, Inc.
    Inventors: Yawei Ni, Kenneth M. Yates
  • Publication number: 20020119941
    Abstract: In-situ gelation of a pectic substance. Composition, method of preparation, and method of use of a pectin in-situ gelling formulation for the delivery and sustained release of a physiologically active agent to the body of an animal. The pectin can be isolated from Aloe vera.
    Type: Application
    Filed: February 28, 2001
    Publication date: August 29, 2002
    Inventors: Yawei Ni, Kenneth M. Yates
  • Patent number: 6313103
    Abstract: Pectic substance from Aloe Vera and other sources is used as a stabilizer and a delivery vehicle for pectin/heparin-binding proteins, such as pectin/heparin binding growth factors. Aloe pectin, a naturally occurring LM (low methoxyl) pectin, binds to pectin/heparin-binding growth factors, i.e., bFGF, aFGF, and KGF of fibroblast growth factor (FGF) family and TGF-&bgr;1 of transforming growth factor-&bgr; (TGF-&bgr;) family. Commercial LM or HM (high methoxyl) citrus pectins tested did not exhibit any binding activity with bFGF. A weak binding to bFGF was observed with a de-esterified pectin (polygalacturonic acid) prepared from citrus. The binding protected the growth factor from protease digestion. The calcium gel beads prepared with Aloe pectin also bound to these pectin/heparin-binding growth factors. The growth factor could also be encapsulated in the pectin calcium gel and Aloe pectin sodium gel. Pectin/heparin-binding growth factor stabilized by pectin is used for wound healing.
    Type: Grant
    Filed: July 24, 1998
    Date of Patent: November 6, 2001
    Assignee: Carrington Laboratories, Inc.
    Inventors: Yawei Ni, Kenneth M. Yates
  • Patent number: 6274548
    Abstract: Pectic substance from Aloe Vera and other sources is used as a stabilizer and a delivery vehicle for pectin/heparin-binding proteins, such as pectin/heparin binding growth factors. Aloe pectin, a naturally occurring LM (low methoxyl) pectin, binds to pectin/heparin-binding growth factors, i.e., bFGF, aFGF, and KGF of fibroblast growth factor (FGF) family and TGF-&bgr;1 of transforming growth factor-&bgr; (TGF-&bgr;) family. Commercial LM or HM (high methoxyl) citrus pectins tested did not exhibit any binding activity with bFGF. A weak binding to bFGF was observed with a de-esterified pectin (polygalacturonic acid) prepared from citrus. The binding protected the growth factor from protease digestion. The calcium gel beads prepared with Aloe pectin also bound to these pectin/heparin-binding growth factors. The growth factor could also be encapsulated in the pectin calcium gel and Aloe pectin sodium gel. Pectin/heparin-binding growth factor stabilized by pectin is used for wound healing.
    Type: Grant
    Filed: June 4, 1999
    Date of Patent: August 14, 2001
    Assignee: Carrington Laboratories, Inc.
    Inventors: Yawei Ni, Kenneth M. Yates
  • Patent number: 5929051
    Abstract: Pectins from gel and rind cell wall fibers of Aloe vera are extracted, isolated and identified. Two classes of Aloe pectin are obtained: the high-molecular-weight (HMW) pectin and the low-molecular-weight (LMW) pectin. Aloe pectins have a low methoxyl (LM) content. Aloe pectins form gel in the presence of calcium, and they, especially, the HMW pectin, form monovalent cation-based gels at low temperature, which revert back to solution when brought to room temperature. The HMW Aloe pectin-calcium gel is used for controlled release. The monovalent cation-based gel is used as a matrix for storing pharmacological substances and also for antigen and antibody precipitation reaction.
    Type: Grant
    Filed: May 13, 1998
    Date of Patent: July 27, 1999
    Assignee: Carrington Laboratories, Inc.
    Inventors: Yawei Ni, Kenneth M. Yates, Ryszard Zarzycki