Patents by Inventor Yayoi YOSHITOMI

Yayoi YOSHITOMI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pyrazoloquinazolinone antitumor agents
    Patent number: 11192893
    Abstract: Compounds of formula: are useful as antitumor agents. In these compounds, R10 is (a) (C1-C10) hydrocarbyl, (C1-C10)halohydrocarbyl, (C1-C6)hydroxyalkyl, or or R10 is (b) in which Q and A are linkers and Ar is optionally substituted monocyclic or bicyclic aryl or heteroaryl.
    Type: Grant
    Filed: May 18, 2018
    Date of Patent: December 7, 2021
    Assignee: The Rockefeller University
    Inventors: Tarun M. Kapoor, Moriteru Asano, Kazuyoshi Aso, Michael A. Foley, Yoshiyuki Fukase, Hideki Furukawa, Yashuhiro Hirata, Sachie Takashima, Tomohiro Okawa, Yuta Tanaka, Yayoi Yoshitomi
  • CYCLIC DINUCLEOTIDE
    Publication number: 20210137962
    Abstract: The present disclosure provides a compound having a STING agonistic activity, which may be expected to be useful as an agent for the prophylaxis or treatment of STING-related diseases. The present disclosure relates to a compound represented by the formula (I): wherein each symbol is as defined in the description, or a salt thereof.
    Type: Application
    Filed: November 9, 2018
    Publication date: May 13, 2021
    Inventors: Masato Yoshikawa, Morihisa Saitoh, Taisuke Kato, Yayoi Yoshitomi, Tomohiro Seki, Yasuo Nakagawa, Yusuke Tominari, Masaki Seto, Akito Shibuya, Kosuke Hidaka, Zenyu Shiokawa, Yoshihisa Nakada, Michiyo Mochizuki
  • PYRAZOLOQUINAZOLINONE ANTITUMOR AGENTS
    Publication number: 20200148687
    Abstract: Compounds of formula: are useful as antitumor agents. In these compounds, R10 is (a) (C1-C10) hydrocarbyl, (C1-C10)halohydrocarbyl, (C1-C6)hydroxyalkyl, or or R10 is (b) in which Q and A are linkers and Ar is optionally substituted monocyclic or bicyclic aryl or heteroaryl.
    Type: Application
    Filed: May 18, 2018
    Publication date: May 14, 2020
    Applicant: The Rockefeller University
    Inventors: Tarun M. KAPOOR, Moriteru ASANO, Kazuyoshi ASO, Michael A. FOLEY, Yoshiyuki FUKASE, Hideki FURUKAWA, Yashuhiro HIRATA, Sachie TAKASHIMA, Tomohiro OKAWA, Yuta TANAKA, Yayoi YOSHITOMI
  • CYCLIC DINUCLEOTIDE
    Publication number: 20190192549
    Abstract: The present disclosure provides a compound having a STING agonistic activity, which may be expected to be useful as an agent for the prophylaxis or treatment of STING-related diseases. The present disclosure relates to a compound represented by the formula (I): wherein each symbol is as defined in the description, or a salt thereof.
    Type: Application
    Filed: November 9, 2018
    Publication date: June 27, 2019
    Inventors: MASATO YOSHIKAWA, Morihisa Saitoh, Taisuke Kato, Yayoi Yoshitomi, Tomohiro Seki, Yasuo Nakagawa, Yusuke Tominari, Masaki Seto, Yusuke Sasaki, Masanori Okaniwa, Tsuneo Oda, Akito Shibuya, Kosuke Hidaka, Zenyu Shiokawa, Shumpei Murata, Atsutoshi Okabe, Yoshihisa Nakada, Michiyo Mochizuki, Brian Scott Freeze, Taisuke Tawaraishi, Yasufumi Wada, Paul D. Greenspan
  • Aromatic compounds with GPR40 agonistic activity
    Patent number: 9776962
    Abstract: Provided is a novel aromatic ring compound having a GPR40 agonist activity and a GLP-1 secretagogue action. A compound represented by the formula: wherein each symbol is as described in the DESCRIPTION, or a salt thereof has a GPR40 agonist activity and a GLP-1 secretagogue action, is useful for the prophylaxis or treatment of cancer, obesity, diabetes, hypertension, hyperlipidemia, cardiac failure, diabetic complications, metabolic syndrome, sarcopenia and the like, and affords superior efficacy.
    Type: Grant
    Filed: August 8, 2014
    Date of Patent: October 3, 2017
    Assignee: TAKEDA PHARMACEUTICAL COMPANY LIMITED
    Inventors: Jumpei Aida, Yayoi Yoshitomi, Yuko Hitomi, Naoyoshi Noguchi, Yasuhiro Hirata, Hideki Furukawa, Akito Shibuya, Koji Watanabe, Yasufumi Miyamoto, Tomohiro Okawa, Nobuyuki Takakura, Seiji Miwatashi
  • AROMATIC COMPOUND
    Publication number: 20160115128
    Abstract: Provided is a novel aromatic ring compound having a GPR40 agonist activity and a GLP-1 secretagogue action. A compound represented by the formula: wherein each symbol is as described in the DESCRIPTION, or a salt thereof has a GPR40 agonist activity and a GLP-1 secretagogue action, is useful for the prophylaxis or treatment of cancer, obesity, diabetes, hypertension, hyperlipidemia, cardiac failure, diabetic complications, metabolic syndrome, sarcopenia and the like, and affords superior efficacy.
    Type: Application
    Filed: August 8, 2014
    Publication date: April 28, 2016
    Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
    Inventors: Jumpei AIDA, Yayoi YOSHITOMI, Yuko HITOMI, Naoyoshi NOGUCHI, Yasuhiro HIRATA, Hideki FURUKAWA, Akito SHIBUYA, Koji WATANABE, Yasufumi MIYAMOTO, Tomohiro OKAWA, Nobuyuki TAKAKURA, Seiji MIWATASHI