Abstract: The present invention falls within the field of medical chemistry and relates to a class of compounds as SHP2 inhibitors and the use thereof. Specifically, the present invention provides a compound represented by formula (I), or an isomer, a pharmaceutically acceptable salt, a solvate, a crystal or a prodrug thereof, a preparation method therefor, a pharmaceutical composition comprising the compounds, and the use of the compounds or the composition for treating a disease mediated by SHP2.

Abstract: An intelligent device for conveying, grading and aligning of tube products includes: a conveying and grading mechanism, which includes: a timing belt, a timing belt power unit, a swing rod, a track, and a swing rod cylinder; wherein multiple baffles are evenly arranged on a surface of the timing belt; multiple track openings are evenly arranged on a surface of the track; the swing rod cylinder is fixed on a side wall of the track; the swing rod is fixed with an output end of the swing rod cylinder; and multiple single-bundle aligning assemblies, each includes: a cross beam, a vertical beam, a stacking unit, a bracket cylinder, a bracket, an aligning cylinder, and a swing bracket; wherein the bracket is fixed with a telescopic end of the bracket cylinder; the stacking unit is fixed on a surface of the vertical beam along a height direction thereof.

Abstract: An electromagnetic component such as a power inductor includes first and second magnetic core pieces and a preformed coil winding therebetween. The preformed coil winding includes a top winding section and a pair of coplanar winding legs defining a U-shaped winding section therewith. The pair of winding legs are oriented perpendicular to a circuit board in use. First and second surface mount terminals respectively extend perpendicular to the pair of winding legs in opposing directions to each other, such that each of them extends only on one of the first and second magnetic core pieces but not the other.

Abstract: The invention relates to an anti-blocking seawater desalination device based on graphene filtering, comprising heating device, solar heat-collecting device, fresh water condensation heat-exchange device and thermal-expansion and cold-shrinkage control valve mechanism; the heating device can fully heat and distill seawater, the sprayed seawater is distilled by graphene heat-conduction layers to improve the distillation efficiency and avoiding blocking; the distilled water vapor enters into fresh water condensation heat-exchange device to exchange heat with seawater, increasing the seawater temperature, making full use of the heat in water vapor, and increasing water vapor condensation speed; the distilled concentrated seawater enters into the thermal-expansion and cold-shrinkage control valve mechanism, the flow of seawater entering into the heating device is controlled by the concentrated seawater temperature, when the temperature is too high, the flow of the seawater entering into the heating device increase

Abstract: The invention relates to an anti-blocking seawater desalination device based on graphene filtering, comprising heating device, solar heat-collecting device, fresh water condensation heat-exchange device and thermal-expansion and cold-shrinkage control valve mechanism; the heating device can fully heat and distill seawater, the sprayed seawater is distilled by graphene heat-conduction layers to improve the distillation efficiency and avoiding blocking; the distilled water vapor enters into fresh water condensation heat-exchange device to exchange heat with seawater, increasing the seawater temperature, making full use of the heat in water vapor, and increasing water vapor condensation speed; the distilled concentrated seawater enters into the thermal-expansion and cold-shrinkage control valve mechanism, the flow of seawater entering into the heating device is controlled by the concentrated seawater temperature, when the temperature is too high, the flow of the seawater entering into the heating device increase

Abstract: Monobactam compounds and a use therefor. Specifically provided are chemical compounds represented by formula (I) or isomers, pharmaceutically acceptable salts, solvates, crystals, or prodrugs thereof, preparation methods therefor, pharmaceutical compositions containing said compounds, and a use of said compounds or compositions in treating bacterial infection. The present compounds feature excellent antibacterial activity, and have great hopes of becoming a therapeutic agent for bacterial infection.

Abstract: The present application relates to a compound as a TGF-? R1 inhibitor and application thereof. Specifically, provided are a compound of formula I, or an isomer, pharmaceutically acceptable salt, solvent, crystal, or prodrug thereof, preparation methods therefor, and pharmaceutical compositions comprising these compounds, and applications of these compounds or compositions in treating and/or preventing TGF-? R1-related diseases, such as cancer, tissue proliferation diseases, fibrosis, and inflammatory diseases. The compound represents a significant inhibitory activity for TGF-? R1 kinase, and is promising as a treatment agent for TGF-? R1-related diseases.

Abstract: Disclosed are a class of compounds which are inhibitors of acetyl-CoA carboxylase (ACC) and the use thereof. In particular, provided are compounds as shown in formula I or isomers, pharmaceutically acceptable salts, solvates, crystals or prodrugs thereof, and methods for preparing the same, and pharmaceutical compositions comprising the compounds and the use of the compounds or compositions for treating and/or preventing diseases associated with ACC expression, such as fibrotic diseases, metabolic diseases, cancers or tissue hyperplasia diseases. The compound has a good inhibitory activity against ACC and shows good promise to be a therapeutic drug for fibrotic diseases, metabolic diseases, cancers or tissue hyperplasia diseases.

Abstract: An electromagnetic component such as a power inductor includes first and second magnetic core pieces and a preformed coil winding therebetween. The preformed coil winding includes a top winding section and a pair of coplanar winding legs defining a U-shaped winding section therewith. The pair of winding legs are oriented perpendicular to a circuit board in use. First and second surface mount terminals respectively extend perpendicular to the pair of winding legs in opposing directions to each other, such that each of them extends only on one of the first and second magnetic core pieces but not the other.

Abstract: An electromagnetic component such as a power inductor includes first and second magnetic core pieces and a preformed conductive coil winding. The coil winding includes a U-shaped winding section including a top winding section and a pair of winding legs extending from opposing ends of the top winding section. The winding legs extend coplanar to one another and are oriented perpendicular to a circuit board in use. The legs are located between the first and second magnetic core pieces, and the top winding section is bent to extend perpendicularly to the plane of the pair of winding legs.

Abstract: The present invention relates to PDE9 inhibitors and their use for treatment of benign prostate hyperplasia and sickle cell disease.

Abstract: Temperature monitoring devices have a primary body with an inner circular perimeter, a temperature monitoring segment held by the primary body, the temperature monitoring segment comprising an inwardly extending thermal probe, and a fastener assembly segment held by the primary body at a location that is circumferentially spaced apart from the temperature monitoring segment. The fastener assembly segment has a circumferentially extending bracket that can be radially extended in a direction that is toward the inner circular perimeter of the device.

Abstract: Disclosed are a class of compounds which are inhibitors of acetyl-CoA carboxylase (ACC) and the use thereof. In particular, provided are compounds as shown in formula I or isomers, pharmaceutically acceptable salts, solvates, crystals or prodrugs thereof, and methods for preparing the same, and pharmaceutical compositions comprising the compounds and the use of the compounds or compositions for treating and/or preventing diseases associated with ACC expression, such as fibrotic diseases, metabolic diseases, cancers or tissue hyperplasia diseases. The compound has a good inhibitory activity against ACC and shows good promise to be a therapeutic drug for fibrotic diseases, metabolic diseases, cancers or tissue hyperplasia diseases.

Abstract: Temperature monitoring devices have a primary body with an inner circular perimeter, a temperature monitoring segment held by the primary body, the temperature monitoring segment comprising an inwardly extending thermal probe, and a fastener assembly segment held by the primary body at a location that is circumferentially spaced apart from the temperature monitoring segment. The fastener assembly segment has a circumferentially extending bracket that can be radially extended in a direction that is toward the inner circular perimeter of the device.

Abstract: The present invention relates to PDE9 inhibitors and their use for treatment of benign prostate hyperplasia and sickle cell disease.

Abstract: The present invention relates to PDE9 inhibitors and their use for treatment of benign prostate hyperplasia and sickle cell disease.

Abstract: Temperature monitoring devices have a primary body with an inner circular perimeter, a temperature monitoring segment held by the primary body, the temperature monitoring segment comprising an inwardly extending thermal probe, and a fastener assembly segment held by the primary body at a location that is circumferentially spaced apart from the temperature monitoring segment. The fastener assembly segment has a circumferentially extending bracket that can be radially extended in a direction that is toward the inner circular perimeter of the device.

Abstract: Temperature monitoring devices have a primary body with an inner circular perimeter, a temperature monitoring segment held by the primary body, the temperature monitoring segment comprising an inwardly extending thermal probe, and a fastener assembly segment held by the primary body at a location that is circumferentially spaced apart from the temperature monitoring segment. The fastener assembly segment has a circumferentially extending bracket that can be radially extended in a direction that is toward the inner circular perimeter of the device.

Abstract: The present application belongs to the field of biopharmaceutical technology and particularly relates to a drug-loaded ganglioside micelle and a method for preparing and use thereof. The present application provides a use of GM1 or a derivative thereof as a carrier material of nano drug delivery system. The blood brain barrier is a key barrier to intracranial drug delivery. The nano drug delivery system provides a powerful tool for non-invasive intracranial combined administration and has important clinical significance. Without introducing other carrier materials, long-circulating modifying materials and nerve repair drugs, the drug-loaded ganglioside micelle prepared by using GM1 or a derivative thereof as a carrier material of nano drug delivery system can achieve nerve injury repair and intracranial combined administration by penetrating the blood-brain barrier.

Abstract: The present invention relates to PDE9 inhibitors and their use for treatment of benign prostate hyperplasia and sickle cell disease.