Patents by Inventor Ye-Su CHAO

Ye-Su CHAO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Anticancer combination of chidamide and celecoxib salts
    Patent number: 11878009
    Abstract: The present invention relates to a combination of a histone deacetylase (HDAC) inhibitor, chidamide in an acidic salt form, and a nonsteroidal anti-inflammatory drugs (NSAIDs), celecoxib in a basic salt form. The present invention also relates to methods which significantly regulate tumor microenvironment and therefore dramatically improve anti-cancer activity.
    Type: Grant
    Filed: September 10, 2019
    Date of Patent: January 23, 2024
    Assignee: GREAT NOVEL THERAPEUTICS BIOTECH & MEDICALS CORPORATION
    Inventors: Jia-Shiong Chen, Mu-Hsuan Yang, Cheng-Han Chou, Yi-Hong Wu, Sz-Hao Chu, Ye-Su Chao, Chia-Nan Chen
  • Pharmaceutical combination and method for regulation of tumor microenvironment and immunotherapy
    Patent number: 11840570
    Abstract: The invention relates to a method of removing immune suppression in a tumor microenvironment or stimulating an immune system against cancer cells, comprising administering to a subject a combination of a HDAC inhibitor and an NSAID in combination with an immune checkpoint inhibitor.
    Type: Grant
    Filed: January 4, 2019
    Date of Patent: December 12, 2023
    Assignee: Great Novel Therapeutics Biotech & Medicals Corporation
    Inventors: Jia-Shiong Chen, Ye-Su Chao, Chia-Nan Chen
  • HISTONE DEACETYLASE INHIBITORS FOR IMMUNOMODULATION IN TUMOR MICROENVIRONMENT
    Publication number: 20230263790
    Abstract: The present disclosure generally relates to compounds class I HDAC inhibitors, their production and applications. The compounds possess epigenetic immunomodulatory activities in the tumor microenvironment (TME) and thus inhibit growth of tumor cells.
    Type: Application
    Filed: May 1, 2023
    Publication date: August 24, 2023
    Inventors: Jia-Shiong CHEN, Mu-Hsuan YANG, Yi-Hong WU, Sz-Hao CHU, Cheng-Han CHOU, Ye-Su CHAO, Chia-Nan CHEN
  • Histone deacetylase inhibitors for immunomodulation in tumor microenvironment
    Patent number: 11672788
    Abstract: The present disclosure generally relates to compounds class I HDAC inhibitors, their production and applications. The compounds possess epigenetic immunomodulatory activities in the tumor microenvironment (TME) and thus inhibit growth of tumor cells.
    Type: Grant
    Filed: April 28, 2021
    Date of Patent: June 13, 2023
    Assignee: Great Novel Therapeutics Biotech & Medicals Corporation
    Inventors: Jia-Shiong Chen, Mu-Hsuan Yang, Yi-Hong Wu, Sz-Hao Chu, Cheng-Han Chou, Ye-Su Chao, Chia-Nan Chen
  • PHARMACEUTICAL COMBINATION AND METHOD FOR OVERCOMING IMMUNE SUPPRESSION OR STIMULATING IMMUNE RESPONSE AGAINST CANCER
    Publication number: 20220251218
    Abstract: The invention relates to a method of overcoming immune suppression in tumor microenvironment or stimulating immune response against cancer, comprising administering to a subject a combination of a histone deacetylase (HDAC) inhibitor and a tyrosine kinase inhibitor (TKI).
    Type: Application
    Filed: February 10, 2021
    Publication date: August 11, 2022
    Inventors: Cheng-Han CHOU, Yi-Hong WU, Jia-Shiong CHEN, Ye-Su CHAO, Chia-Nan CHEN
  • HISTONE DEACETYLASE INHIBITORS FOR IMMUNOMODULATION IN TUMOR MICROENVIRONMENT
    Publication number: 20210379032
    Abstract: The present disclosure generally relates to compounds class I HDAC inhibitors, their production and applications. The compounds possess epigenetic immunomodulatory activities in the tumor microenvironment (TME) and thus inhibit growth of tumor cells.
    Type: Application
    Filed: April 28, 2021
    Publication date: December 9, 2021
    Inventors: Jia-Shiong CHEN, Mu-Hsuan YANG, Yi-Hong WU, Sz-Hao CHU, Cheng-Han CHOU, Ye-Su CHAO, Chia-Nan CHEN
  • ANTICANCER COMBINATION OF CHIDAMIDE AND CELECOXIB SALTS
    Publication number: 20210069163
    Abstract: The present invention relates to a combination of a histone deacetylase (HDAC) inhibitor, chidamide in an acidic salt form, and a nonsteroidal anti-inflammatory drugs (NSAIDs), celecoxib in a basic salt form. The present invention also relates to methods which significantly regulate tumor microenvironment and therefore dramatically improve anti-cancer activity.
    Type: Application
    Filed: September 10, 2019
    Publication date: March 11, 2021
    Inventors: Jia-Shiong CHEN, Mu-Hsuan YANG, Cheng-Han CHOU, Yi-Hong WU, Sz-Hao CHU, Ye-Su CHAO, Chia-Nan CHEN
  • PH-sensitive linkers for delivering a therapeutic agent
    Patent number: 10688193
    Abstract: The invention provides a pH-sensitive linker that can simultaneously bind metallic nanoparticles and one or more agents with various molecular size. The linker of the invention can deliver the agents into cells involved in disease processes or close to cells so that the agents can selectively target and effect on the cells. The target delivery provided by the linker of the invention can be used for example for disease sensing, imaging, drug delivery, and therapy.
    Type: Grant
    Filed: July 21, 2016
    Date of Patent: June 23, 2020
    Assignee: GNT BIOTECH & MEDICALS CORPORATION
    Inventors: Yu-Jung Liao, Wei-Jan Huang, Chia-Nan Chen, Huan-Yu Lin, Ching-Yi Lin, Meng-Ju Tsai, Wan-Yi Hsu, Li-Ling Chi, Ye-Su Chao, Yi-Hong Wu
  • PHARMACEUTICAL COMBINATION AND METHOD FOR REGULATION OF TUMOR MICROENVIRONMENT AND IMMUNOTHERAPY
    Publication number: 20190211103
    Abstract: The invention relates to a method of removing immune suppression in a tumor microenvironment or stimulating an immune system against cancer cells, comprising administering to a subject a combination of a HDAC inhibitor and an NSAID in combination with an immune checkpoint inhibitor.
    Type: Application
    Filed: January 4, 2019
    Publication date: July 11, 2019
    Inventors: JIA-SHIONG CHEN, YE-SU CHAO, CHIA-NAN CHEN
  • PH-SENSITIVE LINKERS FOR DELIVERING A THERAPEUTIC AGENT
    Publication number: 20180221498
    Abstract: The invention provides a pH-sensitive linker that can simultaneously bind metallic nanoparticles and one or more agents with various molecular size. The linker of the invention can deliver the agents into cells involved in disease processes or close to cells so that the agents can selectively target and effect on the cells. The target delivery provided by the linker of the invention can be used for example for disease sensing, imaging, drug delivery, and therapy.
    Type: Application
    Filed: July 21, 2016
    Publication date: August 9, 2018
    Inventors: Yu-Jung LIAO, Wei-Jan HUANG, Chia-Nan CHEN, Huan-Yu LIN, Ching-Yi LIN, Meng-Ju TSAI, Wan-Yi HSU, Li-Ling CHI, Ye-Su CHAO, Yi-Hong WU