Abstract: The present invention relates to polypeptides and cytomegalovirus (CMV) antigens that include at least two introduced amino acid mutations relative to the amino acid sequence of the wild-type HCMV glycoprotein B (gB). In some embodiments, the polypeptide is stabilized in a conformation alternative to the gB postfusion conformation. Also disclosed are compositions including the polypeptides and uses thereof.

Abstract: A message transmission method includes receiving, by a second device, a first message sent by a first device. The first message indicates at least one of the following: a sensing resolution related requirement; a sensing distance related requirement; a sensing area related requirement; a sensing object related requirement; a sensing error related requirement; a sensing signal quality related requirement; or a sensing delay related requirement.

Abstract: There provides an auxiliary structure for floating and sinking the whole offshore wind turbine with suction bucket foundation(s), which includes an upper bracket floated on water and a lower bracket sunk synchronously with a support structure. The upper bracket includes upper floating boxes; upper cross-connectors each of which is fixedly connected to the upper hoop and a corresponding upper floating box; and an upper hoop configured to sleeve on an outer side of the support structure. The upper bracket and the support structure are relatively moved in an up and down direction, and are connected in a manner of limiting position. The lower bracket includes lower floating boxes, a bottom of each of which is adjustable in height; lower cross-connectors each of which is fixedly connected to the lower hoop and a corresponding lower floating box; and a lower hoop that holds the support structure tightly.

Abstract: There provides an auxiliary structure for floating and sinking the whole offshore wind turbine with suction bucket foundation(s), which includes an upper bracket floated on water and a lower bracket sunk synchronously with a support structure. The upper bracket includes upper floating boxes; upper cross-connectors each of which is fixedly connected to the upper hoop and a corresponding upper floating box: and an upper hoop configured to sleeve on an outer side of the support structure. The upper bracket and the support structure are relatively moved in an up and down direction, and are connected in a manner of limiting position, to enable the upper bracket to right the support structure when being sunk.

Abstract: The present disclosure provides a packaging apparatus. The packaging structure may include a main body including one or more base plates and one or more elastic sheets. Each of the base plates may have two opposite first side edges, two opposite second side edges, and an opening. Each of the one or more elastic sheets may correspond to one of the one or more base plates. The one or more elastic sheets may be physically connected with the main body, and each of the one or more elastic sheets may cover at least a part of the opening. The main body may further include a first side plate disposed beside at least one of the two opposite first side edges and a second side plate disposed beside each of the two opposite second side edges.

Abstract: An optical lens and an electronic device comprising same. The optical lens sequentially comprises, from an object side to an image side along an optical axis: a first lens (L1) having a negative focal power, an object side surface (S1) of the first lens being concave; a second lens (L2) having a positive focal power, an object side surface (S3, S4) of the second lens being convex; a third lens (L3) having a positive focal power, an object side surface (S6) of the third lens being convex, and an image side surface (S7) of the third lens being convex; a fourth lens (L4) having a positive focal power, an object side surface (S8) of the fourth lens being convex; a fifth lens (L5) having a negative focal power, an image side surface (S10, S9) of the fifth lens being concave; a sixth lens (L6) having a focal power; and a seventh lens (L7) having a negative focal power, an image-side surface of the fifth lens being a concave surface.

Abstract: A dark circle detection and evaluation method includes: obtaining a to-be-processed image; extracting a dark circle region of interest from the to-be-processed image; performing color clustering on the dark circle region of interest to obtain n types of colors in the dark circle region of interest, where n is a positive integer; recognizing a dark circle region in the dark circle region of interest based on the n types of colors; and obtaining a dark circle evaluation result based on the dark circle region.

Abstract: The present disclosure provides a packaging apparatus. The packaging structure may include a main body including one or more base plates and one or more elastic sheets. Each of the base plates may have two opposite first side edges, two opposite second side edges, and an opening. Each of the one or more elastic sheets may correspond to one of the one or more base plates. The one or more elastic sheets may be physically connected with the main body, and each of the one or more elastic sheets may cover at least a part of the opening. The main body may further include a first side plate disposed beside at least one of the two opposite first side edges and a second side plate disposed beside each of the two opposite second side edges.

Abstract: A dark circle detection and evaluation method includes: obtaining a to-be-processed image; extracting a dark circle region of interest from the to-be-processed image; performing color clustering on the dark circle region of interest to obtain n types of colors in the dark circle region of interest, where n is a positive integer; recognizing a dark circle region in the dark circle region of interest based on the n types of colors; and obtaining a dark circle evaluation result based on the dark circle region.

Abstract: The present invention provides compounds having formula (I): wherein R1, R2, R3 and n are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof in the treatment of inflammatory or autoimmune and proliferative disorders and as inhibitors of cell adhesion molecule expression and inflammatory cytokine signal transduction generally.

Abstract: The present invention provides compounds having formula (I): wherein R1, R2, R3 and n are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof in the treatment of inflammatory or autoimmune and proliferative disorders and as inhibitors of cell adhesion molecule expression and inflammatory cytokine signal transduction generally.

Abstract: As discussed above, there remains a need for the development of novel therapeutic agents useful for treating inflammatory or autoimmune and proliferative diseases. The present invention provides novel compounds of general formula (I), and pharmaceutical compositions thereof, as described generally and in classes and subclasses herein, as well as methods of making and using such compounds.

Abstract: The present invention provides compounds having formula (I) (and pharmaceutically acceptable derivatives thereof): and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of cancer, wherein R1-R14 and n are as defined herein.

Abstract: The present invention provides compounds having formula (I) (and pharmaceutically acceptable derivatives thereof): and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of cancer, wherein R1-R14 and n are as defined herein.

Abstract: As discussed above, there remains a need for the development of novel therapeutic agents useful for treating inflammatory or autoimmune and proliferative diseases.

Abstract: The present invention provides compounds having formula (I), wherein R1, R2, R3 and n are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof in the treatment of inflammatory or autoimmune and proliferative disorders and as inhibitors of cell adhesion molecule expression and inflammatory cytokine signal transduction generally

Abstract: The present invention provides compounds having formula (I) (and pharmaceutically acceptable derivatives thereof): and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of cancer, wherein R1-R14 and n are as defined herein.

Abstract: The present invention provides compounds having formula (I), wherein R1, R2, R3 and n are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof in the treatment of inflammatory or autoimmune and proliferative disorders and as inhibitors of cell adhesion molecule expression and inflammatory cytokine signal transduction generally.