Patents by Inventor Ye Zhang

Ye Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20110224447
    Abstract: The instant invention provides for novel lipid nanoparticles and novel lipid nanoparticle components (specifically cationic lipids) that are useful for the delivery of nucleic acids, specifically siRNA, for therapeutic purposes.
    Type: Application
    Filed: August 11, 2009
    Publication date: September 15, 2011
    Inventors: Keith A. Bowman, James P. Guare, JR., George D. Hartman, Rubina G. Parmar, Chandra Vargeese, Weimin Wang, Ye Zhang
  • Publication number: 20110092739
    Abstract: The present invention relates to novel cationic lipids, transfection agents, microparticles, nanoparticles, and short interfering nucleic acid (siNA) molecules. The invention also features compositions, and methods of use for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of gene expression and/or activity in a subject or organism. Specifically, the invention relates to novel cationic lipids, microparticles, nanoparticles and transfection agents that effectively transfect or deliver biologically active molecules, such as antibodies (e.g., monoclonal, chimeric, humanized etc.
    Type: Application
    Filed: December 20, 2010
    Publication date: April 21, 2011
    Applicant: Sima Therapeutics, Inc.
    Inventors: Tongqian Chen, Chandra Vargeese, Kurt Vagle, Weimin Wang, Ye Zhang
  • Patent number: 7910711
    Abstract: The invention discloses a human cancer-related gene, LAPTM4B, its encoded products and their applications thereof. This human cancer-related gene provided by this invention comprises one of the following nucleotide sequences: (1) SEQ ID No: 1, SEQ ID No: 2, SEQ ID No: 3, SEQ ID No: 6, or SEQ ID No: 8 in the sequence listings; (2) Polynucleotides that encode the protein sequences of SEQ ID No: 4, SEQ ID No: 5, or SEQ ID No: 7 in the sequence listings; (3) DNA sequences having above 90% homology with the DNA sequences specified by SEQ ID No: 1, SEQ ID No: 2, SEQ ID No: 3, SEQ ID No: 6, or SEQ ID No: 8 in the sequence listings, and these DNA sequences encode the proteins with the same or similar functions. This invention enables the developments of new anti-cancer approaches and new anti-cancer medicines. It would create a significant impact on human society.
    Type: Grant
    Filed: December 24, 2003
    Date of Patent: March 22, 2011
    Assignee: Peking University
    Inventors: Rouli Zhou, Genze Shao, Xinrong Liu, Qingyun Zhang, Jingan Rui, Ye Zhang, Yueying Jin, Ming Lin, Sha Zhang
  • Patent number: 7893302
    Abstract: The present invention relates to novel cationic lipids, transfection agents, microparticles, nanoparticles, and short interfering nucleic acid (siNA) molecules. The invention also features compositions, and methods of use for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of gene expression and/or activity in a subject or organism. Specifically, the invention relates to novel cationic lipids, microparticles, nanoparticles and transfection agents that effectively transfect or deliver biologically active molecules.
    Type: Grant
    Filed: November 12, 2009
    Date of Patent: February 22, 2011
    Assignee: Sirna Therapeutics, Inc.
    Inventors: Tongqian Chen, Chandra Vargeese, Kurt Vagle, Weimin Wang, Ye Zhang
  • Patent number: 7769838
    Abstract: A request is received to establish a VPN session with a server-side system from at least one client computer out of a plurality of client computers coupled to a modem within a client-side system. The request contains login details for a user of the at least one client computer. A network address, such as an IP (Internet Protocol) or MAC (Media Access Control) address of the at least one client computer is then determined. The user is authenticated based on the user login details, and a VPN tunnel is established over the modem between the at least one client computer having the network address and the server-side system. The same method is then used for the remainder of the plurality of client computers coupled to the modem within the client-side system.
    Type: Grant
    Filed: August 23, 2001
    Date of Patent: August 3, 2010
    Assignee: The DIRECTV Group, Inc.
    Inventors: Douglas A. Cheline, Michael Ma, Ye Zhang, Lester J. Chong
  • Publication number: 20100105933
    Abstract: The present invention relates to novel cationic lipids, transfection agents, microparticles, nanoparticles, and short interfering nucleic acid (siNA) molecules. The invention also features compositions, and methods of use for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of gene expression and/or activity in a subject or organism. Specifically, the invention relates to novel cationic lipids, microparticles, nanoparticles and transfection agents that effectively transfect or deliver biologically active molecules, such as antibodies (e.g., monoclonal, chimeric, humanized etc.
    Type: Application
    Filed: December 17, 2009
    Publication date: April 29, 2010
    Inventors: Tongqian Chen, Kurt Vagle, Chandra Vargeese, Weimin Wang, Ye Zhang
  • Patent number: 7691405
    Abstract: The present invention relates to novel cationic lipids, transfection agents, microparticles, nanoparticles, and short interfering nucleic acid (siNA) molecules. Specifically, the invention relates to novel cationic lipids, microparticles, nanoparticles and transfection agents that effectively transfect or deliver short interfering nucleic acid (siNA). The compositions described herein are generally referred to as formulated molecular compositions (FMC) or lipid nanoparticles (LNP).
    Type: Grant
    Filed: February 7, 2008
    Date of Patent: April 6, 2010
    Assignee: Sirna Therapeutics, Inc
    Inventors: Tongqian Chen, Kurt Vagle, Chandra Vargeese, Weimin Wang, Ye Zhang
  • Publication number: 20100063308
    Abstract: The present invention relates to novel cationic lipids, transfection agents, microparticles, nanoparticles, and short interfering nucleic acid (siNA) molecules. The invention also features compositions, and methods of use for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of gene expression and/or activity in a subject or organism. Specifically, the invention relates to novel cationic lipids, microparticles, nanoparticles and transfection agents that effectively transfect or deliver biologically active molecules, such as antibodies (e.g., monoclonal, chimeric, humanized etc.
    Type: Application
    Filed: November 12, 2009
    Publication date: March 11, 2010
    Inventors: Tongqian Chen, Chandra Vargeese, Kurt Vagle, Weimin Wang, Ye Zhang
  • Publication number: 20100048888
    Abstract: The present invention relates to novel cationic lipids, transfection agents, microparticles, nanoparticles, and short interfering nucleic acid (siNA) molecules. The invention also features compositions, and methods of use for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of gene expression and/or activity in a subject or organism. Specifically, the invention relates to novel cationic lipids, microparticles, nanoparticles and transfection agents that effectively transfect or deliver biologically active molecules, such as antibodies (e.g., monoclonal, chimeric, humanized etc.
    Type: Application
    Filed: October 17, 2007
    Publication date: February 25, 2010
    Inventors: Tongqian Chen, Kurt Vagle, Chandra Vargeese, Weimin Wang, Ye Zhang
  • Publication number: 20100010861
    Abstract: Methods and systems for operating a virtual collections call center system are described. A system may include a database server, a telephony server, an auto dialer system, a Web server, and call agent computer systems, each geographically separated from the database server, the telephony server, the auto dialer system, the Web server and other call agent computer systems. The database server may store debtor records, each including a debtor telephone number. The telephony server may retrieve a debtor record from the database server. The auto dialer system may initiate a communication session with a debtor based on the debtor telephone number of the retrieved debtor record, establish a connection with the call agent after the debtor has accepted the communication session, and alert the telephony server that the communication session has been established. The Web server may initiate a Web session with the call agent computer system.
    Type: Application
    Filed: July 13, 2009
    Publication date: January 14, 2010
    Applicant: COLLECTIONS MARKETING CENTER, LLC
    Inventors: Ye Zhang, Vytas Alfonsas Kisielius
  • Patent number: 7641915
    Abstract: The present invention relates to novel cationic lipids, transfection agents, microparticles, nanoparticles, and short interfering nucleic acid (siNA) molecules. The invention also features compositions, and methods of use for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of gene expression and/or activity in a subject or organism. Specifically, the invention relates to novel cationic lipids, microparticles, nanoparticles and transfection agents that effectively transfect or deliver biologically active molecules, such as antibodies (e.g., monoclonal, chimeric, humanized etc.
    Type: Grant
    Filed: March 13, 2008
    Date of Patent: January 5, 2010
    Assignee: Sirna Therapeutics, Inc
    Inventors: TongQian Chen, Chandra Vargeese, Kurt Vagle, WeiMin Wang, Ye Zhang
  • Patent number: 7514099
    Abstract: The present invention relates to novel cationic lipids, transfection agents, microparticles, nanoparticles, and short interfering nucleic acid (siNA) molecules. The invention also features compositions, and methods of use for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of gene expression and/or activity in a subject or organism. Specifically, the invention relates to novel cationic lipids, microparticles, nanoparticles and transfection agents that effectively transfect or deliver biologically active molecules, such as antibodies (e.g., monoclonal, chimeric, humanized etc.
    Type: Grant
    Filed: February 14, 2006
    Date of Patent: April 7, 2009
    Assignee: Sirna Therapeutics, Inc.
    Inventors: Tongqian Chen, Chandra Vargeese, Kurt Vagle, Weimin Wang, Ye Zhang
  • Publication number: 20090048197
    Abstract: The present invention relates to novel cationic lipids, transfection agents, microparticles, nanoparticles, and short interfering nucleic acid (siNA) molecules. The invention also features compositions, and methods of use for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of gene expression and/or activity in a subject or organism. Specifically, the invention relates to novel cationic lipids, microparticles, nanoparticles and transfection agents that effectively transfect or deliver biologically active molecules, such as antibodies (e.g., monoclonal, chimeric, humanized etc.
    Type: Application
    Filed: February 7, 2008
    Publication date: February 19, 2009
    Applicant: SIRNA THERAPEUTICS, INC.
    Inventors: Tongqian Chen, Chandra Vargeese, Kurt Vagle, Weimin Wang, Ye Zhang
  • Publication number: 20080188675
    Abstract: The present invention relates to novel cationic lipids, transfection agents, microparticles, nanoparticles, and short interfering nucleic acid (siNA) molecules. The invention also features compositions, and methods of use for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of gene expression and/or activity in a subject or organism. Specifically, the invention relates to novel cationic lipids, microparticles, nanoparticles and transfection agents that effectively transfect or deliver biologically active molecules, such as antibodies (e.g., monoclonal, chimeric, humanized etc.
    Type: Application
    Filed: March 13, 2008
    Publication date: August 7, 2008
    Applicant: SIRNA THERAPEUTICS INC.
    Inventors: Tongqian Chen, Chandra Vargeese, Kurt Vagle, Weimin Wang, Ye Zhang
  • Patent number: 7404969
    Abstract: The present invention relates to novel cationic lipids, transfection agents, microparticles, nanoparticles, and short interfering nucleic acid (siNA) molecules. Specifically, the invention relates to novel cationic lipids, microparticles, nanoparticles and transfection agents that effectively transfect or deliver short interfering nucleic acid (siNA). The compositions described herein are generally referred to as formulated molecular compositions (FMC) or lipid nanoparticles (LNP).
    Type: Grant
    Filed: October 24, 2006
    Date of Patent: July 29, 2008
    Assignee: Sirna Therapeutics, Inc.
    Inventors: Tongqian Chen, Chandra Vargeese, Kurt Vagle, Weimin Wang, Ye Zhang
  • Publication number: 20080158208
    Abstract: An exemplary debugging system (2) for a liquid crystal display device (26) includes a host computer (22). The host computer includes a graphics card (220), a driver layer (225), and an application layer (226). The application layer includes a graphical user interface, and the driver layer includes a plurality of drivers to drive the graphics card. The host computer is configured for storing chip data of a scaler chip (260) of the liquid crystal display device, reading and writing the scaler chip via the graphics card, and displaying corresponding chip data on the liquid crystal display device via the graphical user interface such that the corresponding chip data can be revised in a debugging process of the liquid crystal display device.
    Type: Application
    Filed: December 28, 2007
    Publication date: July 3, 2008
    Inventors: Kuang-Liang Huang, Liang-Yan Dai, Tong-Xiu Cao, Ye Zhang, Wei Wang, Yan-Bo Yu
  • Publication number: 20080079730
    Abstract: A “Character-Level Font Linker” provides character-level linking of fonts via Unicode code-point to font mapping. A lookup table is used to identify glyph-level support for runs of particular characters on a Unicode code-point basis for relative to a set of available fonts. This lookup table enables automatic selection of one or more specific fonts for rendering one or more runs of characters comprising a text string. The lookup table is constructed offline by automatically evaluating glyphs comprising a set of common or default fonts. The table is then used for automatically selecting fonts for rendering text strings. Alternately, the lookup table is generated (or updated) locally to include some or all locally installed fonts. Finally, in another embodiment, if no supporting font is identified in the table for a particular character, the system automatically downloads the necessary glyph from one or more remote servers.
    Type: Application
    Filed: September 29, 2006
    Publication date: April 3, 2008
    Applicant: MICROSOFT CORPORATION
    Inventors: Ye Zhang, Qisheng Zhao, Pung Pengyang Xu
  • Publication number: 20080077525
    Abstract: An integrated multi-channel virtual collections center and methods for using the same are disclosed. The collections center may include a program management module, a communications module and a data analytics module. The program management module may be configured to generate a plurality of scenarios for a debt collection campaign. The communications module may be configured to automatically present a scenario to a debtor and to receive response data from the debtor. The communications module may include a plurality of communication channels. The data analytics module may be configured to automatically analyze response data received from the communications module and to select a communications channel and a scenario for the communications module based on the response data.
    Type: Application
    Filed: September 25, 2007
    Publication date: March 27, 2008
    Applicant: BRIDGEFORCE, INC.
    Inventors: Dawn Willey, Joseph Centrone, Joseph Scarborough, Ye Zhang
  • Patent number: 7345256
    Abstract: A method and apparatus for bonding a pair of tubular members are disclosed. First and second end portions of the tubular members are gripped for rotation about their axis. The tubular members are axially rotated and a laser beam is directed radially toward the tubular members to bond them together.
    Type: Grant
    Filed: March 29, 2005
    Date of Patent: March 18, 2008
    Inventors: Ziyun Chen, Ping Ye Zhang
  • Publication number: 20080020058
    Abstract: The present invention relates to novel cationic lipids, transfection agents, microparticles, nanoparticles, and short interfering nucleic acid (siNA) molecules. The invention also features compositions, and methods of use for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of gene expression and/or activity in a subject or organism. Specifically, the invention relates to novel cationic lipids, microparticles, nanoparticles and transfection agents that effectively transfect or deliver biologically active molecules, such as antibodies (e.g., monoclonal, chimeric, humanized etc.
    Type: Application
    Filed: October 24, 2006
    Publication date: January 24, 2008
    Applicant: Sirna Therapeutics, Inc.
    Inventors: Tongqian Chen, Chandra Vargeese, Kurt Vagle, Weimin Wang, Ye Zhang