Patents by Inventor Yee Hwa Wong

Yee Hwa Wong has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for enzymatic peptide ligation
    Patent number: 11795488
    Abstract: The present invention relates to a method of ligating a first peptide via its C-terminus to the N-terminus of a second peptide, wherein the reaction is catalyzed by an asparagine/aspartate (Asx) peptide ligase OaAEPI Cys247Ala having the amino acid sequence of SEQ ID NO: 1. Further encompassed are a method of preparing a dimer, oligomer, or multimer of one or more peptides of interest and a method of modifying or tagging the surface of a target cell by one or more peptides of interest. Also encompassed in the invention are the ligated peptides and/or tagged target cells obtainable according to any of the methods, the peptide ligase OaAEPI Cys247Ala having the amino acid sequence of SEQ ID NO: 1, as well as kits comprising said peptide ligase.
    Type: Grant
    Filed: September 12, 2017
    Date of Patent: October 24, 2023
    Assignee: NANYANG TECHNOLOGICAL UNIVERSITY
    Inventors: Bin Wu, Renliang Yang, Yee Hwa Wong, Julien Lescar, Chuan Fa Liu, James P Tam, Kien Truc Giang Nguyen, Ziqi Long
  • METHODS FOR ENZYMATIC PEPTIDE LIGATION
    Publication number: 20230128192
    Abstract: The present invention relates to a method of ligating a first peptide via its C-terminus to the N-terminus of a second peptide, wherein the reaction is catalyzed by an asparagine/aspartate (Asx) peptide ligase OaAEPI Cys247Ala having the amino acid sequence of SEQ ID NO: 1. Further encompassed are a method of preparing a dimer, oligomer, or multimer of one or more peptides of interest and a method of modifying or tagging the surface of a target cell by one or more peptides of interest. Also encompassed in the invention are the ligated peptides and/or tagged target cells obtainable according to any of the methods, the peptide ligase OaAEPI Cys247Ala having the amino acid sequence of SEQ ID NO: 1, as well as kits comprising said peptide ligase.
    Type: Application
    Filed: September 30, 2022
    Publication date: April 27, 2023
    Inventors: Bin WU, Renliang YANG, Yee Hwa WONG, Julien LESCAR, Chuan Fa LIU, James P TAM, Kien Truc Giang NGUYEN, Ziqi LONG
  • METHODS FOR ENZYMATIC PEPTIDE LIGATION
    Publication number: 20190218586
    Abstract: The present invention relates to a method of ligating a first peptide via its C-terminus to the N-terminus of a second peptide, wherein the reaction is catalyzed by an asparagine/aspartate (Asx) peptide ligase OaAEPI Cys247Ala having the amino acid sequence of SEQ ID NO: 1. Further encompassed are a method of preparing a dimer, oligomer, or multimer of one or more peptides of interest and a method of modifying or tagging the surface of a target cell by one or more peptides of interest. Also encompassed in the invention are the ligated peptides and/or tagged target cells obtainable according to any of the methods, the peptide ligase OaAEPI Cys247Ala having the amino acid sequence of SEQ ID NO: 1, as well as kits comprising said peptide ligase.
    Type: Application
    Filed: September 12, 2017
    Publication date: July 18, 2019
    Inventors: Bin WU, Renliang YANG, Yee Hwa WONG, Julien LESCAR, Chuan Fa LIU, James P TAM, Kien Truc Giang NGUYEN, Ziqi LONG
  • ANGIOPOIETIN-LIKE 4 ANTIBODY AND A METHOD OF ITS USE IN CANCER TREATMENT
    Publication number: 20150210758
    Abstract: An antibody that binds C terminal region of angiopoietin like 4 protein its use and methods of treating cancer with the same.
    Type: Application
    Filed: August 6, 2013
    Publication date: July 30, 2015
    Inventors: Julien Lescar, Yee Hwa Wong, Wei Min Edmond Chua, Nguan Soon Andrew Tan, Han Chung Kelvin Chong, Ming Jie Tan, Royston-Luke Huang