Patents by Inventor Yee Joo Tan

Yee Joo Tan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CHIMERIZATION AND CHARACTERIZATION OF A MONOCLONAL ANTIBODY WITH POTENT NEUTRALIZING ACTIVITY ACROSS MULTIPLE INFLUENZA A H5N1 CLADES
    Publication number: 20170306001
    Abstract: MAb 9F4 provides heterologous protection against multiple influenza A H5N1 clade viruses, including one of the recently designated subclades, namely 2.3.4, through binding to a novel epitope. The present invention relates to isolated mouse-human chimeric (xi) IgG1-9F4 and IgA1-9F4 MAb which retain high degrees of binding and neutralizing activity against influenza H5N1. The invention also relates to methods of production, kits and uses of the chimeric antibodies in the treatment of influenza A subtype H5N1 disease.
    Type: Application
    Filed: March 27, 2015
    Publication date: October 26, 2017
    Applicant: NATIONAL UNIVERSITY OF SINGAPORE
    Inventors: YEE JOO TAN, TZE MINN MAK
  • HUMANIZED MOUSE MODEL FOR STUDY OF BONA FIDE HEPATITIS VIRUS INFECTION AND USE THEREOF
    Publication number: 20160135437
    Abstract: This invention refers to a mouse for human hepatitis studies wherein the mouse has been injected with CD34+ stem cells and wherein the mouse is immunocompromised, as well as a method of manufacturing a mouse model comprising administering CD34+ stem cells as defined herein into an immunocompromised mouse as defined herein. The invention also refers to the use of a mouse as defined for testing the efficiency of putative anti-HBV or anti-HCV drugs or for characterizing changes in viral quasispecies during HBV or HCV infection.
    Type: Application
    Filed: June 5, 2014
    Publication date: May 19, 2016
    Inventors: Qingfeng CHEN, Choong Tat KENG, Yee Joo TAN, Antonio BERTOLETTI
  • Internalisation of virus into cells
    Patent number: 7341728
    Abstract: A chimeric transmembrane protein which promotes viral entry into cells comprises: (i) an extracellular domain capable of binding a virus; and (ii) an intracellular internalisation signal.
    Type: Grant
    Filed: May 24, 2002
    Date of Patent: March 11, 2008
    Assignee: Agency for Science, Technology and Research
    Inventors: Yin Hwee Tan, Yee Joo Tan, Siew Pheng Lim, Seng Gee Lim, Wan Jin Hong, Phuay Yee Goh
  • Method of treating a disease condition caused or exacerbated by an HPV
    Patent number: 7019000
    Abstract: The invention provides agents and compounds (see (I) and (II)) for use in the treatment or prophylaxis of disease conditions caused or exacerbated by mammalian papillomaviruses, such as human papillomaviruses, as well as methods for the treatment or prevention thereof. In said formulae, R1–R4 and n are as defined herein.
    Type: Grant
    Filed: September 3, 1999
    Date of Patent: March 28, 2006
    Assignee: Institute of Molecular & Cell Biology
    Inventors: Hans-Ulrich Bernard, Yee Joo Tan, Walter Beerheide, Anthony Eugene Ting, Mui Mui Sim
  • Internalisation of virus into cells
    Publication number: 20040241640
    Abstract: A chimeric transmembrane protein which promotes viral entry into cells comprises: (i) an extracellular domain capable of binding a virus; and (ii) an intracellular internalisation signal.
    Type: Application
    Filed: June 4, 2004
    Publication date: December 2, 2004
    Inventors: Yin Hwee Tan, Yee Joo Tan, Siew Pheng Lim, Seng Gee Lim, Wanjin Hong, Phuay Yee Goh