Patents by Inventor Yee Ng

Yee Ng has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 3-ARYL-4-AMIDO-BICYCLIC [4,5,0] HYDROXAMIC ACIDS AS HDAC INHIBITORS
    Publication number: 20190062288
    Abstract: The present disclosure relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with an HDAC, e.g., HDAC6, having a Formula I: where R, L, X1, X2, X3, X4, Y1, Y2, Y3, and Y4 are described herein.
    Type: Application
    Filed: October 29, 2018
    Publication date: February 28, 2019
    Inventors: Xiaozhang Zheng, Pui Yee Ng, Bingsong Han, Jennifer R. Thomason, Mary-Margaret Zablocki, Cuixian Liu, Aleksandra Rudnitskaya, David R. Lancia, JR., David S. Millan, Matthew W. Martin
  • 3-alkyl-4-amido-bicyclic [4,5,0] hydroxamic acids as HDAC inhibitors
    Patent number: 10214500
    Abstract: The present disclosure relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with an HDAC, e.g., HDAC6, having a Formula I: where R, L, X1, X2, X3, X4, Y1, Y2, Y3, and Y4 are described herein.
    Type: Grant
    Filed: February 2, 2016
    Date of Patent: February 26, 2019
    Assignee: Forma Therapeutics, Inc.
    Inventors: Xiaozhang Zheng, Pui Yee Ng, Bingsong Han, Jennifer R. Thomason, Mary-Margaret Zablocki, Cuixian Liu, Heather Davis, Aleksandra Rudnitskaya, David R. Lancia, Jr., Kenneth W. Bair, David S. Millan, Matthew W. Martin
  • 3-alkyl bicyclic [4,5,0] hydroxamic acids as HDAC inhibitors
    Patent number: 10214501
    Abstract: The present disclosure relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with an HDAC, e.g., HDAC6, having a Formula I: where R, L, X1, X2, X3, X4, Y1, Y2, Y3, and Y4 are described herein.
    Type: Grant
    Filed: February 2, 2016
    Date of Patent: February 26, 2019
    Assignee: Forma Therapeutics, Inc.
    Inventors: Xiaozhang Zheng, Pui Yee Ng, Bingsong Han, Jennifer R. Thomason, Mary-Margaret Zablocki, Cuixian Liu, Aleksandra Rudnitskaya, David R. Lancia, Jr., David S. Millan, Matthew W. Martin, Kenneth W. Bair
  • Article comprising a microneedle
    Patent number: 10201691
    Abstract: An article 100 comprising at least one microneedle 160 is provided. The article comprises a first side 112 and a second side 114 opposite the first side. The first side comprises a central cavity portion 120 and a platform portion 130, with at least one microneedle extending therefrom, wherein the platform portion is not coplanar with the central cavity portion. The platform portion substantially surrounds the central cavity portion. The at least one microneedle 160 comprises a body comprising an outer surface 163; a base segment 166 having a base and a first shape; a tip segment 168 having a tip 164 and a second shape, wherein the second shape is distinct from the first shape; a transition plane 167 that delineates the base segment and the tip segment; and a central axis.
    Type: Grant
    Filed: July 10, 2014
    Date of Patent: February 12, 2019
    Assignee: 3M Innovative Properties
    Inventors: Dennis G. Berry, Paul A. Martinson, Chin-Yee Ng, Ryan Patrick Simmers
  • Lutram dummy read scheme during error detection and correction
    Patent number: 10191661
    Abstract: An integrated circuit device includes a first memory cell that stores data representative of configuration data when operating in a first mode, wherein the first memory cell stores data representative of user-accessible data when operating in a second mode. The integrated circuit device also includes a second memory cell that stores a value indicating whether the first memory cell is operating in the first mode or is operating in the second mode. The integrated circuit device further includes a switch coupled to the first memory cell and controlled by the second memory cell, wherein the switch provides a defined value to be read in place of the stored data of the first memory cell when the second memory cell stores the value indicating that the first memory cell is operating in the second mode.
    Type: Grant
    Filed: August 4, 2016
    Date of Patent: January 29, 2019
    Assignee: ALTERA CORPORATION
    Inventors: Bee Yee Ng, Gaik Ming Chan, Jeffrey Christopher Chromczak, Herman Henry Schmit
  • Bicyclic [4,6,0] hydroxamic acids as HDAC inhibitors
    Patent number: 10183934
    Abstract: The present invention relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with HDAC6, having a Formulae I or Formula II: where R, L, X1, X2, X3, X4, X5, Y1, Y2, Y3, and Y4 are described herein.
    Type: Grant
    Filed: February 2, 2016
    Date of Patent: January 22, 2019
    Assignee: Forma Therapeutics, Inc.
    Inventors: Xiaozhang Zheng, Pui Yee Ng, Aleksandra Rudnitskaya, David R. Lancia, Jr.
  • 3-ARYL-BICYCLIC [4,5,0] HYDROXAMIC ACIDS AS HDAC INHIBITORS
    Publication number: 20190016693
    Abstract: The present invention relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with HDAC6, having a Formula I: where R, L, X1, X2, X3, X4, Y1, Y2, Y3, and Y4 are described herein.
    Type: Application
    Filed: September 18, 2018
    Publication date: January 17, 2019
    Inventors: Xiaozhang Zheng, Pui Yee Ng, Bingsong Han, Jennifer R. Thomason, Mary-Margaret Zablocki, Cuixian Liu, Aleksandra Rudnitskaya, David R. Lancia, Jr., David S. Millan, Matthew W. Martin
  • 3-ARYL-BICYCLIC [4,5,0] HYDROXAMIC ACIDS AS HDAC INHIBITORS
    Publication number: 20190016692
    Abstract: The present invention relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with HDAC6, having a Formula I: where R, L, X1, X2, X3, X4, Y1, Y2, Y3, and Y4 are described herein.
    Type: Application
    Filed: September 18, 2018
    Publication date: January 17, 2019
    Inventors: Xiaozhang Zheng, Pui Yee Ng, Bingsong Han, Jennifer R. Thomason, Mary-Margaret Zablocki, Cuixian Liu, Aleksandra Rudnitskaya, David R. Lancia, JR., David S. Millan, Matthew W. Martin
  • [6,6] FUSED BICYCLIC HDAC8 INHIBITORS
    Publication number: 20180354919
    Abstract: The present invention is directed to compounds of Formula I: and pharmaceutically acceptable salts, prodrugs, solvates, hydrates, tautomers, or isomers or thereof, wherein R1, R2, R2?, L, X, W, Y1, Y2, Y3, and Y4 are described herein.
    Type: Application
    Filed: June 8, 2018
    Publication date: December 13, 2018
    Inventors: Xiaozhang Zheng, Pui Yee Ng, Jennifer R. Thomason, Mary-Margaret Zablocki, Bingsong Han, Nicholas Barczak, Cuixian Liu, Aleksandra Rudnitskaya, David R. Lancia, JR., Kenneth W. Bair
  • Polymer conjugate for delivery of a bioactive agent
    Patent number: 10111886
    Abstract: The present invention relates in general to polymer-bioactive agent conjugates for delivering a bioactive agent to a subject. The polymer-bioactive agent conjugates contain triazole moieties in the polymer backbone and a bioactive moiety selected from prostaglandin analogues, .beta.-blockers and mixtures thereof. The present invention also relates to methods for preparing the polymer conjugates using click chemical reactions, to monomer-bioactive agent conjugates suitable for preparing the polymer conjugates, and to pharmaceutical products comprising the polymer conjugates for the treatment of glaucoma.
    Type: Grant
    Filed: February 17, 2017
    Date of Patent: October 30, 2018
    Assignee: POLYACTIVA PTY LTD
    Inventors: Sarah Man Yee Ng, Andrew Craig Donohue, Russell John Tait, Stephen Lonsdale Birkett, Adrian Sulistio, Anton Blencowe
  • 3-aryl bicyclic [4,5,0] hydroxamic acids as HDAC inhibitors
    Patent number: 10112915
    Abstract: The present invention relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with HDAC6, having a Formula I: where R, L, X1, X2, X3, X4, Y1, Y2, Y3, and Y4 are described herein.
    Type: Grant
    Filed: February 2, 2016
    Date of Patent: October 30, 2018
    Assignee: Forma Therapeutics, Inc.
    Inventors: Xiaozhang Zheng, Pui Yee Ng, Bingsong Han, Jennifer R. Thomason, Mary-Margaret Zablocki, Cuixian Liu, Aleksandra Rudnitskaya, David R. Lancia, Jr., David S. Millan, Matthew W. Martin
  • Polymer conjugate for delivery of a bioactive agent
    Patent number: 10113033
    Abstract: The present invention relates in general to polymer-bioactive agent conjugates for delivering a bioactive agent to a subject. The polymer-bioactive agent conjugates contain triazole moieties in the polymer backbone and a bioactive moiety comprising prostaglandin analogues. The present invention also relates to methods for preparing the polymer conjugates using click chemical reactions, to monomer-bioactive agent conjugates suitable for preparing the polymer conjugates, and to pharmaceutical products comprising the polymer conjugates for the treatment of glaucoma.
    Type: Grant
    Filed: March 14, 2017
    Date of Patent: October 30, 2018
    Assignee: POLYACTIVA PTY LTD
    Inventors: Sarah Man Yee Ng, Andrew Craig Donohue, Russell John Tait, Stephen Lonsdale Birkett, Adrian Sulistio, Anton Blencowe, Alan Naylor
  • POLYMER CONJUGATE COMPRISING A BIOACTIVE AGENT
    Publication number: 20180303948
    Abstract: The present invention relates in general to polymer-bioactive agent conjugates for delivering a bioactive agent to a subject. The polymer-bioactive agent conjugates contain triazole moieties in the polymer backbone and a bioactive moiety selected from quinolones, NSAIDs and mixtures thereof. The present invention also relates to methods for preparing the polymer conjugates using click cycloaddition chemical reactions, to monomer-bioactive agent conjugates suitable for preparing the polymer conjugates, and to pharmaceutical products comprising the polymer conjugates for the post-surgical care to treat or prevent infections, provide analgesia and treat inflammation.
    Type: Application
    Filed: September 9, 2016
    Publication date: October 25, 2018
    Applicant: Polyactiva Pty Ltd
    Inventors: Stephen Lonsdale BIRKETT, Andrew Craig DONOHUE, Asha Marina D'SOUZA, Sara Man Yee NG, Adrian SULISTIO, Russell John TAIT, David VALADE
  • HOLLOW MICRONEEDLE ARRAYS
    Publication number: 20180304063
    Abstract: The present disclosure relates to apparatus, assemblies, combinations, and methods for infusing fluids by hollow microneedles.
    Type: Application
    Filed: July 2, 2018
    Publication date: October 25, 2018
    Inventors: BERNARD A. GONZALEZ, SCOTT A. BURTON, JIA HU, CHIN-YEE NG, RYAN PATRICK SIMMERS, THOMAS J. GILBERT, SEAN M. BURKE, ROBERT A. HARKINS, LARRY A. SCHLEIF
  • ALPHA-CINNAMIDE COMPOUNDS AND COMPOSITIONS AS HDAC8 INHIBITORS
    Publication number: 20180297939
    Abstract: The present invention relates to inhibitors of histone deacetylases, in particular HDAC8, that are useful for the treatment of cancer and other diseases and disorders, as well as the synthesis and applications of said inhibitors.
    Type: Application
    Filed: March 19, 2018
    Publication date: October 18, 2018
    Inventors: Kenneth W. Bair, Nicholas Barczak, Bingsong Han, David R. Lancia, JR., Cuixian Liu, Matthew W. Martin, Pui Yee Ng, Aleksandra Rudnitskaya, Jennifer R. Thomason, Mary-Margaret Zablocki, Xiaozhang Zheng
  • Delivery system for hollow microneedle arrays
    Patent number: 10076649
    Abstract: Systems and methods for delivering microneedles to a patient's skin are described. In one aspect, a system for delivering a microneedle array to a patient's skin surface is provided. The system includes a delivery apparatus with a housing, and an infusion device detachably received in the housing.
    Type: Grant
    Filed: September 6, 2012
    Date of Patent: September 18, 2018
    Assignee: 3M Innovative Properties Company
    Inventors: Thomas J. Gilbert, Chin-Yee Ng, Scott A. Burton, Michael C. Molinet, Robert A. Harkins, Bernard A. Gonzalez, Larry A. Schleif, Patrick J. Young
  • [6,6] fused bicyclic HDAC8 inhibitors
    Patent number: 10029995
    Abstract: The present invention is directed to compounds of Formula I: and pharmaceutically acceptable salts, prodrugs, solvates, hydrates, tautomers, or isomers or thereof, wherein R1, R2, R2?, L, X, W, Y1, Y2, Y3, and Y4 are described herein.
    Type: Grant
    Filed: September 2, 2016
    Date of Patent: July 24, 2018
    Assignee: Forma Therapeutics, Inc.
    Inventors: Xiaozhang Zheng, Pui Yee Ng, Jennifer R. Thomason, Mary-Margaret Zablocki, Bingsong Han, Nicholas Barczak, Cuixian Liu, Aleksandra Rudnitskaya, David R. Lancia, Kenneth W. Bair
  • Hollow microneedle arrays
    Patent number: 10010706
    Abstract: The present disclosure relates to apparatus, assemblies, combinations, and methods for infusing fluids by hollow microneedles.
    Type: Grant
    Filed: July 27, 2010
    Date of Patent: July 3, 2018
    Assignee: 3M Innovative Properties Company
    Inventors: Bernard A. Gonzalez, Scott A. Burton, Jia Hu, Chin-Yee Ng, Ryan Patrick Simmers, Thomas J. Gilbert, Sean M. Burke, Robert A. Harkins, Larry A. Schleif
  • Document reader
    Patent number: D821402
    Type: Grant
    Filed: April 6, 2017
    Date of Patent: June 26, 2018
    Assignee: GEMALTO SA
    Inventors: Brett A. Howell, Chin-Yee Ng, John M. Pilgrim, Lori A. Sjolund, Glendon D. Kappel
  • Document reader
    Patent number: D821403
    Type: Grant
    Filed: April 6, 2017
    Date of Patent: June 26, 2018
    Assignee: GEMALTO SA
    Inventors: Brett A. Howell, Chin-Yee Ng, John M. Pilgrim, Lori A. Sjolund, Glendon D. Kappel