Patents by Inventor Yee Sin Leo

Yee Sin Leo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Biomarker detection system
    Patent number: 11719632
    Abstract: Disclosed is a localised surface plasmon resonance (LSPR) nanopillar assembly. The LSPR assembly is for use in sensing the presence of a biomarker when attached to a quantum dot. The LSPR assembly comprises a substrate and an array. The array comprises a LSPR nanopillar and a polymer spacer attached to the nanopillar. The LSPR assembly further comprises an antibody attached to the at least one polymer spacer. In the LSPR assembly, a combined height of the polymer spacer and antibody is selected by varying the number of monomer units of the polymer spacer, so that, when in use with the biomarker and the quantum dot, the quantum dot is at a predetermined distance from the nanopillar.
    Type: Grant
    Filed: July 21, 2017
    Date of Patent: August 8, 2023
    Assignees: Temasek Polytechnic, Agency for Science, Technology and Research, Tan Tock Seng Hospital Pte. Ltd.
    Inventors: Ling Ling Sun, Willie Ng, Xiaodong Zhou, Ten It Wong, Yee Sin Leo
  • An Aptamer for Dengue Virus and Related Methods and Products
    Publication number: 20220315926
    Abstract: There is provided an aptamer for dengue virus, optionally an aptamer for dengue virus NS1 protein. The aptamer comprising at least one unnatural base, wherein the unnatural base may be 7-(2thienyl)imidazo[4,5-b]pyridine (Ds), pyrrole2-carbaldehyde (Pa) or 2-nitro-4-propynylpyrrole (Px). The aptamers of the invention may be used to identify a dengue infection in a subject. Also provided are mixtures and kits comprising the aptamer.
    Type: Application
    Filed: June 18, 2020
    Publication date: October 6, 2022
    Inventors: Ichiro Hirao, Ken-ichiro Matsunaga, Michiko Hirao, William Sun, Yee Sin Leo
  • BIOMARKER DETECTION SYSTEM
    Publication number: 20190302022
    Abstract: Disclosed is a localised surface plasmon resonance (LSPR) nanopillar assembly. The LSPR assembly is for use in sensing the presence of a biomarker when attached to a quantum dot. The LSPR assembly comprises a substrate and an array. The array comprises a LSPR nanopillar and a polymer spacer attached to the nanopillar. The LSPR assembly further comprises an antibody attached to the at least one polymer spacer. In the LSPR assembly, a combined height of the polymer spacer and antibody is selected by varying the number of monomer units of the polymer spacer, so that, when in use with the biomarker and the quantum dot, the quantum dot is at a predetermined distance from the nanopillar.
    Type: Application
    Filed: July 21, 2017
    Publication date: October 3, 2019
    Applicants: Temasek Polytechnic, Agency for Science, Technology and Research, Tan Tock Seng Hospital Pte Ltd
    Inventors: Ling Ling Sun, Willie Ng, Xiaodong Zhou, Ten It Wong, Yee Sin Leo
  • IMMUNOGENIC CHIKUNGUNYA VIRUS PEPTIDES
    Publication number: 20140050754
    Abstract: The present invention relates to immunogenic peptides of Chikungunya Virus and methods for vaccinating a subject using these peptides. Also disclosed are nucleic acids encoding these peptides and methods for their production.
    Type: Application
    Filed: December 12, 2011
    Publication date: February 20, 2014
    Applicants: NATIONAL HEALTHCARE GROUP PTE LTD, AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
    Inventors: Joo Chuan Tong, Jin Kiat Wee, Fong Poh Lisa Ng, Yiu-Wing Jason Kam, Yee Sin Leo, Angela Chow