Patents by Inventor Yefim Gelman

Yefim Gelman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for production of essentially solvent-free small particles
    Publication number: 20040256749
    Abstract: The present invention is concerned with the formation of small particles of an organic compound by mixing a solution of the organic compound dissolved in a water-miscible organic solvent with an aqueous medium to form a mix and simultaneously homogenizing the mix while continuously removing the organic solvent to form an aqueous suspension of small particles essentially free of the organic solvent. These processes are preferably used to prepare an aqueous suspension of small particles of a poorly water-soluble, pharmaceutically active compound suitable for in vivo delivery by an administrative route such as parenteral, oral, pulmonary, nasal, buccal, topical, ophthalmic, rectal, vaginal, transdermal or the like.
    Type: Application
    Filed: October 29, 2003
    Publication date: December 23, 2004
    Inventors: Mahesh Chaubal, Mark J. Doty, Yefim Gelman, Monte Wisler
  • One-pot process for the preparation of .alpha.-L-aspartyl-L-phenylalanine methyl ester hydrochloride
    Patent number: 5476961
    Abstract: A one-pot process for the preparation of .alpha.-L-aspartyl-L-phenylalanine methyl ester hydrochloride is disclosed (.alpha.-APM(HCl)). .alpha.-APM(HCl) is an intermediate in the preparation of aspartame.
    Type: Grant
    Filed: June 21, 1993
    Date of Patent: December 19, 1995
    Assignee: The NutraSweet Company
    Inventors: John B. Hill, Yefim Gelman, Hugh L. Dryden, Jr., Robert Erickson, Kuang Hsu, Mark R. Johnson
  • One-pot process for the preparation of .alpha.-L-aspartyl-L-phenylalanine methyl ester hydrochloride
    Patent number: 5053532
    Abstract: A one-pot process for the preparation of .alpha.-L-aspartyl-L-phenylalanine methyl ester hydrochloride is disclosed (.alpha.-APM(HCl)). .alpha.-APM(HCl) is an intermediate in the preparation of aspartame.
    Type: Grant
    Filed: July 3, 1990
    Date of Patent: October 1, 1991
    Assignee: The Nutra Sweet Company
    Inventors: John B. Hill, Yefim Gelman, Hugh L. Dryden, Jr., Robert Erickson, Kuang Hsu, Mark R. Johnson
  • Process for the preparation of .alpha.-L-aspartyl-L-phenylalanine methyl ester hydrochloride by use of isolated N-formyl L-aspartic anhydride
    Patent number: 4946988
    Abstract: A process for the preparation of .alpha.-L-aspartyl-L-phenylalanine methyl ester hydrochloride (.alpha.-APM(HCl)) is disclosed. .alpha.-APM(HCl) is an intermediate in the preparation of aspartame.
    Type: Grant
    Filed: July 14, 1988
    Date of Patent: August 7, 1990
    Assignee: The NutraSweet Company
    Inventors: John B. Hill, Yefim Gelman