Patents by Inventor Yeh Chen

Yeh Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20260125427
    Abstract: The present disclosure provides a method for preventing formation of amyloid ? aggregation and a method for treating amyloidosis by using a synthetic peptide. The synthetic peptide of the present disclosure achieves the effect of preventing formation of amyloid ? aggregation and treating amyloidosis through various efficacy experiments.
    Type: Application
    Filed: May 15, 2025
    Publication date: May 7, 2026
    Inventors: Der-Yang Cho, Shao-Chih Chiu, Shi-Wei Huang, Chih-Ming Pan, Mei-Chih Chen, Yu-Chuan Lin, Yeh Chen, Chung-Chun Wu
  • Patent number: 12319729
    Abstract: The present disclosure provides an anti-Staphylococcus aureus specific antibody and the nucleic acid encoding sequence thereof, and uses of the same. The anti-Staphylococcus aureus specific antibody of the present disclosure achieves the effect of treating Staphylococcus aureus infection and enhancing immune cells against Staphylococcus aureus through various efficacy experiments.
    Type: Grant
    Filed: April 2, 2024
    Date of Patent: June 3, 2025
    Assignee: CHINA MEDICAL UNIVERSITY HOSPITAL
    Inventors: Der-Yang Cho, Shao-Chih Chiu, Shi-Wei Huang, Chih-Ming Pan, Mei-Chih Chen, Yeh Chen, Po-Ren Hsueh, Tien Ni, Jia-Xin Yu, Chao-Jung Chen
  • Patent number: 12221483
    Abstract: The present disclosure provides a fusion protein and the nucleic acid encoding sequence thereof, and uses of the same. The fusion protein of the present disclosure achieves the effect of treating cancer, immunoregulation and activating immune cells through various efficacy experiments.
    Type: Grant
    Filed: January 30, 2024
    Date of Patent: February 11, 2025
    Assignee: CHINA MEDICAL UNIVERSITY HOSPITAL
    Inventors: Der-Yang Cho, Shao-Chih Chiu, Shi-Wei Huang, Chih-Ming Pan, Mei-Chih Chen, Yu-Chuan Lin, Yeh Chen, Yi-Wen Chen, Ming-You Shie, Kai-Wen Kan
  • Patent number: 12012454
    Abstract: The present disclosure provides an anti-tumor antigen nanobody that specifically binds to a human leukocyte antigen-G. The present disclosure also provides the nucleic acid sequence of the anti-tumor antigen nanobody, use of the anti-tumor antigen nanobody for treating cancer and immune-related disorders, and a method for detecting expression levels of HLA-G.
    Type: Grant
    Filed: March 11, 2022
    Date of Patent: June 18, 2024
    Assignee: CHINA MEDICAL UNIVERSITY HOSPITAL
    Inventors: Der-Yang Cho, Shao-Chih Chiu, Shi-Wei Huang, Chih-Ming Pan, Mei-Chih Chen, Yu-Chuan Lin, Yeh Chen
  • Publication number: 20240016761
    Abstract: The present disclosure relates to a nutritional composition for inhibiting survival of an RNA virus and a method for treating an RNA virus infection. The nutritional composition consists of an astaxanthin extract and at least one probiotic extract. The at least one probiotic extract is selected from the group consisting of a lipoteichoic acid and a peptidoglycan. The method for treating the RNA virus infection includes administering an effective concentration of a nutritional composition to a subject in need thereof, wherein the nutritional composition consists of an astaxanthin extract and at least one probiotic extract, and the at least one probiotic extract is selected from the group consisting of a lipoteichoic acid and a peptidoglycan.
    Type: Application
    Filed: July 11, 2023
    Publication date: January 18, 2024
    Inventors: Jui-Jen Chang, Yeh Chen
  • Patent number: 11795224
    Abstract: The present disclosure provides an anti-T-cell nanobody that specifically binds to CD3 ?. The present disclosure also provides the nucleic acid sequence of the anti-T-cell nanobody, use of the anti-T-cell nanobody for treating cancer, immunoregulation and activating immune cells, and a method for detecting expression levels of CD3 ?.
    Type: Grant
    Filed: March 18, 2022
    Date of Patent: October 24, 2023
    Assignee: CHINA MEDICAL UNIVERSITY HOSPITAL
    Inventors: Der-Yang Cho, Shao-Chih Chiu, Shi-Wei Huang, Chih-Ming Pan, Mei-Chih Chen, Yu-Chuan Lin, Yeh Chen
  • Patent number: 11795227
    Abstract: The present disclosure provides an immunomodulation and anti-tumor-related nanobody that specifically binds to a human leukocyte antigen-G, a programmed cell death ligand 1, and CD3 ?. The present disclosure also provides the nucleic acid sequence of the immunomodulation and anti-tumor-related nanobody, and use of the immunomodulation and anti-tumor-related nanobody for treating cancer and immune-related disorders.
    Type: Grant
    Filed: March 21, 2022
    Date of Patent: October 24, 2023
    Assignee: SHINE-ON BIOMEDICAL CO., LTD.
    Inventors: Der-Yang Cho, Shao-Chih Chiu, Shi-Wei Huang, Chih-Ming Pan, Mei-Chih Chen, Yu-Chuan Lin, Yeh Chen
  • Patent number: 11685784
    Abstract: The present disclosure provides an anti-immune-checkpoint nanobody that specifically binds to a programmed cell death ligand 1. The present disclosure also provides the nucleic acid sequence of the anti-immune-checkpoint nanobody, use of the anti-immune-checkpoint nanobody for treating cancer and immune-related disorders, and a method for detecting expression levels of PD-L1.
    Type: Grant
    Filed: March 11, 2022
    Date of Patent: June 27, 2023
    Assignee: CHINA MEDICAL UNIVERSITY HOSPITAL
    Inventors: Der-Yang Cho, Shao-Chih Chiu, Shi-Wei Huang, Chih-Ming Pan, Mei-Chih Chen, Yu-Chuan Lin, Yeh Chen
  • Publication number: 20220306748
    Abstract: The present disclosure provides an immunomodulation and anti-tumor-related nanobody that specifically binds to a human leukocyte antigen-G, a programmed cell death ligand 1, and CD3 ?. The present disclosure also provides the nucleic acid sequence of the immunomodulation and anti-tumor-related nanobody, and use of the immunomodulation and anti-tumor-related nanobody for treating cancer and immune-related disorders.
    Type: Application
    Filed: March 21, 2022
    Publication date: September 29, 2022
    Inventors: Der-Yang Cho, Shao-Chih Chiu, Shi-Wei Huang, Chih-Ming Pan, Mei-Chih Chen, Yu-Chuan Lin, Yeh Chen
  • Publication number: 20220306742
    Abstract: The present disclosure provides an anti-T-cell nanobody that specifically binds to CD3 ?. The present disclosure also provides the nucleic acid sequence of the anti-T-cell nanobody, use of the anti-T-cell nanobody for treating cancer, immunoregulation and activating immune cells, and a method for detecting expression levels of CD3 ?.
    Type: Application
    Filed: March 18, 2022
    Publication date: September 29, 2022
    Inventors: Der-Yang Cho, Shao-Chih Chiu, Shi-Wei Huang, Chih-Ming Pan, Mei-Chih Chen, Yu-Chuan Lin, Yeh Chen
  • Publication number: 20220306747
    Abstract: The present disclosure provides an anti-tumor antigen nanobody that specifically binds to a human leukocyte antigen-G. The present disclosure also provides the nucleic acid sequence of the anti-tumor antigen nanobody, use of the anti-tumor antigen nanobody for treating cancer and immune-related disorders, and a method for detecting expression levels of HLA-G.
    Type: Application
    Filed: March 11, 2022
    Publication date: September 29, 2022
    Inventors: Der-Yang Cho, Shao-Chih Chiu, Shi-Wei Huang, Chih-Ming Pan, Mei-Chih Chen, Yu-Chuan Lin, Yeh Chen
  • Publication number: 20220306746
    Abstract: The present disclosure provides an anti-immune-checkpoint nanobody that specifically binds to a programmed cell death ligand 1. The present disclosure also provides the nucleic acid sequence of the anti-immune-checkpoint nanobody, use of the anti-immune-checkpoint nanobody for treating cancer and immune-related disorders, and a method for detecting expression levels of PD-L1.
    Type: Application
    Filed: March 11, 2022
    Publication date: September 29, 2022
    Inventors: Der-Yang Cho, Shao-Chih Chiu, Shi-Wei Huang, Chih-Ming Pan, Mei-Chih Chen, Yu-Chuan Lin, Yeh Chen
  • Publication number: 20210386695
    Abstract: The present disclosure relates to a method for inhibiting a binding of a SARS-CoV-2 spike protein of a SARS-CoV-2 to an angiotensin-converting enzyme 2 including contacting the SARS-CoV-2 with a sufficient concentration of disulfiram, a method for inhibiting an activity of a main protease (Mpro) of SARS-CoV-2 including contacting a SARS-CoV-2 with a sufficient concentration of disulfiram, and a method for inhibiting an activity of a papain-like protease (PLpro) of SARS-CoV-2 including contacting a SARS-CoV-2 with a sufficient concentration of disulfiram. A method for inhibiting a replication or an infection of a SARS-CoV-2 in a cell includes contacting the cell with a sufficient concentration of disulfiram and a medical composition for use in a treatment of an infection of SARS-CoV-2 including a therapeutically effective amount of disulfiram are also provided.
    Type: Application
    Filed: June 16, 2021
    Publication date: December 16, 2021
    Applicant: China Medical University
    Inventors: Chang-Hai Tsai, Mien-chie Hung, Yeh Chen, Wen-Hao Yang, Chia-shin Yang, Yu-Lin Hung, Yu-Chuan Wang, Yi-Zhen Chou, Mei-Hui Hou, Chia-Ling Tsai, Bao-Yue Huang, Chian-Fang Hung, Hsiao-Fan Chen, Wen-Chi Su, Wei-Jan Wang
  • Publication number: 20210330661
    Abstract: The present disclosure relates to a method for preventing or inhibiting a synthesis of viral RNA of SARS-CoV-2 in a cell including contacting the cell with a sufficient concentration of tafenoquine, boceprevir or narlaprevir and a method for inhibiting an activity of a main protease (Mpro) of SARS-CoV-2 including contacting a SARS-CoV-2 with a sufficient concentration of tafenoquine, boceprevir or narlaprevir. A medical composition for use in a treatment of an infection of SARS-CoV-2 including a therapeutically effective amount of tafenoquine, boceprevir or narlaprevir is also provided.
    Type: Application
    Filed: April 22, 2021
    Publication date: October 28, 2021
    Applicant: China Medical University
    Inventors: Mien-Chie Hung, Yeh Chen, Wen-Hao Yang, Chia-Shin Yang, Yu-Lin Hung, Yu-Quan Wang, Yi-Zhen Chou, Mei-Hui Hou, Chia-Ling Tsai, Bao-Yue Huang, Chian-Fang Hung
  • Patent number: 10076508
    Abstract: This invention provides an antibiotic drug for inhibiting drug-resistant microorganisms. The antibiotic drug comprises Fmoc-Ala-OPfp, and not only has non-cytotoxic for normal human cell but also can inhibit drug-resistant microorganisms.
    Type: Grant
    Filed: August 3, 2016
    Date of Patent: September 18, 2018
    Assignee: Peptide Cham Biotech Co., Ltd.
    Inventors: Chiu-Hung Chen, Yeh Chen
  • Publication number: 20170035723
    Abstract: This invention provides an antibiotic drug for inhibiting drug-resistant microorganisms. The antibiotic drug comprises Fmoc-Ala-OPfp, and not only has non-cytotoxic for normal human cell but also can inhibit drug-resistant microorganisms.
    Type: Application
    Filed: August 3, 2016
    Publication date: February 9, 2017
    Applicant: Peptide Cham Biotech Co., Ltd.
    Inventors: Chiu-Hung Chen, Yeh Chen