Patents by Inventor Yeh-Hsing LAO

Yeh-Hsing LAO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DNA-TEMPLATED MICELLE AND USES THEREOF
    Publication number: 20220313839
    Abstract: The present invention discloses a multifunctional DNA-templated micelle system that has a payload carrier of at least a DNA bridge and a functionalized polyethylene glycol (PEG) segment. The micelle can be used to deliver molecules, such as drugs and polynucleotides, to targeted cells for pharmaceutical uses. The PEG segment provides a functional group, such as amine, for ligand conjugation. The DNA-templated micelle of the present invention is highly controllable in size, loading efficiency and tissue targeting, and can carry multiple payloads for targeted combination strategies in cancer therapy, such as gene delivery, gene therapy, and immunotherapy.
    Type: Application
    Filed: April 22, 2022
    Publication date: October 6, 2022
    Inventors: Kam W. Leong, Yeh-Hsing Lao, Tzu-Chieh Ho, Smruthi Suryaprakash
  • DNA-templated micelle and uses thereof
    Patent number: 11311629
    Abstract: The present invention discloses a multifunctional DNA-templated micelle system that has a payload carrier of at least a DNA bridge and a functionalized polyethylene glycol (PEG) segment. The micelle can be used to deliver molecules, such as drugs and polynucleotides, to targeted cells for pharmaceutical uses. The PEG segment provides a functional group, such as amine, for ligand conjugation. The DNA-templated micelle of the present invention is highly controllable in size, loading efficiency and tissue targeting, and can carry multiple payloads for targeted combination strategies in cancer therapy, such as gene delivery, gene therapy, and immunotherapy.
    Type: Grant
    Filed: February 27, 2018
    Date of Patent: April 26, 2022
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Kam W. Leong, Yeh-Hsing Lao, Tzu-Chieh Ho, Smruthi Suryaprakash
  • DNA-TEMPLATED MICELLE AND USES THEREOF
    Publication number: 20210128746
    Abstract: The present invention discloses a multifunctional DNA-templated micelle system that has a payload carrier of at least a DNA bridge and a functionalized polyethylene glycol (PEG) segment. The micelle can be used to deliver molecules, such as drugs and polynucleotides, to targeted cells for pharmaceutical uses. The PEG segment provides a functional group, such as amine, for ligand conjugation. The DNA-templated micelle of the present invention is highly controllable in size, loading efficiency and tissue targeting, and can carry multiple payloads for targeted combination strategies in cancer therapy, such as gene delivery, gene therapy, and immunotherapy.
    Type: Application
    Filed: February 27, 2018
    Publication date: May 6, 2021
    Inventors: Kam W. LEONG, Yeh-Hsing LAO, Tzu-Chieh HO, Smruthi SURYAPRAKASH