Patents by Inventor Yehuda G. Assaraf

Yehuda G. Assaraf has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Imidazoacridinone derivative compounds and methods for their use
    Publication number: 20100137351
    Abstract: The present invention provides IA derivative compounds of the formula: where the variables are described herein.
    Type: Application
    Filed: September 10, 2009
    Publication date: June 3, 2010
    Applicant: Technion Research & Development Foundation Ltd.
    Inventors: Yehuda G. Assaraf, Eran E. Bram, Yamit Bney-Moshe, Andrzej M. Skladanowski
  • Method for the monitoring of multiple anticancer drug resistance
    Patent number: 5455161
    Abstract: The invention relates to a method for assessing clinical activity and resistance to multiple anticancer drugs of mammalian cells, based on a dose-dependent inhibition with cytotoxic agents of the cellular rise in ornithine decarboxylase activity, following serum stimulation, which comprises the steps of: (a) determining by an immunological technique the rise in the ornithine decarboxylase protein levels, after adding serum containing medium to quiescent mammalian cells, and (b) obtaining the levels of the anticancer drug resistance from the ratio of 50% inhibitory concentration of ornithine decarboxylase obtained with an anticancer drug for drug resistant cells and drug sensitive cells. The immunological technique is selected from ELISA, radioimmunoassay, immunofluorescence, flow cytometry and fluorescence microscopy. The increase in the ornithine decarboxylase activity results from an increase in the number of ornithine decarboxylase molecules.
    Type: Grant
    Filed: July 20, 1993
    Date of Patent: October 3, 1995
    Assignee: Technicon Reseach & Development Foundation Ltd.
    Inventors: Yehuda G. Assaraf, Uriel Bachrach