Patents by Inventor Yehuda Ivri

Yehuda Ivri has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12290472
    Abstract: Multi-dose preservative-free ocular fluid delivery devices are provided. The fluid delivery device includes a fluid dispensing system and a fluid package for storing a liquid therein and supplying said liquid to the dispensing system. The dispensing system comprises an elongated chamber which includes a check valve which defines a frontal closure to the chamber. The valve is normally closed and hermetically seals the chamber. The dispenser includes a vibration motor that induces oscillations to the chamber and to the fluid within. The oscillations of the chamber impart momentum to the fluid stored in the chamber which in turn imparts force that cyclically opens the valve to dispense streams or liquid droplets. Fluid is dispensed only when the motor oscillates while otherwise the valve is hermetically closed. Preferably, the fluid package and check valve are included in a disposable reservoir assembly.
    Type: Grant
    Filed: March 11, 2022
    Date of Patent: May 6, 2025
    Assignee: BAUSCH + LOMB IRELAND LIMITED
    Inventor: Yehuda Ivri
  • Patent number: 12290471
    Abstract: Aspects of the invention include a device for fluid delivery to the ocular surface having a self-alignment system. The fluid delivery device includes a fluid package having a reservoir and one or more apertures, an actuator component configured to eject fluid from the reservoir through the one or more apertures and an image-based self-alignment system configured to align fluid ejected through the one or more apertures with a target location on the eye of a user. Also provided are methods of using the devices in fluid delivery applications, as well as a kit that includes components of the devices.
    Type: Grant
    Filed: February 11, 2022
    Date of Patent: May 6, 2025
    Assignee: BAUSCH + LOMB IRELAND LIMITED
    Inventors: Daniel V. Palanker, Yehuda Ivri, Mark S. Blumenkranz, Reynaldo Quintana
  • Publication number: 20250108398
    Abstract: A dispenser and methods for transferring liquids are disclosed. The dispenser may include a capillary tube with tip having an aperture, a piezoelectric actuator coupled to the capillary tube at a location. Actuation of the piezoelectric actuator causes a pressure wave to propagate along the capillary tube toward the tip such that radial motion at the location is transmitted as distally extending axial motion of the tip, thereby causing a droplet of a predetermined volume to be ejected from the aperture. In some embodiments, the capillary tube has a modulus of elasticity in a range which dampens acoustical noise from the actuation and provides single drop stability over a range of drop sizes.
    Type: Application
    Filed: April 29, 2024
    Publication date: April 3, 2025
    Inventors: Yehuda Ivri, Thomas C. Tisone, Eric P. Kuo, Shane Gunsalus
  • Publication number: 20250041110
    Abstract: Membrane actuated hydrodynamic dispensing system devices are disclosed. Aspects of the dispensing devices include an ampoule assembly and an actuator. The ampoule assembly contains liquid to be dispensed and includes the actuated membrane, one or more flexible apertures, and a stationary member to seal the aperture. The actuator is configured to vibrate the membrane to hydrodynamic excite the fluid contained in the ampoule assembly. Once the fluid is hydrodynamically excited sufficiently, the liquid is dispensed out of the aperture.
    Type: Application
    Filed: March 24, 2023
    Publication date: February 6, 2025
    Inventors: Yehuda IVRI, Reynaldo QUINTANA
  • Patent number: 12186234
    Abstract: Methods of administering a liquid formulation of an ophthalmic agent to a topical ocular location of an eye are provided. Aspects of the methods include delivering to the topical ocular location a dose of the liquid formulation that can be wholly accommodated by the tear film of the eye. Devices and kits for practicing the methods are also provided. The methods, compositions and kits find use in a variety of applications, including therapeutic, diagnostic and cosmetic applications.
    Type: Grant
    Filed: June 18, 2019
    Date of Patent: January 7, 2025
    Assignee: Bausch + Lomb Ireland Limited
    Inventors: Yehuda Ivri, Mark S. Blumenkranz, Peter Noymer, Daniel V. Palanker
  • Patent number: 12097145
    Abstract: A device for delivery of a precise amount of pharmaceutical fluid to the eye is provided. The device includes an ampoule for storing a liquid and an aperture through which the liquid is discharged. The device further includes a vibrating membrane that includes a needle which protrudes from the membrane and extends to the aperture to form a needle valve. The needle valve provides hermetic closure of the aperture to enable preservative-free storage of the pharmaceutical fluid in the device. The system further includes an electromagnetic transducer to shift the membrane back and forth in order to discharge liquid through the nozzle. Finally, the system further includes a vent to permit air to enter the ampoule as fluid is ejected from the ampoule. Preferably this vent includes a filter to prevent ingress of microbes or other contaminants to the ampoule.
    Type: Grant
    Filed: December 18, 2020
    Date of Patent: September 24, 2024
    Assignee: BAUSCH + LOMB IRELAND LIMITED
    Inventors: Reynaldo Quintana, Yehuda Ivri, Daniel V. Palanker
  • Patent number: 12090087
    Abstract: Multi-dose preservative-free ocular fluid delivery devices are provided. The fluid delivery device includes a fluid dispensing system and a fluid package for storing a liquid therein and supplying said liquid to the dispensing system. The dispensing system comprises an elongated chamber which includes a check valve which defines a frontal closure to the chamber. The valve is normally closed and hermetically seals the chamber. The dispenser includes a vibration motor that induces oscillations to the chamber and to the fluid within. The oscillations of the chamber impart momentum to the fluid stored in the chamber which in turn imparts force that cyclically opens the valve to dispense streams or liquid droplets. Fluid is dispensed only when the motor oscillates while otherwise the valve is hermetically closed. The fluid package can be made collapsible to remove the need to vent it.
    Type: Grant
    Filed: April 16, 2021
    Date of Patent: September 17, 2024
    Assignee: Bausch + Lomb Ireland Limited
    Inventor: Yehuda Ivri
  • Publication number: 20240277516
    Abstract: Multi-dose preservative-free ocular fluid delivery devices are provided. The fluid delivery device includes a fluid dispensing system and a fluid package for storing a liquid therein and supplying said liquid to the dispensing system. The dispensing system comprises an elongated chamber which includes a check valve which defines a frontal closure to the chamber. The valve is normally closed and hermetically seals the chamber. The dispenser includes a vibration motor that induces oscillations to the chamber and to the fluid within. The oscillations of the chamber impart momentum to the fluid stored in the chamber which in turn imparts force that cyclically opens the valve to dispense streams or liquid droplets. Fluid is dispensed only when the motor oscillates while otherwise the valve is hermetically closed. The fluid package can be made collapsible to remove the need to vent it.
    Type: Application
    Filed: May 2, 2024
    Publication date: August 22, 2024
    Applicant: Bausch + Lomb Ireland Limited
    Inventor: Yehuda Ivri
  • Patent number: 12048647
    Abstract: Fluid delivery devices and methods are described, where the device may comprise a piezoelectric actuator operatively coupled to an ampoule with fluid, under a preloading force. The ampoule may comprise a thin-walled thermoplastic package which includes one or more apertures positioned on the wall of the ampoule. The piezoelectric actuator may be configured to clamp at least partially around the circumference of the ampoule and apply oscillations to its wall. The oscillations, typically in ultrasonic frequency, produce cycles of acoustic pressure in the fluid, leading to ejection of the fluid droplets or streams from the apertures.
    Type: Grant
    Filed: January 12, 2021
    Date of Patent: July 30, 2024
    Assignee: Bausch + Lomb Ireland Limited
    Inventors: Yehuda Ivri, Mark S. Blumenkranz, Daniel V. Palanker
  • Publication number: 20240238120
    Abstract: Multi-dose preservative-free ocular fluid delivery devices are provided. The fluid delivery device includes a fluid dispensing system and a fluid package for storing a liquid therein and supplying said liquid to the dispensing system. The dispensing system comprises an elongated chamber which includes a check valve which defines a frontal closure to the chamber. The valve is normally closed and hermetically seals the chamber. The dispenser includes a vibration motor that induces oscillations to the chamber and to the fluid within. The oscillations of the chamber impart momentum to the fluid stored in the chamber which in turn imparts force that cyclically opens the valve to dispense streams or liquid droplets. Fluid is dispensed only when the motor oscillates while otherwise the valve is hermetically closed.
    Type: Application
    Filed: February 7, 2024
    Publication date: July 18, 2024
    Applicant: Bausch + Lomb Ireland Limited
    Inventor: Yehuda Ivri
  • Publication number: 20240189143
    Abstract: Multi-dose preservative-free ocular fluid delivery devices are provided. The fluid delivery device includes a fluid dispensing system and a fluid package for storing a liquid therein and supplying said liquid to the dispensing system. The dispensing system comprises an elongated chamber which includes a check valve which defines a frontal closure to the chamber. The valve is normally closed and hermetically seals the chamber. The dispenser includes a vibration motor that induces oscillations to the chamber and to the fluid within. The oscillations of the chamber impart momentum to the fluid stored in the chamber which in turn imparts force that cyclically opens the valve to dispense streams or liquid droplets. Fluid is dispensed only when the motor oscillates while otherwise the valve is hermetically closed.
    Type: Application
    Filed: February 21, 2024
    Publication date: June 13, 2024
    Applicant: Bausch + Lomb Ireland Limited
    Inventor: Yehuda Ivri
  • Patent number: 11998939
    Abstract: A dispenser and methods for transferring liquids are disclosed. The dispenser may include a capillary tube with tip having an aperture, a piezoelectric actuator coupled to the capillary tube at a location. Actuation of the piezoelectric actuator causes a pressure wave to propagate along the capillary tube toward the tip such that radial motion at the location is transmitted as distally extending axial motion of the tip, thereby causing a droplet of a predetermined volume to be ejected from the aperture. In some embodiments, the capillary tube has a modulus of elasticity in a range which dampens acoustical noise from the actuation and provides single drop stability over a range of drop sizes.
    Type: Grant
    Filed: October 18, 2021
    Date of Patent: June 4, 2024
    Assignee: BioDot, Inc.
    Inventors: Yehuda Ivri, Thomas C. Tisone, Eric P. Kuo, Shane Gunsalus
  • Publication number: 20240156637
    Abstract: Micro-droplet delivery devices and methods are described where the device may comprise a piezoelectric actuator having a piezoelectric chip that is operatively coupled to a drug package under a preloading force. The actuator is configured to generate an acoustic pressure within the drug package to dispense droplets of an agent from an aperture, e.g., to the corneal surface of the eye. The piezoelectric actuator can be coupled or decoupled from the drug package.
    Type: Application
    Filed: October 17, 2023
    Publication date: May 16, 2024
    Applicant: Bausch + Lomb Ireland Limited
    Inventor: Yehuda Ivri
  • Patent number: 11938057
    Abstract: Multi-dose preservative-free ocular fluid delivery devices are provided. The fluid delivery device includes a fluid dispensing system and a fluid package for storing a liquid therein and supplying said liquid to the dispensing system. The dispensing system comprises an elongated chamber which includes a check valve which defines a frontal closure to the chamber. The valve is normally closed and hermetically seals the chamber. The dispenser includes a vibration motor that induces oscillations to the chamber and to the fluid within. The oscillations of the chamber impart momentum to the fluid stored in the chamber which in turn imparts force that cyclically opens the valve to dispense streams or liquid droplets. Fluid is dispensed only when the motor oscillates while otherwise the valve is hermetically closed.
    Type: Grant
    Filed: October 25, 2021
    Date of Patent: March 26, 2024
    Assignee: Bausch + Lomb Ireland Limited
    Inventor: Yehuda Ivri
  • Patent number: 11925577
    Abstract: Multi-dose preservative-free ocular fluid delivery devices are provided. The fluid delivery device includes a fluid dispensing system and a fluid package for storing a liquid therein and supplying said liquid to the dispensing system. The dispensing system comprises an elongated chamber which includes a check valve which defines a frontal closure to the chamber. The valve is normally closed and hermetically seals the chamber. The dispenser includes a vibration motor that induces oscillations to the chamber and to the fluid within. The oscillations of the chamber impart momentum to the fluid stored in the chamber which in turn imparts force that cyclically opens the valve to dispense streams or liquid droplets. Fluid is dispensed only when the motor oscillates while otherwise the valve is hermetically closed.
    Type: Grant
    Filed: April 16, 2021
    Date of Patent: March 12, 2024
    Assignee: Bausch + Lomb Ireland Limted
    Inventor: Yehuda Ivri
  • Publication number: 20240001393
    Abstract: An atomizer is provided for dispensing liquids into the air. In some implementations, a device is provided for generating atomized fluid specifically, but not exclusively, for production of small droplets of scented oil and other fluid-based fragrances, among other types of liquids. In some embodiments, the device comprises a tube-shaped element having a proximal opening and a distal opening, wherein media positioned inside the tube is forced out of the proximal opening via an aperture plate.
    Type: Application
    Filed: January 13, 2023
    Publication date: January 4, 2024
    Applicant: OVR Tech, LLC
    Inventors: Matthew Flego, Yehuda Ivri, Erik Cooper, Aaron Wisniewski, Samuel Wisniewski
  • Patent number: 11833291
    Abstract: An aerosolization system includes a container that is configured to deliver a unit dosage of a liquid when squeezed a single time. The system also includes an aerosolizer that is constructed of a housing defining a mouthpiece, and an aerosol generator disposed in the housing. The aerosol generator includes a vibratable membrane having a front face and a rear face, and a vibratable element used to vibrate the membrane. Further, the housing includes an opening that is adapted to receive a unit dosage of the liquid from the container. The opening provides a liquid path to the rear face of the vibratable membrane.
    Type: Grant
    Filed: July 27, 2022
    Date of Patent: December 5, 2023
    Assignee: Aerami Therapeutics, Inc.
    Inventors: John S. Patton, Ryan S. Patton, Mei-chang Kuo, Yehuda Ivri
  • Patent number: 11819453
    Abstract: Micro-droplet delivery devices and methods are described where the device may comprise a piezoelectric actuator having a piezoelectric chip that is operatively coupled to a drug package under a preloading force. The actuator is configured to generate an acoustic pressure within the drug package to dispense droplets of an agent from an aperture, e.g., to the corneal surface of the eye. The piezoelectric actuator can be coupled or decoupled from the drug package.
    Type: Grant
    Filed: April 17, 2020
    Date of Patent: November 21, 2023
    Assignee: Novartis AG
    Inventor: Yehuda Ivri
  • Patent number: 11786676
    Abstract: A method is described for supplying a metered amount of a liquid medicament to an aerosolizing device. The method utilizes a dispenser comprising an elongate dispenser body having a proximal end and a tip at a distal end through which a liquid medicament is dispensed. The dispenser further comprises a dispensing mechanism that operates to dispense a metered quantity of the liquid medicament from the tip each time the dispenser body is compressed. The dispenser is grasped with one hand such that the fingers wrap around the dispenser body, with the thumb closest to the proximal end and the last finger closest to the tip. The tip is inserted into an opening of an inhaler and the elongate body is forced toward the tip to cause the dispenser body to compress, thereby operating the dispensing mechanism and causing a metered quantity of the liquid medicament to eject into the inhaler.
    Type: Grant
    Filed: September 17, 2018
    Date of Patent: October 17, 2023
    Assignee: Aerami Therapeutics, Inc.
    Inventors: Ryan S. Patton, John S. Patton, Mei-chang Kuo, Yehuda Ivri
  • Publication number: 20230301831
    Abstract: Multi-dose ocular fluid delivery devices are provided. Aspects of the fluid delivery devices include a fluid package and an actuator. The fluid package includes a reservoir of an ophthalmic formulation, an aperture and a valve member for sealing the aperture when fluid is not being ejected therethrough. The actuator is configured to operate the valve member so as to at least reduce, if not prevent, ingress of outside materials or contaminants into the reservoir, such that the ophthalmic formulation present in the reservoir does not require a preservative (e.g., where a preservative-free ophthalmic formulation is present in the reservoir). Also provided are methods of using the devices in fluid delivery applications, as well as a kit that includes components of the devices.
    Type: Application
    Filed: May 3, 2023
    Publication date: September 28, 2023
    Applicant: NOVARTIS AG
    Inventors: Reynaldo Quintana, Yehuda Ivri