Patents by Inventor Yehuda Ivri

Yehuda Ivri has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10525214
    Abstract: An aerosolization system includes a container that is configured to deliver a unit dosage of a liquid when squeezed a single time. The system also includes an aerosolizer that is constructed of a housing defining a mouthpiece, and an aerosol generator disposed in the housing. The aerosol generator includes a vibratable membrane having a front face and a rear face, and a vibratable element used to vibrate the membrane. Further, the housing includes an opening that is adapted to receive a unit dosage of the liquid from the container. The opening provides a liquid path to the rear face of the vibratable membrane.
    Type: Grant
    Filed: May 26, 2016
    Date of Patent: January 7, 2020
    Assignee: Dance Biopharm Inc.
    Inventors: John S. Patton, Ryan S. Patton, Mei-chang Kuo, Yehuda Ivri
  • Publication number: 20190015611
    Abstract: A method is described for supplying a metered amount of a liquid medicament to an aerosolizing device. The method utilizes a dispenser comprising an elongate dispenser body having a proximal end and a tip at a distal end through which a liquid medicament is dispensed. The dispenser further comprises a dispensing mechanism that operates to dispense a metered quantity of the liquid medicament from the tip each time the dispenser body is compressed. The dispenser is grasped with one hand such that the fingers wrap around the dispenser body, with the thumb closest to the proximal end and the last finger closest to the tip. The tip is inserted into an opening of an inhaler and the elongate body is forced toward the tip to cause the dispenser body to compress, thereby operating the dispensing mechanism and causing a metered quantity of the liquid medicament to eject into the inhaler.
    Type: Application
    Filed: September 17, 2018
    Publication date: January 17, 2019
    Inventors: Ryan S. Patton, John S. Patton, Mei-chang Kuo, Yehuda Ivri
  • Publication number: 20180353714
    Abstract: One embodiment describes an insulin formulation that is specifically adapted for aerosolization. The formulation comprises a major amount of water and a minor amount of insulin. Further, the formulation is preservative free, without meta-cresol, cresol or phenol, to permit the formulation to be aerosolized using a vibrating aperture plate without substantial foaming of the insulin formulation.
    Type: Application
    Filed: August 21, 2018
    Publication date: December 13, 2018
    Inventors: John S. Patton, Ryan S. Patton, Mei-chang Kuo, Yehuda Ivri
  • Patent number: 10076613
    Abstract: One embodiment describes an insulin formulation that is specifically adapted for aerosolization. The formulation includes a major amount of water and a minor amount of insulin. Further, the formulation is preservative free, without meta-cresol, cresol or phenol, to permit the formulation to be aerosolized using a vibrating aperture plate without substantial foaming of the insulin formulation.
    Type: Grant
    Filed: October 8, 2015
    Date of Patent: September 18, 2018
    Assignee: Dance Biopharm Inc.
    Inventors: John S. Patton, Ryan S. Patton, Mei-chang Kuo, Yehuda Ivri
  • Publication number: 20180207030
    Abstract: Fluid delivery devices and methods are described, where the device may comprise a piezoelectric actuator operatively coupled to an ampoule with fluid, under a preloading force. The ampoule may comprise a thin-walled thermoplastic package which includes one or more apertures positioned on the wall of the ampoule. The piezoelectric actuator may be configured to clamp at least partially around the circumference of the ampoule and apply oscillations to its wall. The oscillations, typically in ultrasonic frequency, produce cycles of acoustic pressure in the fluid, leading to ejection of the fluid droplets or streams from the apertures.
    Type: Application
    Filed: January 18, 2018
    Publication date: July 26, 2018
    Inventors: Yehuda Ivri, Mark Blumenkranz
  • Publication number: 20170203322
    Abstract: A dispenser and methods for transferring liquids are disclosed. The dispenser may include a capillary tube with tip having an aperture, a piezoelectric actuator coupled to the capillary tube at a location. Actuation of the piezoelectric actuator causes a pressure wave to propagate along the capillary tube toward the tip such that radial motion at the location is transmitted as distally extending axial motion of the tip, thereby causing a droplet of a predetermined volume to be ejected from the aperture. In some embodiments, the capillary tube has a modulus of elasticity in a range which dampens acoustical noise from the actuation and provides single drop stability over a range of drop sizes.
    Type: Application
    Filed: July 24, 2015
    Publication date: July 20, 2017
    Applicant: BioDot, Inc.
    Inventors: Yehuda Ivri, Thomas Tisone, Eric P. Kuo, Shane Gunsalus
  • Patent number: 9545488
    Abstract: An aerosolization system includes a container that is configured to deliver a unit dosage of a liquid when squeezed a single time. The system also includes an aerosolizer that is constructed of a housing defining a mouthpiece, and an aerosol generator disposed in the housing. The aerosol generator includes a vibratable membrane having a front face and a rear face, and a vibratable element used to vibrate the membrane. Further, the housing includes an opening that is adapted to receive a unit dosage of the liquid from the container. The opening provides a liquid path to the rear face of the vibratable membrane.
    Type: Grant
    Filed: January 27, 2015
    Date of Patent: January 17, 2017
    Assignee: Dance Biopharm Inc.
    Inventors: John S. Patton, Ryan S. Patton, Mei-chang Kuo, Yehuda Ivri
  • Publication number: 20160296367
    Abstract: Fluid delivery devices and methods are described where the device may comprise a piezoelectric actuator having a piezoelectric chip that is operatively coupled to a drug package under a preloading force. The actuator is configured to generate an acoustic pressure within the drug package to dispense droplets or a continuous stream of an agent from an aperture, e.g., to the corneal surface of the eye. The piezoelectric actuator can be coupled or decoupled from the drug package via a coupling mechanism which enables the quick release and consistent securement of the drug package to the actuator and housing.
    Type: Application
    Filed: April 8, 2016
    Publication date: October 13, 2016
    Inventor: Yehuda IVRI
  • Publication number: 20160271346
    Abstract: An aerosolization system includes a container that is configured to deliver a unit dosage of a liquid when squeezed a single time. The system also includes an aerosolizer that is constructed of a housing defining a mouthpiece, and an aerosol generator disposed in the housing. The aerosol generator includes a vibratable membrane having a front face and a rear face, and a vibratable element used to vibrate the membrane. Further, the housing includes an opening that is adapted to receive a unit dosage of the liquid from the container. The opening provides a liquid path to the rear face of the vibratable membrane.
    Type: Application
    Filed: May 26, 2016
    Publication date: September 22, 2016
    Inventors: John S. Patton, Ryan S. Patton, Mei-chang Kuo, Yehuda Ivri
  • Publication number: 20160199225
    Abstract: Micro-droplet delivery devices and methods are described where the device may comprise a piezoelectric actuator having a piezoelectric chip that is operatively coupled to a drug package under a preloading force. The actuator is configured to generate an acoustic pressure within the drug package to dispense droplets of an agent from an aperture, e.g., to the corneal surface of the eye. The piezoelectric actuator can be coupled or decoupled from the drug package.
    Type: Application
    Filed: January 11, 2016
    Publication date: July 14, 2016
    Inventor: Yehuda Ivri
  • Patent number: 9375739
    Abstract: A hand-held dispensing device operable to dispense a fluid as an atomized spray by hydraulic pressure. The device includes a cartridge containing a fluid to be dispensed and a pressure-multiplying piston pump operable by liquefied gas pressure and manually controlled by a valve. The pump is configured to receive pressure from a compartment containing liquefied gas and transmit higher pressure to the fluid to be dispensed. The pressure multiplying pump produces high pressure, typically between 6-30 bar, which is suitable for generation of fine spray by hydraulic atomization. The device uses about 1/10th the amount of liquefied gas compared to a propellant-based aerosol therefore it has a significant ecological and health benefits.
    Type: Grant
    Filed: March 5, 2014
    Date of Patent: June 28, 2016
    Inventor: Yehuda Ivri
  • Publication number: 20160129088
    Abstract: One embodiment describes an insulin formulation that is specifically adapted for aerosolization. The formulation comprises a major amount of water and a minor amount of insulin. Further, the formulation is preservative free, without meta-cresol, cresol or phenol, to permit the formulation to be aerosolized using a vibrating aperture plate without substantial foaming of the insulin formulation.
    Type: Application
    Filed: October 8, 2015
    Publication date: May 12, 2016
    Applicant: Dance Biopharm Inc.
    Inventors: John S. Patton, Ryan S. Patton, Mei-chang Kuo, Yehuda Ivri
  • Publication number: 20150340590
    Abstract: In one arrangement, a vibration system includes a vibratable plate, a support member surrounding the vibratable plate, and a vibration-inducing member surrounding the support member. The vibration-inducing member is configured to radially expand and contract against the support member so as to produce axial vibration of the vibratable plate. In another arrangement, the vibratable plate has an outer circumference; a tubular member is concentrically disposed about the outer circumference of the plate, and an annular vibration-inducing member is concentrically disposed about the outer circumference of the tubular member. The vibration-inducing member is preferably a piezoelectric ring that is radially expandable and contractable against the wall of the tubular member to cause the plate to vibrate in the axial direction.
    Type: Application
    Filed: August 3, 2015
    Publication date: November 26, 2015
    Applicant: Nektar Therapeutics
    Inventor: Yehuda Ivri
  • Patent number: 9180261
    Abstract: One embodiment describes an insulin formulation that is specifically adapted for aerosolization. The formulation includes a major amount of water and a minor amount of insulin. Further, the formulation is preservative free, without meta-cresol, cresol or phenol, to permit the formulation to be aerosolized using a vibrating aperture plate without substantial foaming of the insulin formulation.
    Type: Grant
    Filed: January 11, 2011
    Date of Patent: November 10, 2015
    Assignee: Dance Biopharm Inc.
    Inventors: John S. Patton, Ryan S. Patton, Mei-chang Kuo, Yehuda Ivri
  • Patent number: 9108211
    Abstract: In one arrangement, a vibration system includes a vibratable plate, a support member surrounding the vibratable plate, and a vibration-inducing member surrounding the support member. The vibration-inducing member is configured to radially expand and contract against the support member so as to produce axial vibration of the vibratable plate. In another arrangement, the vibratable plate has an outer circumference; a tubular member is concentrically disposed about the outer circumference of the plate, and an annular vibration-inducing member is concentrically disposed about the outer circumference of the tubular member. The vibration-inducing member is preferably a piezoelectric ring that is radially expandable and contractable against the wall of the tubular member to cause the plate to vibrate in the axial direction.
    Type: Grant
    Filed: April 17, 2006
    Date of Patent: August 18, 2015
    Assignee: Nektar Therapeutics
    Inventor: Yehuda Ivri
  • Publication number: 20150196721
    Abstract: An aerosolization system includes a container that is configured to deliver a unit dosage of a liquid when squeezed a single time. The system also includes an aerosolizer that is constructed of a housing defining a mouthpiece, and an aerosol generator disposed in the housing. The aerosol generator includes a vibratable membrane having a front face and a rear face, and a vibratable element used to vibrate the membrane. Further, the housing includes an opening that is adapted to receive a unit dosage of the liquid from the container. The opening provides a liquid path to the rear face of the vibratable membrane.
    Type: Application
    Filed: January 27, 2015
    Publication date: July 16, 2015
    Inventors: John S. Patton, Ryan S. Patton, Mei-chang Kuo, Yehuda Ivri
  • Patent number: 9068566
    Abstract: Systems, devices and methods are provided, for acquiring and dispensing predetermined volumes of liquids and, in particular, to a unique piezoelectric dispenser for acquiring and dispensing of small volumes of fluid in an automatic or manual production of DNA arrays and assays, wherein droplets are dispensed in a single drop format with volumes that may range from about a few picoliters to several nanoliters. The dispenser can advantageously utilize a disposable capillary tube assembly while desirably retaining the piezoelectric actuator for subsequent further uses, thereby mitigating the possibility of cross contamination of fluids and providing an economical and cost effective approach with reuse of the piezoelectric actuator for further operation such as with a variety of liquids to be dispensed and transferred. A unique longitudinal transducer can transmit radial tube displacement into controlled axial motion of the tube.
    Type: Grant
    Filed: January 20, 2012
    Date of Patent: June 30, 2015
    Assignee: BioDot, Inc.
    Inventor: Yehuda Ivri
  • Patent number: 9004061
    Abstract: An aerosolization system includes a container that is configured to deliver a unit dosage of a liquid when squeezed a single time. The system also includes an aerosolizer that is constructed of a housing defining a mouthpiece, and an aerosol generator disposed in the housing. The aerosol generator includes a vibratable membrane having a front face and a rear face, and a vibratable element used to vibrate the membrane. Further, the housing includes an opening that is adapted to receive a unit dosage of the liquid from the container. The opening provides a liquid path to the rear face of the vibratable membrane.
    Type: Grant
    Filed: September 27, 2013
    Date of Patent: April 14, 2015
    Assignee: Dance Biopharm, Inc.
    Inventors: John S. Patton, Ryan S. Patton, Mei-chang Kuo, Yehuda Ivri
  • Patent number: 8950394
    Abstract: An aerosolization system includes a squeezable container having a resilient container body. The container is configured to deliver a unit dosage of a liquid when squeezed a single time. The system also includes an aerosolizer that is constructed of a housing defining a mouthpiece, and an aerosol generator disposed in the housing. The aerosol generator includes a vibratable membrane having a front face and a rear face, and a vibratable element used to vibrate the membrane. Further, the housing includes an opening that is adapted to receive a unit dosage of the liquid from the container. The opening provides a liquid path to the rear face of the vibratable membrane.
    Type: Grant
    Filed: January 11, 2011
    Date of Patent: February 10, 2015
    Assignee: Dance Biopharm Inc.
    Inventors: John S. Patton, Ryan S. Patton, Mei-Chang Kuo, Yehuda Ivri
  • Publication number: 20140252128
    Abstract: A hand-held dispensing device operable to dispense a fluid as an atomized spray by hydraulic pressure. The device includes a cartridge containing a fluid to be dispensed and a pressure-multiplying piston pump operable by liquefied gas pressure and manually controlled by a valve. The pump is configured to receive pressure from a compartment containing liquefied gas and transmit higher pressure to the fluid to be dispensed. The pressure multiplying pump produces high pressure, typically between 6-30 bar, which is suitable for generation of fine spray by hydraulic atomization. The device uses about 1/10th the amount of liquefied gas compared to a propellant-based aerosol therefore it has a significant ecological and health benefits.
    Type: Application
    Filed: March 5, 2014
    Publication date: September 11, 2014
    Inventor: Yehuda Ivri