Abstract: A small interfering duplex oligonucleotide comprising a 15 to 30 base pair sequence being at least 90 % identical to a contiguous nucleic acid sequence of COX-II, as determined using the GCG BestFit software of the Wisconsin sequence analysis package, utilizing the Smith and Waterman algorithm, where gap weight equals 50, length weight equals 3, average match equals 10 and average mismatch equals −9.

Abstract: There is provided a stable vaccine for providing protection against disease having viral proteins transgenically expressed in plant cells. Also provided is a stable vaccine which provides protection against disease containing viral protein and coding sequences cloned into an E. coli expression system. A method of vaccination by transgenically expressing viral proteins capable of providing protection against disease into plant cells and administering the plant cells to an animal in need of vaccination is also provided. Also provided is a method of vaccination by cloning viral protein and coding sequences capable of providing protection against disease into an E. coli expression system and administering the E. coli into the animal in need of vaccination.

Abstract: There is provided a stable vaccine for providing protection against disease having viral proteins transgenically expressed in plant cells. Also provided is a stable vaccine which provides protection against disease containing viral protein and coding sequences cloned into an E. coli expression system. A method of vaccination by transgenically expressing viral proteins capable of providing protection against disease into plant cells and administering the plant cells to an animal in need of vaccination is also provided. Also provided is a method of vaccination by cloning viral protein and coding sequences capable of providing protection against disease into an E. coli expression system and administering the E. coli into the animal in need of vaccination.

Abstract: The invention relates to chimeric plasmids comprising at least one non-sttural potyvirus gene or fragment thereof, which gene is capable of being expressed in a plant transformed with the chimeric plasmid, the thus transformed plant being resistant to an infection by a plant potyvirus. The invention also relates to vectors comprising a chimeric plasmid according to the invention, particularly microorganisms transformed with the chimeric plasmids of the invention.Potyvirus-resistant plants having cells containing in their genomes the chimeric DNA sequences according to the invention, as well as seeds and cells of a potyvirus-resistant plant containing in their genome the said chimeric DNA sequences are also described and claimed, as well as methods of protecting plants against potyvirus infection wherein genomes of cells of the plant are provided with a chimeric DNA sequence according to the invention, whereby the calls become resistant to an infection by a potyvirus.