Patents by Inventor Yehuda Tamari
Yehuda Tamari has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11357898Abstract: The invention is an innovative hybrid venous reservoir designed to receive and store blood during cardiopulmonary bypass (CPB), the hybrid venous reservoir consisting of an air purging chamber that limits air in the venous blood entering the air purging chamber from exiting the air purging chamber in combination with a compliant storage chamber with at least one pliable wall, the combination providing a large volume capacity while limiting the area of the blood-air interface to that of the air purging chamber.Type: GrantFiled: April 15, 2021Date of Patent: June 14, 2022Inventor: Yehuda Tamari
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Publication number: 20150335763Abstract: Disclosed are therapeutic beads comprising agents, such as nucleic acids, that bind to high mobility group box 1 (HMGB1) and methods of treating subjects with conditions that would benefit from reducing the deleterious effects of HMGB1, such as inflammatory bowel diseases, comprising administering the beads to the gastrointestinal tract of the subjects.Type: ApplicationFiled: January 9, 2014Publication date: November 26, 2015Applicant: The Feinstein Institute For Medical ResearchInventors: Sangeeta Chavan, Jacob Levine, Yehuda Tamari, Kevin J. Tracey, Huan Yang
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Patent number: 8882696Abstract: The present invention consists of a venous blood reservoir that has a separate blood chamber to filter vent blood and a separate chamber to filter sucker blood. The two blood chambers are separated by a common wall and are in fluid communication along their top assuring that vacuum applied to the top of either is equally applied to the other. A mean to form communication across the wall allows the user to either accumulate sucker blood in its chamber while letting vent blood to flow freely to the venous blood chamber. Alternately, user can let the blood in the sucker chamber to combine with the venous blood freely too.Type: GrantFiled: April 2, 2012Date of Patent: November 11, 2014Inventor: Yehuda Tamari
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Publication number: 20120253257Abstract: The present invention consists of a venous blood reservoir that has a separate blood chamber to filter vent blood and a separate chamber to filter sucker blood. The two blood chambers are separated by a common wall and are in fluid communication along their top assuring that vacuum applied to the top of either is equally applied to the other. A mean to form communication across the wall allows the user to either accumulate sucker blood in its chamber while letting vent blood to flow freely to the venous blood chamber. Alternately, user can let the blood in the sucker chamber to combine with the venous blood freely too.Type: ApplicationFiled: April 2, 2012Publication date: October 4, 2012Inventor: Yehuda Tamari
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Patent number: 8147440Abstract: The present invention consists of a blood reservoir that incorporates a separate chamber designed to trap condensing water vapor. The blood chamber and the vapor trap are in fluid communication along their top assuring that vacuum applied to the top of the vapor trap is equally applied to the blood chamber. The combination is also structured to prevent condensate water accumulating in the vapor trap chamber from overflowing into the blood chamber as well as provide a structure that allows the end user to empty the water in the vapor trap chamber.Type: GrantFiled: September 20, 2009Date of Patent: April 3, 2012Inventor: Yehuda Tamari
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Publication number: 20100030125Abstract: The present invention consists of a blood reservoir that incorporates a separate chamber designed to trap condensing water vapor. The blood chamber and the vapor trap are in fluid communication along their top assuring that vacuum applied to the top of the vapor trap is equally applied to the blood chamber. The combination is also structured to prevent condensate water accumulating in the vapor trap chamber from overflowing into the blood chamber as well as provide a structure that allows the end user to empty the water in the vapor trap chamber.Type: ApplicationFiled: September 20, 2009Publication date: February 4, 2010Inventor: Yehuda Tamari
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Patent number: 7591812Abstract: The invention is a closed complaint venous reservoir with at least one pliable wall having at least three innovative features: 1) the venous reservoir incorporates means that purge gas bubbles entering the venous reservoir without the user intervention, 2) the venous reservoir incorporates a cardiotomy reservoir, and 3) the pliable wall of the venous reservoir is sealed within a rigid housing allowing control of its “atmospheric” pressure, and therefore the pressure at which that wall collapses. The combination of the three innovative features provides a collapsible compliant reservoir unitized with cardiotomy reservoir having air removal features and enabling vacuum augmented venous drainage (VAVD) that match that of the open hardshell venous-cardiotomy reservoir unit, while retaining the advantages of the closed soft shell venous reservoir.Type: GrantFiled: July 24, 2006Date of Patent: September 22, 2009Inventor: Yehuda Tamari
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Patent number: 7485260Abstract: Venous reservoirs are interposed between the patient and the arterial pump and serve to remove air bubbles and provide compliance that accommodates variations in the volume of blood circulating in the extracorporeal circuit during cardiopulmonary bypass (CPB). The invention is a reservoir that incorporates automated means to remove air bubbles from the venous line prior to the blood entering the arterial blood pump. In another form, the reservoir includes means that handles foam prior to the blood entering the blood pump. In yet another form, the invention is means that improve air removal in a soft shell venous reservoir. These features are applicable to CPB circuits using gravity drainage or vacuum assisted venous drainage.Type: GrantFiled: October 30, 2006Date of Patent: February 3, 2009Inventor: Yehuda Tamari
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Publication number: 20070078369Abstract: Venous reservoirs are interposed between the patient and the arterial pump and serve to remove air bubbles and provide compliance that accommodates variations in the volume of blood circulating in the extracorporeal circuit during cardiopulmonary bypass (CPB). The invention is a reservoir that incorporates automated means to remove air bubbles from the venous line prior to the blood entering the arterial blood pump. In another form, the reservoir includes means that handles foam prior to the blood entering the blood pump. In yet another form, the invention is means that improve air removal in a soft shell venous reservoir. These features are applicable to CPB circuits using gravity drainage or vacuum assisted venous drainage.Type: ApplicationFiled: October 30, 2006Publication date: April 5, 2007Inventor: Yehuda Tamari
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Patent number: 7131966Abstract: Venous reservoirs are interposed between the patient and the arterial pump and serve to remove air bubbles and provide compliance that accommodates variations in the volume of blood circulating in the extracorporeal circuit during cardiopulmonary bypass (CPB). The invention is a reservoir that incorporates automated means to remove air bubbles from the venous line prior to the blood entering the arterial blood pump. In another form, the reservoir includes means that handles foam prior to the blood entering the blood pump. In yet another form, the invention is means that improve air removal in a soft shell venous reservoir. These features are applicable to CPB circuits using gravity drainage or vacuum assisted venous drainage.Type: GrantFiled: August 9, 2004Date of Patent: November 7, 2006Inventor: Yehuda Tamari
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Patent number: 6773425Abstract: The invention is an improved container for collecting, freeze-drying, storing, reconstituting, and administering biological solutions and, in particular, blood products. The container features a pliable bottom wall providing intimate thermal contact with the cooling/heating shelf of the lyophilizer; a top wall incorporating a hydrophobic membrane providing a path for water vapor and a bacterial barrier; and side walls sufficiently stiff to support the ceiling but preferably also sufficiently flexible to collapse and minimize storage space especially once lyophilization is complete. The walls incorporate sealable ports that can be used to load the solution for processing and/or adding reconstituting liquids and/or administering the reconstituted solution to a patient. The top wall may incorporate a removable cover that protects the membrane before freeze-drying takes place.Type: GrantFiled: February 11, 2003Date of Patent: August 10, 2004Inventor: Yehuda Tamari
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Patent number: 6773426Abstract: Venous reservoirs are interposed between the patient and the arterial pump and serve to remove air bubbles and provide compliance that accommodates variations in the volume of blood circulating in the extracorporeal circuit during cardiopulmonary bypass (CPB). The invention is a reservoir that incorporates automated means to remove air bubbles from the venous line prior to the blood entering the arterial blood pump. In form, the reservoir includes means that handle foam prior to the blood entering the blood pump. In another form, the invention provides means that improve air removal in a soft shell venous reservoir. These features are applicable to CPB circuits using gravity drainage or vacuum assisted venous drainage.Type: GrantFiled: February 28, 2001Date of Patent: August 10, 2004Inventor: Yehuda Tamari
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Patent number: 6517526Abstract: The invention is an improved container for collecting, freeze-drying, storing, reconstituting, and administering biological solutions and, in particular, blood products. The container features a pliable bottom wall providing intimate thermal contact with the cooling/heating shelf of the lyophilizer; a top wall incorporating a hydrophobic membrane providing a path for water vapor and a bacterial barrier; and side walls sufficiently stiff to support the ceiling but preferably also sufficiently flexible to collapse and minimize storage space especially once lyophilization is complete. The walls incorporate sealable ports that can be used to load the solution for processing and/or adding reconstituting liquids and/or administering the reconstituted solution to a patient. The top wall may incorporate a removable cover that protects the membrane before freeze-drying takes place.Type: GrantFiled: January 2, 2002Date of Patent: February 11, 2003Inventor: Yehuda Tamari
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Patent number: 6337049Abstract: The venous reservoir accommodates variations in the total volume of blood circulating in the extracorporeal circuit during cardiopulmonary bypass (CPB). It is connected between the patient and the arterial pump and serves as a compliance chamber. Venous drainage by gravity alone provides an inadequate rate of blood return during procedures such as minimally invasive cardiac surgery and bypass via femoral cannulation. In these cases the resistance of the venous cannula limits the maximum achievable flow. Vacuum augmented venous drainage (VAVD) is a technique that overcomes flow limitations by applying suction to the hard shell reservoir thereby increasing the pressure difference between the venous site and venous reservoir. VAVD allows for a decrease in the inner diameter of the venous line, thereby reducing prime volume, as well as the use of a smaller cannula that translates to an easier insertion, a better surgical view, and a smaller surgical incision.Type: GrantFiled: August 28, 1998Date of Patent: January 8, 2002Inventor: Yehuda Tamari
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Publication number: 20010010802Abstract: Venous reservoirs are interposed between the patient and the arterial pump and serve to remove air bubbles and provide compliance that accommodates variations in the volume of blood circulating in the extracorporeal circuit during cardiopulmonary bypass (CPB).Type: ApplicationFiled: February 28, 2001Publication date: August 2, 2001Inventor: Yehuda Tamari
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Patent number: 6039078Abstract: The specification describes several uses for pressure sensitive valves during extracorporeal pumping in one embodiment, an improved pumping loop for a roller pump is used in an extracorporeal circuit with a pressure relief valve and pump tubing. The inlet and outlet of the tubing are connected respectively to the outlet and inlet of said valve via two 3 way connections, across the outlet of the pump. The pumping loop allows recirculation of pumped liquid between the inlet and outlet of the pump when the outlet pressure generated by said pump exceeds a set value thereby limiting the pump outlet pressure to the set pressure. The pressure relief valve can also be placed at the inlet if the pump to protect the circuit from excess negative pressure that the pump can generate. The pressure relief valve in combination with the pump loop provides an accurate means to dynamically set the occlusion of the tubing within the roller pump.Type: GrantFiled: June 7, 1995Date of Patent: March 21, 2000Inventor: Yehuda Tamari
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Patent number: 5927951Abstract: The present invention is a disposable combination of tubing components for use with the roller pump that limits the negative pressure said pump generates (e.g. during left ventricular venting). The device consists of pump tubing and a shunt with resistance to flow placed between the inlet and outlet of the pump tubing. The device may also incorporate interconnecting tubing and a one way valve at the pump inlet tubing. The valve decreases the likelihood of pumping air or fluid into the ventricle with accidental pump reversal. In one preferred embodiment the device is called the Better-Ventera. The pump tubing of the device collapses more readily than tubing currently being used for either venting or suction applications, thus limiting the negative pressure generated by the pump to safer levels. In addition, the maximum suction generated by the pump is further limited by recirculation of flow between the pump inlet and outlet. The recirculation acts to "break" high suction.Type: GrantFiled: April 2, 1997Date of Patent: July 27, 1999Inventor: Yehuda Tamari
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Patent number: 5814004Abstract: The specification describes several uses for pressure sensitive valves during extracorporeal pumping in one embodiment, an improved pumping loop for a roller pump is used in an extracorporeal circuit with a pressure relief valve and pump tubing. The inlet and outlet of the tubing are connected respectively to the outlet and inlet of said valve via two 3 way connections, across the outlet of the pump. The pumping loop allows recirculation of pumped liquid between the inlet and outlet of the pump when the outlet pressure generated by said pump exceeds a set value thereby limiting the pump outlet pressure to the set pressure. The pressure relief valve can also be placed at the inlet if the pump to protect the circuit from excess negative pressure that the pump can generate. The pressure relief valve in combination with the pump loop provides an accurate means to dynamically set the occlusion of the tubing within the roller pump.Type: GrantFiled: June 7, 1995Date of Patent: September 29, 1998Inventor: Yehuda Tamari
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Patent number: 5813842Abstract: The specification describes several uses for pressure sensitive valves during extracorporeal pumping in one embodiment, an improved pumping loop for a roller pump is used in an extracorporeal circuit with a pressure relief valve and pump tubing. The inlet and outlet of the tubing are connected respectively to the outlet and inlet of said valve via two 3 way connections, across the outlet of the pump. The pumping loop allows recirculation of pumped liquid between the inlet and outlet of the pump when the outlet pressure generated by said pump exceeds a set value thereby limiting the pump outlet pressure to the set pressure. The pressure relief valve can also be placed at the inlet if the pump to protect the circuit from excess negative pressure that the pump can generate. The pressure relief valve in combination with the pump loop provides an accurate means to dynamically set the occlusion of the tubing within the roller pump.Type: GrantFiled: June 7, 1995Date of Patent: September 29, 1998Inventor: Yehuda Tamari
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Patent number: 5429483Abstract: The specification describes several uses for pressure sensitive valves during extracorporeal pumping in one embodiment, an improved pumping loop for a roller pump is used in an extracorporeal circuit with a pressure relief valve and pump tubing. The inlet and outlet of the tubing are connected respectively to the outlet and inlet of said valve via two 3 way connections, across the outlet of the pump. The pumping loop allows recirculation of pumped liquid between the inlet and outlet of the pump when the outlet pressure generated by said pump exceeds a set value thereby limiting the pump outlet pressure to the set pressure. The pressure relief valve can also be placed at the inlet if the pump to protect the circuit from excess negative pressure that the pump can generate. The pressure relief valve in combination with the pump loop provides an accurate means to dynamically set the occlusion of the tubing within the roller pump.Type: GrantFiled: February 10, 1993Date of Patent: July 4, 1995Inventor: Yehuda Tamari