Patents by Inventor Yehuda Zadok
Yehuda Zadok has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11678932Abstract: Apparatus comprises: (a) a longitudinal member (32), having a distal portion (34); (b) a plurality of electrodes (38) disposed on the distal portion of the longitudinal member, such that a first electrode (38a) of the plurality of electrodes is disposed distally along the longitudinal member from a second electrode (38b) of the plurality of electrodes; and (c) a controller (40). The controller comprises an actuator, and circuitry (42) electrically connected to the electrodes via the longitudinal member. The actuator is configured to move the longitudinal member in discrete incremental movements such that for each incremental movement, (i) before the incremental movement the first electrode is disposed in a starting position, (ii) during each incremental movement the actuator moves second electrode toward the starting position, and (iii) at the end of each incremental movement the second electrode is stationary at the starting position.Type: GrantFiled: May 15, 2017Date of Patent: June 20, 2023Assignee: SYMAP MEDICAL (SUZHOU) LIMITEDInventors: Yossi Gross, Yehuda Zadok, Yaron Tal
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Publication number: 20220347464Abstract: A method for treating an intervertebral disc of a subject is provided, the method including delivering a growth factor to a nucleus pulposus of the intervertebral disc. At least one intra-pulposus exposed electrode surface is implanted in the nucleus pulposus. At least one extra-pulposus exposed electrode surface is implanted in a body of the subject outside the nucleus pulposus. The growth factor is supported by activating control circuitry to drive the intra-pulposus and the extra-pulposus exposed electrode surfaces to electroosmotically drive nutrient-containing fluid into the nucleus pulposus. Other embodiments are also described.Type: ApplicationFiled: March 14, 2022Publication date: November 3, 2022Applicant: DISCURE TECHNOLOGIES LTD.Inventors: Yuval MANDELBAUM, Yossi GROSS, Yehuda ZADOK
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Publication number: 20220287634Abstract: The present invention, in some embodiments thereof, relates to methods and/or apparatus for measuring the effectiveness of a renal denervation treatment. In some embodiments, a method for determining effectiveness of the denervation treatment comprises tracking at least one of arterial wall movement, arterial blood flow rate, arterial blood flow velocity, blood pressure and arterial diameter at one or more selected locations in the renal artery over time, and assessing the effectiveness of said renal denervation treatment according to results obtained by tracking.Type: ApplicationFiled: May 25, 2022Publication date: September 15, 2022Applicant: Sonivie Ltd.Inventors: Ariel SVERDLIK, Benny DILMONEY, Yehuda ZADOK, Or SHABTAY
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Patent number: 11357447Abstract: The present invention, in some embodiments thereof, relates to methods and/or apparatus for measuring the effectiveness of a renal denervation treatment. In some embodiments, a method for determining effectiveness of the denervation treatment comprises tracking at least one of arterial wall movement, arterial blood flow rate, arterial blood flow velocity, blood pressure and arterial diameter at one or more selected locations in the renal artery over time, and assessing the effectiveness of said renal denervation treatment according to results obtained by tracking.Type: GrantFiled: May 30, 2013Date of Patent: June 14, 2022Assignee: Sonivie Ltd.Inventors: Ariel Sverdlik, Benny Dilmoney, Yehuda Zadok, Or Shabtay
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Patent number: 11298530Abstract: A method is provided for treating an intervertebral disc of a subject, the method including delivering cells to a nucleus pulposus of the intervertebral disc. At least one intra-pulposus exposed electrode surface is implanted in the nucleus pulposus. At least one extra-pulposus exposed electrode surface is implanted in a body of the subject outside the nucleus pulposus. The delivered cells are supported by activating control circuitry to drive the intra-pulposus and the extra-pulposus exposed electrode surfaces to electroosmotically drive nutrient-containing fluid into the nucleus pulposus. Other embodiments are also described.Type: GrantFiled: May 3, 2021Date of Patent: April 12, 2022Assignee: DISCURE TECHNOLOGIES LTD.Inventors: Yuval Mandelbaum, Yossi Gross, Yehuda Zadok
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Publication number: 20210178194Abstract: The present invention, in some embodiments thereof, relates to a devices and methods for intravascular denervation and assessment thereof and, more particularly, but not exclusively, to devices and methods for renal denervation. Some embodiments of the invention relate to an intravascular catheter configured for ultrasonic ablation of the tissue, comprising a plurality of piezoelectric transceivers. In some embodiments, an intravascular distancing device is provided, the device adapted for obtaining at least a minimal distance between an ultrasound emitting element and a tissue, such as the blood vessel wall. Some embodiments of the invention relate to assessment of renal sympathetic denervation (RSD) treatment effectiveness. Some embodiments of the invention relate to processing echo of signals, such as processing of signals to characterize physical and/or mechanical properties of the blood vessel.Type: ApplicationFiled: February 28, 2021Publication date: June 17, 2021Applicant: Sonivie Ltd.Inventors: Ariel SVERDLIK, Or SHABTAY, Ronen NEEMAN, Giora BEIT-YAAKOV, Lilah MARZIANO, Avital SCHAUDER, Marina DUBINSKY, Yehuda ZADOK, Jonathan YALOM
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Patent number: 10933259Abstract: The present invention, in some embodiments thereof, relates to a devices and methods for intravascular denervation and assessment thereof and, more particularly, but not exclusively, to devices and methods for renal denervation. Some embodiments of the invention relate to an intravascular catheter configured for ultrasonic ablation of the tissue, comprising a plurality of piezoelectric transceivers. In some embodiments, an intravascular distancing device is provided, the device adapted for obtaining at least a minimal distance between an ultrasound emitting element and a tissue, such as the blood vessel wall. Some embodiments of the invention relate to assessment of renal sympathetic denervation (RSD) treatment effectiveness. Some embodiments of the invention relate to processing echo of signals, such as processing of signals to characterize physical and/or mechanical properties of the blood vessel.Type: GrantFiled: May 22, 2014Date of Patent: March 2, 2021Assignee: CardioSonic Ltd.Inventors: Ariel Sverdlik, Or Shabtay, Ronen Neeman, Giora Beit-Yaakov, Lilah Marziano, Avital Schauder, Marina Dubinsky, Yehuda Zadok, Jonathan Yalom
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Publication number: 20200179044Abstract: Apparatus comprises: (a) a longitudinal member (32), having a distal portion (34); (b) a plurality of electrodes (38) disposed on the distal portion of the longitudinal member, such that a first electrode (38a) of the plurality of electrodes is disposed distally along the longitudinal member from a second electrode (38b) of the plurality of electrodes; and (c) a controller (40). The controller comprises an actuator, and circuitry (42) electrically connected to the electrodes via the longitudinal member. The actuator is configured to move the longitudinal member in discrete incremental movements such that for each incremental movement, (i) before the incremental movement the first electrode is disposed in a starting position, (ii) during each incremental movement the actuator moves second electrode toward the starting position, and (iii) at the end of each incremental movement the second electrode is stationary at the starting position.Type: ApplicationFiled: May 15, 2017Publication date: June 11, 2020Applicant: PYTHAGORAS MEDICAL LTD.Inventors: Yossi GROSS, Yehuda ZADOK, Yaron TAL
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Patent number: 10478249Abstract: Apparatus and methods are described, including a method for use with tissue of a renal nerve (770) passing longitudinally within a wall of a renal artery (8) of a subject. Using one or more stimulating electrodes (850a, 850b) disposed within the renal artery, the tissue is stimulated by passing a stimulating current through the wall of the renal artery. Using a sensor (26), a rate of change of blood pressure of the subject is sensed, following the start of the stimulation of the tissue. In response to the rate of change, it is decided whether to ablate the tissue, and in response to deciding to ablate the tissue, the tissue is ablated. Other applications are also described.Type: GrantFiled: May 7, 2015Date of Patent: November 19, 2019Assignee: PYTHAGORAS MEDICAL LTD.Inventors: Yossi Gross, Gideon Meiry, Yehuda Zadok
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Publication number: 20190290350Abstract: There is provided in accordance with an exemplary embodiment of the invention a method and/or a device of treating tissue near a first lumen comprising inserting an energy emission element into a second lumen and delivering energy in an amount sufficient to cause one or more spaced apart areas of tissue damage at preselected locations in tissue near the first lumen. There is also provided a method and/or a device for treating a carotid artery wall, for example, to reduce signal conduction. There is also provided a method and/or a device for treating a wall of a lumen in a limb, for example, to increase blood flow. There is also provided a method and/or a device for treating a wall of a heart, for example, to stop abnormal signal propagation.Type: ApplicationFiled: June 13, 2019Publication date: September 26, 2019Applicant: CardioSonic Ltd.Inventors: Ariel SVERDLIK, Yehuda ZADOK, Or SHABTAY, Iris SZWARCFITER, Avital SCHAUDER, Krishna J. ROCHA-SINGH
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Patent number: 10383685Abstract: A method is provided, comprising: (1) applying an excitatory current to renal nerve fibers of a subject; (2) determining a change in a parameter of the subject in response to the excitatory current, the parameter being a fastest rate of increase in arterial pressure during a systolic upstroke of an arterial pressure wave of the subject; (3) in response to the change, deciding whether to ablate the renal nerve fibers; and (4) in response to the deciding, applying ablation energy to the renal nerve fibers. Other embodiments are also described.Type: GrantFiled: May 5, 2016Date of Patent: August 20, 2019Assignee: PYTHAGORAS MEDICAL LTD.Inventors: Yossi Gross, Yehuda Zadok
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Patent number: 10357304Abstract: There is provided in accordance with an exemplary embodiment of the invention a method and/or a device of treating tissue near a first lumen comprising inserting an energy emission element into a second lumen and delivering energy in an amount sufficient to cause one or more spaced apart areas of tissue damage at preselected locations in tissue near the first lumen. There is also provided a method and/or a device for treating a carotid artery wall, for example, to reduce signal conduction. There is also provided a method and/or a device for treating a wall of a lumen in a limb, for example, to increase blood flow. There is also provided a method and/or a device for treating a wall of a heart, for example, to stop abnormal signal propagation.Type: GrantFiled: April 18, 2013Date of Patent: July 23, 2019Assignee: CardioSonic Ltd.Inventors: Ariel Sverdlik, Yehuda Zadok, Or Shabtay, Iris Szwarcfiter, Avital Schauder, Krishna J. Rocha-Singh
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Publication number: 20180250054Abstract: Apparatus is provided, comprising: (a) an elongate member, having a proximal portion and a distal portion; (b) an extracorporeal controller, coupled to the proximal portion of the elongate member, and comprising a user interface and control circuitry; and (c) an effector unit. The effector unit is coupled to the distal portion of the elongate member, defines a longitudinal axis, and has a contracted state and an expanded state. The effector unit comprises a plurality of electrodes, operable by the control circuitry, and disposed circumferentially around the central longitudinal axis of the effector unit; and an ultrasound transducer, operable by the control circuitry. In the expanded state, each electrode is disposed further radially outward from (i) the central longitudinal axis of the effector unit, and (ii) the transducer compared to the contracted state, and the transducer is oriented to direct ultrasound radially outwardly.Type: ApplicationFiled: March 6, 2017Publication date: September 6, 2018Applicant: PYTHAGORAS MEDICAL LTD.Inventors: Yossi GROSS, Yehuda ZADOK, Ronen NEEMAN
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Publication number: 20180055557Abstract: During a dual-signal period, a dual electric signal is applied at a site of a nerve of a subject, and during an ablation-signal period that is separate from the dual-signal period, an ablation electric signal is applied at the site. The dual electric signal has an excitation component and an ablation component, and the ablation electric signal has the ablation component but not the excitation component. Other embodiments are also described.Type: ApplicationFiled: September 1, 2016Publication date: March 1, 2018Applicant: RAINBOW MEDICAL LTD.Inventors: Yossi GROSS, Yehuda ZADOK
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Publication number: 20170215950Abstract: Apparatus and methods are described, including a method for use with tissue of a renal nerve (770) passing longitudinally within a wall of a renal artery (8) of a subject. Using one or more stimulating electrodes (850a, 850b) disposed within the renal artery, the tissue is stimulated by passing a stimulating current through the wall of the renal artery. Using a sensor (26), a rate of change of blood pressure of the subject is sensed, following the start of the stimulation of the tissue. In response to the rate of change, it is decided whether to ablate the tissue, and in response to deciding to ablate the tissue, the tissue is ablated. Other applications are also described.Type: ApplicationFiled: May 7, 2015Publication date: August 3, 2017Applicant: PYTHAGORAS MEDICAL LTD.Inventors: Yossi GROSS, Gideon MEIRY, Yehuda ZADOK
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Publication number: 20170202614Abstract: A method includes, using a computer processor: (1) generating a map of vasculature of a subject, by: (a) displaying (i) a schematic representation of the vasculature including a blood vessel, and (ii) on the schematic representation, a first plurality of branch-site options; (b) receiving a user-selected first branch site, and responsively displaying (i) a schematic representation of a first branch of the vasculature that branches from the schematic representation of the blood vessel at the user-selected first branch site, and (ii) a second plurality of branch-site options; and (c) receiving a user-selected second branch site; (2) in response to receiving the user-selected second branch site, displaying the map; (3) detecting a physiological parameter of the subject; and (4) in response to the detected physiological parameter, determining a value for the parameter, and storing, in association with a location on the map, data representative of the value.Type: ApplicationFiled: January 20, 2016Publication date: July 20, 2017Applicant: RAINBOW MEDICAL LTD.Inventors: Yossi Gross, Yehuda Zadok
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Publication number: 20170172651Abstract: A method is described, including: (i) advancing a catheter to a first portion of a renal artery, the catheter having a plurality of electrodes coupled thereto; (ii) using one or more of the electrodes to apply ablating energy at a first portion of the renal artery; (iii) using one or more of the electrodes to apply excitatory current at a second portion of the renal artery that is at or efferent to the first portion; (iv) using a physiological sensor, sensing that a physiological response to the excitatory current is below a threshold response; (v) subsequently, advancing the catheter distally, and (vi) subsequently, using one or more of the electrodes to apply ablating energy at a third portion of the renal artery that is the same as or efferent to the second portion. Other embodiments are also described.Type: ApplicationFiled: December 17, 2015Publication date: June 22, 2017Applicant: RAINBOW MEDICAL LTD.Inventors: Yossi GROSS, Yehuda ZADOK, Assaf Israel Pele LEON
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Publication number: 20170007158Abstract: A method includes disposing at least one pair of electrodes in or on a body of a subject, including disposing at least one intrarenal electrode of the pair in a renal artery. Control circuitry is activate to (a) apply electrical pulses between the pair of electrodes, (b) calculate at least one time-varying component of electrode-tissue impedance based on applying the pulses, (c) sense a periodic hemodynamic signal of the subject, (d) calculate a level of correlation between the at least one time-varying component of the electrode-tissue impedance and the periodic hemodynamic signal, and (e) based on the level of correlation, ascertain a level of contact between the at least one intrarenal electrodes and a wall of the renal artery. In response to the level of contact being less than a threshold level of contact, a disposition of the at least one intrarenal electrodes in the renal artery is adjusted.Type: ApplicationFiled: July 9, 2015Publication date: January 12, 2017Inventors: Yossi GROSS, Yehuda ZADOK, Yoel ATLACEVITZ
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Publication number: 20170007157Abstract: A method includes disposing a pair of current-application electrodes in or on a body, including disposing an intrarenal current-application electrode of the pair in a renal artery. Two or more sensing electrodes are disposed in or on the body, including disposing one of the sensing electrodes on en external surface of skin. Control circuitry is activated to (a) apply an electrical current between the pair of current-application electrodes, (b) while applying the electrical current, sense an electrical signal between the sensing electrodes, including the sensing electrode disposed on the external surface of the skin, and (c) based on the electrical signal, ascertain a level of contact between the intrarenal current-application electrode and a wall of the renal artery. In response to the level of contact being less than a threshold level of contact, a disposition of the intrarenal current-application electrode in the renal artery is adjusted.Type: ApplicationFiled: July 8, 2015Publication date: January 12, 2017Inventors: Yossi GROSS, Yehuda ZADOK, Assaf Israel Pele LEON
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Publication number: 20160324572Abstract: A method is provided, comprising: (1) applying an excitatory current to renal nerve fibers of a subject; (2) determining a change in a parameter of the subject in response to the excitatory current, the parameter being a fastest rate of increase in arterial pressure during a systolic upstroke of an arterial pressure wave of the subject; (3) in response to the change, deciding whether to ablate the renal nerve fibers; and (4) in response to the deciding, applying ablation energy to the renal nerve fibers. Other embodiments are also described.Type: ApplicationFiled: May 5, 2016Publication date: November 10, 2016Applicant: RAINBOW MEDICAL LTD.Inventors: Yossi GROSS, Yehuda ZADOK