Patents by Inventor Yehudit Natan
Yehudit Natan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230124095Abstract: The preset invention is directed to ACC particles stabilized by at least one stabilizing agent, a pharmaceutical composition including same, and methods of using same, such as for treating or preventing an acidosis-related disease or condition in a subject in need thereof.Type: ApplicationFiled: January 28, 2021Publication date: April 20, 2023Inventors: Yossi BEN, Yigal BLUM, Yehudit NATAN
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Publication number: 20140127172Abstract: A method of preserving functionality of an organ is disclosed herein, including removing a whole organ including vasculature from a donor, cryo-preserving the whole organ including vasculature, thawing the whole organ including vasculature so that at least a portion of cells contained therein resume biological activity, and introducing the whole organ including vasculature into a recipient so that a blood vessel in the vasculature is supplied with blood. Further disclosed herein is a method of preserving fertility of a patient undergoing a treatment expected to cause sterility, including removing at least one whole gonadal organ including vasculature from the patient, preserving functionality of the gonadal organ as described herein, conducting the treatment and waiting for an effect thereof to subside, and introducing the gonadal organ into the patient.Type: ApplicationFiled: November 8, 2013Publication date: May 8, 2014Inventors: Amir ARAV, Yehudit NATAN, Saar YAVIN, Uri MEIR, Udi DAMARI
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Patent number: 8580487Abstract: A method of preserving functionality of an organ. The method includes removing a whole organ and associated vasculature, cryo-preserving the whole organ, allowing a period of time to elapse, thawing the whole organ including vasculature and introducing the whole organ into a recipient so that the organ is supplied with blood by vasculature belonging to the recipient. Further disclosed is a method of preserving fertility of a patient undergoing a treatment expected to cause sterility. The method include removing a whole gonadal organ from the patient, cryo-preserving the whole gonadal organ, conducting the treatment and waiting for an effect thereof to subside, thawing the whole gonadal organ and introducing the whole gonadal organ where it is supplied with blood by the vasculature system of the patient.Type: GrantFiled: April 11, 2005Date of Patent: November 12, 2013Assignee: Core Dynamics LimitedInventors: Amir Arav, Yehudit Natan, Saar Yavin, Uri Meir, Udi Damari
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Patent number: 8512941Abstract: Provided is a preservation solution for preserving biological material at low temperature including one or more polyphenols and a method for preservation of biological material, the method includes adding the preservation solution to biological material, cooling the biological material and storing it under appropriate storing conditions. The present method may be used for hypothermic preservation or for cryopreservation, including freezing and lyophilization, and may be used with any biological material, including cells selected from RBC, WBC, MNC, UCB MNC and bacteria. In the case of RBC, also disclosed is a method for its freezing such that upon thawing, the material has less than 2% free hemoglobin.Type: GrantFiled: March 29, 2011Date of Patent: August 20, 2013Assignee: Core Dynamics LimitedInventor: Yehudit Natan
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Publication number: 20120276581Abstract: The claimed subject matter is based on the finding that it is possible to cryopreserve cancellous bone tissue with viable cells (after reconstitution by either thawing or rehydration), the viability after reconstitution being comparable to that of a fresh sample (without freezing) and of beneficial value for use in, for example, transplantation. Thus, provided is a method for cryopreserving a cancellous bone sample. The cryopreserved cancellous bone sample can be in dry form, for example, lyophilized. Also provided is a cryopreserved, in dry form, bone sample and the use of a cryopreserved bone sample; a method for identifying such cryopreserved cancellous bone tissue and uses thereof.Type: ApplicationFiled: January 6, 2011Publication date: November 1, 2012Applicant: CORE DYNAMICS LTD.Inventors: Amir Arav, Victor Rzepakovsky, Isachar Norman, Olga Shneerson, Yehudit Natan
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Patent number: 8198085Abstract: The present invention generally concerns cell therapy and products for use in such therapy. Particularly, the invention provides a preserved cell preparation essentially free of one or more members of a group of cryoprotecting agents consisting of polyalcohols, DMSO and cryoprotecting proteins, the preserved cell preparation comprising somatic cells and at least one polyphenol, wherein upon reconstitution of cells in the cell preparation, at least a portion of said stem cells are viable, said portion being sufficient for use of the cell preparation in stem cell therapy. The invention also provides cells reconstituted from preserved somatic cells, and the use of the reconstituted cells in cell therapy. A preferred cell preparation in accordance with the invention comprises stem cells, preferably human stem cells.Type: GrantFiled: August 3, 2006Date of Patent: June 12, 2012Assignee: Core Dynamics LimitedInventors: Tamir Kanias, Yehudit Natan
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Publication number: 20110177488Abstract: Provided is a preservation solution for preserving biological material at low temperature including one or more polyphenols and a method for preservation of biological material, the method includes adding the preservation solution to biological material, cooling the biological material and storing it under appropriate storing conditions. The present method may be used for hypothermic preservation or for cryopreservation, including freezing and lyophilization, and may be used with any biological material, including cells selected from RBC, WBC, MNC, UCB MNC and bacteria. In the case of RBC, also disclosed is a method for its freezing such that upon thawing, the material has less than 2% free hemoglobin.Type: ApplicationFiled: March 29, 2011Publication date: July 21, 2011Applicant: CORE DYNAMICS LIMITEDInventors: Yehudit NATAN, Tamir KANIAS
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Patent number: 7935478Abstract: A preservation solution for preserving a biological material at a low temperature including one or more polyphenols, and a method for preserving a biological material are provided. The method includes adding the preservation solution to a biological material, cooling the biological material and storing it under appropriate storing conditions. The method can be used for hypothermic preservation or for cryopreservation, including freezing and lyophilization, of any biological material, including cells selected from RBC, WBC, MNC, UCB, HSC and bacteria. A method is also provided for freezing RBCs such that upon thawing, the RBCs include less than 2% free hemoglobin.Type: GrantFiled: February 2, 2005Date of Patent: May 3, 2011Assignee: Core Dynamics LimitedInventors: Yehudit Natan, Tamir Kanias
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Patent number: 7892726Abstract: The invention provides a method for the sterilization of a biological preparation comprising desired viable biological entities. The method comprises irradiating a dried (e.g. freeze-dried) biological preparation with ionizing or UV radiation at an intensity and for a duration sufficient to reduce the amount or activity of living-matter contaminants in the biological preparation, the intensity and duration selected such that at least part of the desired biological entities in the sample remains viable. The method of the invention is particularly suitable for the reduction of the amount or activity of contaminants such as bacteria or viruses from biological preparations comprising red blood cells or platelets.Type: GrantFiled: June 7, 2005Date of Patent: February 22, 2011Assignee: Core Dynamics LimitedInventors: Yehudit Natan, Tamir Kanias
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Publication number: 20100281886Abstract: There are provided a system and a method for cryopreserving a liquid biological material disposed in a bag having a longitudinal axis. The system comprises a bag holder for holding the bag, so that the biological material therein has a surface area S, and a volume V, a tank containing a cryogenic fluid, a mechanism for the immersion of the bag holder into the tank along the longitudinal axis, an opening in the tank for insertion therethrough of the bag holder, and a guide member extending from the opening into the tank. There are further provided a system and a method for warming a cryopreserved liquid biological material disposed in a bag.Type: ApplicationFiled: September 11, 2007Publication date: November 11, 2010Applicant: Core Dynamics LimitedInventors: Ginadi Shaham, Yehudit Natan, Dana Lorber, Peter Bartal, Yoram Amsalem, Yaniv Damari
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Publication number: 20100197017Abstract: Provided is a method for the sterilization of a biological preparation including desired viable biological entities. The method includes irradiating a dried (e.g. freeze-dried) biological preparation with UV radiation at an intensity and for a duration sufficient to reduce the amount or activity of living-matter contaminants in the biological preparation, the intensity and duration selected such that at least part of the desired biological entities in the sample remains viable. The described method is particularly suitable for the reduction of the amount or activity of contaminants such as bacteria or viruses from biological preparations including red blood cells or platelets.Type: ApplicationFiled: April 9, 2010Publication date: August 5, 2010Applicant: CORE DYNAMICS LIMITEDInventors: Yehudit NATAN, Tamir KANIAS
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Publication number: 20100105133Abstract: The present invention generally concerns cell therapy and products for use in such therapy. Particularly, the invention provides a preserved cell preparation essentially free of one or more members of a group of cryoprotecting agents consisting of polyalcohols, DMSO and cryoprotecting proteins, the preserved cell preparation comprising somatic cells and at least one polyphenol, wherein upon reconstitution of cells in the cell preparation, at least a portion of said stem cells are viable, said portion being sufficient for use of the cell preparation in stem cell therapy. The invention also provides cells reconstituted from preserved somatic cells, and the use of the reconstituted cells in cell therapy. A preferred cell preparation in accordance with the invention comprises stem cells, preferably human stem cells.Type: ApplicationFiled: August 3, 2006Publication date: April 29, 2010Applicant: CORE DYNAMICS LIMITEDInventors: Tamir Kanias, Yehudit Natan
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Patent number: 7659111Abstract: A method and a device for improved freezing of biological containing living cells is disclosed. Directional cooling coupled with agitation, preferably rotation, of the vessel containing the biological sample allows for the freezing of large volume samples at much greater rates than before. Whether a sample is large or not, the greater thermal homogeneity during the freezing process as well as the resulting crystal morphology yield a frozen sample which is exceptionally suited for lyophilization.Type: GrantFiled: September 5, 2002Date of Patent: February 9, 2010Assignee: Core Dynamics LimitedInventors: Uri Meir, Yoram Amsalem, Yehudit Natan, Amir Arav
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Publication number: 20080038818Abstract: The invention provides a method for the sterilization of a biological preparation comprising desired viable biological entities. The method comprises irradiating a dried (e.g. freeze-dried) biological preparation with ionizing or UV radiation at an intensity and for a duration sufficient to reduce the amount or activity of living-matter contaminants in the biological preparation, the intensity and duration selected such that at least part of the desired biological entities in the sample remains viable. The method of the invention is particularly suitable for the reduction of the amount or activity of contaminants such as bacteria or viruses from biological preparations comprising red blood cells or platelets.Type: ApplicationFiled: June 7, 2005Publication date: February 14, 2008Inventors: Yehudit Natan, Tamir Kanias
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Publication number: 20070178434Abstract: A preservation solution for preserving a biological material at a low temperature including one or more polyphenols, and a method for preserving a biological material are provided. The method includes adding the preservation solution to a biological material, cooling the biological material and storing it under appropriate storing conditions. The method can be used for hypothermic preservation or for cryopreservation, including freezing and lyophilization, of any biological material, including cells selected from RBC, WBC, MNC, UCB, MNC, and bacteria. A method is also provided for freezing RBCs such that upon thawing, the RBCs include less than 2% free hemoglobin.Type: ApplicationFiled: February 2, 2005Publication date: August 2, 2007Applicant: I.M.T. INTERFACE MULTIGRAD TECHNOLOGY LTD.Inventors: Yehudit Natan, Tamir Kanias
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Publication number: 20050175975Abstract: A method of preserving functionality of an organ. The method includes removing a whole organ and associated vasculature, cryo-preserving the whole organ, allowing a period of time to elapse, thawing the whole organ including vasculature and introducing the whole organ into a recipient so that the organ is supplied with blood by vasculature belonging to the recipient. Further disclosed is a method of preserving fertility of a patient undergoing a treatment expected to cause sterility. The method include removing a whole gonadal organ from the patient, cryo-preserving the whole gonadal organ,conducting the treatment and waiting for an effect thereof to subside, thawing the whole gonadal organ and introducing the whole gonadal organ where it is supplied with blood by the vasculature system of the patient.Type: ApplicationFiled: April 11, 2005Publication date: August 11, 2005Inventors: Amir Arav, Yehudit Natan, Saar Yavin, Uri Meir, Udi Damari
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Publication number: 20040191754Abstract: A method and a device for improved freezing of biological containing living cells is disclosed. Directional cooling coupled with agitation, preferably rotation, of the vessel containing the biological sample allows for the freezing of large volume samples at much grater rates than before. Whether a sample is large or not, the greater thermal homogeneity during the freezing process as well as the resulting crystal morphology yield a frozen sample which is exceptionally suited for lyophilization.Type: ApplicationFiled: March 2, 2004Publication date: September 30, 2004Inventors: Uri Meir, Yoram Amsalem, Yehudit Natan, Amir Arav