Abstract: The present disclosure discloses a use of a ZNF124 gene in early screening or auxiliary diagnosis of retinitis pigmentosa disease. The present disclosure also discloses a use of a detection reagent for detecting ZNF124 gene mutation in preparation of a reagent or a kit for early screening or auxiliary diagnosis of the retinitis pigmentosa disease. Research of the present disclosure finds that the mutation of the ZNF124 gene is related to the retinitis pigmentosa disease, early screening or auxiliary diagnosis can be performed on the retinitis pigmentosa disease by detecting the mutation of the ZNF124 gene.

Abstract: Provided is a construction method for an animal model for retinitis pigmentosa diseases and the application thereof, which relate to the technical field of medical engineering. According to the construction method for the animal model for retinitis pigmentosa diseases, by knocking out Hkdc1 gene sequences on genomes of target animals, the animal model for retinitis pigmentosa diseases is obtained. The animal model presents typical characteristics of retinitis pigmentosa, such as retina function damage and gradual apoptosis of photoreceptor cells. The animal model can be applied to research of retinitis pigmentosa diseases and for to screening medicine for the treatment of retinitis pigmentosa diseases.