Patents by Inventor Yen-Chen Huang
Yen-Chen Huang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20210106725Abstract: Compositions including a first soft tissue-derived matrix and a second soft tissue-derived matrix are provided, as well as methods of making such compositions. In some embodiments, the composition comprises dilapidated, decellularized adipose tissue-derived matrix and dilapidated, decellularized fascial tissue-derived matrix, which may be combined in various proportions. Such adipose-fascia matrix compositions provide improved volume retention when implanted into a patient. The composition may further include exogenous cells or other substances, and/or a carrier. The composition is suitable for use inplastic surgery procedures, including reconstructive or cosmetic surgery procedures, as well as procedures for wound treatment and tissue regeneration.Type: ApplicationFiled: December 22, 2020Publication date: April 15, 2021Inventors: Benjamin Schilling, Andrew Madans, Abigail Phipps, Thomas Tylutki, Todd Nilsen, Yen-Chen Huang, Evangelia Chnari
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Patent number: 10973953Abstract: Methods and compositions for preparing and priming a tissue graft for an accelerated therapeutic effect are provided herein. In one embodiment, the method includes obtaining a tissue containing viable cells from a donor, wherein the viable cells are endogenous to the tissue and remain resident in the tissue; and priming the viable cells with one or more stimuli to produce a primed tissue, wherein when grafted to a recipient the primed tissue provides a benefit compared to non-primed tissue.Type: GrantFiled: August 17, 2017Date of Patent: April 13, 2021Assignee: Musculoskeletal Transplant FoundationInventors: Eric Semler, Mark Spilker, Kevin Wu, Yen-Chen Huang, Evangelia Chnari, Jeffrey Cartmell, Morris Jacobs, Alison Ling, Moon Hae Sunwoo
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Patent number: 10912864Abstract: Compositions including a first soft tissue-derived matrix and a second soft tissue-derived matrix are provided, as well as methods of making such compositions. In some embodiments, the composition comprises delipidated, decellularized adipose tissue-derived matrix and delipidated, decellularized fascial tissue-derived matrix, which may be combined in various proportions. Such adipose-fascia matrix compositions provide improved volume retention when implanted into a patient. The composition may further include exogenous cells or other substances, and/or a carrier. The composition is suitable for use inplastic surgery procedures, including reconstructive or cosmetic surgery procedures, as well as procedures for wound treatment and tissue regeneration.Type: GrantFiled: May 31, 2019Date of Patent: February 9, 2021Assignee: Musculoskeletal Transplant FoundationInventors: Benjamin Schilling, Andrew Madans, Abigail Phipps, Thomas Tylutki, Todd Nilsen, Yen-Chen Huang, Evangelia Chnari
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Publication number: 20200171094Abstract: An acellular soft tissue-derived matrix includes a collagenous tissue that has been delipidated and decellularized. Adipose tissue is among the soft tissues suitable for manufacturing an acellular soft tissue-derived matrix. Exogenous tissuegenic cells and other biologically-active factors may be added to the acellular matrix. The acellular matrix may be provided as particles, a slurry, a paste, a gel, or in some other form. The acellular matrix may be provided as a three-dimensional scaffold that has been reconstituted from particles of the three-dimensional tissue. The three-dimensional scaffold may have the shape of an anatomical feature and serve as a template for tissue repair or replacement. A method of making an acellular soft tissue-derived matrix includes steps of removing lipid from the soft tissue by solvent extraction and chemical decellularization of the soft tissue.Type: ApplicationFiled: February 5, 2020Publication date: June 4, 2020Inventors: Yen-Chen Huang, Asia Ivery, Bryan Choi, Benjamin Schilling, Manh-Dan Ngo
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Patent number: 10596201Abstract: An acellular soft tissue-derived matrix includes a collagenous tissue that has been delipidated and decellularized. Adipose tissue is among the soft tissues suitable for manufacturing an acellular soft tissue-derived matrix. Exogenous tissuegenic cells and other biologically-active factors may be added to the acellular matrix. The acellular matrix may be provided as particles, a slurry, a paste, a gel, or in some other form. The acellular matrix may be provided as a three-dimensional scaffold that has been reconstituted from particles of the three-dimensional tissue. The three-dimensional scaffold may have the shape of an anatomical feature and serve as a template for tissue repair or replacement. A method of making an acellular soft tissue-derived matrix includes steps of removing lipid from the soft tissue by solvent extraction and chemical decellularization of the soft tissue.Type: GrantFiled: September 5, 2018Date of Patent: March 24, 2020Assignee: Musculoskeletal Transplant FoundationInventors: Yen-Chen Huang, Asia Ivery, Bryan Choi, Benjamin Schilling, Manh-Dan Ngo
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Publication number: 20190298885Abstract: Compositions including a first soft tissue-derived matrix and a second soft tissue-derived matrix are provided, as well as methods of making such compositions. In some embodiments, the composition comprises delipidated, decellularized adipose tissue-derived matrix and delipidated, decellularized fascial tissue-derived matrix, which may be combined in various proportions. Such adipose-fascia matrix compositions provide improved volume retention when implanted into a patient. The composition may further include exogenous cells or other substances, and/or a carrier. The composition is suitable for use inplastic surgery procedures, including reconstructive or cosmetic surgery procedures, as well as procedures for wound treatment and tissue regeneration.Type: ApplicationFiled: May 31, 2019Publication date: October 3, 2019Inventors: Benjamin Schilling, Andrew Madans, Abigail Phipps, Thomas Tylutki, Todd Nilsen, Yen-Chen Huang, Evangelia Chnari
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Publication number: 20190008903Abstract: An acellular soft tissue-derived matrix includes a collagenous tissue that has been delipidated and decellularized. Adipose tissue is among the soft tissues suitable for manufacturing an acellular soft tissue-derived matrix. Exogenous tissuegenic cells and other biologically-active factors may be added to the acellular matrix. The acellular matrix may be provided as particles, a slurry, a paste, a gel, or in some other form. The acellular matrix may be provided as a three-dimensional scaffold that has been reconstituted from particles of the three-dimensional tissue. The three-dimensional scaffold may have the shape of an anatomical feature and serve as a template for tissue repair or replacement. A method of making an acellular soft tissue-derived matrix includes steps of removing lipid from the soft tissue by solvent extraction and chemical decellularization of the soft tissue.Type: ApplicationFiled: September 5, 2018Publication date: January 10, 2019Inventors: Yen-Chen Huang, Asia Ivery, Bryan Choi, Benjamin Schilling, Manh-Dan Ngo
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Patent number: 10092600Abstract: An acellular soft tissue-derived matrix includes a collagenous tissue that has been delipidated and decellularized. Adipose tissue is among the soft tissues suitable for manufacturing an acellular soft tissue-derived matrix. Exogenous tissuegenic cells and other biologically-active factors may be added to the acellular matrix. The acellular matrix may be provided as particles, a slurry, a paste, a gel, or in some other form. The acellular matrix may be provided as a three-dimensional scaffold that has been reconstituted from particles of the three-dimensional tissue. The three-dimensional scaffold may have the shape of an anatomical feature and serve as a template for tissue repair or replacement. A method of making an acellular soft tissue-derived matrix includes steps of removing lipid from the soft tissue by solvent extraction and chemical decellularization of the soft tissue.Type: GrantFiled: December 22, 2016Date of Patent: October 9, 2018Assignee: Musculoskeletal Transplant FoundationInventors: Yen-Chen Huang, Asia Ivery, Bryan Choi, Benjamin Schilling, Manh-Dan Ngo
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Publication number: 20170119826Abstract: An acellular soft tissue-derived matrix includes a collagenous tissue that has been delipidated and decellularized. Adipose tissue is among the soft tissues suitable for manufacturing an acellular soft tissue-derived matrix. Exogenous tissuegenic cells and other biologically-active factors may be added to the acellular matrix. The acellular matrix may be provided as particles, a slurry, a paste, a gel, or in some other form. The acellular matrix may be provided as a three-dimensional scaffold that has been reconstituted from particles of the three-dimensional tissue. The three-dimensional scaffold may have the shape of an anatomical feature and serve as a template for tissue repair or replacement. A method of making an acellular soft tissue-derived matrix includes steps of removing lipid from the soft tissue by solvent extraction and chemical decellularization of the soft tissue.Type: ApplicationFiled: December 22, 2016Publication date: May 4, 2017Applicant: MUSCULOSKELETAL TRANSPLANT FOUNDATIONInventors: Yen-Chen Huang, Asia Ivery, Bryan Choi, Benjamin Schilling, Manh-Dan Ngo
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Publication number: 20170021058Abstract: A composition including delipidated, decellularized adipose tissue and delipidated, decellularized fascial tissue is provided. The composition may further include exogenous tissuegenic cells, an exogenous growth-inductive substance, and/or a carrier. The composition is suitable for implantation into a living body in plastic surgery procedures, including reconstructive or cosmetic surgery procedures, wound care procedures or other procedures of regenerative medicine. A method of preparing an acellular soft tissue-derived matrix from adipose tissue and fascial tissue is also provided.Type: ApplicationFiled: July 22, 2016Publication date: January 26, 2017Applicant: MUSCULOSKELETAL TRANSPLANT FOUNDATIONInventors: Yen-Chen Huang, Asia Ivery, Bryan Choi, Benjamin Schilling, Manh-Dan Ngo, Evangelia Chnari, Todd Nilsen
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Publication number: 20150037436Abstract: An acellular soft tissue-derived matrix includes a collagenous tissue that has been delipidated and decellularized. Adipose tissue is among the soft tissues suitable for manufacturing an acellular soft tissue-derived matrix. Exogenous tissuegenic cells and other biologically-active factors may be added to the acellular matrix. The acellular matrix may be provided as particles, a slurry, a paste, a gel, or in some other form. The acellular matrix may be provided as a three-dimensional scaffold that has been reconstituted from particles of the three-dimensional tissue. The three-dimensional scaffold may have the shape of an anatomical feature and serve as a template for tissue repair or replacement. A method of making an acellular soft tissue-derived matrix includes steps of removing lipid from the soft tissue by solvent extraction and chemical decellularization of the soft tissue.Type: ApplicationFiled: July 30, 2014Publication date: February 5, 2015Applicant: MUSCULOSKELETAL TRANSPLANT FOUNDATIONInventors: Yen-Chen Huang, Asia Ivery, Bryan Choi, Benjamin Schilling, Manh-Dan Ngo
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Patent number: 8883210Abstract: The disclosure provides implants containing a plurality of particles containing at least one population of viable tissuegenic cells adherent to and resident in the growth-conductive matrix or at least viable population of tissuegenic cells caused to be in contact with the growth-conductive matrix; methods to fabricate implants; methods of fabricating the implants; and use of the implants in tissue repair.Type: GrantFiled: May 16, 2011Date of Patent: November 11, 2014Assignee: Musculoskeletal Transplant FoundationInventors: Katherine Gomes Truncale, Arthur A. Gertzman, Yen-Chen Huang, Eric Semler, Evangelia Chnari, Anouska Dasgupta, Judith Yannariello-Brown, Terri Riley
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Patent number: 8834928Abstract: The disclosure provides implants containing a plurality of particles containing at least one population of viable tissuegenic cells adherent to and resident in the growth-conductive matrix or at least viable population of tissuegenic cells caused to be in contact with the growth-conductive matrix; methods to fabricate implants; methods of fabricating the implants; and use of the implants in tissue repair.Type: GrantFiled: July 23, 2013Date of Patent: September 16, 2014Assignee: Musculoskeletal Transplant FoundationInventors: Katherine Gomes Truncale, Arthur A. Gertzman, Yen-Chen Huang, Eric Semler, Evangelia Chnari, Anouska Dasgupta, Judith Yannariello-Brown, Terri Riley
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Patent number: 8435551Abstract: The invention is directed toward an osteochondral repair assembly comprising a shaped allograft construct comprising an unbalanced barbell-shaped cylindrical cancellous bone primary member formed with a mineralized cylindrical base section having a smaller diameter cylindrical stem leading to a second cylindrical section which is demineralized. A mineralized ring-shaped support member is forced over the compressed demineralized second demineralized the aperture of the ring-shaped member to fit around the stem with one ring surface being adjacent the bottom surface to the second cylindrical section and the opposite ring surface being adjacent the upper surface of the mineralized cylindrical base section.Type: GrantFiled: July 24, 2009Date of Patent: May 7, 2013Assignee: Musculoskeletal Transplant FoundationInventors: Eric J. Semler, Roman Shikhanovich, Alex B. Callahan, Katherine Gomes Truncale, Judith I. Yannariello-Brown, Yen-Chen Huang
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Publication number: 20120251609Abstract: A demineralized cancellous bone matrix comprising a cancellous bone matrix that has been demineralized is described herein. The demineralized cancellous bone matrix is rigid and has certain dimensions, including a certain length. Implants comprising at least one demineralized cancellous bone matrix are also described. Also disclosed are methods for treating bone having a void or defect in a patient using at least one demineralized cancellous bone matrix. In addition, methods of making a demineralized cancellous bone matrix are disclosed.Type: ApplicationFiled: March 29, 2011Publication date: October 4, 2012Inventors: Yen-Chen Huang, Moon Hae Sunwoo, Arthur A. Gertzman
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Publication number: 20110060412Abstract: A meniscus repair composition for application to a meniscus injury to promote growth of new tissue at the meniscus injury site is provided. The composition comprises: from about 10 to about 50 percent by weight of allograft meniscus particles having an average particle size of from about 10 ?m to about 500 ?m; and a carrier comprising a solid fibrin web matrix. When introduced to a defect site in a meniscus, the composition is non-adhering to the defect site. A method for repairing a meniscus injury comprises administering a meniscus repair composition to the injury site.Type: ApplicationFiled: September 3, 2010Publication date: March 10, 2011Applicant: MUSCULOSKELETAL TRANSPLANT FOUNDATION INC.Inventors: Eric J. Semler, Arthur A. Gertzman, Yen-Chen Huang, Judith Yannariello-Brown, Katherine Gomes Truncale
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Publication number: 20110059178Abstract: A meniscus repair composition for application to a meniscus defect site to promote growth of new tissue at the meniscus defect site is provided. The composition comprises: from about 10 to about 50 percent by weight of allograft meniscus particles having an average particle size of from about 10 ?m to about 500 ?m; a carrier selected from the group consisting of sodium hyaluronate, gelatin, collagen, polyethylene glycol, glycerin, carboxymethylcellulose, dextrose, blood derivatives, aqueous solutions thereof, and mixtures thereof; and a curing agent. The curing agent may be the carrier where the carrier is cross-linkable. When introduced to a defect site in a meniscus and cured, the composition will not flow away from the defect site, and the composition is non-adhering to the defect site after it is cured.Type: ApplicationFiled: September 3, 2010Publication date: March 10, 2011Applicant: MUSCULOSKELETAL TRANSPLANT FOUNDATION INC.Inventors: Eric J. Semler, Arthur A. Gertzman, Yen-Chen Huang, Judith Yannariello-Brown, Katherine Gomes Truncale
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Publication number: 20100274362Abstract: Mixtures, such as gels or pastes, comprising freeze-milled cartilage particles and exogenous growth factors are used for repairing chondral defects. Such mixtures may be applied to constructs comprising cancellous bone for implantation at the defect site. Suitable growth factors include variants of FGF-2, particularly variants that include a sole amino acid substitution for asparagine at amino acid 111 of the ?8-?9 loop of the FGF-2 peptide. Such FGF-2 variants are released slowly and continuously at a constant rate from cartilage pastes. In other embodiments, the amino acid substituted for asparigine is glycine. Other variants that may be used include FGF-9 variants having truncated chains and a sole amino acid substitution in the ?8-?9 loop of the FGF-9 peptide either for tryptophan at amino acid 144 or for asparagine at amino acid 143.Type: ApplicationFiled: January 14, 2010Publication date: October 28, 2010Inventors: Avner Yayon, Katherine G. Truncale, Hilla Barkay-Olami, Alex B. Callahan, Arthur A. Gertzman, Yen-Chen Huang, Morris L. Jacobs, John C. Munson, Eric J. Semler, Roman Shikhanovich, Baruch Stern, Moon Hae Sunwoo, William W. Tomford, Judith I. Yannariello-Brown
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Patent number: 7741790Abstract: A lamp current balance and feedback system and related method are disclosed for balancing the input and output currents of a lamp by making use of a lamp current balance and feedback mechanism. The operation of the lamp current balance and feedback mechanism includes coupling the input current of the lamp for generating a first balance current by a first transformer, coupling the output current of the lamp for generating a second balance current by a second transformer, coupling the first and second transformers for substantially equalizing the first and second balance currents, generating a feedback signal based on the first or second balance current by a feedback circuit, generating a pulse width modulation signal based on the feedback signal by a pulse width modulation signal generation circuit, and driving the input and output currents of the lamp based on the pulse width modulation signal by a driving circuit.Type: GrantFiled: March 24, 2008Date of Patent: June 22, 2010Assignee: AU Optronics Corp.Inventors: Yen-Chen Huang, Chia-Hung Sun, Huang-Ti Lin, Yuan-Pin Cho
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Publication number: 20100015202Abstract: The invention is directed toward an osteochondral repair assembly comprising a shaped allograft construct comprising an unbalanced barbell-shaped cylindrical cancellous bone primary member formed with a mineralized cylindrical base section having a smaller diameter cylindrical stem leading to a second cylindrical section which is demineralized. A mineralized ring-shaped support member is forced over the compressed demineralized second demineralized the aperture of the ring-shaped member to fit around the stem with one ring surface being adjacent the bottom surface to the second cylindrical section and the opposite ring surface being adjacent the upper surface of the mineralized cylindrical base section.Type: ApplicationFiled: July 24, 2009Publication date: January 21, 2010Inventors: Eric J. Semler, Roman Shikhanovich, Alex B. Callahan, Katherine Gomes Truncale, Judith I. Yannariello-Brown, Yen-Chen Huang