Abstract: An attaching apparatus, an intermediary mechanism thereof, and an attaching method are provided. The intermediary mechanism is provided for being selectively arranged between a pressing mechanism and a carrying mechanism. The intermediary mechanism includes a frame, a deformable sheet fixed on the frame, and an adhesive layer disposed on the deformable sheet. The frame is provided for being fastened to one of the pressing mechanism and the carrying mechanism. The adhesive layer is provided for adhering at least one attaching object onto one side of the deformable sheet facing the carrying mechanism. The deformable sheet is configured to be gradually deformed toward the carrying mechanism by being pressed with the pressing mechanism, so that the at least one attaching object is abutted against an attached object on the carrying mechanism.

Abstract: An attaching apparatus, an intermediary mechanism thereof, and an attaching method are provided. The intermediary mechanism is provided for being selectively arranged between a pressing mechanism and a carrying mechanism. The intermediary mechanism includes a frame, a deformable sheet fixed on the frame, and an adhesive layer disposed on the deformable sheet. The frame is provided for being fastened to one of the pressing mechanism and the carrying mechanism. The adhesive layer is provided for adhering at least one attaching object onto one side of the deformable sheet facing the carrying mechanism. The deformable sheet is configured to be gradually deformed toward the carrying mechanism by being pressed with the pressing mechanism, so that the at least one attaching object is abutted against an attached object on the carrying mechanism.

Abstract: The present invention provides compounds of the Formula I: wherein X is a bond or CH2; R is selected from the group consisting of R1 and R2 are each independently selected from the group consisting of CH and N; R3 is H or CH3; R4 is H or CH3; L is selected from the group consisting of —O(CH2)3—, —C(O)NH(CH2)2—, —CH2C(O)NH(CH2)2—, —(CH2)3N(C(O)CH3)CH2—, —(CH2)2N(C(O)CH3)CH2—, —(CH2)3NH—, (CH2)2OCH2—, —(CH2)4—, —(CH2)2NHCH2—, —(CH2)3O—, and —CH2O(CH2)2—; or a pharmaceutically acceptable salt thereof. Compounds of this invention are autotaxin inhibitors.

Abstract: The present invention provides compounds of the Formula I: wherein X is a bond or CH2; R is selected from the group consisting of R1 and R2 are each independently selected from the group consisting of CH and N; R3 is H or CH3; R4 is H or CH3; L is selected from the group consisting of —O(CH2)3—, —C(O)NH(CH2)2—, —CH2C(O)NH(CH2)2—, —(CH2)3N(C(O)CH3)CH2—, —(CH2)2N(C(O)CH3)CH2—, —(CH2)3NH—, (CH2)2OCH2—, —(CH2)4—, —(CH2)2NHCH2—, —(CH2)3O—, and —CH2O(CH2)2—; or a pharmaceutically acceptable salt thereof. Compounds of this invention are autotaxin inhibitors.

Abstract: The present invention relates to a melanin concentrating hormone antagonist compound of formula (I) wherein R1, Ra, Rb, R2, L1, R3, R4 and R5 are as defined, or a pharmaceutically acceptable salt, enantiomer, diastereomer or mixture of diasteromers thereof useful in the treatment, obesity and related diseases.

Abstract: The present invention relates to a melanin concentrating hormone antagonist compound of formula (1): wherein R1, Ra, Rb, R2, L1, R3, R4 and R5 are as defined, or a pharmaceutically acceptable salt, enantiomer, diastereomer or mixture of diasteromers thereof useful in the treatment, obesity and related diseases.

Abstract: The present invention relates to a melanin concentrating hormone antagonist compound of formula (I): wherein R1, Ra, Rb, R2, L1, R3, R4 and R5 are as defined, or a pharmaceutically acceptable salt, enantiomer, diastereomer or mixture of diasteromers thereof useful in the treatment, obesity and related diseases.

Abstract: The present invention relates to a melanin concentrating hormone antagonist compound of formula (I): wherein R1, Ra, Rb, R2, L1, R3, R4 and R5 are as defined, or a pharmaceutically acceptable salt, enantiomer, diastereomer or mixture of diasteromers thereof useful in the treatment, obesity and related diseases.

Abstract: The present invention relates to a melanin concentrating hormone antagonist compound of formula (1): wherein R1, Ra, Rb, R2, L1, R3, R4 and R5 are as defined, or a pharmaceutically acceptable salt, enantiomer, diastereomer or mixture of diasteromers thereof useful in the treatment, obesity and related diseases.