Abstract: In one aspect, the present disclosure pertains to lubricous coating compositions that comprise (a) a higher molecular weight polyvinylpyrrolidone, (b) a lower molecular weight polyvinylpyrrolidone, and (c) a polyfunctional unsaturated crosslinking agent. In some embodiments, such lubricous coating compositions are present in crosslinked form on the surface of a medical article. In some embodiments, the lubricous coating compositions further comprise a solvent, in which case such compositions may be, for example, applied to a substrate in the form of a layer and subsequently crosslinked, thereby forming a lubricious coating on the substrate. In another aspect, the present disclosure is directed to methods for forming various medical articles.

Abstract: A method for converting an amorphous drug, such as everolimus, or other macrolide immunosuppressive drug, into a crystalline form. The method utilizes a slurry of the drug in organic liquid phase and ages the slurry to achieve the conversion.

Abstract: A medical device having a polymer-free outer surface layer comprising a crystalline drug selected from the group consisting of everolimus, tacrolimus, sirolimus, zotarolimus, biolimus, and rapamycin. The device may be produced by a method comprising the steps of providing a medical device; applying a solution of the drug to said portion of the outer surface to form a coating of amorphous drug; and vapor annealing the drug with a solvent vapor to form crystalline drug; wherein a seed layer of a crystalline form of said drug having a maximum particle size of about 10 ?m or less is applied to at least said portion of the outer surface of the device before or after applying the drug solution, but before vapor annealing the amorphous coating.

Abstract: A method for converting an amorphous drug, such as everolimus, or other macrolide immunosuppressive drug, into a crystalline form. The method utilizes a slurry of the drug in organic liquid phase and ages the slurry to achieve the conversion.

Abstract: A bioadhesive composition that adheres suitably to a mucosal surface and is capable of delivering drugs in sustained fashion, and a patch comprising the bioadhesive composition. Methods of using and processes for preparing the bioadhesive composition are also described.

Abstract: Drug delivery balloons have densely packed crystals of small particle size of the drug thereon. An amorphous drug coating is applied to a balloon surface and annealed to provide the crystals. The balloon surface is nucleated to induce formation of drug crystals in the annealing step to provide the crystals in high density with small size.

Abstract: When making a medical device having a drug coating thereon, the drug having a plurality of characteristic morphological forms, the manufacturing process is controlled to produce a predetermined ratio of said morphological forms on the device. The process has application to drug coated balloons.

Abstract: The present invention is directed to mucosal originated drug delivery systems and methods for using the drug delivery system to treat conditions in animals. Conditions amenable to treatment according to the invention are also described. The described mucosal drug delivery systems provide for drug release across a mucosal membrane as well as release away from the mucosal membrane.

Abstract: A method of detecting wear on a substrate including coating a composition that includes a fluorescent compound on the surface of a first substrate, exposing the coated surface to wear, exposing the coated surface to radiation capable of exciting the fluorescent compound, and detecting the presence or absence of fluorescence.

Abstract: A wet stick pressure sensitive adhesive comprising the solventless polymerization product of: a) about 30 to about 70 parts by weight of an (meth)acrylate ester monomer wherein the (meth)acrylate ester monomer, when homopolymerized, has a Tg of less than about 10° C.; b) about 70 to about 30 parts by weight of a hydrophilic acidic comonomer; and c) about 10 to 100 parts based on 100 parts of the sum of components (a+b) of a non-reactive plasticizing agent, wherein the pressure sensitive adhesive adheres to wet substrate surfaces and a method of making.

Abstract: A concentrated liquid soap composition that readily increases in viscosity upon dilution with water, the concentrated liquid soap composition containing an amine oxide surfactant or mixture thereof having the general formula R1R2 R3N→O, where R1 and R2 are the same or different and are selected from methyl or ethyl and R3 is a straight chain saturated or unsaturated alkyl group having from about 6-24 carbon atoms; an anionic surfactant or mixture thereof; an electrolyte; water; and a buffering agent, sufficient to maintain the pH of the composition between about 8 and about 10.

Abstract: An aqueous composition that includes silane including n-alkylalkoxysilane, condensates of n-alkylalkoxysilane or a combination thereof, and from about 0.01 % by weight to about 2 % by weight cationic quaternary surfactant. The composition optionally includes a siloxane selected from the group consisting of methylhydrogen siloxane, methylhydrogen-methylalkyl siloxane copolymer, methylhydrogen-cyclosiloxane copolymer, methylhydrogen-methylalkyl cyclosiloxane copolymer and combinations thereof, and volatile carrier.

Abstract: A method of detecting wear on a substrate including coating a composition that includes a fluorescent compound on the surface of a first substrate, exposing the coated surface to wear, exposing the coated surface to radiation capable of exciting the fluorescent compound, and detecting the presence or absence of fluorescence.

Abstract: A concentrated liquid soap composition that readily increases in viscosity upon dilution with water, the concentrated liquid soap composition containing an amine oxide surfactant or mixture thereof having the general formula R1R2 R3N→O, where R1 and R2 are the same or different and are selected from methyl or ethyl and R3 is a straight chain saturated or unsaturated alkyl group having from about 6-24 carbon atoms; an anionic surfactant or mixture thereof; an electrolyte; water; and a buffering agent, sufficient to maintain the pH of the composition between about 8 and about 10.

Abstract: A bioadhesive composition that adheres suitably to a mucosal surface and is capable of delivering drugs in sustained fashion, and a patch comprising the bioadhesive composition. Methods of using and processes for preparing the bioadhesive composition are also described.

Abstract: A bioadhesive composition that adheres suitably to a mucosal surface and is capable of delivering drugs in sustained fashion, and a patch comprising the bioadhesive composition. Methods of using and processes for preparing the bioadhesive composition are also described.

Abstract: An absorbent dressing that includes a transparent, elastomeric, body fluid-absorbing composition that is essentially free of hydrocolloidal gel particles. The composition includes the reaction product of:(a) 20 to 80 parts by weight of an acrylic or methacrylic acid ester of a non-tertiary alcohol having between 4 and 14 carbon atoms, inclusive;(b) 30 to 60 parts by weight of a hydrophilic, ethylenically unsaturated monomer; and p1 (c) 5 to 25 parts by weight of a polar, ethylenically unsaturated monomer different from the hydrophilic, ethylenically unsaturated monomer. The composition is capable of absorbing moderate to heavy amounts of body fluids, while retaining its structural integrity and transparency.

Abstract: Hydrocolloid adhesive compositions are disclosed comprising a hydrophobic unsaturated aliphatic homopolymer, a compatible tackifier, and at least one hydrocolloid absorbent. The compositions have enhanced resistance to breakdown by body fluids, adjustable absorbency, improved adhesive and cohesive properties, as well as a reduced tendency to leave an adhesive residue after application. Also disclosed are wound dressings, ostomy or prosthesis adhesives, methods of using wound dressings, and methods for forming the hydrocolloid adhesive compositions.

Abstract: Hydrocolloid adhesive compositions for use as wound dressings or ostomy/prosthesis adhesives are disclosed. These adhesive compositions are made of a mixture of a hydrophobic, unsaturated, elastomeric homopolymer, a polyisobutylene tackifier and a hydrocolloid absorbent which is cross-linked by 5-200 kGy gamma radiation to provide a cross-linked matrix having a wet integrity value of at least about eighty percent, a shear hold value of at least about 500 min/500 g and a dry cohesive strength which prevents adhesive composition breakage or delamination. Methods of using such wound dressings or ostomy/prosthesis adhesives and methods of making the hydrocolloid adhesive compositions are also disclosed.