Patents by Inventor Yen Ping Liu

Yen Ping Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190244861
    Abstract: A method of packaging an integrated circuit includes forming a first integrated circuit and a second integrated circuit on a wafer, the first and second integrated circuit separated by a singulation region. The method includes covering the first and second integrated circuits with a molding compound, and sawing through the molding compound and a top portion of the wafer using a beveled saw blade, while leaving a bottom portion of the wafer remaining. The method further includes sawing through the bottom portion of the wafer using a second saw blade, the second saw blade having a thickness that is less than a thickness of the beveled saw blade. The resulting structure is within the scope of the present disclosure.
    Type: Application
    Filed: April 22, 2019
    Publication date: August 8, 2019
    Inventors: Yen-Ping Wang, Ming-Kai Liu, Kai-Chiang Wu
  • Patent number: 10312209
    Abstract: The present disclosure provides a semiconductor package, which includes a substrate, a passivation layer, a post-passivation interconnect (PPI) having a top surface; and a conductive structure. The top surface of the PPI includes a first region receiving the conductive structure, and a second region surrounding the first region. The second region includes metal derivative transformed from materials made of the first region. The present disclosure provide a method of manufacturing a semiconductor package, including forming a first flux layer covering a portion of a top surface of a PPI; transforming a portion of the top surface of the PPI uncovered by the first flux layer into a metal derivative layer; removing the first flux layer; forming a second flux layer on the first region of the PPI; dropping a solder ball on the flux layer; and forming electrical connection between the solder ball and the PPI.
    Type: Grant
    Filed: April 12, 2018
    Date of Patent: June 4, 2019
    Assignee: TAIWAN SEMICONDUCTOR MANUFACTURING COMPANY LTD.
    Inventors: Chao-Wen Shih, Kai-Chiang Wu, Ching-Feng Yang, Ming-Kai Liu, Shih-Wei Liang, Yen-Ping Wang
  • Publication number: 20040198703
    Abstract: Alpha-haloketones are useful alkylating agents for coupling to sulfhydryl-containing biomolecules. However, they react spontaneously with water, alkali and organic bases and therefore cannot be stored for extended periods of time in aqueous solutions, particularly in the presence of proteins at physiological pH. The present invention provides novel solutions to these problems, however, as novel compounds and compositions comprising protected haloketones are disclosed herein. Methods of preparing and using protected haloketones which are useful in a variety of applications—e.g., in assays and conjugation reactions—are also disclosed herein.
    Type: Application
    Filed: April 27, 2004
    Publication date: October 7, 2004
    Inventors: Steye de Keczer, Yen Ping Liu, Dariush Davalian, Nurith Kurn, Edwin F. Ullman
  • Patent number: 6783947
    Abstract: Alpha-haloketones are useful alkylating agents for coupling to sulfhydryl-containing biomolecules. However, they react spontaneously with water, alkali and organic bases and therefore cannot be stored for extended periods of time in aqueous solutions, particularly in the presence of proteins at physiological pH. The present invention provides novel solutions to these problems, however, as novel compounds and compositions comprising protected haloketones are disclosed herein. Methods of preparing and using protected haloketones which are useful in a variety of applications—e.g., in assays and conjugation reactions—are also disclosed herein.
    Type: Grant
    Filed: September 9, 1999
    Date of Patent: August 31, 2004
    Assignee: Dade Behring Marburg GmbH
    Inventors: Steve de Keczer, Yen Ping Liu, Dariush Davalian, Nurith Kurn, Edwin F. Ullman
  • Publication number: 20030165917
    Abstract: A method for detection of nucleic acid targets using as reagents: (1) a stem loop probe having a long strand for hybridizing to a target, a short strand, usually with a free 3′-end for extension, hybridized to a portion of the long strand and a linker forming a loop and joining the short and long strands; and (2) a hybridizing reagent that hybridizes to the short strand when released by the target. The target is detected by extension of one or both the probe or hybridizing reagent along each other. A circular hybridizing reagent can be employed with DNA polymerase for concatenated extension of the probe 3′-end or extension of the 3′-end of the probe along a hybridizing reagent having a promoter sequence for forming transcripts of at least a portion of the long strand or the hybridizing reagent.
    Type: Application
    Filed: August 14, 2002
    Publication date: September 4, 2003
    Inventors: Edwin F. Ullman, Ming Wu, Yen Ping Liu
  • Patent number: 6200757
    Abstract: The present invention relates to a method for selectively extending an oligonucleotide primer along a specific target polynucleotide sequence in a mixture of polynucleotides. A combination is provided comprising the mixture, an oligonucleotide primer having a modification, and a binding substance for the modification wherein the binding substance binds to the oligonucleotide and prevents the extension of the oligonucleotide along the target polynucleotide sequence. The temperature of the combination is adjusted to a level sufficient to irreversibly denature the binding substance and permit the extension of the oligonucleotide primer along the specific target polynucleotide sequence. The invention has particular application in the amplification of nucleic acids. Also disclosed are kits for carrying out a method in accordance with the present invention.
    Type: Grant
    Filed: January 19, 1999
    Date of Patent: March 13, 2001
    Assignee: Dade Behring Inc.
    Inventors: Nurith Kurn, Yen Ping Liu, Alla Lishanski, Marc Taylor
  • Patent number: 5914230
    Abstract: The present invention relates to a method for detecting or amplifying and detecting a target polynucleotide sequence. The method comprises providing in combination (i) a medium suspected of containing the target polynucleotide sequence, (ii) all reagents required for conducting an amplification of the target polynucleotide sequence when amplification is desired, and (iii) two oligonucleotide probes capable of binding to a single strand of the product of the amplification. At least one of the probes has two sequences that either (i) are non-contiguous and bind to contiguous or non-contiguous sites on the single strand or (ii) can bind to non-contiguous sites on the single strand. Each probe may contain a label. The combination is subjected to conditions for amplifying the target polynucleotide sequence. Next, the combination is subjected to conditions under which both of the probes hybridize to one of the strands to form a termolecular complex, which is detected by means of the label.
    Type: Grant
    Filed: December 20, 1996
    Date of Patent: June 22, 1999
    Assignee: Dade Behring Inc.
    Inventors: Yen Ping Liu, Rajesh D. Patel, Nurith Kurn, Claire Lin, Samuel J. Rose, Edwin F. Ullman
  • Patent number: 4650770
    Abstract: Assays are provided employing particles and absorbent particles, wherein the absorbent particles substantially inhibit fluorescence when bound to the fluorescent particles through specific non-covalent binding.
    Type: Grant
    Filed: December 7, 1983
    Date of Patent: March 17, 1987
    Assignee: Syntex (U.S.A.) Inc.
    Inventors: Yen-Ping Liu, Edwin F. Ullman, Martin J. Becker
  • Patent number: 4550017
    Abstract: A sensitive method for identifying red blood cell antigens or antibodies thereto is provided. A fluorescent bead is conjugated to a receptor specific for a red blood cell antigen (ligand) or alternatively with an antigen for determination of antibodies. The conjugate is mixed with a red blood cell containing composition. A change in fluorescence compared with a control reveals the presence or absence of the antigen or antibody.
    Type: Grant
    Filed: October 15, 1982
    Date of Patent: October 29, 1985
    Assignee: Syntex (U.S.A.) Inc.
    Inventors: Yen-Ping Liu, Edwin F. Ullman, Martin J. Becker