Abstract: A sealing disc for vacuum closure suitable for using in reciprocating movement to an open position or a closed position to open or seal a valve port of an all-metal valve is disclosed. A sealing plate of the sealing disc is formed with a first sealing surface. When the sealing disc is in the closed position, the first sealing surface directly abuts against the valve port of the all-metal vacuum valve. A vacuum sealability can be improved and a service lifetime can be prolonged through compensating movement and adjusting movement between two metallic sealing surfaces abutting each other.

Abstract: A method of forming a pattern of doped region includes the following steps. At first, a device layout pattern including a gate layout pattern and a doped region layout pattern is provided to a computer system. Subsequently, the device layout pattern is split into a plurality of sub regions, and the sub regions have different pattern densities of the gate layout pattern. Then, at least an optical proximity correction (OPC) calculation is respectively performed on the doped region layout pattern in each of the sub regions to respectively form a corrected sub doped region layout pattern in each of the sub regions. Afterwards, the corrected sub doped region layout patterns are combined to form a corrected doped region layout pattern, and the corrected doped region layout pattern is outputted onto a mask through the computer system.

Abstract: A biosensor, a method of fabricating the sensing unit for the biosensor, and a measuring system comprising the biosensor. The biosensor has an extended gate field effect transistor (EGFET) structure and comprises a metal oxide semiconductor field effect transistor (MOSFET) on a semiconductor substrate, a sensing unit comprising a substrate, a silicon dioxide layer on the substrate, a tin oxide layer on the silicon dioxide layer, and a urease layer immobilized on the tin oxide layer, and a conductive wire connecting the MOSFET and the sensing unit.