Patents by Inventor Yen-Yu Wu

Yen-Yu Wu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250136709
    Abstract: The present invention relates to a novel antibody, an antigen-binding fragment thereof and the uses of the antibody and fragment, wherein the antibody and the fragment comprise specific complementarity-determining regions (CDRs) and/or specifically bind to human CD73 at specific epitopes.
    Type: Application
    Filed: November 12, 2024
    Publication date: May 1, 2025
    Inventors: Chun-Chung LEE, Yu-Hsun LO, Chu-Bin LIAO, Chen-Jei HONG, Sih-Yu CHEN, Yen-Yu WU, Szu-Liang LAI, Chih-Yung HU, Wen-Bin KE, Ya-Ting JUAN, Kao-Jean HUANG
  • Patent number: 12187806
    Abstract: The present invention relates to a novel antibody, an antigen-binding fragment thereof and the uses of the antibody and fragment, wherein the antibody and the fragment comprise specific complementarity-determining regions (CDRs) and/or specifically bind to human CD73 at specific epitopes.
    Type: Grant
    Filed: March 4, 2022
    Date of Patent: January 7, 2025
    Assignee: DEVELOPMENT CENTER FOR BIOTECHNOLOGY
    Inventors: Chun-Chung Lee, Yu-Hsun Lo, Chu-Bin Liao, Chen-Jei Hong, Sih-Yu Chen, Yen-Yu Wu, Szu-Liang Lai, Chih-Yung Hu, Wen-Bin Ke, Ya-Ting Juan, Kao-Jean Huang
  • Publication number: 20230279139
    Abstract: The present invention relates to a novel antibody, an antigen-binding fragment thereof and the uses of the antibody and fragment, wherein the antibody and the fragment comprise specific complementarity-determining regions (CDRs) and/or specifically bind to human CD73 at specific epitopes.
    Type: Application
    Filed: March 4, 2022
    Publication date: September 7, 2023
    Inventors: Chun-Chung LEE, Yu-Hsun LO, Chu-Bin LIAO, Chen-Jei HONG, Sih-Yu CHEN, Yen-Yu WU, Szu-Liang LAI, Chih-Yung HU, Wen-Bin KE, Ya-Ting JUAN, Kao-Jean HUANG
  • Patent number: 10138300
    Abstract: The present invention relates to an antibody or antigen-binding fragment thereof that bind human vascular endothelial growth factor receptor 2 (VEGFR-2). The present invention also relates to a method for inhibiting VEGFR-2-mediated signaling in a subject in need, a method for treating diseases and/or disorders caused by or related to VEGFR-2 activity and/or signaling in a subject afflicted with the diseases and disorders, a method for treating tumor in a subject afflicted with the tumor, a method for inhibiting cell proliferation of endothelial cells in a subject in need, and a method for detecting human vascular endothelial growth factor receptor in a sample.
    Type: Grant
    Filed: July 3, 2017
    Date of Patent: November 27, 2018
    Assignee: DEVELOPMENT CENTER FOR BIOTECHNOLOGY
    Inventors: Jiann-Shiun Lai, Li-Shuang Ai, Yan-Da Lai, Yen-Yu Wu, Yi-San Tsai, Yi-Jiue Tsai, Juo-Yu Huang, Cheng-Chou Yu, Chuan-Lung Hsu, Chien-Tsun Kuan, Szu-Liang Lai, Li-Ya Wang
  • Publication number: 20180186884
    Abstract: The present invention relates to an antibody or antigen-binding fragment thereof that bind human vascular endothelial growth factor receptor 2 (VEGFR-2). The present invention also relates to a method for inhibiting VEGFR-2-mediated signaling in a subject in need, a method for treating diseases and/or disorders caused by or related to VEGFR-2 activity and/or signaling in a subject afflicted with the diseases and disorders, a method for treating tumor in a subject afflicted with the tumor, a method for inhibiting cell proliferation of endothelial cells in a subject in need, and a method for detecting human vascular endothelial growth factor receptor in a sample.
    Type: Application
    Filed: July 3, 2017
    Publication date: July 5, 2018
    Inventors: JIANN-SHIUN LAI, Li-Shuang Ai, Yan-Da Lai, Yen-Yu Wu, Yi-San Tsai, Yi-Jiue Tsai, Juo-Yu Huang, Cheng-Chou Yu, Chuan-Lung Hsu, Chien-Tsun Kuan, Szu-Liang Lai, Li-Ya Wang
  • Publication number: 20170233480
    Abstract: The present invention relates to an antibody or antigen-binding fragment thereof that bind human vascular endothelial growth factor receptor 2 (VEGFR-2). The present invention also relates to a method for inhibiting VEGFR-2-mediated signaling in a subject in need, a method for treating diseases and/or disorders caused by or related to VEGFR-2 activity and/or signaling in a subject afflicted with the diseases and disorders, a method for treating tumor in a subject afflicted with the tumor, a method for inhibiting cell proliferation of endothelial cells in a subject in need, and a method for detecting human vascular endothelial growth factor receptor in a sample.
    Type: Application
    Filed: December 29, 2016
    Publication date: August 17, 2017
    Applicant: DEVELOPMENT CENTER FOR BIOTECHNOLOGY
    Inventors: JIANN-SHIUN LAI, LI-SHUANG AI, YAN-DA LAI, YEN-YU WU, YI-SAN TSAI, YI-JIUE TSAI, JUO-YU HUANG, CHENG-CHOU YU, CHUAN-LUNG HSU, CHIEN-TSUN KUAN, SZU-LIANG LAI, LI-YA WANG
  • Publication number: 20160130336
    Abstract: An anti-VEGF antibody, or a binding fragment thereof, includes a heavy-chain variable region that comprises: (1) a CDRH1 sequence selected from SEQ ID NO: 17, 20, 23, 26, 29, 32, 35, or 38), (2) a CDRH2 sequence selected from SEQ ID NO:18, 21, 24, 27, 30, 33, 36, or 39, and (3) a CDRH3 sequence selected from SEQ ID NO:19, 22, 25, 28, 31, 34, 37, or 40; and a light-chain variable region that comprises: (1) a CDRL1 sequence selected from SEQ ID NO: 41, 44, 47, 50, 53, 56, 59, or 62, (2) a CDRL2 sequence selected from SEQ ID NO: 42, 45, 48, 51, 54, 57, 60, or 63, and (3) a CDRL3 sequence selected from SEQ ID NO: 43, 46, 49, 52, 55, 58, 61, or 64. A method for treating or preventing a VEGF-related disorder, e.g., diabetic retinopathy, age-related macular degeneration, or cancer, uses the antibodies.
    Type: Application
    Filed: December 29, 2014
    Publication date: May 12, 2016
    Applicants: Development Center for Biotechnology, DCB-USA LLC
    Inventors: Jiann-Shiun Lai, Yan-Da Lai, Yen-Yu Wu, Yi-Jiue Tsai, Yu-Ying Lin
  • Patent number: 8928046
    Abstract: A transistor including a gate, an active stacked structure, a dielectric layer, a source and a drain. The gate is located over a first surface of the dielectric layer. The active stacked structure, including a first active layer and a second active layer, is located over a second surface of the dielectric layer. The source and the drain are located over the second surface of the dielectric layer and at two sides of the active stacked structure and extend between the first active layer and the second active layer of the active stacked structure.
    Type: Grant
    Filed: October 13, 2010
    Date of Patent: January 6, 2015
    Assignee: Industrial Technology Research Institute
    Inventors: Jing-Yi Yan, Chu-Yin Hung, Hsiao-Chiang Yao, Yen-Yu Wu, Yen-Shih Huang
  • Publication number: 20110254061
    Abstract: A transistor including a gate, an active stacked structure, a dielectric layer, a source and a drain. The gate is located over a first surface of the dielectric layer. The active stacked structure, including a first active layer and a second active layer, is located over a second surface of the dielectric layer. The source and the drain are located over the second surface of the dielectric layer and at two sides of the active stacked structure and extend between the first active layer and the second active layer of the active stacked structure.
    Type: Application
    Filed: October 13, 2010
    Publication date: October 20, 2011
    Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: Jing-Yi Yan, Chu-Yin Hung, Hsiao-Chiang Yao, Yen-Yu Wu, Yen-Shih Huang