Abstract: A plasma glucose estimation system is provided comprising a sensor which generates a signal from a glucose concentration measured in a medium, filtering means and a glycemic estimator. Also a method comprising: i) generating a signal which represents the glucose concentration measured in the medium; ii) filtering the signal generated; iii) applying a set of local estimation models, to the previous signal, obtaining a set of local plasma glucose estimates; iv) applying a weighting to each one of the local estimates previously obtained; v) estimating a plasma glucose concentration by the sum of the weighted local estimates obtained in the previous step; vi) correcting the signal obtained from the previous step from reference glycemia measurements and obtaining the final plasma glucose estimate.