Patents by Inventor Yeon-ja Cho
Yeon-ja Cho has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8357957Abstract: Provided are a FET-based sensor for detecting an ionic material, an ionic material detecting device including the FET-based sensor, and a method of detecting an ionic material using the FET-based sensor. The FET-based sensor includes: a sensing chamber including a reference electrode and a plurality of sensing FETs; and a reference chamber including a reference electrode and a plurality of reference FETs. The method includes: flowing a first solution into and out of the sensing chamber and the reference chamber of the FET-based sensor; flowing a second solution expected to contain an ionic material into and out of the sensing chamber while continuously flowing the first solution into and out of the reference chamber; measuring a current in a channel region between the source and drain of each of the sensing and reference FETs; and correcting the current of the sensing FETs.Type: GrantFiled: October 26, 2010Date of Patent: January 22, 2013Assignee: Samsung Electronics Co., Ltd.Inventors: Kyu-sang Lee, Kyu-tae Yoo, Jeo-young Shim, Jin-tae Kim, Yeon-ja Cho
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Patent number: 8293591Abstract: A field effect transistor for detecting an analyte having a thiol group includes a substrate, a source region and a drain region formed apart from each other on the substrate, the source region and the drain region being doped such that a polarity of the source and drain region is opposite to a polarity of the substrate, a channel region disposed between the source region and the drain region, an insulating layer formed of an electrically insulating material and disposed on the channel region, a gold layer disposed on the insulating layer and a reference electrode disposed apart from the gold layer.Type: GrantFiled: April 10, 2007Date of Patent: October 23, 2012Assignee: Samsung Electronics Co., Ltd.Inventors: Jeo-young Shim, Kyu-tae Yoo, Kyu-sang Lee, Won-seok Chung, Yeon-ja Cho, Chang-eun Yoo
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Patent number: 8038943Abstract: A method of detecting a presence of bio-molecules, or a concentration of the target bio-molecules using a field effect transistor, includes allowing a first sample including a first target bio-molecule to contact a sensing surface of the field effect transistor and measuring a change in an electric signal of the field effect transistor, the field effect transistor including a substrate, a source region and a drain region, the source region and the drain region formed apart from each other on the substrate, the source region and the drain region each doped to having an opposite polarity than a polarity of the substrate, a channel region disposed between the source region and the drain region and an insulating layer including the sensing surface, the insulating layer disposed on the channel region.Type: GrantFiled: April 3, 2007Date of Patent: October 18, 2011Assignee: Samsung Electronics Co., Ltd.Inventors: Kyu-tae Yoo, Kyu-sang Lee, Won-seok Chung, Jeo-young Shim, Yeon-ja Cho
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Method of detecting bio-molecules using the same field effect transistor on the gate sensing surface
Patent number: 7943970Abstract: Provided is a method of detecting the presence of a target bio-molecule or a concentration of the bio-molecule using a field effect transistor. The method includes: contacting a first sample having a first target bio-molecule with a reference electrode of a field effect transistor; measuring a first electric signal change of the field effect transistor; contacting a second sample with a sensing surface of the same field effect transistor; measuring a second electric signal change of the field effect transistor; and comparing the first electric signal with the second electric signal.Type: GrantFiled: April 3, 2007Date of Patent: May 17, 2011Assignee: Samsung Electronics Co., Ltd.Inventors: Kyu-tae Yoo, Kyu-sang Lee, Jeo-young Shim, Won-seok Chung, Yeon-ja Cho -
Publication number: 20110043213Abstract: Provided are a FET-based sensor for detecting an ionic material, an ionic material detecting device including the FET-based sensor, and a method of detecting an ionic material using the FET-based sensor. The FET-based sensor includes: a sensing chamber including a reference electrode and a plurality of sensing FETs; and a reference chamber including a reference electrode and a plurality of reference FETs. The method includes: flowing a first solution into and out of the sensing chamber and the reference chamber of the FET-based sensor; flowing a second solution expected to contain an ionic material into and out of the sensing chamber while continuously flowing the first solution into and out of the reference chamber; measuring a current in a channel region between the source and drain of each of the sensing and reference FETs; and correcting the current of the sensing FETs.Type: ApplicationFiled: October 26, 2010Publication date: February 24, 2011Applicant: SAMSUNG ELECTRONICS CO., LTD.,Inventors: Kyu-sang LEE, Kyu-tae YOO, Jeo-young SHIM, Jin-tae KIM, Yeon-ja CHO
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Patent number: 7859029Abstract: Provided are a FET-based sensor for detecting an ionic material, an ionic material detecting device including the FET-based sensor, and a method of detecting an ionic material using the FET-based sensor. The FET-based sensor includes: a sensing chamber including a reference electrode and a plurality of sensing FETs; and a reference chamber including a reference electrode and a plurality of reference FETs. The method includes: flowing a first solution into and out of the sensing chamber and the reference chamber of the FET-based sensor; flowing a second solution expected to contain an ionic material into and out of the sensing chamber while continuously flowing the first solution into and out of the reference chamber; measuring a current in a channel region between the source and drain of each of the sensing and reference FETs; and correcting the current of the sensing FETs.Type: GrantFiled: January 9, 2007Date of Patent: December 28, 2010Assignee: Samsung Electronics Co., Ltd.Inventors: Kyu-sang Lee, Kyu-tae Yoo, Jeo-young Shim, Jin-tae Kim, Yeon-ja Cho
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Patent number: 7855069Abstract: A method and apparatus for a rapid disruption of cells or viruses using micro magnetic beads and a laser are provided. According to the method and apparatus for a rapid disruption of cells or viruses using micro magnetic beads and a laser, cell lysis within 40 seconds is possible, the apparatus can be miniaturized using a laser diode, a DNA purification step can be directly performed after a disruption of cells or viruses, and a solution containing DNA can be transferred to a subsequent step after cell debris and beads to which inhibitors of a subsequent reaction are attached are removed with an electromagnet. In addition, by means of the cell lysis chip, an evaporation problem is solved, vibrations can be efficiently transferred to cells through magnetic beads, a microfluidics problem on a rough surface is solved by hydrophobically treating the inner surface of the chip, and the cell lysis chip can be applied to LOC.Type: GrantFiled: October 19, 2005Date of Patent: December 21, 2010Assignee: Samsung Electronics Co., Ltd.Inventors: Jeong-gun Lee, Young-nam Kwon, Young-a Kim, Myo-yong Lee, Shin-i Yoo, Yeon-ja Cho, Kwang-ho Cheong, Chang-eun Yoo, Seung-yeon Yang
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Patent number: 7839134Abstract: A method for simultaneously detecting a size and concentration of ionic materials includes measuring voltage drop values of at least three ionic materials of which sizes and concentrations are known using each of at least two FET-based sensors having different electrical characteristics, determining at least three points in a three-dimensional plot from the known sizes, concentrations and the measured voltage drop values, approximating the at least three points into a single plane, measuring a voltage drop value of an ionic material of which size and concentration are unknown using the at least two FET-based sensors, determining equipotential lines existing on the plane using the voltage drop value of the unknown ionic material and determining a cross point between each of the equipotential lines.Type: GrantFiled: January 4, 2007Date of Patent: November 23, 2010Assignee: Samsung Electronics Co., Ltd.Inventors: Kyu-sang Lee, Kyu-tae Yoo, Jeo-young Shim, Won-seok Chung, Yeon-ja Cho
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Patent number: 7785787Abstract: Provided are methods of isolating and amplifying nucleic acids from and in a nucleic acid-containing sample. The nucleic acid isolation method includes contacting a nucleic acid-containing sample to a silanized solid support to capture nucleic acids to the silanized solid support and treating the nucleic acid-captured solid support with an alkaline solution of pH 9 to 14. The nucleic acid amplification method includes contacting a nucleic acid-containing sample to a silanized solid support to capture nucleic acids to the silanized solid support; treating the nucleic acid-captured solid support with an alkaline solution of pH 9 to 14; and adding a nucleic acid amplification solution to the resultant solution after the alkaline solution treatment to perform nucleic acid amplification.Type: GrantFiled: February 1, 2006Date of Patent: August 31, 2010Assignee: Samsung Electronics Co., Ltd.Inventors: Myo-yong Lee, Joong-gun Lee, Young-nam Kwon, Young-a Kim, Yeon-ja Cho, Shin-i Yoo
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Publication number: 20090322354Abstract: A method of detecting a presence of bio-molecules, or a concentration of the target bio-molecules using a field effect transistor, includes allowing a first sample including a first target bio-molecule to contact a sensing surface of the field effect transistor and measuring a change in an electric signal of the field effect transistor, the field effect transistor including a substrate, a source region and a drain region, the source region and the drain region formed apart from each other on the substrate, the source region and the drain region each doped to having an opposite polarity than a polarity of the substrate, a channel region disposed between the source region and the drain region and an insulating layer including the sensing surface, the insulating layer disposed on the channel region.Type: ApplicationFiled: April 3, 2007Publication date: December 31, 2009Applicant: SAMSUNG ELECTRONICS CO., LTDInventors: Kyu-tae YOO, Kyu-sang LEE, Won-seok CHUNG, Jeo-young SHIM, Yeon-ja CHO
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Publication number: 20090153130Abstract: Provided is a Field-Effect Transistor (FET)-based biosensor including: a substrate; a source and a drain, disposed on the substrate, having opposite polarity to the substrate; a gate, disposed on the substrate, contacting the source and the drain; and an inorganic film capable of binding with a biomolecule, disposed on a surface of the gate. A method of manufacturing the FET-based biosensor and a method of detecting a biomolecule using the FET-based biosensor is also provided. The FET-based biosensor can be manufactured using a semiconductor fabrication process without performing an additional process. Therefore, the inorganic film can be selectively deposited on a surface of a specific gate of a single FET, or on the surfaces of some gates of a plurality of FETs using patterning. Furthermore, the FET-based biosensor can be used to effectively detect trace amounts of a target biomolecule in a sample.Type: ApplicationFiled: November 6, 2006Publication date: June 18, 2009Applicant: SAMSUNG ELECTRONICS CO., LTD.Inventors: Jeo-young SHIM, Kyu-sang LEE, Chang-eun YOO, Kyu-youn HWANG, Young-a KIM, Kyu-tae YOO, Yeon-ja CHO
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Publication number: 20080199930Abstract: A method and apparatus for rapid disruption of cells or viruses using beads and a laser are provided. According to the method and apparatus for rapid disruption of cells or viruses using beads and a laser, cell lysis within 40 seconds is possible, the apparatus can be miniaturized using a laser diode, a DNA purification step can be directly performed after a disruption of cells or viruses, and a solution containing DNA can be transferred to a subsequent step after cell debris and beads to which inhibitors of a subsequent reaction are attached are removed with an electromagnet. In addition, by means of the cell lysis chip, an evaporation problem is solved, vibrations can be efficiently transferred to cells through magnetic beads, a microfluidics problem on a rough surface is solved by hydrophobically treating the inner surface of the chip, and the cell lysis chip can be applied to LOC.Type: ApplicationFiled: February 15, 2008Publication date: August 21, 2008Applicant: SAMSUNG ELECTRONICS CO., LTD.Inventors: Jeong-gun LEE, Young-nam KWON, Young-a KIM, Myo-yong LEE, Shin-i YOO, Yeon-ja CHO, Kwang-ho CHEONG, Chang-eun YOO, Seung-yeon YANG
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Publication number: 20070251301Abstract: A method for simultaneously detecting a size and concentration of ionic materials includes measuring voltage drop values of at least three ionic materials of which sizes and concentrations are known using each of at least two FET-based sensors having different electrical characteristics, determining at least three points in a three-dimensional plot from the known sizes, concentrations and the measured voltage drop values, approximating the at least three points into a single plane, measuring a voltage drop value of an ionic material of which size and concentration are unknown using the at least two FET-based sensors, determining equipotential lines existing on the plane using the voltage drop value of the unknown ionic material and determining a cross point between each of the equipotential lines.Type: ApplicationFiled: January 4, 2007Publication date: November 1, 2007Applicant: SAMSUNG ELECTRONICS CO., LTD.Inventors: Kyu-sang LEE, Kyu-tae YOO, Jeo-young SHIM, Won-seok CHUNG, Yeon-ja CHO
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Publication number: 20070235760Abstract: A field effect transistor for detecting an analyte having a thiol group includes a substrate, a source region and a drain region formed apart from each other on the substrate, the source region and the drain region being doped such that a polarity of the source and drain region is opposite to a polarity of the substrate, a channel region disposed between the source region and the drain region, an insulating layer formed of an electrically insulating material and disposed on the channel region, a gold layer disposed on the insulating layer and a reference electrode disposed apart from the gold layer.Type: ApplicationFiled: April 10, 2007Publication date: October 11, 2007Applicant: Samsung Electronics Co., LtdInventors: Jeo-young Shim, Kyu-tae Yoo, Kyu-sang Lee, Won-seok Chung, Yeon-ja Cho, Chang-eun Yoo
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Publication number: 20070231211Abstract: Provided is a method of detecting the presence of a target bio-molecule or a concentration of the bio-molecule using a field effect transistor. The method includes: contacting a first sample having a first target bio-molecule with a reference electrode of a field effect transistor; measuring a first electric signal change of the field effect transistor; contacting a second sample with a sensing surface of the same field effect transistor; measuring a second electric signal change of the field effect transistor; and comparing the first electric signal with the second electric signal.Type: ApplicationFiled: April 3, 2007Publication date: October 4, 2007Applicant: SAMSUNG ELECTRONICS CO., LTD.Inventors: Kyu-tae Yoo, Kyu-sang Lee, Jeo-young Shim, Won-seok Chung, Yeon-ja Cho
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Publication number: 20070159216Abstract: Provided are a FET-based sensor for detecting an ionic material, an ionic material detecting device including the FET-based sensor, and a method of detecting an ionic material using the FET-based sensor. The FET-based sensor includes: a sensing chamber including a reference electrode and a plurality of sensing FETs; and a reference chamber including a reference electrode and a plurality of reference FETs. The method includes: flowing a first solution into and out of the sensing chamber and the reference chamber of the FET-based sensor; flowing a second solution expected to contain an ionic material into and out of the sensing chamber while continuously flowing the first solution into and out of the reference chamber; measuring a current in a channel region between the source and drain of each of the sensing and reference FETs; and correcting the current of the sensing FETs.Type: ApplicationFiled: January 9, 2007Publication date: July 12, 2007Applicant: SAMSUNG ELECTRONICS CO., LTD.,Inventors: Kyu-sang LEE, Kyu-tae YOO, Jeo-young SHIM, Jin-tae KIM, Yeon-ja CHO
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Publication number: 20060264620Abstract: Provided are methods of isolating and amplifying nucleic acids from and in a nucleic acid-containing sample. The nucleic acid isolation method includes contacting a nucleic acid-containing sample to a silanized solid support to capture nucleic acids to the silanized solid support and treating the nucleic acid-captured solid support with an alkaline solution of pH 9 to 14. The nucleic acid amplification method includes contacting a nucleic acid-containing sample to a silanized solid support to capture nucleic acids to the silanized solid support; treating the nucleic acid-captured solid support with an alkaline solution of pH 9 to 14; and adding a nucleic acid amplification solution to the resultant solution after the alkaline solution treatment to perform nucleic acid amplification.Type: ApplicationFiled: February 1, 2006Publication date: November 23, 2006Inventors: Myo-yong Lee, Joong-gun Lee, Young-nam Kwon, Young-a Kim, Yeon-ja Cho, Shin-i Yoo
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Publication number: 20060110725Abstract: An apparatus for and method of purifying nucleic acids of cells or viruses are provided. The nucleic acid purification apparatus includes: a cell lysis capillary having a sample inlet through which samples, magnetic beads, and a solid support are introduced; a vibrator attached to the capillary and mixing the samples, magnetic beads, and solid support in the capillary; a laser generator attached to the capillary and irradiating a laser beam onto the capillary; a magnetic force generator attached to the capillary and fixing the magnetic beads to a capillary wall; a waste chamber attached to the capillary and discharging a lysate; an elution buffer chamber attached to the capillary and eluting nucleic acids from the solid support having nucleic acids bound thereto; and a neutralization buffer chamber attached to the capillary and supplying a neutralization buffer for neutralizing the eluted nucleic acid solution.Type: ApplicationFiled: July 26, 2005Publication date: May 25, 2006Inventors: Jeong-gun Lee, Young-nam Kwon, Myo-yong Lee, Shin-i Yoo, Yeon-ja Cho, Young-a Kim
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Publication number: 20060084165Abstract: A method and apparatus for a rapid disruption of cells or viruses using micro magnetic beads and a laser are provided. According to the method and apparatus for a rapid disruption of cells or viruses using micro magnetic beads and a laser, cell lysis within 40 seconds is possible, the apparatus can be miniaturized using a laser diode, a DNA purification step can be directly performed after a disruption of cells or viruses, and a solution containing DNA can be transferred to a subsequent step after cell debris and beads to which inhibitors of a subsequent reaction are attached are removed with an electromagnet. In addition, by means of the cell lysis chip, an evaporation problem is solved, vibrations can be efficiently transferred to cells through magnetic beads, a microfluidics problem on a rough surface is solved by hydrophobically treating the inner surface of the chip, and the cell lysis chip can be applied to LOC.Type: ApplicationFiled: October 19, 2005Publication date: April 20, 2006Inventors: Jeong-gun Lee, Young-nam Kwon, Young-a Kim, Myo-yong Lee, Shin-i Yoo, Yeon-ja Cho, Kwang-ho Cheong, Chang-eun Yoo, Seung-yeon Yang