Abstract: Proposed are an unsupported metallic catalyst for a selective ring-opening (SRO) reaction and a method of using the same catalyst, wherein the catalyst contains nickel (Ni), molybdenum (Mo), and tungsten (W).

Abstract: The present invention provides a stable liquid pharmaceutical formulation containing: an antibody or its antigen-binding fragment; a surfactant; a sugar or its derivative; and a buffer. The stable liquid pharmaceutical formulation according to the present invention has low viscosity while containing a high content of the antibody, has excellent long-term storage stability based on excellent stability under accelerated conditions and severe conditions, and may be administered subcutaneously.

Abstract: The present disclosure relates to an isolated anti-FcRN antibody, which is an antibody binding to FcRN (stands for neonatal Fc receptor, also called FcRP, FcRB or Brambell receptor) that is a receptor with a high affinity for IgG or a fragment thereof, a method of preparing thereof, a composition for treating autoimmune disease, which comprises the antibody, and a method of treating and diagnosing autoimmunre diseases using the antibody. The FcRn-specific antibody according to the present disclosure binds to FcRn non-competitively with IgG to reduce serum pathogenic auto-antibody levels, and thus can be used for the treatment of autoimmune diseases.

Abstract: An in-vivo release-sustained recombinant coagulation factor VIII and a method for making it are disclosed. The recombinant coagulation factor VIII has a biocompatible polymer that is conjugated to at least one sugar chain terminus. The in-vivo release-sustained recombinant coagulation factor VIII has a protein surface modified through a method more elaborate and safer than conventional glycoconjugation techniques and enjoys the advantage of decreasing in immunogenicity and increasing in in-vivo sustainability.

Abstract: The present invention relates to a method for separating antibody isoforms using cation exchange chromatography and, more specifically, to a method for separating and purifying several isoforms, which are generated during an antibody production procedure, using a washing buffer for cation exchange chromatography.

Abstract: An electronic device comprising: a communication interface; a memory; and at least one processor coupled to the memory and the communication interface, wherein the at least one processor is configured to: detect a change of state of the electronic device; transmit to a secondary electronic device a first information item associated with the change of state of the electronic device; receive a second information item from the secondary electronic device in response to the first information item; and perform an operation based on the secondary information item.

Abstract: The present invention relates to an antibody-linker-drug conjugate in which an antibody and a cytotoxic drug are conjugated through an enzyme cleavable peptide linker capable of directly binding to a lysine residue of an antibody, a preparation method therefor, and an anticancer drug composition containing the same as an active ingredient.

Abstract: Provided is a system and method for providing a surrounding area search result. A search system may include a searcher configured to search for a reference location in response to a nearby point of interest (POI) search request based on the reference location, and to search for POIs located around the reference location, and a display configured to display a search result about the POIs based on each reference location when at least two reference locations are retrieved.

Abstract: An electronic device comprising: a communication interface; a memory; and at least one processor coupled to the memory and the communication interface, wherein the at least one processor is configured to: detect a change of state of the electronic device; transmit to a secondary electronic device a first information item associated with the change of state of the electronic device; receive a second information item from the secondary electronic device in response to the first information item; and perform an operation based on the secondary information item.

Abstract: An electronic device comprising: a communication interface; a memory; and at least one processor coupled to the memory and the communication interface, wherein the at least one processor is configured to: detect a change of state of the electronic device; transmit to a secondary electronic device a first information item associated with the change of state of the electronic device; receive a second information item from the secondary electronic device in response to the first information item; and perform an operation based on the secondary information item.

Abstract: The present invention relates to a method for separating antibody isoforms using cation exchange chromatography and, more specifically, to a method for separating and purifying several isoforms, which are generated during an antibody production procedure, using a washing buffer for cation exchange chromatography.

Abstract: An electronic device comprising: a communication interface; a memory; and at least one processor coupled to the memory and the communication interface, wherein the at least one processor is configured to: detect a change of state of the electronic device; transmit to a secondary electronic device a first information item associated with the change of state of the electronic device; receive a second information item from the secondary electronic device in response to the first information item; and perform an operation based on the secondary information item.

Abstract: The present invention relates to an antibody-linker-drug conjugate in which an antibody and a cytotoxic drug are conjugated through an enzyme cleavable peptide linker capable of directly binding to a lysine residue of an antibody, a preparation method therefor, and an anticancer drug composition containing the same as an active ingredient.

Abstract: Provided is a search system and method for an expanded administrative area using nearby administrative area information. A search system may include a setter configured to set, as a search area, an administrative district corresponding to an administrative name in response to a query comprising the administrative name, and a searcher configured to conduct a search associated with the query in the search area. Here, the setter may expand the search area to another administrative district adjacent to the administrative district when a search result obtained from the search area is unsatisfactory.

Abstract: Provided is a system and method for providing a surrounding area search result. A search system may include a searcher configured to search for a reference location in response to a nearby point of interest (POI) search request based on the reference location, and to search for POIs located around the reference location, and a display configured to display a search result about the POIs based on each reference location when at least two reference locations are retrieved.

Abstract: An electronic device and method for creating a virtual folder and managing stored applications capable of displaying a list of at least one application associated with a selected virtual folder based on metadata information of an application. A method of an electronic device can include receiving a touch input of any one of at least one virtual folder, calling at least one application registered to the touch-input virtual folder, and displaying the called at least one application.

Abstract: There is provided a T cell-based universal influenza vaccine including internal genes capable of preparing against infection by broad hetero-subtypic influenza viruses, and thereby preparing for unpredictable epidemic influenza. The present invention selected internal genes of the consensus sequence obtained from bird, pig, and human influenza isolates in order to develop the T cell-based universal flu vaccine. The T cell-based universal flu vaccine according to the present invention is characterized by including at least one CTL epitope, by containing a plurality of internal genes and using the entire sequence of the internal gene itself. The T cell-based universal flu vaccine can achieve broad defense in infection with hetero-subtypic influenza viruses.

Abstract: There is provided a T cell-based universal influenza vaccine including internal genes capable of preparing against infection by broad hetero-subtypic influenza viruses, and thereby preparing for unpredictable epidemic influenza. The present invention selected internal genes of the consensus sequence obtained from bird, pig, and human influenza isolates in order to develop the T cell-based universal flu vaccine. The T cell-based universal flu vaccine according to the present invention is characterized by including at least one CTL epitope, by containing a plurality of internal genes and using the entire sequence of the internal gene itself. The T cell-based universal flu vaccine can achieve broad defense in infection with hetero-subtypic influenza viruses.