Abstract: The present invention relates to a heteroaryl derivative compound and a use thereof. Since the heteroaryl derivative of the present invention exhibits excellent inhibitory activity against EGFR, the heteroaryl derivative can be usefully used as a therapeutic agent for EGFR-associated diseases.

Abstract: A tunable optical filter comprises a resonant grating layer having an aperiodic pattern, an optional sublayer, a waveguide layer, and a substrate layer, wherein at least one of the waveguide layer and the sublayer, when present is inhomogenous. In some instances, the optional sublayer and/or the waveguide layer may comprise a thickness gradient. Incident light may be filtered and/or reflected by an optical filter, for instance a band of incident electromagnetic radiation has 90% or greater transmittance or reflectance and adjacent bands of incident electromagnetic radiation have 10% or less transmittance or reflectance, respectively.

Abstract: Unpolarized broadband reflectors enabled by a serial arrangement of a pair of polarized subwavelength gratings are disclosed. Device illustrations include partially-etched crystalline-silicon films on quartz substrates and amorphous silicon films on glass. The individual reflectors exhibit extremely wide spectral reflection bands in one polarization. By arranging two such reflectors sequentially with orthogonal periodicities, there results an unpolarized spectral band that exceeds those of the individual polarized bands. In the prototypes disclosed, there results zero-order reflectance exceeding 97% under unpolarized light incidence over a 500-nm-wide wavelength band. This wideband represents a ˜44% fractional band in the near infrared spectral band. The elemental polarization-sensitive reflectors based on one-dimensional resonant gratings have simple design, robust performance, and are straightforward to fabricate.

Abstract: Narrow bandpass filters are useful in numerous practical applications including laser systems, imaging, telecommunications, and astronomy. Traditionally implemented with thin-film stacks, there exists alternate means incorporating photonic resonance effects. Accordingly, here we disclose a new approach to bandpass filters that engages the guided-mode resonance effect working in conjunction with a cavity-based Fabry-Pérot resonance to flatten and steepen the pass band. Both of these resonance mechanisms are native to simple resonant bandpass filters placed in a cascade. To support the disclosure, numerical examples provide quantitative spectral characteristics including pass-band shape and sideband levels. Thus, we compare the spectra of single-layer 1D- and 2D-patterned resonant gratings with a dual-grating cascade design incorporating mathematically identical gratings. Dual and triple cascade designs are measured against a classic multi-cavity thin-film filter with 151 layers.

Abstract: There is immense scientific interest in the properties of resonant thin films embroidered with periodic nanoscale features. This device class possesses considerable innovation potential. Accordingly, we report unpolarized broadband reflectors enabled by a serial arrangement of a pair of polarized subwavelength gratings. Optimized with numerical methods, the elemental gratings can be fabricated in various materials systems. Illustrative examples provided consist of a partially-etched crystalline-silicon films on a quartz substrate and amorphous silicon films on glass. The resulting reflectors exhibit extremely wide spectral reflection bands in one polarization. By arranging two such reflectors sequentially with orthogonal there results an unpolarized spectral band that exceeds those of the individual polarized bands. In the prototypes disclosed herein, there results zero-order reflectance exceeding 97% under unpolarized light incidence over a 500-nm-wide wavelength band.