Patents by Inventor Yeongsook Kim

Yeongsook Kim has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Preparation process useful in synthesis of atorvastatin
    Patent number: 8124790
    Abstract: The present invention relates to a preparation process useful in synthesis of atorvastatin, more particularly a process for preparing atorvastatin is effective in treating hyperlipemia, comprising protecting the dihydroxy group at C3 and C5 positions of the starting material cis-t-butyl-6-substituted-3,5-dihydroxy-hexanoate with trialkyl orthoformate, reducing the terminal nitro or cyano group to amine group, performing JV-alkylation by sequentially reacting with ethyl 4-fluorobenzene-2-haloacetate and isobutyryl chloride, cyclizing with JV,3-diphenylpropynamide, and performing deprotection and hydrolysis.
    Type: Grant
    Filed: April 4, 2008
    Date of Patent: February 28, 2012
    Assignee: Medichem Korea Co., Ltd.
    Inventors: Dong-Ock Cho, Younja Kwon, Kyeong-Hoi Cha, Yeongsook Kim, Hyun-Seop Tae
  • PREPARATION PROCESS USEFUL IN SYNTHESIS OF ATORVASTATIN
    Publication number: 20110112309
    Abstract: The present invention relates to a preparation process useful in synthesis of atorvastatin, more particularly a process for preparing atorvastatin is effective in treating hyperlipemia, comprising protecting the dihydroxy group at C3 and C5 positions of the starting material cis-t-butyl-6-substituted-3,5-dihydroxy-hexanoate with trialkyl orthoformate, reducing the terminal nitro or cyano group to amine group, performing JV-alkylation by sequentially reacting with ethyl 4-fluorobenzene-2-haloacetate and isobutyryl chloride, cyclizing with JV,3-diphenylpropynamide, and performing deprotection and hydrolysis.
    Type: Application
    Filed: April 4, 2008
    Publication date: May 12, 2011
    Inventors: Dong-Ock Cho, Younja Kwon, Kyeong-Hoe Cha, Yeongsook Kim, Hyun-Seop Tae