Patents by Inventor Yero J. Espinoza

Yero J. Espinoza has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • EXCIPIENTS FOR USE IN ADENO-ASSOCIATED VIRUS PHARMACEUTICAL FORMULATIONS AND PHARMACEUTICAL FORMULATIONS MADE THEREWITH
    Publication number: 20180055939
    Abstract: Stable pharmaceutical compositions comprising recombinant adeno-associated virus (AAV) virions are described. The compositions provide protection against loss of recombinant AAV vector genomes and transduceability under conditions such as exposure to cycles of freezing and thawing and storage in glass or polypropylene vials. The compositions comprise recombinant AAV virions in combination with one or more dihydric or polyhydric alcohols, and, optionally, a detergent, such as a sorbitan ester. Also described are methods of using the compositions.
    Type: Application
    Filed: March 28, 2017
    Publication date: March 1, 2018
    Applicant: Genzyme Corporation
    Inventors: Hema S. Sista, Yero J. Espinoza
  • EXCIPIENTS FOR USE IN ADENO-ASSOCIATED VIRUS PHARMACEUTICAL FORMULATIONS, AND PHARMACEUTICAL FORMULATIONS MADE THEREWITH
    Publication number: 20150238610
    Abstract: Stable pharmaceutical compositions comprising recombinant adeno-associated virus (AAV) virions are described. The compositions provide protection against loss of recombinant AAV vector genomes and transduceability under conditions such as exposure to cycles of freezing and thawing and storage in glass or polypropylene vials. The compositions comprise recombinant AAV virions in combination with one or more dihydric or polyhydric alcohols, and, optionally, a detergent, such as a sorbitan ester. Also described are methods of using the compositions.
    Type: Application
    Filed: October 3, 2014
    Publication date: August 27, 2015
    Applicant: Genzyme Corporation
    Inventors: Hema S. SISTA, Yero J. ESPINOZA
  • Excipients for use in adeno-associated virus pharmaceutical formulations, and pharmaceutical formulations made therewith
    Patent number: 8852607
    Abstract: Stable pharmaceutical compositions comprising recombinant adeno-associated virus (AAV) virions are described. The compositions provide protection against loss of recombinant AAV vector genomes and transduceability under conditions such as exposure to cycles of freezing and thawing and storage in glass or polypropylene vials. The compositions comprise recombinant AAV virions in combination with one or more dihydric or polyhydric alcohols, and, optionally, a detergent, such as a sorbitan ester. Also described are methods of using the compositions.
    Type: Grant
    Filed: May 4, 2012
    Date of Patent: October 7, 2014
    Assignee: Genzyme Corporation
    Inventors: Hema S. Sista, Yero J. Espinoza
  • Excipients for use in adeno-associated virus pharmaceutical formulations, and pharmaceutical formulations made therewith
    Publication number: 20120219528
    Abstract: Stable pharmaceutical compositions comprising recombinant adeno-associated virus (AAV) virions are described. The compositions provide protection against loss of recombinant AAV vector genomes and transduceability under conditions such as exposure to cycles of freezing and thawing and storage in glass or polypropylene vials. The compositions comprise recombinant AAV virions in combination with one or more dihydric or polyhydric alcohols, and, optionally, a detergent, such as a sorbitan ester. Also described are methods of using the compositions.
    Type: Application
    Filed: May 4, 2012
    Publication date: August 30, 2012
    Inventors: Hema S. SISTA, Yero J. ESPINOZA
  • Excipients for use in adeno-associated virus pharmaceutical formulations, and pharmaceutical formulations made therewith
    Patent number: 8192975
    Abstract: Stable pharmaceutical compositions comprising recombinant adeno-associated virus (AAV) virions are described. The compositions provide protection against loss of recombinant AAV vector genomes and transduceability under conditions such as exposure to cycles of freezing and thawing and storage in glass or polypropylene vials. The compositions comprise recombinant AAV virions in combination with one or more dihydric or polyhydric alcohols, and, optionally, a detergent, such as a sorbitan ester. Also described are methods of using the compositions.
    Type: Grant
    Filed: August 24, 2009
    Date of Patent: June 5, 2012
    Assignee: Genzyme Corporation
    Inventors: Hema S. Sista, Yero J. Espinoza
  • Excipients for use in adeno-associated virus pharmaceutical formulations, and pharmaceutical formulations made therewith
    Publication number: 20100209392
    Abstract: Stable pharmaceutical compositions comprising recombinant adeno-associated virus (AAV) virions are described. The compositions provide protection against loss of recombinant AAV vector genomes and transduceability under conditions such as exposure to cycles of freezing and thawing and storage in glass or polypropylene vials. The compositions comprise recombinant AAV virions in combination with one or more dihydric or polyhydric alcohols, and, optionally, a detergent, such as a sorbitan ester. Also described are methods of using the compositions.
    Type: Application
    Filed: August 24, 2009
    Publication date: August 19, 2010
    Inventors: Hema S. Sista, Yero J. Espinoza
  • Excipients for use in adeno-associated virus pharmaceutical formulations, and pharmaceutical formulations made therewith
    Patent number: 7598070
    Abstract: Stable pharmaceutical compositions comprising recombinant adeno-associated virus (AAV) virions are described. The compositions provide protection against loss of recombinant AAV vector genomes and transduceability under conditions such as exposure to cycles of freezing and thawing and storage in glass or polypropylene vials. The compositions comprise recombinant AAV virions in combination with one or more dihydric or polyhydric alcohols, and, optionally, a detergent, such as a sorbitan ester. Also described are methods of using the compositions.
    Type: Grant
    Filed: June 4, 2004
    Date of Patent: October 6, 2009
    Assignee: Genzyme Corporation
    Inventors: Hema S. Sista, Yero J. Espinoza
  • Excipients for use in adeno-associated virus pharmaceutical formulations, and pharmaceutical formulations made therewith
    Publication number: 20040258665
    Abstract: Stable pharmaceutical compositions comprising recombinant adeno-associated virus (AAV) virions are described. The compositions provide protection against loss of recombinant AAV vector genomes and transduceability under conditions such as exposure to cycles of freezing and thawing and storage in glass or polypropylene vials. The compositions comprise recombinant AAV virions in combination with one or more dihydric or polyhydric alcohols, and, optionally, a detergent, such as a sorbitan ester. Also described are methods of using the compositions.
    Type: Application
    Filed: June 4, 2004
    Publication date: December 23, 2004
    Applicant: Avigen, Inc.
    Inventors: Hema S. Sista, Yero J. Espinoza
  • Excipients for use in adeno-associated virus pharmaceutical formulations, and pharmaceutical formulations made therewith
    Patent number: 6764845
    Abstract: Stable pharmaceutical compositions comprising recombinant adeno-associated virus (AAV) virions are described. The compositions provide protection against loss of recombinant AAV vector genomes and transduceability under conditions such as exposure to cycles of freezing and thawing and storage in glass or polypropylene vials. The compositions comprise recombinant AAV virions in combination with one or more dihydric or polyhydric alcohols, and, optionally, a detergent, such as a sorbitan ester. Also described are methods of using the compositions.
    Type: Grant
    Filed: January 10, 2003
    Date of Patent: July 20, 2004
    Assignee: Avigen, Inc.
    Inventors: Hema S. Sista, Yero J. Espinoza
  • Excipients for use in adeno-associated virus pharmaceutical formulations, and pharmaceutical formulations made therewith
    Patent number: 6759050
    Abstract: Stable pharmaceutical compositions comprising recombinant adeno-associated virus (AAV) virions are described. The compositions provide protection against loss of recombinant AAV vector genomes and transduceability under conditions such as exposure to cycles of freezing and thawing and storage in glass or polypropylene vials. The compositions comprise recombinant AAV virions in combination with one or more dihydric or polyhydric alcohols, and, optionally, a detergent, such as a sorbitan ester. Also described are methods of using the compositions.
    Type: Grant
    Filed: December 2, 1999
    Date of Patent: July 6, 2004
    Assignee: Avigen, Inc.
    Inventors: Hema S. Sista, Yero J. Espinoza
  • Excipients for use in adeno-associated virus pharmaceutical formulations, and pharmaceutical formulations made therewith
    Publication number: 20030108525
    Abstract: Stable pharmaceutical compositions comprising recombinant adeno-associated virus (AAV) virions are described. The compositions provide protection against loss of recombinant AAV vector genomes and transduceability under conditions such as exposure to cycles of freezing and thawing and storage in glass or polypropylene vials. The compositions comprise recombinant AAV virions in combination with one or more dihydric or polyhydric alcohols, and, optionally, a detergent, such as a sorbitan ester. Also described are methods of using the compositions.
    Type: Application
    Filed: January 10, 2003
    Publication date: June 12, 2003
    Inventors: Hema S. Sista, Yero J. Espinoza