Patents by Inventor Yerramilli Murthy

Yerramilli Murthy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20080090912
    Abstract: The present invention provides compositions and methods for administering florfenicol to mammals. The compositions contain a prodrug of florfenicol in a pharmaceutically acceptable carrier. In one embodiment the prodrug is an esterized form of florfenicol. Examples of suitable prodrugs include one or a combination of one or a combination of the following: florfenicol acetate, florfenicol propionate, florfenicol butyrate, florfenicol pentanoate, florfenicol hexanoate, florfenicol heptanoate, florfenicol octanoate, florfenicol nanoate, florfenicol decanoate, florfenicol undecanoate, florfenicol dodecanoate, and florfenicol phthalate. In another embodiment the prodrug is converted into the florfenicol in vivo by the action of one or more endogenous esterases. The invention also provides new compounds, pharmaceutical compositions containing the compounds, and methods for their administration.
    Type: Application
    Filed: October 10, 2007
    Publication date: April 17, 2008
    Inventors: Yerramilli Murthy, Robert Suva
  • Publication number: 20070203097
    Abstract: The invention relates to pharmaceutical compositions that are a solution of a salt formed between a fluoroquinolone and a carboxylic acid, a cyclodextrin, and a pharmaceutically acceptable organic solvent and to methods of treating a condition in an animal by administering to an animal in need thereof the pharmaceutical composition of the invention.
    Type: Application
    Filed: March 22, 2007
    Publication date: August 30, 2007
    Inventor: Yerramilli Murthy
  • Publication number: 20070197823
    Abstract: Methods of preparing compounds of formula (I): wherein Y, Y1, and R2 are defined herein; methods of making D-(threo)-1-aryl-2-acylamido-1-propanol compounds, D-(threo)-1-aryl-2-acylamido-3-fluoro-1-propanol compounds, and D-(threo)-1-aryl-2-acylamido-3-hydroxy-1-propanol compounds (collectively, “fenicol compounds”) from the compound of formula (I); and new fenicol compounds, which can be made using the method.
    Type: Application
    Filed: January 31, 2007
    Publication date: August 23, 2007
    Inventors: Yerramilli Murthy, Felix Vattakunnel
  • Publication number: 20070197469
    Abstract: The invention relates to pharmaceutical compositions that are a solution of a salt formed between a fluoroquinolone and a carboxylic acid, a cyclodextrin, and a pharmaceutically acceptable organic solvent and to methods of treating a condition in an animal by administering to an animal in need thereof the pharmaceutical composition of the invention.
    Type: Application
    Filed: January 31, 2007
    Publication date: August 23, 2007
    Inventor: Yerramilli Murthy
  • Publication number: 20070197548
    Abstract: The invention relates to pharmaceutical compositions comprising (i) a fluoroquinolone, (ii) a salt formed between a carboxylate anion and a divalent metal cation, (iii) a liquid comprising an organic solvent selected from the group consisting of glycerol, propylene glycol, glycerol formal, and (iv) optionally water. The invention further relates to methods of treating or preventing a condition in an animal comprising administering to the animal in need thereof a pharmaceutical composition of the invention.
    Type: Application
    Filed: February 17, 2006
    Publication date: August 23, 2007
    Inventor: Yerramilli Murthy
  • Publication number: 20070196398
    Abstract: The invention relates to pharmaceutical compositions of a fatty acid salt of a fluoroquinolone and to methods of treating a condition in an animal by administering to an animal in need thereof the pharmaceutical composition of the invention.
    Type: Application
    Filed: February 17, 2006
    Publication date: August 23, 2007
    Inventor: Yerramilli Murthy
  • Publication number: 20070142468
    Abstract: The present invention provides compositions and methods for administering florfenicol to mammals. The compositions contain a prodrug of florfenicol in a pharmaceutically acceptable carrier. In one embodiment the prodrug is an esterized form of florfenicol. Examples of suitable prodrugs include one or a combination of one or a combination of the following: florfenicol acetate, florfenicol propionate, florfenicol butyrate, florfenicol pentanoate, florfenicol hexanoate, florfenicol heptanoate, florfenicol octanoate, florfenicol nanoate, florfenicol decanoate, florfenicol undecanoate, florfenicol dodecanoate, and florfenicol phthalate. In another embodiment the prodrug is converted into the florfenicol in vivo by the action of one or more endogenous esterases. The invention also provides new compounds, pharmaceutical compositions containing the compounds, and methods for their administration.
    Type: Application
    Filed: January 31, 2007
    Publication date: June 21, 2007
    Inventors: Yerramilli Murthy, Robert Suva
  • Publication number: 20070141162
    Abstract: The present invention provides compositions and methods for extending the release times and lowering the toxicity of pharmacologically active compounds. The compounds comprise a salt of the pharmacologically active compound with a lipophilic counterion and a pharmaceutically acceptable water soluble solvent combined together to form an injectable composition. The lipophilic counterion may be a saturated or unsaturated C8-C22 fatty acid, and preferably may be a saturated or unsaturated C10-C18 fatty acid. When injected into a mammal, at least a portion of the composition precipitates and releases the active compound over time. Thus, the composition forms a slowly releasing drug depot of the active compound in the mammal. Therefore, the present invention enables one to provide a controlled dose administration of the active compound for a periods of up to 15 days or even longer.
    Type: Application
    Filed: January 31, 2007
    Publication date: June 21, 2007
    Inventors: Yerramilli Murthy, Robert Suva
  • Publication number: 20070111969
    Abstract: Pharmaceutical compositions comprising an aptamer and an amino acid ester or amide or an aptamer; a divalent metal cation; and a carboxylic acid, a phospholipid, a phosphatidyl choline, or a sphingomyelin. Methods of treating or preventing a condition in an animal comprising administering to the animal the pharmaceutical compositions.
    Type: Application
    Filed: April 10, 2006
    Publication date: May 17, 2007
    Inventor: Yerramilli Murthy
  • Publication number: 20070110827
    Abstract: Pharmaceutical compositions comprising an aptamer and an amino acid ester or amide or an aptamer; a divalent metal cation; and a carboxylic acid, a phospholipid, a phosphatidyl choline, or a sphingomyelin. Methods of treating or preventing a condition in an animal comprising administering to the animal the pharmaceutical compositions.
    Type: Application
    Filed: April 10, 2006
    Publication date: May 17, 2007
    Inventor: Yerramilli Murthy
  • Publication number: 20070110775
    Abstract: The present invention relates to pharmaceutical compositions in the form of a gel for controlled- or sustained-release of an aptamer and to methods for treating or preventing a condition in an animal by administering to an animal in need thereof the pharmaceutical compositions.
    Type: Application
    Filed: April 10, 2006
    Publication date: May 17, 2007
    Inventor: Yerramilli Murthy
  • Patent number: 7053249
    Abstract: ?-diketone fluorescent tags are disclosed, particularly those enabling the use of excitation energy in the near visible or visible spectrum. In some cases, these tags allow the use of cost-effective excitation devices such as LED's. The compounds form fluorescent chelates (complexes) with lanthanide (III) rare earth metal ions (such as Eu3+). The fluorescent complex may be included in a latex microparticle, such as a styrene latex particle. Ideally, the complex has an absorption maximum ? equal to or greater than 360 nm, and the compound is characterized by a pKa<9.0. Kits and methods for detecting target molecules (e.g. immunoassays) are also disclosed. Such methods and kits typically use a ligand for binding to the target molecule and a labeling agent attached to the ligand. The fluorescent complexes described above are at least part of the labeling agent.
    Type: Grant
    Filed: October 25, 2002
    Date of Patent: May 30, 2006
    Assignee: IDEXX Laboratories, Inc.
    Inventors: Yerramilli Murthy, Robert H. Suva
  • Publication number: 20060094669
    Abstract: The invention relates to methods of treating a bacterial infection in a horse or a pig.
    Type: Application
    Filed: October 28, 2004
    Publication date: May 4, 2006
    Inventor: Yerramilli Murthy
  • Publication number: 20060093632
    Abstract: The invention relates to pharmaceutical compositions that provide sustained-release of a pharmaceutically active compound and to methods of treating or preventing a condition in an animal by administering the pharmaceutical compositions to the animal by injection. When the pharmaceutical compositions are administered to an animal by injection, they form a drug depot that releases the pharmaceutically active compound over time. The pharmaceutical compositions can also be administered orally.
    Type: Application
    Filed: October 27, 2005
    Publication date: May 4, 2006
    Inventor: Yerramilli Murthy
  • Publication number: 20060047138
    Abstract: D-(threo)-1-aryl-2-disubstitutedacylamido-3-fluoro-1-propanol compounds compounds and analogues thereof (“Fenicol Compounds”), compositions comprising an effective amount of a Fenicol Compound, and methods for treating or preventing a bacterial infection in an animal comprising administering to an animal in need thereof an effective amount of a Fenicol Compound are disclosed.
    Type: Application
    Filed: August 23, 2005
    Publication date: March 2, 2006
    Inventor: Yerramilli Murthy
  • Publication number: 20050287181
    Abstract: The present invention relates to pharmaceutical compositions in the form of a gel for controlled- or sustained-release of a pharmaceutically active agent and to methods for treating or preventing a condition in an animal by administering to an animal in need thereof the pharmaceutical compositions. One particular type of condition for which the pharmaceutical compositions are useful is a microbial infection, e.g., of the skin, ear, or eye, especially for veterinary applications.
    Type: Application
    Filed: June 23, 2005
    Publication date: December 29, 2005
    Inventor: Yerramilli Murthy
  • Publication number: 20050287200
    Abstract: The present invention relates to pharmaceutical compositions in the form of a gel for controlled- or sustained-release of a pharmaceutically active agent and to methods for treating or preventing a condition in an animal by administering to an animal in need thereof the pharmaceutical compositions. One particular type of condition for which the pharmaceutical compositions are useful is a microbial infection, e.g., of the skin, ear, or eye, especially for veterinary applications.
    Type: Application
    Filed: December 23, 2004
    Publication date: December 29, 2005
    Applicant: IDEXX Laboratories
    Inventor: Yerramilli Murthy
  • Publication number: 20050287198
    Abstract: The present invention relates to pharmaceutical compositions in the form of a gel for controlled- or sustained-release of a pharmaceutically active agent and to methods for treating or preventing a condition in an animal by administering to an animal in need thereof the pharmaceutical compositions. One particular type of condition for which the pharmaceutical compositions are useful is a microbial infection, e.g., of the skin, ear, or eye, especially for veterinary applications.
    Type: Application
    Filed: June 24, 2004
    Publication date: December 29, 2005
    Inventor: Yerramilli Murthy
  • Publication number: 20050287220
    Abstract: The present invention relates to pharmaceutical compositions in the form of a gel for controlled- or sustained-release of a pharmaceutically active agent and to methods for treating or preventing or preventing a condition in an animal by administering to an animal in need thereof the pharmaceutical compositions. One particular type of condition for which the pharmaceutical compositions are useful is a microbial infection, e.g., of the skin, ear, or eye, especially for veterinary applications.
    Type: Application
    Filed: December 23, 2004
    Publication date: December 29, 2005
    Applicant: IDEXX Laboratories, Inc.
    Inventor: Yerramilli Murthy
  • Publication number: 20050287219
    Abstract: The present invention relates to pharmaceutical compositions in the form of a gel for controlled- or sustained-release of a pharmaceutically active agent and to methods for treating or preventing or preventing a condition in an animal by administering to an animal in need thereof the pharmaceutical compositions. One particular type of condition for which the pharmaceutical compositions are useful is a microbial infection, e.g., of the skin, ear, or eye, especially for veterinary applications.
    Type: Application
    Filed: June 24, 2004
    Publication date: December 29, 2005
    Inventor: Yerramilli Murthy