Patents by Inventor Yerramilli V. S. N. Murthy

Yerramilli V. S. N. Murthy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BIOCHEMICAL PROBES ATTACHED TO EPOXY-BASED RESINS
    Publication number: 20220283159
    Abstract: The present invention is directed to a method for making a solid substrate for conducting biological and chemical assays and to the solid substrate made by the method.
    Type: Application
    Filed: February 28, 2022
    Publication date: September 8, 2022
    Inventors: Alexei Boris Shvets, Darrin Leighton Ramsdell, Michelle M. Straub, Yerramilli V.S.N. Murthy, Phillip Sheldon Smith, Anne Catherine Fitzpatrick
  • Fluoroquinolone compositions
    Patent number: 9012474
    Abstract: The invention relates to pharmaceutical compositions comprising (i) a fluoroquinolone, (ii) a salt formed between a carboxylate anion and a divalent metal cation, (iii) a liquid comprising an organic solvent selected from the group consisting of glycerol, propylene glycol, glycerol formal, and (iv) optionally water. The invention further relates to methods of treating or preventing a condition in an animal comprising administering to the animal in need thereof a pharmaceutical composition of the invention.
    Type: Grant
    Filed: September 15, 2008
    Date of Patent: April 21, 2015
    Assignee: Idexx Laboratories Inc.
    Inventor: Yerramilli V. S. N. Murthy
  • Amino acid vitamin ester compositions for controlled delivery of pharmaceutically active compounds
    Patent number: 8828960
    Abstract: The invention relates to pharmaceutical compositions that provide sustained-release of a pharmaceutically active compound and to methods of treating or preventing a condition in an animal by administering the pharmaceutical compositions to the animal. When the pharmaceutical compositions are administered to an animal by injection, they form a drug depot that releases the pharmaceutically active compound over time. The pharmaceutical compositions can also be administered orally.
    Type: Grant
    Filed: July 11, 2008
    Date of Patent: September 9, 2014
    Assignee: IDEXX Laboratories, Inc.
    Inventors: Yerramilli V.S.N. Murthy, Michael Atkinson
  • Methods for detecting symmetrical dimethylarginine
    Patent number: 8481690
    Abstract: Method of detecting Symmetrical dimethyl arginine (SDMA) in biological samples. SDMA analogs for generating anti-SDMA antibodies having little or no cross-reactivity with asymmetrical dimethyl arginine, arginine, and monomethylarginine. The analogs have a protected or free thiol (—SH) group or hydroxyl (—OH) group that allow them to be linked to a suitable conjugation target which can be, for example, a protein containing molecule of a label. The anti-SDMA antibodies can be used in diagnostic immunoassay for the diagnosis of SDMA associated disorders and/or diseases.
    Type: Grant
    Filed: July 30, 2009
    Date of Patent: July 9, 2013
    Assignee: IDEXX Laboratories, Inc.
    Inventors: Yerramilli V. S. N. Murthy, Mahalakshmi Padmanabhan, Michael Atkinson, Kwok Kam Yeung
  • Compositions for controlled delivery of pharmaceutically active compounds
    Patent number: 8293253
    Abstract: The invention relates to pharmaceutical compositions that provide sustained-release of a pharmaceutically active compound and to methods of treating or preventing a condition in an animal by administering the pharmaceutical compositions to the animal by injection. When the pharmaceutical compositions are administered to an animal by injection, they form a drug depot that releases the pharmaceutically active compound over time. The pharmaceutical compositions can also be administered orally.
    Type: Grant
    Filed: October 27, 2005
    Date of Patent: October 23, 2012
    Assignee: IDEXX Laboratories, Inc.
    Inventor: Yerramilli V. S. N. Murthy
  • Process for preparing cefsulodin sodium
    Patent number: 8198434
    Abstract: The invention is directed to an improved process for preparing cefsulodin sodium. The process involves: (i) dissolving cefsulodin in a solvent comprising an organic solvent to provide a solution of cefsulodin, (ii) adding about 1 equivalent of a sodium salt of a base to the solution of cefsulodin to provide a solution of cefsulodin sodium, and (iii) separating the cefsulodin sodium from the solution of cefsulodin sodium.
    Type: Grant
    Filed: May 5, 2009
    Date of Patent: June 12, 2012
    Assignee: IDEXX Laboratories, Inc.
    Inventors: Yerramilli V. S. N. Murthy, Edward Obare, Hengguang Li
  • Pharmaceutical compositions for the administration of aptamers
    Patent number: 8114440
    Abstract: Pharmaceutical compositions comprising an aptamer and an amino acid ester or amide or an aptamer; a divalent metal cation; and a carboxylic acid, a phospholipid, a phosphatidyl choline, or a sphingomyelin. Methods of treating or preventing a condition in an animal comprising administering to the animal the pharmaceutical compositions.
    Type: Grant
    Filed: April 10, 2006
    Date of Patent: February 14, 2012
    Assignee: Idexx Laboratories Inc.
    Inventor: Yerramilli V. S. N. Murthy
  • Phospholipid gel compositions for delivery of aptamers and methods of treating conditions using same
    Patent number: 8017159
    Abstract: The present invention relates to pharmaceutical compositions in the form of a gel for controlled- or sustained-release of an aptamer and to methods for treating or preventing a condition in an animal by administering to an animal in need thereof the pharmaceutical compositions.
    Type: Grant
    Filed: April 10, 2006
    Date of Patent: September 13, 2011
    Assignee: IDEXX Laboratories, Inc.
    Inventor: Yerramilli V. S. N. Murthy
  • Fluoroquinolone carboxylic acid salt compositions
    Patent number: 7973022
    Abstract: The invention relates to pharmaceutical compositions that are a solution of a salt formed between a fluoroquinolone and a carboxylic acid, a cyclodextrin, and a pharmaceutically acceptable organic solvent and to methods of treating a condition in an animal by administering to an animal in need thereof the pharmaceutical composition of the invention.
    Type: Grant
    Filed: March 22, 2007
    Date of Patent: July 5, 2011
    Assignee: IDEXX Laboratories, Inc.
    Inventor: Yerramilli V. S. N. Murthy
  • Phospholipid Gel Compositions for Drug Delivery and Methods of Treating Conditions Using Same
    Publication number: 20110034430
    Abstract: The present invention relates to pharmaceutical compositions in the form of a gel for controlled- or sustained-release of a pharmaceutically active agent and to methods for treating or preventing a condition in an animal by administering to an animal in need thereof the pharmaceutical compositions. One particular type of condition for which the pharmaceutical compositions are useful is a microbial infection, e.g., of the skin, ear, or eye, especially for veterinary applications.
    Type: Application
    Filed: October 21, 2010
    Publication date: February 10, 2011
    Applicant: IDEXX Laboratories, Inc.
    Inventor: Yerramilli V.S.N. Murthy
  • Phospholipid gel compositions for drug delivery and methods of treating conditions using same
    Patent number: 7858115
    Abstract: The present invention relates to pharmaceutical compositions in the form of a gel for controlled- or sustained-release of a pharmaceutically active agent and to methods for treating or preventing a condition in an animal by administering to an animal in need thereof the pharmaceutical compositions. One particular type of condition for which the pharmaceutical compositions are useful is a microbial infection, e.g., of the skin, ear, or eye, especially for veterinary applications.
    Type: Grant
    Filed: December 23, 2004
    Date of Patent: December 28, 2010
    Assignee: IDEXX Laboratories
    Inventor: Yerramilli V. S. N. Murthy
  • Phospholipid gel compositions for drug delivery and methods of treating conditions using same
    Patent number: 7854943
    Abstract: The present invention relates to pharmaceutical compositions in the form of a gel for controlled- or sustained-release of a pharmaceutically active agent and to methods for treating or preventing a condition in an animal by administering to an animal in need thereof the pharmaceutical compositions. One particular type of condition for which the pharmaceutical compositions are useful is a microbial infection, e.g., of the skin, ear, or eye, especially for veterinary applications.
    Type: Grant
    Filed: June 24, 2004
    Date of Patent: December 21, 2010
    Assignee: IDEXX Laboratories
    Inventor: Yerramilli V. S. N. Murthy
  • Phospholipid gel compositions for drug delivery and methods of treating conditions using same
    Patent number: 7846472
    Abstract: The present invention relates to pharmaceutical compositions in the form of a gel for controlled- or sustained-release of a pharmaceutically active agent and to methods for treating or preventing a condition in an animal by administering to an animal in need thereof the pharmaceutical compositions. One particular type of condition for which the pharmaceutical compositions are useful is a microbial infection, e.g., of the skin, ear, or eye, especially for veterinary applications.
    Type: Grant
    Filed: June 23, 2005
    Date of Patent: December 7, 2010
    Assignee: IDEXX Laboratories
    Inventor: Yerramilli V. S. N. Murthy
  • PHARMACEUTICAL COMPOSITIONS FOR THE ADMINISTRATION OF APTAMERS
    Publication number: 20100240741
    Abstract: Pharmaceutical compositions comprising an aptamer and an amino acid ester or amide or an aptamer; a divalent metal cation; and a carboxylic acid, a phospholipid, a phosphatidyl choline, or a sphingomyelin. Methods of treating or preventing a condition in an animal comprising administering to the animal the pharmaceutical compositions.
    Type: Application
    Filed: May 28, 2010
    Publication date: September 23, 2010
    Applicant: IDEXX Laboratories, Inc.
    Inventor: Yerramilli V.S.N. Murthy
  • Compositions containing prodrugs of florfenicol and methods of use
    Patent number: 7786167
    Abstract: The present invention provides compositions and methods for administering florfenicol to mammals. The compositions contain a prodrug of florfenicol in a pharmaceutically acceptable carrier. In one embodiment the prodrug is an esterized form of florfenicol. Examples of suitable prodrugs include one or a combination of one or a combination of the following: florfenicol acetate, florfenicol propionate, florfenicol butyrate, florfenicol pentanoate, florfenicol hexanoate, florfenicol heptanoate, florfenicol octanoate, florfenicol nanoate, florfenicol decanoate, florfenicol undecanoate, florfenicol dodecanoate, and florfenicol phthalate. In another embodiment the prodrug is converted into the florfenicol in vivo by the action of one or more endogenous esterases. The invention also provides new compounds, pharmaceutical compositions containing the compounds, and methods for their administration.
    Type: Grant
    Filed: October 10, 2007
    Date of Patent: August 31, 2010
    Assignee: IDEXX Laboratories, Inc.
    Inventors: Yerramilli V. S. N. Murthy, Robert H. Suva
  • Pharmaceutical Compositions for Administering Oligonucleotides
    Publication number: 20100204303
    Abstract: The invention relates to pharmaceutical compositions useful for administering an oligonucleotide to an animal in need thereof. The pharmaceutical compositions include nano-particles or micro-particles of (i) a protonated oligonucleotide and (ii) a pharmaceutically acceptable organic base or include nano-particles or micro-particles of (i) an oligonucleotide and (ii) a divalent metal ion.
    Type: Application
    Filed: September 24, 2008
    Publication date: August 12, 2010
    Applicant: IDEXX Laboratories, Inc.
    Inventors: Yerramilli V.S.N. Murthy, Michael Atkinson
  • Pharmaceutical compositions for the administration of aptamers
    Patent number: 7754679
    Abstract: Pharmaceutical compositions comprising an aptamer and an amino acid ester or amide or an aptamer; a divalent metal cation; and a carboxylic acid, a phospholipid, a phosphatidyl choline, or a sphingomyelin. Methods of treating or preventing a condition in an animal comprising administering to the animal the pharmaceutical compositions.
    Type: Grant
    Filed: April 10, 2006
    Date of Patent: July 13, 2010
    Assignee: IDEXX Laboratories, Inc.
    Inventor: Yerramilli V. S. N. Murthy
  • PROCESS FOR PREPARING CEFSULODIN SODIUM
    Publication number: 20100113768
    Abstract: The invention is directed to an improved process for preparing cefsulodin sodium. The process involves: (i) dissolving cefsulodin in a solvent comprising an organic solvent to provide a solution of cefsulodin, (ii) adding about 1 equivalent of a sodium salt of a base to the solution of cefsulodin to provide a solution of cefsulodin sodium, and (iii) separating the cefsulodin sodium from the solution of cefsulodin sodium.
    Type: Application
    Filed: May 5, 2009
    Publication date: May 6, 2010
    Applicant: IDEXX Laboratories, Inc.
    Inventors: Yerramilli V.S.N. Murthy, Edward Obare, Hengguang Li
  • Compositions containing prodrugs of florfenicol and methods of use
    Patent number: 7662861
    Abstract: The present invention provides compositions and methods for administering florfenicol to mammals. The compositions contain a prodrug of florfenicol in a pharmaceutically acceptable carrier. In one embodiment the prodrug is an esterized form of florfenicol. Examples of suitable prodrugs include one or a combination of one or a combination of the following: florfenicol acetate, florfenicol propionate, florfenicol butyrate, florfenicol pentanoate, florfenicol hexanoate, florfenicol heptanoate, florfenicol octanoate, florfenicol nanoate, florfenicol decanoate, florfenicol undecanoate, florfenicol dodecanoate, and florfenicol phthalate. In another embodiment the prodrug is converted into the florfenicol in vivo by the action of one or more endogenous esterases. The invention also provides new compounds, pharmaceutical compositions containing the compounds, and methods for their administration.
    Type: Grant
    Filed: January 31, 2007
    Date of Patent: February 16, 2010
    Assignee: IDEXX Laboratories, Inc.
    Inventors: Yerramilli V. S. N. Murthy, Robert H. Suva
  • Methods for Detecting Symmetrical Dimethylarginine
    Publication number: 20100035274
    Abstract: Method of detecting Symmetrical dimethyl arginine (SDMA) in biological samples. SDMA analogs for generating anti-SDMA antibodies having little or no cross-reactivity with asymmetrical dimethyl arginine, arginine, and monomethylarginine. The analogs have a protected or free thiol (—SH) group or hydroxyl (—OH) group that allow them to be linked to a suitable conjugation target which can be, for example, a protein containing molecule of a label. The anti-SDMA antibodies can be used in diagnostic immunoassay for the diagnosis of SDMA associated disorders and/or diseases.
    Type: Application
    Filed: July 30, 2009
    Publication date: February 11, 2010
    Inventors: Yerramilli V.S.N. Murthy, Mahalakshmi Padmanabhan, Michael Atkinson, Kwok Kam Yeung