Abstract: Methods, apparatus, systems, and articles of manufacture to manage memory in a computing apparatus are disclosed. Methods, apparatus, systems, and articles of manufacture to optimize or improve buffer invalidation to reduce memory management performance overhead are disclosed. An example apparatus includes an input-output memory management unit (IOMMU) circuitry to control access to memory circuitry, the IOMMU circuitry to increment a counter from a first value to a second value when a memory access to a location in the memory circuitry is allocated and to decrement the counter from the second value to the first value when the memory access to the location in the memory circuitry is deallocated; and an operating system (OS) memory manager to enable reallocation of the location in the memory circuitry when the counter is at the first value.

Abstract: Methods and systems are provided for validating variant calls. Sequencing data is received for a sample read along the genomic sequence of interest. An indication is received of a potential variant call at a designated position within the sequence of nucleotides along the genomic sequence of interest. The methods and systems obtain baseline variant frequencies at the designated position within one or more baseline genomic sequences, determine a sample variant frequency at the designated position for the genomic sequence of interest, analyze the baseline and sample variant frequencies at the designated position to obtain a quality score, and validate the potential variant call for the genomic sequence of interest based on the quality score.