Patents by Inventor Yftah TAL-GAN

Yftah TAL-GAN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CYCLIC DOMINANT NEGATIVE COMPETENCE STIMULATING PEPTIDE ANALOGS AND METHODS OF TREATING STREPTOCOCCUS PNEUMONIAE INFECTIONS
    Publication number: 20220227814
    Abstract: Disclosed herein are compositions, methods of treatment and kits for treating Streptococcus Pneumoniae infections. In some examples, compositions including cyclic dominant negative competence stimulating peptide analogs are disclosed and used for treating Streptococcus Pneumoniae infections.
    Type: Application
    Filed: May 21, 2020
    Publication date: July 21, 2022
    Inventors: Yftah TAL-GAN, Gee W. LAU, Yifang YANG
  • Peptide-Based Quorum Sensing Inhibitors for the Attenuation of Virulence in Staphylococcus Aureus
    Publication number: 20200140489
    Abstract: Compounds that affect quorum sensing (QS) in Staphylococcus aureus and related Staphylococcus species (e.g., S. epidermidis). Compounds which modulate one or more of the four AgrC receptors of Staphylococcus species, particularly of Staphylococcus aureus. Modulation includes inhibition or activation of one or more of these four AgrC receptors. These compounds are useful for bacterial interference and are useful for treating bacterial infections, particularly staphylococcal infection. Treatment can include combination of one or more of the compounds of the invention in combination with one or more antibiotics.
    Type: Application
    Filed: January 8, 2020
    Publication date: May 7, 2020
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Helen BLACKWELL, Yftah TAL-GAN, Danielle STACY
  • Simplified Structural Mimetics of AIPS as Quorum Sensing Inhibitors
    Publication number: 20180170889
    Abstract: Compounds that regulate quorum sensing in Staphylococcal bacteria and in particular in Staphylococcus aureus are provided. Compounds are described in formulas I, II, III, IV, V and VI herein. One or more compounds herein can be employed to inhibit QS and to thus inhibit virulence in Staphylococcus bacteria and in particular in Staphylococcus aureus. Compounds herein and pharmaceutical compositions containing one or more of these compounds are useful, for example, in treating infections of Staphylococcus bacteria and in particular of Staphylococcus aureus. Methods for treating such bacterial infections are provided.
    Type: Application
    Filed: December 21, 2017
    Publication date: June 21, 2018
    Inventors: Helen BLACKWELL, Joseph VASQUEZ, Yftah TAL-GAN
  • PEPTIDE-BASED QUORUM SENSING INHIBITORS FOR THE ATTENUATION OF VIRULENCE IN STAPHYLOCOCCUS AUREUS
    Publication number: 20160194360
    Abstract: Compounds that affect quorum sensing (QS) in Staphylococcus aureus and related Staphylococcus species (e.g., S. epidermidis). Compounds which modulate one or more of the four AgrC receptors of Staphylococcus species, particularly of Staphylococcus aureus. Modulation includes inhibition or activation of one or more of these four AgrC receptors. These compounds are useful for bacterial interference and are useful for treating bacterial infections, particularly staphylococcal infection. Treatment can include combination of one or more of the compounds of the invention in combination with one or more antibiotics.
    Type: Application
    Filed: January 4, 2016
    Publication date: July 7, 2016
    Inventors: Helen BLACKWELL, Yftah TAL-GAN, Danielle STACY
  • Peptide-based quorum sensing inhibitors for the attenuation of virulence in
    Patent number: 9227996
    Abstract: Compounds that affect quorum sensing (QS) in Staphylococcus aureus and related Staphylococcus species (e.g., S. epidermidis). Compounds which modulate one or more of the four AgrC receptors of Staphylococcus species, particularly of Staphylococcus aureus. Modulation includes inhibition or activation of one or more of these four AgrC receptors. These compounds are useful for bacterial interference and are useful for treating bacterial infections, particularly staphylococcal infection. Treatment can include combination of one or more of the compounds of the invention in combination with one or more antibiotics.
    Type: Grant
    Filed: December 17, 2013
    Date of Patent: January 5, 2016
    Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Helen Blackwell, Yftah Tal-Gan, Danielle Stacy
  • PEPTIDE-BASED QUORUM SENSING INHIBITORS FOR THE ATTENUATION OF VIRULENCE IN STAPHYLOCOCCUS AUREUS
    Publication number: 20140256615
    Abstract: Compounds that affect quorum sensing (QS) in Staphylococcus aureus and related Staphylococcus species (e.g., S. epidermidis). Compounds which modulate one or more of the four AgrC receptors of Staphylococcus species, particularly of Staphylococcus aureus. Modulation includes inhibition or activation of one or more of these four AgrC receptors. These compounds are useful for bacterial interference and are useful for treating bacterial infections, particularly staphylococcal infection. Treatment can include combination of one or more of the compounds of the invention in combination with one or more antibiotics.
    Type: Application
    Filed: December 17, 2013
    Publication date: September 11, 2014
    Applicant: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Helen BLACKWELL, Yftah TAL-GAN, Danielle STACY