Patents by Inventor Ygal Rotenstreich
Ygal Rotenstreich has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11903879Abstract: The present invention discloses a device suitable for delivery of a fluid composition to an eye, especially therapeutic compositions, comprising: a hollow needle with a bore having a proximal end and a distal end, said distal end configured to pass into a passage in a sclera of an eye, said bore configured to function as a conduit for a fluid from said proximal end to said distal end, and a solid separator having a distal tip, configured to move inside said bore of said hollow needle allowing said distal tip of said separator to protrude from said distal end of said needle.Type: GrantFiled: March 26, 2020Date of Patent: February 20, 2024Assignee: Everads Therapy Ltd.Inventor: Ygal Rotenstreich
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Publication number: 20240033246Abstract: The invention concerns 3,5,4?-trihydroxy-6,7,3?-trimethoxyflavone (TTF) or a pharmaceutically acceptable salt or solvate thereof for use in treating, preventing, or ameliorating an eye disease or disorder, or for providing adjunct treatment to an ocular therapeutic procedure. The invention also concerns ophthalmic compositions comprising TTF.Type: ApplicationFiled: December 9, 2021Publication date: February 1, 2024Inventors: Anat Elmann, Ygal Rotenstreich, Ifat Sher
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Publication number: 20230355727Abstract: Ophthalmic formulations comprising a PAR1 antagonist and/or an agent that interferes with an interaction of PAR1 and a protease (e.g., thrombin), and an ophthalmically acceptable carrier, and uses thereof in treating or preventing retinal pathologies such as retinal degeneration, are provided. The agent can be, for example, a peptide conjugate represented by Formula I, as defined in the specification.Type: ApplicationFiled: May 9, 2023Publication date: November 9, 2023Applicant: Tel HaShomer Medical Research Infrastructure and Services Ltd.Inventors: Joab CHAPMAN, Efrat SHAVIT STEIN, Ygal ROTENSTREICH, Ifat SHER ROSENTHAL
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Publication number: 20230360220Abstract: A method of diagnosing a condition of a subject, comprises: receiving image data of an anterior of an eye of the subject, and analyzing the image data to detect at least one of: flow of individual blood cells in libmal or conjunctival blood vessels of the eye, morphology of limbal or conjunctival blood vessels. The method also comprises determining the condition of the subject based on the detection(s).Type: ApplicationFiled: July 18, 2023Publication date: November 9, 2023Applicants: Ramot at Tel-Aviv University Ltd., Tel HaShomer Medical Research Infrastructure and Services Ltd.Inventors: Ygal ROTENSTREICH, Ifat SHER ROSENTHAL, Haim SUCHOWSKI, Michael MREJEN, Shahar KATZ
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Publication number: 20230301829Abstract: Embodiments pertain to an apparatus for injecting a medicament into a tissue, the apparatus comprising: a rotary motion drive having a motion drive rotary axis and which is configured to receive a needle and operable to rotate the needle about the motion drive rotary axis; and a linear motion drive comprising a drive screw and configured to translate the needle selectively in either proximal and distal direction along a translation axis, and further configured such that, when the apparatus is operably engaged with the tissue, the drive screw remains translationally stationary relative to the tissue during operation of the rotation motion drive to longitudinally translate the needle; and wherein the rotary motion drive and the linear motion drive are independently operatable.Type: ApplicationFiled: August 17, 2021Publication date: September 28, 2023Inventor: Ygal ROTENSTREICH
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Publication number: 20230050186Abstract: Provided herein are systems, devices and methods for monitoring the progression of, determining and/or assessing brain related conditions in a subject based on pupil light responses (PLRs) to focal central and peripheral chromatic light stimuli, in particular, by classifying the PLR based on one or more PLR parameter values, wherein the classifying allows monitoring the progression of, determining and/or assessing the brain related conditionType: ApplicationFiled: August 11, 2022Publication date: February 16, 2023Inventors: Ygal ROTENSTREICH, Ifat SHER
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Publication number: 20220023654Abstract: The invention provides a method of noninvasively treating a condition associated with reduced integrity or increased permeability of an epithelial layer by a series of magnetic pulses having a magnitude of up to 3 T, wherein the magnetic pulses are designed to induce an electric field having a magnitude of up to 250 Volt per meter adjacent to a target treatment area, the condition particularly being ocular condition associated with reduced barrier function of the cornea. The invention provides a device for effecting the tissue treatment, creating series of pulses exhibiting a rate of change of more than 200 T/s in the absolute value.Type: ApplicationFiled: August 9, 2021Publication date: January 27, 2022Applicant: EPITECH MAG LTD.Inventors: Tomer CARMELI, Ifat SHER-ROSENTHAL, Ygal ROTENSTREICH, Itzik RONEN
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Publication number: 20210353456Abstract: The present invention discloses a device suitable for delivery of a fluid composition to an eye, especially therapeutic compositions, comprising: a hollow needle with a bore having a proximal end and a distal end, said distal end configured to pass into a passage in a sclera of an eye, said bore configured to function as a conduit for a fluid from said proximal end to said distal end, and a solid separator having a distal tip, configured to move inside said bore of said hollow needle allowing said distal tip of said separator to protrude from said distal end of said needle.Type: ApplicationFiled: August 2, 2021Publication date: November 18, 2021Applicant: Tel Hashomer Medical Research Infrastructure and Services Ltd.Inventor: Ygal Rotenstreich
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Patent number: 11083908Abstract: The invention provides a method of noninvasively treating a condition associated with reduced integrity or increased permeability of an epithelial layer by a series of magnetic pulses having a magnitude of up to 3 T, wherein the magnetic pulses are designed to induce an electric field having a magnitude of up to 250 Volt per meter adjacent to a target treatment area, the condition particularly being ocular condition associated with reduced barrier function of the cornea. The invention provides a device for effecting the tissue treatment, creating series of pulses exhibiting a rate of change of more than 200 T/s in the absolute value.Type: GrantFiled: July 19, 2018Date of Patent: August 10, 2021Assignee: EPITECH MAG LTD.Inventors: Tomer Carmeli, Ifat Sher-Rosenthal, Ygal Rotenstreich, Itzik Ronen
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Publication number: 20210236743Abstract: Provided is a device for injection into an interlayer of an organ of a subject. The device includes a needle having a size transitional portion terminating in a sharp needle distal tip. The device also includes an elongated tissue separator that is shiftable in the needle lumen. An actuator shifts the tissue separator in the needle lumen between a first position, in which the separator distal tip is fixedly positioned proximally to the needle distal tip, and a second position in which the separator distal tip is fixedly positioned a predetermined distance distally from the needle distal tip.Type: ApplicationFiled: April 18, 2019Publication date: August 5, 2021Applicant: Everads Therapy Ltd.Inventors: Ifat Sher, Ygal Rotenstreich, Gad Lewkonya, David Daily, Lior Raday, Hagay Drori
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Patent number: 11076757Abstract: A system and method for determining a state of health of an eye using a pupillometer is provided comprising an ocular fixture, a testing compartment, a camera, and a controller. The testing compartment comprises a plurality of chromatic beam emitters arranged about a visual field. The ocular fixture is positioned to facilitate exposure of light sensitive ocular structures of the eye to a chromatic stimuli. The camera is positioned to record temporal pupil responses of the eye. The controller controls emission wavelength, intensity, and duration of the chromatic beam emitters. The controller processes temporal pupil response data to generate signals representative of the eye positioned at the ocular fixture in response to the chromatic stimuli at a plurality of locations in the visual field. The method comprises driving the chromatic beam emitters with the controller to generate signals using chromatic stimuli and determining the state of health of the eye.Type: GrantFiled: January 12, 2017Date of Patent: August 3, 2021Assignee: TEL HASHOMERMEDICAL RESEARCH INFRASTRUCTURE AND SERVICES, LTDInventors: Ygal Rotenstreich, Ifat Sher
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Publication number: 20200222233Abstract: The present invention discloses a device suitable for delivery of a fluid composition to an eye, especially therapeutic compositions, comprising: a hollow needle with a bore having a proximal end and a distal end, said distal end configured to pass into a passage in a sclera of an eye, said bore configured to function as a conduit for a fluid from said proximal end to said distal end, and a solid separator having a distal tip, configured to move inside said bore of said hollow needle allowing said distal tip of said separator to protrude from said distal end of said needle.Type: ApplicationFiled: March 26, 2020Publication date: July 16, 2020Inventor: Ygal ROTENSTREICH
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Patent number: 10285852Abstract: Disclosed are methods of subretinal delivery of therapeutic compositions to the eye of a mammal. Also disclosed are devices useful for the subretinal delivery of therapeutic compositions to the eye of a mammal.Type: GrantFiled: November 28, 2011Date of Patent: May 14, 2019Assignee: TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD., THE CHAIM SHEBA MEDICAL CENTERInventor: Ygal Rotenstreich
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Patent number: 10264962Abstract: A pupillometer system includes a computer, a camera, and a testing compartment provided in the form of a substantially hemispheric bowl, where the substantially hemispheric bowl includes a plurality of chromatic beam emitters arranged about a visual field forming a plurality of visual field testing points. The plurality of chromatic beam emitters generate a first chromatic stimulus that stimulates a first anatomical structure of an eye and a second chromatic stimulus that stimulates a second anatomical structure of the eye where the first anatomical structure is different than the second anatomical structure. The camera records a pupil response of one or more eyes. The computer generates quantitative pupillary light reflex (PLR) measurements of the PLR in response to the stimuli, determines at least one PLR response ratio, and determines a state of health of the one or more eyes utilizing the at least one PLR response ratio.Type: GrantFiled: May 4, 2018Date of Patent: April 23, 2019Assignee: Tel Hashomer Medical Research Infrastructure and Services, Ltd.Inventors: Ygal Rotenstreich, Mordecai Rosner
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Patent number: 10258230Abstract: In one embodiment, a portable pupillometer including a testing compartment, at least one ocular disposed on the testing compartment, two or more light sources disposed in the testing compartment and forming a plurality of visual stimuli for a subject looking through the at least one ocular, at least one camera configured to capture images of a pupil of the subject via infrared detection, the images indicating pupillary responses to the two or more light sources, and an interface for connection with a computing device external to the pupillometer, the interface adapted to (i) provide, to the computing device, images from the at least one camera, and (ii) receive, from the computing device, control signals for controlling the plurality of light sources.Type: GrantFiled: October 30, 2014Date of Patent: April 16, 2019Assignee: Tel Hashomer Medical Research Infrastructure and Services, Ltd.Inventor: Ygal Rotenstreich
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Publication number: 20190046810Abstract: The invention provides a method of noninvasively treating a condition associated with reduced integrity or increased permeability of an epithelial layer by a series of magnetic pulses having a magnitude of up to 3 T, wherein the magnetic pulses are designed to induce an electric field having a magnitude of up to 250 Volt per meter adjacent to a target treatment area, the condition particularly being ocular condition associated with reduced barrier function of the cornea. The invention provides a device for effecting the tissue treatment, creating series of pulses exhibiting a rate of change of more than 200 T/s in the absolute value.Type: ApplicationFiled: July 19, 2018Publication date: February 14, 2019Inventors: Tomer CARMELI, Ifat SHER-ROSENTHAL, Ygal ROTENSTREICH, Itzik RONEN
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Publication number: 20190008381Abstract: A system and method for determining a state of health of an eye using a pupillometer is provided comprising an ocular fixture, a testing compartment, a camera, and a controller. The testing compartment comprises a plurality of chromatic beam emitters arranged about a visual field. The ocular fixture is positioned to facilitate exposure of light sensitive ocular structures of the eye to a chromatic stimuli. The camera is positioned to record temporal pupil responses of the eye. The controller controls emission wavelength, intensity, and duration of the chromatic beam emitters. The controller processes temporal pupil response data to generate signals representative of the eye positioned at the ocular fixture in response to the chromatic stimuli at a plurality of locations in the visual field. The method comprises driving the chromatic beam emitters with the controller to generate signals using chromatic stimuli and determining the state of health of the eye.Type: ApplicationFiled: January 12, 2017Publication date: January 10, 2019Inventors: Ygal ROTENSTREICH, Ifat SHER
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Publication number: 20180249904Abstract: A pupillometer system includes a computer, a camera, and a testing compartment provided in the form of a substantially hemispheric bowl, where the substantially hemispheric bowl includes a plurality of chromatic beam emitters arranged about a visual field forming a plurality of visual field testing points. The plurality of chromatic beam emitters generate a first chromatic stimulus that stimulates a first anatomical structure of an eye and a second chromatic stimulus that stimulates a second anatomical structure of the eye where the first anatomical structure is different than the second anatomical structure. The camera records a pupil response of one or more eyes. The computer generates quantitative pupillary light reflex (PLR) measurements of the PLR in response to the stimuli, determines at least one PLR response ratio, and determines a state of health of the one or more eyes utilizing the at least one PLR response ratio.Type: ApplicationFiled: May 4, 2018Publication date: September 6, 2018Applicant: Tel Hashomer Medical Research Infrastructure and Services Ltd.Inventors: Ygal Rotenstreich, Mordecai Rosner
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Patent number: 10058710Abstract: The present invention provides a device and a method for non-invasively enhancing the integrity of the cornea by applying a magnetic field, thereby treating eye disorders.Type: GrantFiled: May 4, 2014Date of Patent: August 28, 2018Assignee: Tel Hashomer Medical Research Infrastructure and Services Ltd.Inventors: Ifat Sher-Rosenthal, Ygal Rotenstreich
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Patent number: 9986907Abstract: The present invention relates to a system, device and a method for objective visual field testing and in particular, to such a system and method in which provides objective chromatic perimetry test or color vision test using a pupillometer.Type: GrantFiled: April 7, 2017Date of Patent: June 5, 2018Assignee: Tel HaShomer Medical Research Infrastructure and Services Ltd.Inventors: Ygal Rotenstreich, Mordecai Rosner