Abstract: The present invention relates to the manufacture and use of off-specification fly ash (OSFA), which would have otherwise been landfilled, in preparing ultra-high-performance concrete (UHPC). The present invention aims to provide a new avenue for valorization of OSFA in the concrete industry by utilizing high-volume OSFA in producing UHPC. Compared with conventional concrete and high-performance concrete, UHPC is a family of advanced concrete featuring exceptional compressive strength, ductility, and long-term durability. Application in UHPC is expected to be a new and feasible technology to efficiently recycle OSFA.

Abstract: The present disclosure provides methods for treating cancer comprising administering 13-isobutyl-4-methyl-10-(pyrimidin-2-ylamino)-1,2,4,7,8,13-hexahydro-6H-indazolo[5,4-a]pyrrolo[3,4-c]carbazol-6-one or N-[(E)-(3-methylphenyl)methylideneamino]-6-morpholin-4-yl-2-(2-pyridin-2-ylethoxy)pyrimidin-4-amine to a subject in combination with adoptive cell therapy (ACT) or a personalized cancer vaccine to a subject.

Abstract: Methods for treating or improving a retinal degenerative disease or condition in a subject in need thereof are provided. In some embodiments described herein, the methods comprise administering to the subject a therapeutically effective amount of a retinoic acid-inducible gene I (RIG-I) inhibitor.

Abstract: A smoke generation product and a manufacturing method therefor, which relate to the technical field of tobaccos. The smoke generation product comprises a filter tip base body, a second connecting component, and an aroma generation portion. The filter tip base body comprises a first connecting component, and comprises a cooling portion and a filtering portion that are sequentially disposed in a smoking direction. The filtering portion and the cooling portion are connected by means of the first connecting component. A filtering passage and a cooling passage are in mutual communication. The aroma generation portion is connected to the filter tip base body by means of the second connecting portion, and the aroma generation portion is configured to release smoke by means of heating and make the smoke enter the cooling passage.

Abstract: A smoke generation product and a manufacturing method therefor, which relate to the technical field of tobaccos. The smoke generation product comprises a filter tip base body, a second connecting component, and an aroma generation portion. The filter tip base body comprises a first connecting component, and comprises a cooling portion and a filtering portion that are sequentially disposed in a smoking direction. The filtering portion and the cooling portion are connected by means of the first connecting component. A filtering passage and a cooling passage are in mutual communication. The aroma generation portion is connected to the filter tip base body by means of the second connecting portion, and the aroma generation portion is configured to release smoke by means of heating and make the smoke enter the cooling passage.

Abstract: The disclosure relates to the therapeutic utility of CD36 antagonists to reduce body weight, inhibit fat accumulation and especially visceral fat accumulation, improve insulin sensitivity, lower blood glucose levels, and treat and prevent metabolic syndrome, pre-diabetes and diabetes, and lower plasma cholesterol levels and decrease fat deposit in the liver. CD36 antagonists, including SAB or its metabolites, such as RA and DSS, are useful for these purposes.

Abstract: The disclosure relates to the therapeutic utility of CD36 antagonists to reduce body weight, inhibit fat accumulation and especially visceral fat accumulation, improve insulin sensitivity, lower blood glucose levels, and treat and prevent metabolic syndrome, pre-diabetes and diabetes, and lower plasma cholesterol levels and decrease fat deposit in the liver. CD36 antagonists, including SAB or its metabolites, such as RA and DSS, are useful for these purposes.

Abstract: A baseball bat including: a core section comprising a plurality of wood strips adhered to each other; and an outer section at least partially surrounding the core section, the outer section comprising a plurality of wood strips adhered to each other and to the central core section, wherein the direction of at least some of the plurality of wood strips comprising the core section are offset from the direction of at least some of the plurality of wood strips comprising the outer section. Preferably, at least some of the wood strips are bamboo.

Abstract: A baseball bat including: a core section comprising a plurality of wood strips adhered to each other; and an outer section at least partially surrounding the core section, the outer section comprising a plurality of wood strips adhered to each other and to the central core section, wherein the direction of at least some of the plurality of wood strips comprising the core section are offset from the direction of at least some of the plurality of wood strips comprising the outer section. Preferably, at least some of the wood strips are bamboo.