Abstract: Disclosure is a compound with one or more arm(s) for drug conjugation and a conjugate including the compound so as to provide high drug-to-moiety ratio and conjugate more drugs to the conjugate.

Abstract: Method of manufacturing semiconductor device includes forming photoresist layer over substrate. Forming photoresist layer includes combining first precursor and second precursor in vapor state to form photoresist material, wherein first precursor is organometallic having formula: MaRbXc, where M at least one of Sn, Bi, Sb, In, Te, Ti, Zr, Hf, V, Co, Mo, W, Al, Ga, Si, Ge, P, As, Y, La, Ce, Lu; R is substituted or unsubstituted alkyl, alkenyl, carboxylate group; X is halide or sulfonate group; and 1?a?2, b?1, c?1, and b+c?5. Second precursor is at least one of an amine, a borane, a phosphine. Forming photoresist layer includes depositing photoresist material over the substrate. The photoresist layer is selectively exposed to actinic radiation to form latent pattern, and the latent pattern is developed by applying developer to selectively exposed photoresist layer to form pattern.

Abstract: A reacting device of dual path synchronous immunochromatographic platform includes a seat, an upper housing, and a fluid dividing funnel. The seat contains two immunochromatographic carriers. The hollow pipe portion has two sloped structures. A force bearing portion of the fluid dividing funnel can be pressed down, so two fluid exits of the fluid dividing funnel move towards these two sloped structures. The specimen drops and is guided into these two immunochromatographic carriers respectively. A reaction result can be observable. The fluid dividing funnel can divide the specimen into two immunochromatographic carriers evenly. The sloped structure can increase the accuracy of specimen supply. Excess specimen can be scraped off for enhancing the solving accuracy. In addition, it can decrease the possibility of false positive problem.

Abstract: A method of manufacturing semiconductor device includes forming a multilayer photoresist structure including a metal-containing photoresist over a substrate. The multilayer photoresist structure includes two or more metal-containing photoresist layers having different physical parameters. The metal-containing photoresist is a reaction product of a first precursor and a second precursor, and each layer of the multilayer photoresist structure is formed using different photoresist layer formation parameters. The different photoresist layer formation parameters are one or more selected from the group consisting of the first precursor, an amount of the first precursor, the second precursor, an amount of the second precursor, a length of time each photoresist layer formation operation, and heating conditions of the photoresist layers.

Abstract: Asymmetry may be used to tune electrical properties of tunnel field effect transistors (TFETs). An exemplary TFET includes a gate stack disposed over a semiconductor layer, a source disposed in the semiconductor layer, and a drain disposed in the semiconductor layer. The gate stack includes a gate electrode disposed over a gate dielectric. The gate stack is disposed between the source and the drain. The source has a first conductivity type, and the drain has a second conductivity type different than the first conductivity type. The gate stack is asymmetric. For example, the gate stack has an asymmetric gate dielectric, an asymmetric gate electrode, asymmetric gate footing, asymmetric sidewalls, or combinations thereof. In some embodiments, the source and the drain have asymmetric profiles. In some embodiments, the semiconductor layer is a semiconductor fin, and the gate stack wraps the semiconductor fin.

Abstract: An electrostatic field strength measuring apparatus includes an electrostatic field detection device and a processor. The electrostatic field detection device includes a ring light source configured to emit a light signal to a target object, and a reflection detector disposed within and surrounded by the ring light source and configured to receive a reflection signal, of the light signal, reflected by a surface of the target object and generate an electrical signal based upon the reflection signal. The processor is configured to determine, based upon the electrical signal, measures of electrostatic field strength at the surface of the target object.

Abstract: Operations to recognize clock ports within a simulation circuit component and/or recognize a clock signal within simulation waveforms are described. One or more of the operations include generating a plurality of output values at an output port of a circuit simulation component by applying, during a simulation, a plurality of input values to a first input port of the circuit simulation component. The operations also include calculating a correlation vector based on bit sequences in the input values and bit sequences in the output values. The first input port is determined to be a clock port by applying a machine learning model to the correlation vector.

Abstract: A method and a kit for detecting Mycobacterium tuberculosis are provided. The method includes a step of performing a nested qPCR assay to a specimen. The nested qPCR assay includes a first round of amplification using external primers and a second round of amplification using internal primers and a probe. The external primers have sequences of SEQ ID NOs. 1 and 2, and the internal primers and the probe have sequences of SEQ ID NOs. 3 to 5.

Abstract: An apparatus is provided. The apparatus includes a laser generation device configured to emit a laser signal to a semiconductor fabrication component. The apparatus includes a reflection detection device configured to receive a reflection signal comprising light, of the laser signal, reflected by a surface of the semiconductor fabrication component. The reflection detection device includes an optical filter. The optical filter is configured to block light, of the reflection signal, that has a wavelength outside a defined range of wavelengths. The optical filter is configured to provide filtered light, from the reflection signal, that has a wavelength within the defined range of wavelengths. The reflection detection device includes a light sensor configured to generate an electrical signal based upon the filtered light. The apparatus includes a computer configured to determine, based upon the electrical signal, measures of electrostatic field strength at the surface of the semiconductor fabrication component.

Abstract: A turbo device provides a flow-path arrangement in a generator device. Part of a working fluid are used to lubricate at least one of a first bearing part, a second bearing part and a bearing assembly, or the working fluid of an auxiliary flow channel is led to a generator housing for cooling the generator device. In addition, a circulatory system is also provided to include bearing loops and auxiliary loops for leading the working fluid to lubricate at least one of the first bearing part, the second bearing part and the bearing assemble part, and to cool the generator device.

Abstract: The present invention provides an extraction cassette, which includes an extraction module and a liquid receiving module. The liquid receiving module communicates with the extraction module. The liquid receiving module includes a receiving module body, a sample compartment, a sealing member, an alcohol compartment and a first path. The receiving module body includes a first side, a second side and a sample feeding hole. The sample compartment is formed on the receiving module body. The sample compartment communicates with the sample feeding hole, the sample compartment includes a first sample compartment connection hole and a second sample compartment connection hole. The sealing member is adapted to seal the sample feeding hole. The alcohol compartment is formed on the receiving module body. The alcohol compartment communicates with the first sample compartment connection hole of the first sample compartment via the first path.

Abstract: A method and a kit for detecting Mycobacterium tuberculosis are provided. The method includes a step of performing a nested qPCR assay to a specimen. The nested qPCR assay includes a first round of amplification using external primers and a second round of amplification using internal primers and a probe. The external primers have sequences of SEQ ID NOs. 1 and 2, and the internal primers and the probe have sequences of SEQ ID NOs. 3 to 5.

Abstract: The present invention provides an extraction cassette, which includes an extraction module. The extraction module includes an extraction module body, an expansion compartment, a reaction compartment, a filter, a collection compartment, a first waste-liquid compartment and a second waste-liquid compartment. The expansion compartment is formed on the extraction module body. The reaction compartment includes a reaction compartment inlet, a reaction compartment outlet and a reaction compartment notch, the expansion compartment is connected to the reaction compartment notch, and the reaction compartment notch is located between the reaction compartment inlet and the reaction compartment outlet. The filter is disposed in the reaction compartment and corresponding to the reaction compartment outlet. The collection compartment communicates with the reaction compartment outlet. The first waste-liquid compartment communicates with the reaction compartment outlet.

Abstract: The present disclosure provides a carrying device and an operation method thereof. The carrying device includes: a floating platform; and at least one flexible unit provided on a bottom side of the floating plate and having a cavity formed therein. The flexible unit is deformed under a stress to reduce the friction force between the flexible unit and the solid in the water, which allows the carrying device to break free from the solid without external help.

Abstract: A separable buoy includes a center float having a top surface that includes an upper peripheral end and an engagement bevel provided on the upper peripheral end that extends below the top surface; a separable float unit detachably disposed at the center float and including a dome wall that is provided in a lower central portion thereof and that has a peripheral edge configured to detachably engage the engagement bevel: and a chamber defined between the dome wall of the separable float unit and the top surface of the center float when the separable float unit engages the center float, wherein the center float has a vertical height that substantially equals or exceeds that of a lower portion of the separable float unit.

Abstract: The present disclosure provides a carrying device and an operation method thereof. The carrying device includes: a floating platform; and at least one flexible unit provided on a bottom side of the floating plate and having a cavity formed therein. The flexible unit is deformed under a stress to reduce the friction force between the flexible unit and the solid in the water, which allows the carrying device to break free from the solid without external help.

Abstract: The present invention provides an extraction cassette, which includes an extraction module. The extraction module includes an extraction module body, an expansion compartment, a reaction compartment, a filter, a collection compartment, a first waste-liquid compartment and a second waste-liquid compartment. The expansion compartment is formed on the extraction module body. The reaction compartment includes a reaction compartment inlet, a reaction compartment outlet and a reaction compartment notch, the expansion compartment is connected to the reaction compartment notch, and the reaction compartment notch is located between the reaction compartment inlet and the reaction compartment outlet. The filter is disposed in the reaction compartment and corresponding to the reaction compartment outlet. The collection compartment communicates with the reaction compartment outlet. The first waste-liquid compartment communicates with the reaction compartment outlet.

Abstract: The present invention provides an extraction cassette, which includes an extraction module and a liquid receiving module. The liquid receiving module communicates with the extraction module. The liquid receiving module includes a receiving module body, a sample compartment, a sealing member, an alcohol compartment and a first path. The receiving module body includes a first side, a second side and a sample feeding hole. The sample compartment is formed on the receiving module body. The sample compartment communicates with the sample feeding hole, the sample compartment includes a first sample compartment connection hole and a second sample compartment connection hole. The sealing member is adapted to seal the sample feeding hole. The alcohol compartment is formed on the receiving module body. The alcohol compartment communicates with the first sample compartment connection hole of the first sample compartment via the first path.

Abstract: A storage device includes a base and a plurality of wire management modules. The wire management module includes a partition and a positioning assembly. The partition is disposed to the base and has a supporting surface and a wire management groove. The wire management groove is located at the supporting surface for accommodating a wire. The positioning assembly includes a first positioning member, a second positioning member and an assembling member. The first positioning member is disposed to the partition. The second positioning member is connected to the assembling member. The assembling member is assembled together with the partition. The second positioning member is rotatable around the edge of the second positioning member as a rotation axis in relation to the assembling member to be at either a fastening position or a releasing position. The partitions and the base jointly form a plurality of accommodation spaces.