Patents by Inventor Yi-Chung Chang

Yi-Chung Chang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11457421
    Abstract: An auxiliary Bluetooth circuit of a multi-member Bluetooth device for communicating data with a source Bluetooth device acting as a master in a first piconet. A main Bluetooth circuit of the multi-member Bluetooth device acts as a slave in the first piconet, acts as a master in a second piconet, and generates a first slave clock and a second main clock according to a first main clock generated by the source Bluetooth device, with which both the first slave clock and the second main clock are synchronized. The auxiliary Bluetooth circuit acts as a slave in the second piconet and generates a second slave clock and a third slave clock according to the second main clock, with which both the second slave clock and the third slave clock are synchronized. The auxiliary Bluetooth circuit sniffs Bluetooth packets transmitted through the first piconet from the source Bluetooth device.
    Type: Grant
    Filed: October 27, 2020
    Date of Patent: September 27, 2022
    Assignee: REALTEK SEMICONDUCTOR CORP.
    Inventors: Yi-Cheng Chen, Kuan-Chung Huang, Hung-Chuan Chang, Chin-Wen Wang
  • Publication number: 20220295429
    Abstract: A multi-member Bluetooth device for communicating data with a source Bluetooth device, wherein the source Bluetooth device acts as a master in a first piconet. The multi-member Bluetooth device includes a main Bluetooth circuit and an auxiliary Bluetooth circuit. The main Bluetooth circuit acts as a slave in the first piconet, and acts as a master in a second piconet. The auxiliary Bluetooth circuit acts as a slave in the second piconet. The main Bluetooth circuit generates a first slave clock and a second main clock synchronized with a first main clock generated by the source Bluetooth device, and samples a first audio data to be playback. The auxiliary Bluetooth circuit generates a second slave clock and a third slave clock synchronized with the second main clock, and samples a second audio data to be playback.
    Type: Application
    Filed: June 3, 2022
    Publication date: September 15, 2022
    Applicant: Realtek Semiconductor Corp.
    Inventors: Hung-Chuan CHANG, Yi-Cheng CHEN, Kuan-Chung HUANG, Chin-Wen WANG
  • Publication number: 20220241321
    Abstract: Pharmaceutical compositions comprising a CpG oligonucleotide, a buffer agent, and one or more salts having a total salt concentration of about 80-130 mM. A majority population of the CpG oligonucleotides in the composition is in dimeric form. Also provided herein are uses of the pharmaceutical compositions for modulating immune responses in subjects in need of the treatment, for example, cancer patient.
    Type: Application
    Filed: May 8, 2020
    Publication date: August 4, 2022
    Inventors: Yi-Chung CHANG, Shih-Chi YEH, Chih-Keng CHEN, Chien-Hao CHANG, Chu-Ying PENG
  • Patent number: 11405880
    Abstract: A main Bluetooth circuit and an auxiliary Bluetooth circuit of a multi-member Bluetooth device are disclosed. The multi-member Bluetooth device is utilized for communicating data with a source Bluetooth device, and the source Bluetooth device acts as a master in a first piconet. The main Bluetooth circuit acts as a slave in the first piconet, and acts as a master in a second piconet. The auxiliary Bluetooth circuit acts as a slave in the second piconet. The main Bluetooth circuit generates a first slave clock and a second main clock synchronized with a first main clock generated by the source Bluetooth device, and samples a first audio data to be playback. The auxiliary Bluetooth circuit generates a second slave clock and a third slave clock synchronized with the second main clock, and samples a second audio data to be playback.
    Type: Grant
    Filed: October 27, 2020
    Date of Patent: August 2, 2022
    Assignee: REALTEK SEMICONDUCTOR CORP.
    Inventors: Hung-Chuan Chang, Yi-Cheng Chen, Kuan-Chung Huang, Chin-Wen Wang
  • Patent number: 11373878
    Abstract: A technique for semiconductor manufacturing is provided. The technique includes the operations as follows. A semiconductor structure having a first material and a second material is revived. The first material has a first incubation time to a first etching chemistry. The second material has a second incubation time to the first etching chemistry. The first incubation time is shorter than the second incubation time. A first main etch to the semiconductor structure for a first duration by the first etching chemistry is performed. The first duration is greater than the first incubation time and shorter than the second incubation time.
    Type: Grant
    Filed: January 20, 2021
    Date of Patent: June 28, 2022
    Assignee: TAIWAN SEMICONDUCTOR MANUFACTURING COMPANY LTD.
    Inventors: Han-Yu Lin, Li-Te Lin, Tze-Chung Lin, Fang-Wei Lee, Yi-Lun Chen, Jung-Hao Chang, Yi-Chen Lo, Fo-Ju Lin, Kenichi Sano, Pinyen Lin
  • Patent number: 11129769
    Abstract: A method for measuring strokes of CPR and a system using the method are disclosed. The system includes at least one permanent magnet and stroke detecting device which has a magnetic sensor, an accelerometer, a CPR detector, a controller, a power unit, and a housing. The system can measure strokes of CPR without a detector making patients uncomfortable. Meanwhile, the system is tiny and can be used to cooperate with AED.
    Type: Grant
    Filed: September 6, 2018
    Date of Patent: September 28, 2021
    Assignee: SANTCHAN CO., LTD.
    Inventors: Yi-Chung Chang, Li-Chung Chang
  • Publication number: 20210115447
    Abstract: Nucleic acid aptamers capable of binding to lymphocyte activation gene 3 (LAG-3) and uses thereof for modulating immune responses. Such aptamers may comprise a G-rich motif, for example, GX1GGGX2GGTX3A (SEQ ID No: 1), in which each of X1 and X2 are independently G, C, or absent, and X3 is T or C, or L-(G)n-L?, in which n is an integer of 5-9 inclusive, and L and L? are nucleotide segments having complementary sequences. Also provided herein are multimeric nucleic acid aptamers containing a backbone moiety, which comprises a palindromic sequence.
    Type: Application
    Filed: June 12, 2019
    Publication date: April 22, 2021
    Applicant: Oneness Biotech Co., Ltd.
    Inventors: Yi-Chung CHANG, Chien-Hao CHIANG, Yi-Wei KAO
  • Publication number: 20200093426
    Abstract: A method and system of obstructed area determination for sleep apnea syndrome are disclosed. The method comprising obtaining a snoring signal from an individual; obtaining a spectrogram of the snoring signal based on short-time Fourier Transform; obtaining a snoring signal feature based on a harmonic wave of the spectrogram; and obtaining a collapse index by comparing the snoring signal feature against a snoring signal feature-collapse index correlation database. The present invention enables the diagnosis of sleep apnea syndrome and determination the obstructed area for the sleep apnea syndrome with only the snoring signal of an individual during sleep.
    Type: Application
    Filed: November 29, 2019
    Publication date: March 26, 2020
    Inventors: Yi-Chung CHANG, Leh-Kiong HUON, Van-Truong PHAM, Yunn-Jy CHEN, Tiffany Ting-Fang SHIH, Thi-Thao TRAN, Chen LIN, Men-Tzung LO, Pa-Chun WANG
  • Publication number: 20200078262
    Abstract: A method for measuring strokes of CPR and a system using the method are disclosed. The system includes at least one permanent magnet and stroke detecting device which has a magnetic sensor, an accelerometer, a CPR detector, a controller, a power unit, and a housing. The system can measure strokes of CPR without a detector making patients uncomfortable. Meanwhile, the system is tiny and can be used to cooperate with AED.
    Type: Application
    Filed: September 6, 2018
    Publication date: March 12, 2020
    Inventors: YI-CHUNG CHANG, Li-Chung Chang
  • Patent number: 10533179
    Abstract: Aptamers that bind to and inhibit CTLA-4 and uses thereof in enhancing immune activities, and treating cancer and HIV infection are provided.
    Type: Grant
    Filed: July 31, 2015
    Date of Patent: January 14, 2020
    Assignees: Academia Sinica, National Taiwan University, Taipei Medical University
    Inventors: Konan Peck, Pan-Chyr Yang, Yi-Chung Chang, Bo-Tsang Huang, Shauh-Der Yeh
  • Patent number: 10329570
    Abstract: Aptamers that bind to and antagonize programmed cell death protein 1 (PD-1). Also provided herein are pharmaceutical compositions comprising such anti-PD-1 aptamers and methods for using the same for promoting T cell proliferation, treating cancer or infectious diseases, such as human immunodeficiency virus (HIV) infection.
    Type: Grant
    Filed: July 31, 2015
    Date of Patent: June 25, 2019
    Assignees: Academia Sinica, National Taiwan University
    Inventors: Pan-Chyr Yang, Yi-Chung Chang, Wei-Yun Lai
  • Patent number: 9891227
    Abstract: Methods of assaying a biological target are disclosed. The method comprises: (a) providing a sample containing the biological target; (b) providing biotin-labeled first aptamers conjugated to a gold nanoparticle (GNP), and second aptamers conjugated to a magnetic bead, wherein the first and the second aptamers exhibit specific binding affinities to the target; (c) incubating the sample with the first and the second aptamers to obtain target-bound aptamers; (d) separating the target-bound aptamers from unbound aptamers; (e) eluting the first aptamers from the GNP; (f) incubating the eluted biotin-labeled first aptamers with streptavidin-magnetic beads and reporter gold nanoparticles (GNPs) to obtain a complex comprising: the bead, the first aptamers, attached to the bead; and the reporter GNPs captured by the bead through the first aptamers; (g) eluting the reporter GNPs captured; and (h) detecting the target by measuring and analyzing a light-scattering signal of the eluted reporter GNPs.
    Type: Grant
    Filed: April 30, 2015
    Date of Patent: February 13, 2018
    Assignee: ACADEMIA SINICA
    Inventors: Konan Peck, Pan-Chyr Yang, Yi-Chung Chang
  • Patent number: 9760540
    Abstract: A method implemented through an electronic system for processing a sequential data to identify possible peak points is disclosed. The method defines a decayed threshold function and partition the sequential data into a plurality of segments by grouping each data point with surrounding data points into one of the segments. After that, a plurality of weighted segments are derived through weighting the surrounding data points by the decayed threshold function in each of the segments, and the peak points are identified through corresponding weighted segment.
    Type: Grant
    Filed: November 21, 2012
    Date of Patent: September 12, 2017
    Assignee: National Central University
    Inventors: Yi-Chung Chang, Men-Tzung Lo
  • Publication number: 20170218369
    Abstract: Aptamers that bind to and antagonize PD-1 and uses thereof in promoting T cell proliferation, treating cancer or infectious diseases such as HIV infection.
    Type: Application
    Filed: July 31, 2015
    Publication date: August 3, 2017
    Applicants: Academia Sinica, National Taiwan University
    Inventors: Pan-Chyr Yang, Yi-Chung Chang, Wei-Yun Lai
  • Publication number: 20170211067
    Abstract: Aptamers that bind to and inhibit CTLA-4 and uses thereof in enhancing immune activities, and treating cancer and HIV infection are provided.
    Type: Application
    Filed: July 31, 2015
    Publication date: July 27, 2017
    Applicants: Academia Sinica, National Taiwan University, Taipei Medical University
    Inventors: Konan Peck, Pan-Chyr Yang, Yi-Chung Chang, Bo-Tsang Huang, Shauh-Der Yeh
  • Publication number: 20160331306
    Abstract: A method and system of obstructed area determination for sleep apnea syndrome are disclosed. The method comprising obtaining a snoring signal from an individual; obtaining a spectrogram of the snoring signal based on short-time Fourier Transform; obtaining a snoring signal feature based on a harmonic wave of the spectrogram; and obtaining a collapse index by comparing the snoring signal feature against a snoring signal feature-collapse index correlation database. The present invention enables the diagnosis of sleep apnea syndrome and determination the obstructed area for the sleep apnea syndrome with only the snoring signal of an individual during sleep.
    Type: Application
    Filed: September 18, 2015
    Publication date: November 17, 2016
    Inventors: Yi-Chung CHANG, Leh-Kiong HUON, Van-Truong PHAM, Yunn-Jy CHEN, Tiffany Ting-Fang SHIH, Thi-Thao TRAN, Chen LIN, Men-Tzung LO, Pa-Chun WANG
  • Patent number: 9433365
    Abstract: A computer-assisted method for quantitative characterizing atrial fibrillation (AF) in a patient includes recording unipolar atrial fibrillation signals from multiple sites in a patient's atria, calculating bipolar electrograms using unipolar AF signals recorded at adjacent sites by a computer system, applying Empirical Mode Decomposition to remove a background from the bipolar electrogram signal to obtain a filtered bipolar electrogram signal, applying Hilbert transform to an envelope function of the filtered bipolar electrogram signal to obtain a time series of instantaneous phases of the filtered bipolar electrogram signal, and identifying a rotor region in patient's atria using the instantaneous phases in the filtered bipolar electrogram signal.
    Type: Grant
    Filed: September 2, 2014
    Date of Patent: September 6, 2016
    Assignee: National Yang-Ming University
    Inventors: Yenn-Jiang Lin, Shih-Ann Chen, Men-Tzung Lo, Yi-Chung Chang, Chen Lin
  • Publication number: 20160084793
    Abstract: An electrode reaction area testing method of biosensor test strip includes: (1) preparing a semi-finished or finished test strip product having at least one sensing window corresponding to an electrode reaction area; a plural electrodes exposed from the electrode reaction area; (2) detecting the electrode reaction current of the electrode reaction area to obtain a first electrode reaction current and a third electrode reaction current; (3) calculating a current ratio of the first electrode reaction current to the third electrode reaction current; (4) determining the current ratio; (5) completing the detection of the electrode reaction area to determine whether the semi-finished or finished test strip product is good or defective, so as to test the accuracy of the separating plate attaching position or the insulating position and the applicability of the electrode reaction area in the manufacture of the test strip.
    Type: Application
    Filed: September 18, 2014
    Publication date: March 24, 2016
    Inventors: YI LUNG CHEN, CHIEN HUNG LAI, YA SIAN LIN, FANG YI JIANG, CHIH CHUN YU, YI CHUNG CHANG
  • Patent number: 9259167
    Abstract: This invention discloses a system and method for extracting VF signal in ECG recorded during uninterrupted CPR. The method and system applies an adaptive algorithm incorporating the EMD and least mean square (LMS) filtering to effectively model the CPR artifacts such as chest compression signals. Thus, A VF signal in ECG recorded during uninterrupted CPR can be extracted without deteriorating the reliability of the waveform parameter (i.e. AMSA) of shockability. The present invention enables uninterrupted CPR performed during recording ECG for accessing the shockability, so that an increase the probability of successful resuscitation is achieved.
    Type: Grant
    Filed: July 2, 2014
    Date of Patent: February 16, 2016
    Assignee: NATIONAL CENTRAL UNIVERSITY
    Inventors: Men-Tzung Lo, Wan-Hsin Hsieh, Chen Lin, Yi-Chung Chang, Hsiang-Chih Chang, Lian-Yu Lin, Patrick Chow-In Ko, Wen-Chu Chiang, Matthew Huei-Ming Ma, Kun Hu
  • Publication number: 20160000346
    Abstract: This invention discloses a system and method for extracting VF signal in ECG recorded during uninterrupted CPR. The method and system applies an adaptive algorithm incorporating the EMD and least mean square (LMS) filtering to effectively model the CPR artifacts such as chest compression signals. Thus, A VF signal in ECG recorded during uninterrupted CPR can be extracted without deteriorating the reliability of the waveform parameter (i.e. AMSA) of shockability. The present invention enables uninterrupted CPR performed during recording ECG for accessing the shockability, so that an increase the probability of successful resuscitation is achieved.
    Type: Application
    Filed: July 2, 2014
    Publication date: January 7, 2016
    Inventors: Men-Tzung LO, Wan-Hsin HSIEH, Chen LIN, Yi-Chung CHANG, Hsiang-Chih CHANG, Lian-Yu LIN, Patrick Chow-In KO, Wen-Chu CHIANG, Matthew Huei-Ming MA, Kun HU