Abstract: A method is provided. The method includes: receiving a semiconductor structure having a first material and a second material; performing a first etch on the first material for a first duration under a first etching chemistry; and performing a second etch on the second material for a second duration under a second etching chemistry, wherein the first material includes a first incubation time and the second material includes a second incubation time greater than the first incubation time under the first etching chemistry. The first material includes a third incubation time and the second material includes a fourth incubation time less than the third incubation time under the second etching chemistry.

Abstract: Small interfering RNAs (siRNA) having specific modification patterns to improve interference efficiencies thereof. The modification patterns each comprises a combination of 2?-O methyl modification, 2?-O-fluoro-modification, and phosphorothioate (PS) bonds at defined positions in the sense strand and anti-sense strand of each siRNA, and optionally 5? phosphate modifications.

Abstract: A ballistocardiogram detection device for noise reduction includes a bearing module, a force sensor, a vibration sensor, and a signal processing module. The bearing module is disposed directly or indirectly on a body or back of a test subject. The force sensor and the vibration sensor are disposed on the bearing module. A distance between the vibration sensor and the force sensor is less than 20 cm. The signal processing module is electrically connected to the force sensor and the vibration sensor. The signal processing module is configured to receive signals output from the force sensor and the vibration sensor.

Abstract: The present disclosure provides a molding system for fabricating a FRP composite article. The molding system includes a detector, a resin dispenser, a processing module, and a molding machine. The detector is configured to capture a graph of a woven fiber from a top view. The resin dispenser is configured to provide a resin to the woven fiber to form a FRP. The processing module is configured to receive the graph and a plurality of parameters of the FRP. The processing module includes a CNN model, and is configured to use the CNN model to obtain a plurality of predicted mechanical properties of the FRP according to the graph and the plurality of parameters of the FRP. The molding machine is configured to mold the FRP to fabricate the FRP composite article according to the plurality of predicted mechanical properties.

Abstract: A semiconductor device includes a first channel region, a second channel region, and a first insulating fin, the first insulating fin being interposed between the first channel region and the second channel region. The first insulating fin includes a lower portion and an upper portion. The lower portion includes a fill material. The upper portion includes a first dielectric layer on the lower portion, the first dielectric layer being a first dielectric material, a first capping layer on the first dielectric layer, the first capping layer being a second dielectric material, the second dielectric material being different than the first dielectric material, and a second dielectric layer on the first capping layer, the second dielectric layer being the first dielectric material.

Abstract: An information handling system stylus self-cleans a magnet garage arrangement with a garage variable magnet having a first magnetic attraction when the stylus is proximate and information handling system garage and a second magnetic attraction when the stylus is distal the information handling system garage. The second magnetic attraction has a reduced attractive force at the stylus housing outer surface to discourage attraction of contaminants that might scratch or otherwise damage the housing.

Abstract: A modified small interfering RNA (siRNA) molecule comprising phosphorothioate (PS) intemucleotide linkages in the antisense strand for reducing off-target effects and methods and uses thereof. The siRNAs targeting Hypoxia Inducible Factor 1 Subunit Alpha (HIF1a) with high specificity and silencing efficiency.

Abstract: A conjugate comprising a cyclic peptide scaffold and one or more N-acetylgalactosamine (GalNAc) moieties. The conjugate may further carry a diagnostic or therapeutic agent for use in delivering the agent to liver cells. In some embodiments, the cyclic peptide may have 4-10 amino acid residues. The GalNAc moieties can be covalently bound to the cyclic peptide scaffold via a first linker and the agent can be covalently bound to the cyclic peptide scaffold via a second linker.

Abstract: Provided are interfering RNAs (e.g., siRNAs) targeting SARS-CoV (e.g., the POL, Spike, Helicase, or Envelop gene thereof) and therapeutic uses thereof for inhibiting SARS-CoV infection and/or treating diseases associated with the infection (e.g., COVID-19).

Abstract: Pharmaceutical compositions comprising a CpG oligonucleotide, a buffer agent, and one or more salts having a total salt concentration of about 80-130 mM. A majority population of the CpG oligonucleotides in the composition is in dimeric form. Also provided herein are uses of the pharmaceutical compositions for modulating immune responses in subjects in need of the treatment, for example, cancer patient.

Abstract: A method for measuring strokes of CPR and a system using the method are disclosed. The system includes at least one permanent magnet and stroke detecting device which has a magnetic sensor, an accelerometer, a CPR detector, a controller, a power unit, and a housing. The system can measure strokes of CPR without a detector making patients uncomfortable. Meanwhile, the system is tiny and can be used to cooperate with AED.

Abstract: Nucleic acid aptamers capable of binding to lymphocyte activation gene 3 (LAG-3) and uses thereof for modulating immune responses. Such aptamers may comprise a G-rich motif, for example, GX1GGGX2GGTX3A (SEQ ID No: 1), in which each of X1 and X2 are independently G, C, or absent, and X3 is T or C, or L-(G)n-L?, in which n is an integer of 5-9 inclusive, and L and L? are nucleotide segments having complementary sequences. Also provided herein are multimeric nucleic acid aptamers containing a backbone moiety, which comprises a palindromic sequence.

Abstract: A method and system of obstructed area determination for sleep apnea syndrome are disclosed. The method comprising obtaining a snoring signal from an individual; obtaining a spectrogram of the snoring signal based on short-time Fourier Transform; obtaining a snoring signal feature based on a harmonic wave of the spectrogram; and obtaining a collapse index by comparing the snoring signal feature against a snoring signal feature-collapse index correlation database. The present invention enables the diagnosis of sleep apnea syndrome and determination the obstructed area for the sleep apnea syndrome with only the snoring signal of an individual during sleep.

Abstract: A method for measuring strokes of CPR and a system using the method are disclosed. The system includes at least one permanent magnet and stroke detecting device which has a magnetic sensor, an accelerometer, a CPR detector, a controller, a power unit, and a housing. The system can measure strokes of CPR without a detector making patients uncomfortable. Meanwhile, the system is tiny and can be used to cooperate with AED.

Abstract: Aptamers that bind to and inhibit CTLA-4 and uses thereof in enhancing immune activities, and treating cancer and HIV infection are provided.

Abstract: Aptamers that bind to and antagonize programmed cell death protein 1 (PD-1). Also provided herein are pharmaceutical compositions comprising such anti-PD-1 aptamers and methods for using the same for promoting T cell proliferation, treating cancer or infectious diseases, such as human immunodeficiency virus (HIV) infection.

Abstract: Methods of assaying a biological target are disclosed. The method comprises: (a) providing a sample containing the biological target; (b) providing biotin-labeled first aptamers conjugated to a gold nanoparticle (GNP), and second aptamers conjugated to a magnetic bead, wherein the first and the second aptamers exhibit specific binding affinities to the target; (c) incubating the sample with the first and the second aptamers to obtain target-bound aptamers; (d) separating the target-bound aptamers from unbound aptamers; (e) eluting the first aptamers from the GNP; (f) incubating the eluted biotin-labeled first aptamers with streptavidin-magnetic beads and reporter gold nanoparticles (GNPs) to obtain a complex comprising: the bead, the first aptamers, attached to the bead; and the reporter GNPs captured by the bead through the first aptamers; (g) eluting the reporter GNPs captured; and (h) detecting the target by measuring and analyzing a light-scattering signal of the eluted reporter GNPs.

Abstract: A method implemented through an electronic system for processing a sequential data to identify possible peak points is disclosed. The method defines a decayed threshold function and partition the sequential data into a plurality of segments by grouping each data point with surrounding data points into one of the segments. After that, a plurality of weighted segments are derived through weighting the surrounding data points by the decayed threshold function in each of the segments, and the peak points are identified through corresponding weighted segment.

Abstract: Aptamers that bind to and antagonize PD-1 and uses thereof in promoting T cell proliferation, treating cancer or infectious diseases such as HIV infection.

Abstract: Aptamers that bind to and inhibit CTLA-4 and uses thereof in enhancing immune activities, and treating cancer and HIV infection are provided.