Abstract: Disclosed herein are methods of producing tumor antigen-specific T cells and uses thereof. In the present method, peripheral blood mononuclear cells (PBMCs) isolated from a subject are cultivated with bi-specific antibodies (BsAbs) in a culture medium so as to produce the tumor antigen-specific T cells from the PBMCs. Also provided in the present disclosure are tumor antigen-specific T cells produced by the present method, and uses thereof in treating subjects suffering from cancers.

Abstract: Provided are methods of inducing differentiation and/or proliferation of T cells and uses thereof. In the present method, peripheral blood mononuclear cells (PBMCs) isolated from a subject are cultivated with bi-specific antibodies (BsAbs) in a culture medium so as to differentiate the PBMCs into the T cells. Each of the T cells has an anti-tumor antigen moiety and an anti-CD3 moiety on its surface. Also provided are methods and pharmaceutical kits for treating subjects suffering from cancers.

Abstract: An imaging optical lens assembly includes five lens elements, which are, in order from an object side to an image side along an optical path, a first lens element, a second lens element, a third lens element, a fourth lens element and a fifth lens element. Each of the five lens elements has an object-side surface towards the object side and an image-side surface towards the image side. The third lens element has positive refractive power. At least one of the object-side surface and the image-side surface of at least one of the five lens elements includes at least one critical point in an off-axis region thereof.

Abstract: An imaging system lens assembly includes four lens elements, the four lens elements are, in order from an object side to an image side along an optical path: a first lens element, a second lens element, a third lens element and a fourth lens element. Each of the four lens elements has an object-side surface towards the object side and an image-side surface towards the image side. The second lens element has negative refractive power, the object-side surface of the second lens element is concave in a paraxial region thereof. The object-side surface of the third lens element is convex in a paraxial region thereof, the image-side surface of the third lens element is concave in a paraxial region thereof.

Abstract: An image capturing lens assembly includes six lens elements which are, in order from an object side to an image side along an optical path: a first lens element, a second lens element, a third lens element, a fourth lens element, a fifth lens element and a sixth lens element. The first lens element with positive refractive power has an object-side surface being convex in a paraxial region thereof. The fourth lens element with positive refractive power has an object-side surface being concave in a paraxial region thereof and an image-side surface being convex in a paraxial region thereof. The sixth lens element with negative refractive power has an image-side surface being concave in a paraxial region thereof. At least one of an object-side surface and an image-side surface of at least one lens element has at least one inflection in an off-axis region thereof.

Abstract: An optical imaging system includes six lens elements which are, in order from an object side to an image side along an optical path: a first lens element, a second lens element, a third lens element, a fourth lens element, a fifth lens element and a sixth lens element. Each of the six lens elements has an object-side surface facing toward the object side and an image-side surface facing toward the image side. The first lens element has negative refractive power, and the object-side surface of the first lens element is concave in a paraxial region thereof. The image-side surface of the second lens element is concave in a paraxial region thereof. The fourth lens element has negative refractive power. The image-side surface of the sixth lens element is concave in a paraxial region thereof and has at least one critical point in an off-axis region thereof.

Abstract: A photographing optical lens system includes five lens elements being, in order from an object side to an image side along an optical path, a first lens element, a second lens element, a third lens element, a fourth lens element and a fifth lens element. Each lens element has an object-side surface facing the object side and an image-side surface facing the image side. The first lens element has positive refractive power and the object-side surface being convex in a paraxial region thereof. The image-side surface of the third lens element is convex in a paraxial region thereof. The object-side surface of the fourth lens element is convex in a paraxial region thereof. The fifth lens element has negative refractive power, the object-side surface being convex, and the image-side surface being concave in a paraxial region thereof.

Abstract: An image capturing lens assembly includes six lens elements which are, in order from an object side to an image side along an optical path: a first lens element, a second lens element, a third lens element, a fourth lens element, a fifth lens element and a sixth lens element. The first lens element with positive refractive power has an object-side surface being convex in a paraxial region thereof. The fourth lens element with positive refractive power has an object-side surface being concave in a paraxial region thereof and an image-side surface being convex in a paraxial region thereof. The sixth lens element with negative refractive power has an image-side surface being concave in a paraxial region thereof. At least one of an object-side surface and an image-side surface of at least one lens element has at least one inflection in an off-axis region thereof.

Abstract: An imaging optical lens assembly includes five lens elements, which are, in order from an object side to an image side along an optical path, a first lens element, a second lens element, a third lens element, a fourth lens element and a fifth lens element. Each of the five lens elements has an object-side surface towards the object side and an image-side surface towards the image side. The third lens element has positive refractive power. At least one of the object-side surface and the image-side surface of at least one of the five lens elements includes at least one critical point in an off-axis region thereof.

Abstract: An ultrasound transducer system includes an alignment-guidance transducer device and a control device. The alignment-guidance transducer device includes a transducer module for emitting ultrasound waves and receiving ultrasound signals reflected from a target hollow organ, and an indicator module for indicating a state of alignment between the alignment-guidance transducer device and the target hollow organ. The control device is in communication with the alignment-guidance transducer device for processing the ultrasound signals received from the transducer module and transmitting instructions to the indicator module according to the processed ultrasound signals, so as to guide a user to align the ultrasound transducer device to an extension direction of the target hollow organ.