Patents by Inventor Yi-Jhang Ciou

Yi-Jhang Ciou has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for conjugating nucleic acids with small molecules
    Patent number: 8765934
    Abstract: A method for conjugating a nucleic acid with a molecule is provided. The method includes steps of (a) reacting the nucleic acid having a 5?-monophosphate with an activating agent in a first buffer to form a solution; (b) mixing an alcohol with the solution formed in the step (a) to obtain an intermediate; and (c) dissolving the intermediate in a second buffer containing an ethylenediaminetetraacetic acid (EDTA) and adding a nucleophile thereinto to react the intermediate with the nucleophile.
    Type: Grant
    Filed: July 22, 2011
    Date of Patent: July 1, 2014
    Assignee: Kaohsiung Medical University
    Inventors: Tzu-Pin Wang, Yi-Jhang Ciou
  • METHODS FOR CONJUGATING NUCLEIC ACIDS WITH SMALL MOLECULES
    Publication number: 20120177573
    Abstract: A method for conjugating a nucleic acid with a molecule is provided. The method includes steps of (a) reacting the nucleic acid having a 5?-monophosphate with an activating agent in a first buffer to form a solution; (b) mixing an alcohol with the solution formed in the step (a) to obtain an intermediate; and (c) dissolving the intermediate in a second buffer containing an ethylenediaminetetraacetic acid (EDTA) and adding a nucleophile thereinto to react the intermediate with the nucleophile.
    Type: Application
    Filed: July 22, 2011
    Publication date: July 12, 2012
    Applicant: KAOHSIUNG MEDICAL UNIVERSITY
    Inventors: Tzu-Pin Wang, Yi-Jhang Ciou