Abstract: A pulse current-assisted roll bonding method for a magnesium/titanium composite plate with a large thickness ratio is provided. The specific steps are as follows: 1, pre-treating a slab; 2, applying a pulse current; 3, rolling and bonding; and 4, post-treating the slab. The magnesium/titanium composite plate with the large thickness ratio is obtained.

Abstract: A pulse current-assisted roll bonding method for a magnesium/titanium composite plate with a large thickness ratio is provided. The specific steps are as follows: 1, pre-treating a slab; 2, applying a pulse current; 3, rolling and bonding; and 4, post-treating the slab. The magnesium/titanium composite plate with the large thickness ratio is obtained.

Abstract: Compositions and methods are provided for the improved expression and regulation of transgenes in plants, including a method of identifying gene expression gene cross-talk blocking and modulating elements, as well as the compositions of said elements. Also provided are plant cells and plants comprising or produced by the methods and compositions described herein.

Abstract: Provided is an efficient preparation method of a bimetallic seamless composite pipe, and belongs to the technical field of steel pipe manufacture. The efficient preparation method of the bimetallic seamless composite pipe includes following steps: sheathing a base pipe blank on a cladding pipe blank to obtain a composite pipe blank, and carrying out a stress relief annealing treatment on the composite pipe blank, where the base pipe blank and the cladding pipe blank are made of different materials; heating the composite pipe blank after the stress relief annealing treatment to a hot working window temperature, and sheathing on a core rod of an extrusion cylinder after an insulation treatment, and then extruding along an axial direction of the extrusion cylinder to obtain a bimetallic seamless composite pipe.

Abstract: A magnesium/titanium composite plate with large thickness ratios and a gradient heterothermal rolling bonding method are provided by the present disclosure, relating to the technical field of rolling bonding plates. The method includes following steps: assembling blanks according to a sequence of titanium strip, transition layer foil and magnesium alloy plate to obtain a composite blank; carrying out induction heating treatment on one side of the titanium strip of the composite blank, then rolling, and carrying out heat treatment on a composite plate blank after rolling to obtain the magnesium/titanium composite plate with large thickness ratios; and a thickness ratio of the magnesium alloy plate to the titanium strip is greater than or equal to 20:1.

Abstract: A magnesium/titanium composite plate with large thickness ratios and a gradient heterothermal rolling bonding method are provided by the present disclosure, relating to the technical field of rolling bonding plates. The method includes following steps: assembling blanks according to a sequence of titanium strip, transition layer foil and magnesium alloy plate to obtain a composite blank; carrying out induction heating treatment on one side of the titanium strip of the composite blank, then rolling, and carrying out heat treatment on a composite plate blank after rolling to obtain the magnesium/titanium composite plate with large thickness ratios; and a thickness ratio of the magnesium alloy plate to the titanium strip is greater than or equal to 20:1.

Abstract: A system coupled to a packet-based network is configured to generate geo-blocks for location-based information services. Each of the geo-blocks corresponds to a geographical region within a geographical area and has at least one border defined by a real-world object. The system is configured to obtain geo data related to real-world objects including transportation routes and natural boundaries in the geographical area, partition the geographical area into initial geo-blocks using the geo data, process a plurality of information requests with respect to at least some of the initial geo-blocks and with respect to initial geo-fences associated with a plurality of points of interests (POIs) to generate entries in one or more databases, and machine train a mobile device location prediction model based on the entries in the one or more databases.

Abstract: The present disclosure provides a pulse current assisted uncanned rolling method for titanium-TiAl composite plates, including the following specific steps: 1. preparing titanium alloy sheets; 2. preparing TiAl alloy sheets; 3. uncanned lay-up; 4. pulse current assisted hot-rolling; 5. separation and subsequent processing, thus getting the titanium-TiAl composite plates. The composite plates are of good quality on the surface without oxide layer shedding, no cracks at the edges and the ends, with uniform and fine microstructures, good bonding interface and excellent mechanical properties.

Abstract: A system coupled to a packet-based network is configured to generate geo-blocks for location-based information services. Each of the geo-blocks corresponds to a geographical region within a geographical area and has at least one border defined by a real-world object. The system is configured to obtain geo data related to real-world objects including transportation routes and natural boundaries in the geographical area, partition the geographical area into initial geo-blocks using the geo data, process a plurality of information requests with respect to at least some of the initial geo-blocks and with respect to initial geo-fences associated with a plurality of points of interests (POIs) to generate entries in one or more databases, and machine train a mobile device location prediction model based on the entries in the one or more databases.

Abstract: Biomarkers, methods, devices, reagents, systems, and kits used to assess an individual having heart failure with preserved ejection fraction (HFpEF) or having heart failure with reduced ejection fraction (HFrEF) for the prediction of risk of developing a Cardiovascular (CV) Event over a 90 day, 180 day, or 1 year period are provided.

Abstract: The disclosure provides methods and compositions for treating or categorizing chin retrusion in a subject such as an East Asian subject. The disclosure also provides a chin retrusion scale useful for determining a degree of chin retrusion in a subject such as an East Asian subject.

Abstract: A system coupled to a packet-based network is configured to generate geo-blocks for location-based information services. Each of the geo-blocks corresponds to a geographical region within a geographical area and has at least one border defined by a real-world object. The system is configured to obtain geo data related to real-world objects including transportation routes and natural boundaries in the geographical area, partition the geographical area into initial geo-blocks using the geo data, process a plurality of information requests with respect to at least some of the initial geo-blocks and with respect to initial geo-fences associated with a plurality of points of interests (POIs) to generate entries in one or more databases, and enrich at least some of the initial geo-block with block-level meta data derived from the entries in the one or more databases to form enriched geo-blocks that are highly indicative of location dependent attributes such as intention and demographics.

Abstract: Methods and compositions are provided for massively parallel base editing in the genome of an organism, such as a plant. Multiple loci are selected based on one or more specific criteria, such as evolutionary conservation, recombination frequency, nonsense mutations, and/or missense mutations. Predictive models for deleterious alleles and biologically-informed phenotype prediction may be developed and refined based on the editing results, and improved plant lines for commercial or breeding purposes may be obtained.

Abstract: Methods and systems to predict phenotypes for one or more organisms, such as plants, using multi-omics or multi-modal data are provided. In some aspects, two or more types of the same or different multi-omics or multi-modal data are encoded into a universal integrated latent space representation.

Abstract: The present disclosure provides a pulse current assisted uncanned rolling method for titanium-TiAl composite plates, including the following specific steps: 1. preparing titanium alloy sheets; 2. preparing TiAl alloy sheets; 3. uncanned lay-up; 4. pulse current assisted hot-rolling; 5. separation and subsequent processing, thus getting the titanium-TiAl composite plates. The composite plates are of good quality on the surface without oxide layer shedding, no cracks at the edges and the ends, with uniform and fine microstructures, good bonding interface and excellent mechanical properties.

Abstract: Provided are panaxdiol-type ginsenoside derivatives having structures as shown in formula I or formula II. Also provided are the uses thereof in the preparation of drugs for preventing and treating atherosclerosis. The panaxdiol-type ginsenoside derivatives have low cytotoxicities, can significantly reduce the percentages of the areas of atherosclerotic plaques in apoE?/? mice, can also effectively reduce the levels of low-density lipoprotein cholesterol and increase the levels of high-density lipoprotein cholesterol in serums of mice, and can significantly reduce the local TNF-? levels in the arteries of apoE?/? mice and have good anti-inflammatory effects; at a dose of 30 ?M, the panaxdiol-type ginsenoside derivatives can significantly reduce the degrees of the formation of RAW264.7 cell-derived foam cells. In addition, the preparation methods for the panaxdiol-type ginsenoside derivatives are easy to operate and obtain high yields.

Abstract: A system coupled to a packet-based network is configured to generate geo-blocks for location-based information services. Each of the geo-blocks corresponds to a geographical region within a geographical area and has at least one border defined by a real-world object. The system is configured to obtain geo data related to real-world objects including transportation routes and natural boundaries in the geographical area, partition the geographical area into initial geo-blocks using the geo data, process a plurality of information requests with respect to at least some of the initial geo-blocks and with respect to initial geo-fences associated with a plurality of points of interests (POIs) to generate entries in one or more databases, and enrich at least some of the initial geo-block with block-level meta data derived from the entries in the one or more databases to form enriched geo-blocks that are highly indicative of location dependent attributes such as intention and demographics.

Abstract: A system coupled to a packet-based network is configured to generate geo-blocks for location-based information services. Each of the geo-blocks corresponds to a geographical region within a geographical area and has at least one border defined by a real-world object. The system is configured to obtain geo data related to real-world objects including transportation routes and natural boundaries in the geographical area, partition the geographical area into initial geo-blocks using the geo data, process a plurality of information requests with respect to at least some of the initial geo-blocks and with respect to initial geo-fences associated with a plurality of points of interests (POIs) to generate entries in one or more databases, and enrich at least some of the initial geo-block with block-level meta data extracted from the entries in the one or more databases to form enriched geo-blocks that are highly indicative of location dependent attributes such as intention and demographics.

Abstract: A system coupled to a packet-based network is configured to generate geo-blocks for location-based information services. Each of the geo-blocks corresponds to a geographical region within a geographical area and has at least one border defined by a real-world object. The system is configured to obtain geo data related to real-world objects including transportation routes and natural boundaries in the geographical area, partition the geographical area into initial geo-blocks using the geo data, process a plurality of information requests with respect to at least some of the initial geo-blocks and with respect to initial geo-fences associated with a plurality of points of interests (POIs) to generate entries in one or more databases, and enrich at least some of the initial geo-block with block-level meta data extracted from the entries in the one or more databases to form enriched geo-blocks that are highly indicative of location dependent attributes such as intention and demographics.

Abstract: A system coupled to a packet-based network is configured to generate geo-blocks based on geo data related to real-world objects including transportation routes and natural boundaries in a geographical area such that each of the geo-blocks corresponds to a geographical region within the geographical area and has at least one border defined by a real-world object. The system is further configured to determine a performance measure with respect to a point of interest (POI) for each of a set of geo-blocks, and to select one or more geo-blocks each having a performance measure above a threshold from the set of geo-blocks to form a geo-fence for the POI. The threshold is adjustable based on a pacing status of an information campaign associated with the POI.