Abstract: A system coupled to a packet-based network is configured to generate geo-blocks for location-based information services. Each of the geo-blocks corresponds to a geographical region within a geographical area and has at least one border defined by a real-world object. The system is configured to obtain geo data related to real-world objects including transportation routes and natural boundaries in the geographical area, partition the geographical area into initial geo-blocks using the geo data, process a plurality of information requests with respect to at least some of the initial geo-blocks and with respect to initial geo-fences associated with a plurality of points of interests (POIs) to generate entries in one or more databases, and machine train a mobile device location prediction model based on the entries in the one or more databases.

Abstract: A kit for extracting mycotoxin residues in agricultural products according to the present disclosure includes a pipe, a first powder mixture layer and a second powder mixture layer. The pipe has an output port at the bottom thereof and an input port at the top thereof for inputting a sample solution. The first powder mixture layer is in the form of powder and filled in the pipe. The first powder mixture layer contains cation exchange resin powder, C18 and diatomaceous earth powder. The second powder mixture layer is in the form of powder and filled in the pipe. The second powder mixture layer is located below the first powder mixture layer and above the output port. The second powder mixture layer contains PSA powder, anhydrous magnesium sulfate powder, activated carbon, PLS powder, diatomaceous earth powder and C18 powder. The present disclosure further provides a method of obtaining a primary test liquid from agricultural products using the above kit.

Abstract: The present disclosure provides a pulse current assisted uncanned rolling method for titanium-TiAl composite plates, including the following specific steps: 1. preparing titanium alloy sheets; 2. preparing TiAl alloy sheets; 3. uncanned lay-up; 4. pulse current assisted hot-rolling; 5. separation and subsequent processing, thus getting the titanium-TiAl composite plates. The composite plates are of good quality on the surface without oxide layer shedding, no cracks at the edges and the ends, with uniform and fine microstructures, good bonding interface and excellent mechanical properties.

Abstract: A kit for extracting mycotoxin residues in agricultural products according to the present disclosure includes a pipe, a first powder mixture layer and a second powder mixture layer. The pipe has an output port at the bottom thereof and an input port at the top thereof for inputting a sample solution. The first powder mixture layer is in the form of powder and filled in the pipe. The first powder mixture layer contains cation exchange resin powder, C18 and diatomaceous earth powder. The second powder mixture layer is in the form of powder and filled in the pipe. The second powder mixture layer is located below the first powder mixture layer and above the output port. The second powder mixture layer contains PSA powder, anhydrous magnesium sulfate powder, activated carbon, PLS powder, diatomaceous earth powder and C18 powder. The present disclosure further provides a method of obtaining a primary test liquid from agricultural products using the above kit.

Abstract: Provided herein are, inter alia, complexes useful for editing (e.g., repairing, modifying) DNA in a cell in vitro and in vivo. The complexes provided herein include a DNA editing agent bound to a phosphorothioate nucleic acid through a chemical linker. The chemical linker (e.g., disulfide linker) may be a linker that dissociates once the complex has entered the inside of the cell, thereby releasing the DNA editing agent and allowing the DNA editing agent to access and edit a cellular target sequence. The complexes provided herein exhibit high transfection efficiency and editing efficacy and therefore provide for useful therapeutic and diagnostic tools.

Abstract: A system coupled to a packet-based network is configured to generate geo-blocks for location-based information services. Each of the geo-blocks corresponds to a geographical region within a geographical area and has at least one border defined by a real-world object. The system is configured to obtain geo data related to real-world objects including transportation routes and natural boundaries in the geographical area, partition the geographical area into initial geo-blocks using the geo data, process a plurality of information requests with respect to at least some of the initial geo-blocks and with respect to initial geo-fences associated with a plurality of points of interests (POIs) to generate entries in one or more databases, and machine train a mobile device location prediction model based on the entries in the one or more databases.

Abstract: Biomarkers, methods, devices, reagents, systems, and kits used to assess an individual having heart failure with preserved ejection fraction (HFpEF) or having heart failure with reduced ejection fraction (HFrEF) for the prediction of risk of developing a Cardiovascular (CV) Event over a 90 day, 180 day, or 1 year period are provided.

Abstract: The disclosure provides methods and compositions for treating or categorizing chin retrusion in a subject such as an East Asian subject. The disclosure also provides a chin retrusion scale useful for determining a degree of chin retrusion in a subject such as an East Asian subject.

Abstract: A system coupled to a packet-based network is configured to generate geo-blocks for location-based information services. Each of the geo-blocks corresponds to a geographical region within a geographical area and has at least one border defined by a real-world object. The system is configured to obtain geo data related to real-world objects including transportation routes and natural boundaries in the geographical area, partition the geographical area into initial geo-blocks using the geo data, process a plurality of information requests with respect to at least some of the initial geo-blocks and with respect to initial geo-fences associated with a plurality of points of interests (POIs) to generate entries in one or more databases, and enrich at least some of the initial geo-block with block-level meta data derived from the entries in the one or more databases to form enriched geo-blocks that are highly indicative of location dependent attributes such as intention and demographics.

Abstract: Methods and compositions are provided for massively parallel base editing in the genome of an organism, such as a plant. Multiple loci are selected based on one or more specific criteria, such as evolutionary conservation, recombination frequency, nonsense mutations, and/or missense mutations. Predictive models for deleterious alleles and biologically-informed phenotype prediction may be developed and refined based on the editing results, and improved plant lines for commercial or breeding purposes may be obtained.

Abstract: Methods and systems to predict phenotypes for one or more organisms, such as plants, using multi-omics or multi-modal data are provided. In some aspects, two or more types of the same or different multi-omics or multi-modal data are encoded into a universal integrated latent space representation.

Abstract: A kit for extracting drug residues from livestock or poultry aquatic products according to the present disclosure includes a pipe, a first powder mixture layer and a second powder mixture layer. The pipe has an output port at the bottom thereof and an input port at the top thereof for inputting a sample solution. The first powder mixture layer is in the form of powder and filled in the pipe. The first powder mixture layer contains anhydrous sodium sulfate powder and sodium chloride powder. The second powder mixture layer is in the form of powder and filled in the pipe. The second powder mixture layer is located below the first powder mixture layer and above the output port. The second powder mixture layer contains anhydrous sodium sulfate powder and C18 powder. The present disclosure further provides a method of obtaining a primary test liquid from livestock or poultry aquatic products using the above kit.

Abstract: The present disclosure provides a pulse current assisted uncanned rolling method for titanium-TiAl composite plates, including the following specific steps: 1. preparing titanium alloy sheets; 2. preparing TiAl alloy sheets; 3. uncanned lay-up; 4. pulse current assisted hot-rolling; 5. separation and subsequent processing, thus getting the titanium-TiAl composite plates. The composite plates are of good quality on the surface without oxide layer shedding, no cracks at the edges and the ends, with uniform and fine microstructures, good bonding interface and excellent mechanical properties.

Abstract: A power tool which contains a casing, a brushless motor (22) mounted inside the casing, a user actuated switch (38) mounted on the casing, and a circuit board (32) mounted inside the casing. The brushless motor (22) is adapted to drive one or more movable parts in the power tool. The circuit board (32) is mechanically connected to the brushless motor (22) and the switch (38) at the same time. As only a single, integrated circuit board (32) is configured in the power tool, the manufacturing cost is reduced and greater reliance and electrical safety can be achieved.

Abstract: Provided are panaxdiol-type ginsenoside derivatives having structures as shown in formula I or formula II. Also provided are the uses thereof in the preparation of drugs for preventing and treating atherosclerosis. The panaxdiol-type ginsenoside derivatives have low cytotoxicities, can significantly reduce the percentages of the areas of atherosclerotic plaques in apoE?/? mice, can also effectively reduce the levels of low-density lipoprotein cholesterol and increase the levels of high-density lipoprotein cholesterol in serums of mice, and can significantly reduce the local TNF-? levels in the arteries of apoE?/? mice and have good anti-inflammatory effects; at a dose of 30 ?M, the panaxdiol-type ginsenoside derivatives can significantly reduce the degrees of the formation of RAW264.7 cell-derived foam cells. In addition, the preparation methods for the panaxdiol-type ginsenoside derivatives are easy to operate and obtain high yields.

Abstract: A system coupled to a packet-based network is configured to generate geo-blocks for location-based information services. Each of the geo-blocks corresponds to a geographical region within a geographical area and has at least one border defined by a real-world object. The system is configured to obtain geo data related to real-world objects including transportation routes and natural boundaries in the geographical area, partition the geographical area into initial geo-blocks using the geo data, process a plurality of information requests with respect to at least some of the initial geo-blocks and with respect to initial geo-fences associated with a plurality of points of interests (POIs) to generate entries in one or more databases, and enrich at least some of the initial geo-block with block-level meta data derived from the entries in the one or more databases to form enriched geo-blocks that are highly indicative of location dependent attributes such as intention and demographics.

Abstract: A system coupled to a packet-based network is configured to generate geo-blocks for location-based information services. Each of the geo-blocks corresponds to a geographical region within a geographical area and has at least one border defined by a real-world object. The system is configured to obtain geo data related to real-world objects including transportation routes and natural boundaries in the geographical area, partition the geographical area into initial geo-blocks using the geo data, process a plurality of information requests with respect to at least some of the initial geo-blocks and with respect to initial geo-fences associated with a plurality of points of interests (POIs) to generate entries in one or more databases, and enrich at least some of the initial geo-block with block-level meta data extracted from the entries in the one or more databases to form enriched geo-blocks that are highly indicative of location dependent attributes such as intention and demographics.

Abstract: A kit for extracting drug residues from livestock or poultry aquatic products according to the present disclosure includes a pipe, a first powder mixture layer and a second powder mixture layer. The pipe has an output port at the bottom thereof and an input port at the top thereof for inputting a sample solution. The first powder mixture layer is in the form of powder and filled in the pipe. The first powder mixture layer contains anhydrous sodium sulfate powder and sodium chloride powder. The second powder mixture layer is in the form of powder and filled in the pipe. The second powder mixture layer is located below the first powder mixture layer and above the output port. The second powder mixture layer contains anhydrous sodium sulfate powder and C18 powder. The present disclosure further provides a method of obtaining a primary test liquid from livestock or poultry aquatic products using the above kit.

Abstract: A system coupled to a packet-based network is configured to generate geo-blocks for location-based information services. Each of the geo-blocks corresponds to a geographical region within a geographical area and has at least one border defined by a real-world object. The system is configured to obtain geo data related to real-world objects including transportation routes and natural boundaries in the geographical area, partition the geographical area into initial geo-blocks using the geo data, process a plurality of information requests with respect to at least some of the initial geo-blocks and with respect to initial geo-fences associated with a plurality of points of interests (POIs) to generate entries in one or more databases, and enrich at least some of the initial geo-block with block-level meta data extracted from the entries in the one or more databases to form enriched geo-blocks that are highly indicative of location dependent attributes such as intention and demographics.

Abstract: A system coupled to a packet-based network is configured to generate geo-blocks based on geo data related to real-world objects including transportation routes and natural boundaries in a geographical area such that each of the geo-blocks corresponds to a geographical region within the geographical area and has at least one border defined by a real-world object. The system is further configured to determine a performance measure with respect to a point of interest (POI) for each of a set of geo-blocks, and to select one or more geo-blocks each having a performance measure above a threshold from the set of geo-blocks to form a geo-fence for the POI. The threshold is adjustable based on a pacing status of an information campaign associated with the POI.