Patents by Inventor Yijun Huang
Yijun Huang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12378538Abstract: The present invention relates to the technical field of biology, in particular to a phytase mutant, a preparation method therefor and an application thereof, a DNA molecule encoding the phytase mutant, a vector, and a host cell. The mutant provided by the present invention contains the substituent of an amino acid at at least one position selected from the following group: 36, 69, 89, 91, 111, 202, 213, 225, 238, 243, 253, 258, and 266. The heat resistance of the mutant is significantly improved, thereby facilitating the wide application of the phytase in feed.Type: GrantFiled: February 11, 2020Date of Patent: August 5, 2025Assignee: QINGDAO VLAND BIOTECH GROUP CO., LTDInventors: Xiuxiu Wu, Yijun Huang, Yang Liu, Xia Zhang, Sida Cheng
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Patent number: 12254627Abstract: Provided herein is technology relating to analysis of images and particularly, but not exclusively, to methods and systems for determining the area and/or volume of a region of interest using optical coherence tomography data. Some embodiments provide for determining the area and/or volume of a lesion in retinal tissue using three-dimensional optical coherence tomography data and a two-dimensional optical coherence tomography fundus image.Type: GrantFiled: December 15, 2023Date of Patent: March 18, 2025Assignee: MERIT CRO, Inc.Inventor: Yijun Huang
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Publication number: 20240384252Abstract: A high temperature resistant mannanase mutant, comprising at least one mutation site among D49C/I/N, G58D/E/S, H90L, T99Y, K120Y, N124P, T130D/N/P/Q/R/S, Y132F, S136M, S140L/K, T148K, F206Y, A212N/S/P, L257F, S263R, D268A/E/G/P, G273P, S302M/E, S306M/Q, T315P, T353L/F, D360E/N/K, and A362R. The high temperature resistant mannanase mutant has heat resistance significantly higher than the wild type mannanase, and can be widely used in the field of feeds.Type: ApplicationFiled: September 16, 2022Publication date: November 21, 2024Applicant: QINGDAO VLAND BIOTECH GROUP CO., LTD.Inventors: Xiuxiu WU, Rui LI, Yuqiang LI, Yijun HUANG, Xinpei LI, Lihong XU, Qingqing SONG, Wen XIN
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Patent number: 12057216Abstract: The present invention is related to improved methods for analysis of images of the vitreous and/or retina and/or choroid obtained by optical coherence tomography and to methods for making diagnoses of retinal disease based on the reflectivity profiles of various vitreous and/or retinal and/or choroidal layers of the retina.Type: GrantFiled: June 15, 2023Date of Patent: August 6, 2024Assignee: MERIT CRO, INC.Inventor: Yijun Huang
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Patent number: 12018262Abstract: Provided is a method for producing washing enzyme having protease resistance. According to the method, the washing enzyme having resistance to protease is obtained by carrying out fusion expression on a gene of the washing enzyme with the gene of a protease inhibitory peptide, thereby facilitating maintaining the stability of various enzyme components in an enzyme-containing detergent, and improving the use effect of the detergent.Type: GrantFiled: October 28, 2019Date of Patent: June 25, 2024Assignee: QINGDAO VLAND BIOTECH GROUP CO., LTDInventors: Qing Zhang, Zhibing Chen, Yanping Liu, Yanjun Tian, Wei Xu, Yinan Guan, Yijun Huang, Jiahua Lyu
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Publication number: 20240193771Abstract: Provided herein is technology relating to analysis of images and particularly, but not exclusively, to methods and systems for determining the area and/or volume of a region of interest using optical coherence tomography data. Some embodiments provide for determining the area and/or volume of a lesion in retinal tissue using three-dimensional optical coherence tomography data and a two-dimensional optical coherence tomography fundus image.Type: ApplicationFiled: December 15, 2023Publication date: June 13, 2024Inventor: Yijun Huang
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Patent number: 11911396Abstract: Disclosed is use of 5?-androst-3?,5,6?-triol or an analogue, a deuterated compound or a pharmaceutically acceptable salt thereof in the manufacture of a medicament for the treatment of cerebral small vessel disease in a patient. The cerebral small vessel disease is preferably cerebral microbleed. The cerebral microbleed is spontaneous cerebral microbleed, drug-related cerebral microbleed, or traumatic cerebral microbleed. The present invention demonstrates that these compounds significantly enhance the clearance of extravascular hemoglobin, and thus can be used to treat cerebral small vessel disease.Type: GrantFiled: December 28, 2018Date of Patent: February 27, 2024Assignee: GUANGZHOU CELLPROTEK PHARMACEUTICAL CO., LTDInventors: Guangmei Yan, Wei Yin, Longxiang Sheng, Bingzheng Lu, Yijun Huang, Suizhen Lin
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Patent number: 11861830Abstract: Provided herein is technology relating to analysis of images and particularly, but not exclusively, to methods and systems for determining the area and/or volume of a region of interest using optical coherence tomography data. Some embodiments provide for determining the area and/or volume of a lesion in retinal tissue using three-dimensional optical coherence tomography data and a two-dimensional optical coherence tomography fundus image.Type: GrantFiled: January 24, 2022Date of Patent: January 2, 2024Assignee: MERIT CRO, INC.Inventor: Yijun Huang
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Publication number: 20230343440Abstract: The present invention is related to improved methods for analysis of images of the vitreous and/or retina and/or choroid obtained by optical coherence tomography and to methods for making diagnoses of retinal disease based on the reflectivity profiles of various vitreous and/or retinal and/or choroidal layers of the retina.Type: ApplicationFiled: June 15, 2023Publication date: October 26, 2023Inventor: Yijun Huang
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Publication number: 20230242890Abstract: Provided are a phytase mutant and a coding DNA molecule thereof, a vector, and a host cell. The phytase mutant comprises an amino acid sequence having at least 90% identity with SEQ ID NO: 3, and compared with SEQ ID NO: 3, and contains an amino acid substitution at at least one position selected from the group consisting of 36, 126, 211, 253, 258, and 266. The heat resistance of the mutant is significantly improved, thus facilitating the wide application of phytase in feed.Type: ApplicationFiled: May 20, 2021Publication date: August 3, 2023Applicant: QINGDAO VLAND BIOTECH GROUP CO., LTD.Inventors: Xiuxiu WU, Xinpei LI, Rui LI, Qingqing SONG, Yijun HUANG
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Patent number: 11682484Abstract: The present invention is related to improved methods for analysis of images of the vitreous and/or retina and/or choroid obtained by optical coherence tomography and to methods for making diagnoses of retinal disease based on the reflectivity profiles of various vitreous and/or retinal and/or choroidal layers of the retina.Type: GrantFiled: June 27, 2022Date of Patent: June 20, 2023Assignee: MERIT CRO, INC.Inventor: Yijun Huang
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Publication number: 20230099386Abstract: A system of recommending an item, a method of recommending an item by a system of recommending an item, a computer system, and a computer-readable storage medium are provided. The system includes: an item expansion module configured to expand a content input by a user in response to the content input by the user, to generate an item set of interest to the user, the item set includes one or more items; a price radar module configured to monitor a discount information of the item in the item set; and a price monitoring module configured to calculate an actual price of the item based on the discount information of the item, maintain a price change record of the item in the item set, and determine whether to push a prompt information to the user or not according to the calculated actual price of the item and the price change record.Type: ApplicationFiled: February 24, 2021Publication date: March 30, 2023Inventors: Wei ZHANG, Xin SHANG, Guangming ZHU, Fan YANG, Xiaoting SI, Hongguang LIU, Weiran WANG, Jiang LAN, Yijun HUANG, Hongkai JIANG, Xuedi QIAN
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Publication number: 20230053859Abstract: A method and device for outputting information are provided. The method includes: in response to receiving an item addition request sent by a user, acquiring a base item; acquiring a candidate item set; acquiring associated items of the base item to form an associated item set; and acquiring an initial item combination, and selecting an item from the candidate item set and adding same to the initial item combination, obtaining a first item combination; and based on the first item combination, deleting an item from the first item combination, obtaining an intermediate item combination ; selecting an item from the associated item set and adding same to the intermediate item combination, obtaining a second item combination; selecting a result item combination from the first item combination and the second item combination; and in response to the result item combination satisfying preset conditions, outputting the result item combination.Type: ApplicationFiled: December 28, 2020Publication date: February 23, 2023Inventors: Guangming ZHU, Wei ZHANG, Xin SHANG, Zilian CHANG, Chenjie ZHANG, Xiaoting SI, Yijun HUANG, Jianhua ZHU, Fan YANG
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Patent number: 11576930Abstract: Methods for treatment of a multi-drug resistant (MDR) tumor in a subject are disclosed. The methods comprise administering to the subject in need of treatment a therapeutically effective amount of an anti-mycoplasma agent and/or an agent blocking the interaction between membrane protein P37 of mycoplasma and Annexin A2 of host cells of the subject, prior to, at the same time with, or after chemotherapy. Relevant pharmaceutical compositions, kits, uses are also disclosed.Type: GrantFiled: August 8, 2017Date of Patent: February 14, 2023Assignee: SUN YAT-SEN UNIVERSITYInventors: Yijun Huang, Danyang Liu, Juncheng Pan, Yang Hu, Zhu Zhu
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Publication number: 20220380778Abstract: Provided is a xylanase mutant having improved specific activity, comprising any one or more mutation sites of M78F, V1431, R148K, F163W, I177V, and V206L. The specific activity of the mutant is improved, the production cost of xylanase is reduced, and the mutant can be used in feed.Type: ApplicationFiled: May 15, 2020Publication date: December 1, 2022Applicant: QINGDAO VLAND BIOTECH GROUP CO., LTD.Inventors: Xiuxiu WU, Rongxi SONG, Yijun HUANG
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Publication number: 20220374778Abstract: Systems and methods implement a modular computing environment for Bayesian optimization, decoupling steps of Bayesian optimization across multiple modules; minimizing inter-module dependency; extending functionality of each module; and reusing computing resources and intermediate results within each module. Variable hyperparameterization may reduce computational costs of optimization iterations, while also averting overfitting and destabilization of the Gaussian kernel based on sparser observations of the objective function. Computational complexity of updating the Gaussian kernel may be reduced from the cube to the square of the set of sampled outputs, by deferring computing updates to each hyperparameter while the optimization iterations are ongoing.Type: ApplicationFiled: May 20, 2021Publication date: November 24, 2022Inventor: Yijun Huang
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Publication number: 20220344035Abstract: The present invention is related to improved methods for analysis of images of the vitreous and/or retina and/or choroid obtained by optical coherence tomography and to methods for making diagnoses of retinal disease based on the reflectivity profiles of various vitreous and/or retinal and/or choroidal layers of the retina.Type: ApplicationFiled: June 27, 2022Publication date: October 27, 2022Inventor: Yijun Huang
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Publication number: 20220254011Abstract: Provided herein is technology relating to analysis of images and particularly, but not exclusively, to methods and systems for determining the area and/or volume of a region of interest using optical coherence tomography data. Some embodiments provide for determining the area and/or volume of a lesion in retinal tissue using three-dimensional optical coherence tomography data and a two-dimensional optical coherence tomography fundus image.Type: ApplicationFiled: January 24, 2022Publication date: August 11, 2022Inventor: Yijun Huang
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Patent number: 11382921Abstract: Disclosed is a use of 5?-androstane-3?,5,6?-triol, an analogue, a deuterated derivative, and a pharmaceutically acceptable salt thereof in manufacture of a medicament for the treatment of hemorrhagic stroke in a patient. The hemorrhagic stroke is intracerebral hemorrhage or subarachnoid hemorrhage.Type: GrantFiled: December 28, 2018Date of Patent: July 12, 2022Assignee: GUANGZHOU CELLPROTEK PHARMACEUTICAL CO., LTDInventors: Guangmei Yan, Yijun Huang, Wei Yin, Suizhen Lin
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Patent number: 11373749Abstract: The present invention is related to improved methods for analysis of images of the vitreous and/or retina and/or choroid obtained by optical coherence tomography and to methods for making diagnoses of retinal disease based on the reflectivity profiles of various vitreous and/or retinal and/or choroidal layers of the retina.Type: GrantFiled: May 11, 2018Date of Patent: June 28, 2022Assignee: EyeKor, LLCInventor: Yijun Huang