Patents by Inventor Yi-Kai CHIU
Yi-Kai CHIU has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20240013406Abstract: A trajectory predicting method and a computing system for trajectory prediction are provided. In the method, feature extraction is respectively performed on past trajectories of multiple target objects through an encoder to generate first trajectory information of the target objects. A pooling process is performed on the first trajectory information of the target objects to generate second trajectory information of the target objects. The second trajectory information of each target object includes location relationships relative to other target objects. Third trajectory information is obtained from the past trajectories of the target objects. The third trajectory information includes a moving direction, scene information, and/or a moving mode. The predicted trajectories of the target objects are generated according to the second trajectory information and the third trajectory information through a decoder. Accordingly, the accuracy of prediction can be improved.Type: ApplicationFiled: October 27, 2022Publication date: January 11, 2024Applicant: Wistron CorporationInventors: Xiu Zhi Chen, Jyun Hong He, Yen Lin Chen, Yung Jen Chen, Yi Kai Chiu, You Shiuan Lin, Kuo-Lun Huang, Ke Kang Chen, Shao-Chi Chen
-
Patent number: 11434277Abstract: Disclosed herein are methods for high-throughput screening of a virus-specific neutralizing antibody. According to certain embodiments of the present disclosure, the virus is an influenza virus. Also disclosed herein are the antibodies selected by the high-throughput screening method, and the uses thereof in the prophylaxis and/or treatment of viral infection.Type: GrantFiled: October 19, 2018Date of Patent: September 6, 2022Assignee: ACADEMIA SINICAInventors: An-Suei Yang, Ing-Chien Chen, Yi-Kai Chiu, Chung-Ming Yu, Cheng-Chung Lee, Chao-Ping Tung, Yueh-Liang Tsou, Yi-Jen Huang, Chia-Lung Lin, Hong-Sen Chen, Hwei-Jiung Wang
-
Publication number: 20210070843Abstract: Disclosed herein are methods for high-throughput screening of a virus-specific neutralizing antibody. According to certain embodiments of the present disclosure, the virus is an influenza virus. Also disclosed herein are the antibodies selected by the high-throughput screening method, and the uses thereof in the prophylaxis and/or treatment of viral infection.Type: ApplicationFiled: October 19, 2018Publication date: March 11, 2021Inventors: An-Suei YANG, Ing-Chien CHEN, Yi-Kai CHIU, Chung-Ming YU, Cheng-Chung LEE, Chao-Ping TUNG, Yueh-Liang TSOU, Yi-Jen HUANG, Chia-Lung LIN, Hong-Sen CHEN, Hwei-Jiung WANG
-
Patent number: 10752673Abstract: Disclosed herein are methods for high-throughput screening of a functional antibody fragment for an immunoconjugate that targets a protein antigen. The method combines a phage-displayed synthetic antibody library and high-throughput cytotoxicity screening of non-covalently assembled immunotoxins or cytotoxic drug to identify highly functional synthetic antibody fragments for delivering toxin payloads.Type: GrantFiled: June 12, 2017Date of Patent: August 25, 2020Assignee: ACADEMIA SINICAInventors: An-Suei Yang, Hong-Sen Chen, Chung-Ming Yu, Shin-Chen Hou, Wei-Ying Kuo, Yi-Kai Chiu, Yueh-Liang Tsou, Hung-Ju Hsu, Hwei-Jiung Wang, Shih-Hsien Chuang, Chao-Pin Lee
-
Patent number: 10562976Abstract: Disclosed herein is an immunoconjugate comprising an antibody, a functional motif, and a linker connecting the functional motif to the antibody. According to embodiments of the present disclosure, the antibody may recognize tumor-associated antigens (TAAs), and serves as a targeting module for delivering the functional motif connected therewith to the tumor cells thereby inhibiting tumor growth or detecting the distribution of tumor cells. Also disclosed herein are methods of treating cancers and methods of diagnosing cancers by use of the present immunoconjugate.Type: GrantFiled: October 22, 2018Date of Patent: February 18, 2020Assignee: Academia SinicaInventors: An-Suei Yang, Wei-Ying Kuo, Hung-Ju Hsu, Hong-Sen Chen, Yu-Chi Chou, Yueh-Liang Tsou, Hung-Pin Peng, Jhih-Wei Jian, Chung-Ming Yu, Yi-Kai Chiu, Ing-Chein Chen, Chao-Ping Tung, Michael Hsiao, Hwei-Jiung Wang
-
Patent number: 10472411Abstract: Disclosed herein is a phage-displayed single-chain variable fragment (scFv) library, that comprised a plurality of phage-displayed scFvs characterized with (1) a specific CS combination; (2) a specific distribution of aromatic residues in each CDR; and (3) a specific sequence in each CDR. The present scFv library could be used to efficiently produce different antibodies with binding affinity to different antigens. Accordingly, the present disclosure provides a potential means to generate different antigen-specific antibodies promptly in accordance with the need in experimental researches and/or clinical applications.Type: GrantFiled: May 13, 2019Date of Patent: November 12, 2019Assignee: Academia SinicaInventors: An-Suei Yang, Hong-Sen Chen, Ing-Chien Chen, Chao-Ping Tung, Shin-Chen Hou, Chung-Ming Yu, Chi-Kai Yang, Yi-Kai Chiu
-
Patent number: 10415033Abstract: Disclosed herein is a phage-displayed single-chain variable fragment (scFv) library, which comprises a plurality of phage-displayed scFvs characterized in having a specific CS combination and a specific sequence in each CDR. The present scFv library is useful in efficiently producing different antibodies with binding affinity to different antigens. Accordingly, the present disclosure provides a potential means to generate different antigen-specific antibodies promptly in accordance with the need in experimental researches and/or clinical applications.Type: GrantFiled: November 28, 2018Date of Patent: September 17, 2019Assignee: Academia SinicaInventors: An-Suei Yang, Jhih-Wei Jian, Hong-Sen Chen, Yi-Kai Chiu, Hung-Pin Peng, Chao-Ping Tung, Chung-Ming Yu, Wei-Ying Kuo, Hung-Ju Hsu
-
Publication number: 20190263893Abstract: Disclosed herein is a phage-displayed single-chain variable fragment (scFv) library, that comprised a plurality of phage-displayed scFvs characterized with (1) a specific CS combination; (2) a specific distribution of aromatic residues in each CDR; and (3) a specific sequence in each CDR. The present scFv library could be used to efficiently produce different antibodies with binding affinity to different antigens. Accordingly, the present disclosure provides a potential means to generate different antigen-specific antibodies promptly in accordance with the need in experimental researches and/or clinical applications.Type: ApplicationFiled: May 13, 2019Publication date: August 29, 2019Applicant: Academia SinicaInventors: An-Suei YANG, Hong-Sen CHEN, Ing-Chien CHEN, Chao-Ping TUNG, Shin-Chen HOU, Chung-Ming YU, Chi-Kai YANG, Yi-Kai CHIU
-
Patent number: 10336816Abstract: Disclosed herein is a phage-displayed single-chain variable fragment (scFv) library, that comprised a plurality of phage-displayed scFvs characterized with (1) a specific CS combination; (2) a specific distribution of aromatic residues in each CDR; and (3) a specific sequence in each CDR. The present scFv library could be used to efficiently produce different antibodies with binding affinity to different antigens. Accordingly, the present disclosure provides a potential means to generate different antigen-specific antibodies promptly in accordance with the need in experimental researches and/or clinical applications.Type: GrantFiled: February 23, 2016Date of Patent: July 2, 2019Assignee: Academia SinicaInventors: An-Suei Yang, Hong-Sen Chen, Ing-Chien Chen, Chao-Ping Tung, Shin-Chen Hou, Chung-Ming Yu, Chi-Kai Yang, Yi-Kai Chiu
-
Publication number: 20190085323Abstract: Disclosed herein is a phage-displayed single-chain variable fragment (scFv) library, which comprises a plurality of phage-displayed scFvs characterized in having a specific CS combination and a specific sequence in each CDR. The present scFv library is useful in efficiently producing different antibodies with binding affinity to different antigens. Accordingly, the present disclosure provides a potential means to generate different antigen-specific antibodies promptly in accordance with the need in experimental researches and/or clinical applications.Type: ApplicationFiled: November 28, 2018Publication date: March 21, 2019Applicant: Academia SinicaInventors: An-Suei Yang, Jhih-Wei Jian, Hong-Sen Chen, Yi-Kai Chiu, Hung-Pin Peng, Chao-Ping Tung, Chung-Ming Yu, Wei-Ying Kuo, Hung-Ju Hsu
-
Publication number: 20190040151Abstract: Disclosed herein is an immunoconjugate comprising an antibody, a functional motif, and a linker connecting the functional motif to the antibody. According to embodiments of the present disclosure, the antibody may recognize tumor-associated antigens (TAAs), and serves as a targeting module for delivering the functional motif connected therewith to the tumor cells thereby inhibiting tumor growth or detecting the distribution of tumor cells. Also disclosed herein are methods of treating cancers and methods of diagnosing cancers by use of the present immunoconjugate.Type: ApplicationFiled: October 22, 2018Publication date: February 7, 2019Applicant: Academia SinicaInventors: An-Suei YANG, Wei-Ying KUO, Hung-Ju HSU, Hong-Sen CHEN, Yu-Chi CHOU, Yueh-Liang TSOU, Hung-Pin PENG, Jhih-Wei JIAN, Chung-Ming YU, Yi-Kai CHIU, Ing-Chein CHEN, Chao-Ping TUNG, Michael HSIAO, Hwei-Jiung WANG
-
Publication number: 20180009877Abstract: Disclosed herein is a phage-displayed single-chain variable fragment (scFv) library, that comprised a plurality of phage-displayed scFvs characterized with (1) a specific CS combination; (2) a specific distribution of aromatic residues in each CDR; and (3) a specific sequence in each CDR. The present scFv library could be used to efficiently produce different antibodies with binding affinity to different antigens. Accordingly, the present disclosure provides a potential means to generate different antigen-specific antibodies promptly in accordance with the need in experimental researches and/or clinical applications.Type: ApplicationFiled: February 23, 2016Publication date: January 11, 2018Applicant: Academia SinicaInventors: An-Suei YANG, Hong-Sen CHEN, Ing-Chien CHEN, Chao-Ping TUNG, Shin-Chen HOU, Chung-Ming YU, Chi-Kai YANG, Yi-Kai CHIU
-
Publication number: 20170355750Abstract: Disclosed herein are methods for high-throughput screening of a functional antibody fragment for an immunoconjugate that targets a protein antigen. The method combines a phage-displayed synthetic antibody library and high-throughput cytotoxicity screening of non-covalently assembled immunotoxins or cytotoxic drug to identify highly functional synthetic antibody fragments for delivering toxin payloads.Type: ApplicationFiled: June 12, 2017Publication date: December 14, 2017Applicant: Academia SinicaInventors: An-Suei YANG, Hong-Sen CHEN, Chung-Ming YU, Shin-Chen HOU, Wei-Ying KUO, Yi-Kai CHIU, Yueh-Liang TSOU, Hung-Ju HSU, Hwei-Jiung WANG, Shih-Hsien CHUANG, Chao-Pin LEE