Abstract: The present disclosure includes, among other things, CFTR modulators, pharmaceutical compositions, and methods of making and using the same.

Abstract: The present disclosure includes, among other things, CFTR modulators, pharmaceutical compositions, and methods of making and using the same.

Abstract: A network processor includes a scheduler, a plurality of scheduling control modules, and a plurality of cache queues. The plurality of scheduling control modules are configured to separately obtain a first quantity of instructions from one of a plurality of non-empty cache queues, generate a scheduling request, to obtain a plurality of scheduling requests, and send the plurality of scheduling requests to the scheduler. The scheduler is configured to respond to the plurality of scheduling requests and send at least one scheduling response signal to at least one scheduling control module. The at least one scheduling control module is further configured to respond to the at least one scheduling response signal, and generate a to-be-executed instruction word based on the first quantity of instructions in a target cache queue and a target scheduling mode.

Abstract: Techniques for determining parameters for a seed train process for growing a culture of cells. The techniques include obtaining a specification of seed train process constraints for multiple stages of the seed train process; determining the seed train process parameters using the seed train process constraints, the seed train process parameters comprising a respective set of parameters for each particular stage of multiple stages of the seed train process; determining, using historical cell growth data and the seed train process parameters, a likelihood indicative of whether performing the seed train process using the seed train process parameters will satisfy seed train process success criteria; and outputting the set of seed train process parameters for each stage of the multiple stages of the seed train process and the likelihood indicative of whether performing the seed train process will satisfy the seed train process success criteria.

Abstract: The present disclosure includes, among other things, CFTR modulators, pharmaceutical compositions, and methods of making and using the same.

Abstract: Methods, systems, and computer program products are provided for determining performance of a machine learning model using decision boundary geometry. A method may include receiving data associated with a machine learning model, determining a decision boundary of the machine learning model, generating one or more metrics associated with a geometry of the decision boundary of the machine learning model, and determining whether to perform an action on the machine learning model based on the one or more metrics associated with the geometry of the decision boundary.

Abstract: A processing and buffering device compatible with various conveying lines is disclosed and includes a fixing and installation mechanism, a jacking component and a clamping component. The fixing and installation mechanism is used for fixing the processing and buffering device on a lateral side of a conveying line. The jacking component is disposed on the fixing and installation mechanism, and includes a jacking cylinder and a connection element, wherein the jacking component is allowed moving up and down in a vertical direction under the action of the jacking cylinder. The clamping component is disposed on the fixing and installation mechanism, connected to the jacking component through the connection element, and includes a horizontal displacement cylinder and two clamping elements. The clamping component is driven by the jacking component to move. The clamping elements are driven by a horizontal displacement cylinder to perform a clamping operation or a releasing operation.

Abstract: Some aspects of the disclosure provide a heat absorption device. The heat absorption device includes an accommodating member that includes an inner sealing portion in an annular shape and an outer sealing portion. The inner sealing portion in the annular shape defines a sealed cavity containing a heat absorption material. The heat absorption material is configured to vaporize when heat is absorbed. The outer sealing portion is disposed on an outer side of the inner sealing portion, and the outer sealing portion is spaced apart from the inner sealing portion to form an exhaust channel having an exhaust port to an outside environment. Some aspects of the disclosure provide a battery pack that includes a battery cell and the heat absorption device that is in contact with the battery cell. Further, some aspects of the disclosure provide an electric device that includes the battery pack.

Abstract: The present invention relates to T cell receptors (TCRs) which bind the HLA-A*02 restricted peptide SLYNTVATL (SEQ ID NO: 1) derived from the HIV Gag gene product, p17. Said TCRs comprise non-natural mutations within the alpha and/or beta variable domains relative to a native HIV TCR. The TCRs of the invention possess unexpectedly high affinity, specificity and sensitivity for a complex of SEQ ID NO: 1 and HLA-A*02, and drive a particularly potent T cell response. Such TCRs are particularly useful in the development of soluble immunotherapeutic reagents for the treatment of HIV infected individuals.

Abstract: The present application relates to a control system with a security management device.

Abstract: The present application provides an electro-optical phase shifter, an optical chip, a method for manufacturing an optical chip, and a LiDAR, where the electro-optical phase shifter includes a ridge waveguide, a planar region located on at least one side of the ridge waveguide along a first direction, and an electrode region; where the planar region includes a connection section and a side section arranged in sequence along a second direction, and the electrode region is located on an outer side of the connection section along the first direction, the first direction and the second direction being perpendicular to each other; and along the second direction and on at least one side of the electrode region, an edge of the side section gradually approaches the ridge waveguide from the electrode region in a direction away from the electrode region.

Abstract: A control valve mechanism and an oral irrigator handle, wherein the oral irrigator handle includes: a handle housing, the control valve mechanism, a nozzle, and a water pipe mechanism; wherein the water pipe mechanism and the nozzle are each in communication with the control valve mechanism, and the handle housing encloses the aforementioned structures to provide protection therefor and prepare for gripping for the user. When the control valve mechanism is opened, the water pipe mechanism transmits the pulsed waterflow from the oral irrigator main body through the control valve mechanism to the nozzle for ejection. Alternatively, when the control valve mechanism is closed, the transmission between the water pipe mechanism and the nozzle is interrupted, and is not under the influence of leakage caused by the pressure difference between the residual water in the water pipe mechanism and the water level of the oral irrigator main body.

Abstract: In one embodiment, a substrate includes a glass core layer with conductive through glass vias (TGVs). The substrate also includes a polymer layer between the glass core layer and the TGVs.

Abstract: An assembled oral irrigator handle with a waterflow switch relates to the field of oral cavity cleaning and nursing, and comprises a handle housing, a waterflow switch control mechanism, a nozzle mechanism and a water pipe mechanism; wherein the water pipe mechanism and the nozzle mechanism are respectively in communication with the waterflow switch control mechanism, and the handle housing encloses the above structure to provide protection therefor and to serve as a grip for the user. When the waterflow switch control mechanism is turned on, the water pipe mechanism transmits the pulsed water flow from the oral irrigator main body through the waterflow switch control mechanism to the nozzle mechanism for ejection; when the control valve mechanism is turned off, the transmission between the water pipe mechanism and the nozzle mechanism is cut off.

Abstract: A shear-type cavitation nozzle and its applications, as well as a shear-type cavitation oral irrigator; wherein the shear-type cavitation nozzle includes a main body and a shearing member; the main body has a cavitation chamber inside, and the main body is provided at its two ends with respectively a water inlet port and a water outlet port that are both in communication with the cavitation chamber. The shearing member is provided inside the cavitation chamber and has an inner flow channel and an outer flow channel. The inner flow channel and the outer flow channel each has a water inlet end corresponding to the water inlet port, and the inner flow channel and the outer flow channel each has a water outlet end corresponding to the water outlet port. The shearing member reciprocates inside the cavitation chamber under action of pulsed water flow from the water inlet port.

Abstract: The present disclosure relates to the field of laser detection technology, and provides a LiDAR and a control method thereof. The LiDAR includes a light source, a beam splitting structure, a transceiver module and a detection module; the beam splitting structure includes a first coupler, a first phase shifter and a second coupler that are sequentially connected along an optical path. Among them, the first phase shifter is used to alter a phase difference between the first light beam and the second light beam, that enables the second coupler to dynamically adjust the splitting ratio of the detection light and the local oscillator light, effectively reduces an overall loss and improves an efficiency of light energy utilization.

Abstract: Using risk metrics to facilitate transactions is described. A payment service computing platform may, in association with a request to initiate an interaction with a merchant, determine a user risk metric associated with a user of a payment service. The platform may determine, based on transaction data associated with merchants, merchant risk metrics associated with the merchants, filter the merchants based on the user risk metric and the merchant risk metrics to generate a list of merchants, and cause a user interface of a payment application associated with the payment service and executing on a device of the user to present at least a portion of the list of merchants. The platform may then receive indications of a selected merchant and an item(s) to be purchased from the selected merchant, use a single-use payment instrument to complete a transaction for the item(s), and generate a loan associated with the transaction.

Abstract: Disclosed in the present application are a reservoir computing network optimization method and a related apparatus. The method comprises: sampling an input signal to obtain a sampling signal; performing quantization processing on the sampling signal by means of at least two kinds of quantization modes, so as to obtain at least two kinds of digital signals, values of elements in different digital signals being different; inputting voltage pulses corresponding to the elements in the different digital signals into reservoirs constructed by different quantities of virtual nodes, so as to extract signal features of the input signal in different quantization modes by the different reservoirs. By quantizing signals in different modes and inputting same into reservoirs constructed by different quantities of virtual nodes, the richness of internal states of the reservoirs can be improved, thereby further improving the signal identification accuracy of a reservoir system.

Abstract: Disclosed is an apparatus for detecting a corrosion rate of a soil-covered storage tank after cathodic protection in the technical field of detection equipment for measuring electrical variables, including: a tank body, a guard plate, bases symmetrically and fixedly connected to both bottom sides of the tank body, spherical heads fixedly connected to both ends of the tank body, a corrosion rate detection mechanism, and a computing chip, where guide rails are symmetrically and fixedly connected to an inner side of the guard plate, limit plates are fixedly connected to both ends of the guide rails, a threaded rod is rotatably connected between the two limit plates, guide rods are symmetrically arranged on an outer side of the threaded rod, a moving plate is threadedly connected to the outer side of the threaded rod, the threaded rod is fixedly connected to an output end of a motor.