Patents by Inventor Yi Lun

Yi Lun has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Recombinant human acid alpha-glucosidase
    Patent number: 12246062
    Abstract: Provided are a recombinant acid ?-glucosidase and pharmaceutical composition comprising a recombinant acid ?-glucosidase, wherein the recombinant acid ?-glucosidase is expressed in Chinese hamster ovary (CHO) cells and comprises an increased content of N-glycan units bearing one or two mannose-6-phosphate residues when compared to a content of N-glycan units bearing one or two mannose-6-phosphate residues of alglucosidase alfa. Also provided herein are methods of producing, purifying, and formulating the recombinant acid ?-glucosidase or pharmaceutical composition for administration to a subject and methods of treating a disease or disorder such as Pompe disease using the recombinant acid ?-glucosidase or pharmaceutical composition.
    Type: Grant
    Filed: May 15, 2018
    Date of Patent: March 11, 2025
    Assignee: Amicus Therapeutics, Inc.
    Inventors: Hung Do, Russell Gotschall, Richie Khanna, Yi Lun, Hing Char, Sergey Tesler, Wendy Sunderland, Enrique Diloné
  • Recombinant Human Acid Alpha-Glucosidase
    Publication number: 20250057925
    Abstract: Provided are a recombinant acid ?-glucosidase and pharmaceutical composition comprising a recombinant acid ?-glucosidase, wherein the recombinant acid ?-glucosidase is expressed in Chinese hamster ovary (CHO) cells and comprises an increased content of N-glycan units bearing one or two mannose-6-phosphate residues when compared to a content of N-glycan units bearing one or two mannose-6-phosphate residues of alglucosidase alfa. Also provided herein are methods of producing, purifying, and formulating the recombinant acid ?-glucosidase or pharmaceutical composition for administration to a subject and methods of treating a disease or disorder such as Pompe disease using the recombinant acid ?-glucosidase or pharmaceutical composition.
    Type: Application
    Filed: November 11, 2024
    Publication date: February 20, 2025
    Applicant: Amicus Therapeutics, Inc.
    Inventors: Hung V. Do, Russell Gotschall, Richie Khanna, Yi Lun, Hing Char, Sergey Tesler, Wendy Sunderland, Enrique Diloné
  • RECOMBINANT HUMAN ACID ALPHA-GLUCOSIDASE
    Publication number: 20210393747
    Abstract: Provided are a recombinant acid ?-glucosidase and pharmaceutical composition comprising a recombinant acid ?-glucosidase, wherein the recombinant acid ?-glucosidase is expressed in Chinese hamster ovary (CHO) cells and comprises an increased content of N-glycan units bearing one or two mannose-6-phosphate residues when compared to a content of N-glycan units bearing one or two mannose-6-phosphate residues of alglucosidase alfa. Also provided herein are methods of producing, purifying, and formulating the recombinant acid ?-glucosidase or pharmaceutical composition for administration to a subject and methods of treating a disease or disorder such as Pompe disease using the recombinant acid ?-glucosidase or pharmaceutical composition.
    Type: Application
    Filed: May 15, 2018
    Publication date: December 23, 2021
    Inventors: Hung DO, Russell Gotschall, Richie Khanna, Yi Lun, Hing Char, Sergey Tesler, Wendy Sunderland, Enrique Diloné
  • Faucet
    Patent number: D515181
    Type: Grant
    Filed: April 30, 2004
    Date of Patent: February 14, 2006
    Assignee: Globe Union Industrial Corp.
    Inventors: Yi Lun, Tan Wan-Hong