Abstract: The present invention relates to nucleic acid sequences that encode hepatitis C viruses (HCV) of genotype 6a that are useful in the fundamental research of HCV as well as in the search of antivirals and vaccines against HCV. In particular, the present invention relates to nucleic acid sequences that comprises HCVs, which are capable of expressing said virus when transfected into cells and are capable of replication or infectivity in cultured cells.

Abstract: The present invention relates to nucleic acid sequences that encode hepatitis C viruses (HCV) of genotype 6a that are useful in the fundamental research of HCV as well as in the search of antivirals and vaccines against HCV. In particular, the present invention relates to nucleic acid sequences that comprises HCVs, which are capable of expressing said virus when transfected into cells and are capable of replication or infectivity in cultured cells.

Abstract: Method of reducing or preventing muscle loss, such as from cancer-induced cachexia, p38? MAPK inhibitors are provided. Compositions for use in such methods are also provided.

Abstract: A pulse modulation method for adjusting pulse signals according to a working voltage of a load, the method includes the following steps. The working voltage of the load is detected by a feedback terminal of a PWM controller. Whether the load is a light load or a heavy load is determined, if the load is a light load, a pulse skipping mode is entered; the voltage output to the load is detected by the feedback terminal. Whether the voltage output to the load is normal is determined, if the voltage output to the load is low, the pulse skipping mode is stayed for a number of clock cycles; the voltage output to the load is detected to determine whether the voltage is normal. If the voltage output to the load is still low, the pulse skipping mode is jumped out and a normal working mode is entered.

Abstract: A pulse modulation method for adjusting pulse signals according to a working voltage of a load, the method includes the following steps. The working voltage of the load is detected by a feedback terminal of a PWM controller. Whether the load is a light load or a heavy load is determined, if the load is a light load, a pulse skipping mode is entered; the voltage output to the load is detected by the feedback terminal. Whether the voltage output to the load is normal is determined, if the voltage output to the load is low, the pulse skipping mode is stayed for a number of clock cycles; the voltage output to the load is detected to determine whether the voltage is normal. If the voltage output to the load is still low, the pulse skipping mode is jumped out and a normal working mode is entered.

Abstract: A PWM control system includes a multi-phase PWM controller and at least one single-phase PWM controller. The multi-phase PWM controller is capable of generating a multi-phase PWM signal. The at least one single-phase PWM controller is capable of generating a single-phase PWM signal. A phase difference between the single-phase PWM signal and the multi-phase signal is greater than 0 degree and less than 180 degree.

Abstract: A PWM control system includes a multi-phase PWM controller and at least one single-phase PWM controller. The multi-phase PWM controller is capable of generating a multi-phase PWM signal. The at least one single-phase PWM controller is capable of generating a single-phase PWM signal. A phase difference between the single-phase PWM signal and the multi-phase signal is greater than 0 degree and less than 180 degree.

Abstract: The invention provides nucleic acid molecules derived from human osteoblasts. The nucleic acid molecules are used in applications such as diagnostic methods, screening assays and as hybridization probes and primers.

Abstract: Novel gene encoding a human 116-kDa osteoclast proton pump subunit and the protein encoded thereby. Methods of treatment of bone mass disorders utilizing said gene, and antibodies that bind to the protein encoded by said gene.

Abstract: Novel gene encoding a human 116-kDa osteoclast proton pump subunit and the protein encoded thereby. Methods of treatment of bone mass disorders utilizing said gene, and antibodies that bind to the protein encoded by said gene.

Abstract: The present invention relates to purified osteoclast-specific or -related DNA sequences and a method for identifying such sequences. DNA constructs capable of replicating osteoclast-specific or -related DNA and DNA constructs capable of directing expression in a host cell of osteoclast-specific or -related DNA are also described.

Abstract: The present invention relates to purified DNA sequences encoding all or a portion of an osteoclast-specific or -related gene products and a method for identifying such sequences. The invention also relates to antibodies directed against an osteoclast-specific or -related gene product. Also claimed are DNA constructs capable of replicating DNA encoding all or a portion of an osteoclast-specific or -related gene product, and DNA constructs capable of directing expression in a host cell of an osteoclast-specific or -related gene product.

Abstract: The present invention relates to a method of identifying DNA encoding an osteoclast-specific or -related gene product. The method comprises hybridizing DNA with a stromal cell+, osteoclast+probe, or with cDNA or mRNA from an osteoclastoma, and with a stromal cell+, osteoclast-probe, or with cDNA or mRNA from stromal cells; and identifying DNA which hybridizes to the stromal cell+, osteoclast+probe, or to cDNA or mRNA from osteoclastoma, but not to the stromal cell+, osteoclast-probe, or to cDNA or mRNA from stromal cells.

Abstract: The present invention relates to purified DNA sequences encoding all or a portion of an osteoclast-specific or -related gene products and a method for identifying such sequences. The invention also relates to antibodies directed against an osteoclast-specific or -related gene product. Also claimed are DNA constructs capable of replicating DNA encoding all or a portion of an osteoclast-specific or -related gene product, and DNA constructs capable of directing expression in a host cell of an osteoclast-specific or -related gene product.